Synthesis of Novel Quaternary Ammonium Salts and Their in Vitro Antileishmanial Activity and U-937 Cell Cytotoxicity

ABSTRACT: This work describes the synthesis of a series of quaternary ammonium salts and the assessment of their in vitro antileishmanial activity and cytotoxicity. A preliminary discussion on a structure-activity relationship of the compounds is also included. Three series of quaternary ammonium sa...

Full description

Autores:

Robledo Restrepo, Sara María
Vélez Bernal, Iván Darío
Ríos Vásquez, Luz Amalia
Ocampo Cardona, Rogelio
Duque Benítez, Sandra Milena
Cedeño, David L.
Jones, Marjorie A.

Tipo de recurso:

Article of investigation

Fecha de publicación:

2016

Institución:

Universidad de Antioquia

Repositorio:

Repositorio UdeA

Idioma:

eng

OAI Identifier:

oai:bibliotecadigital.udea.edu.co:10495/43316

Acceso en línea:

https://hdl.handle.net/10495/43316

Palabra clave:

Leishmania
Leishmaniasis
Compuestos de Amonio
Ammonium Compounds
Antiprotozoarios
Antiprotozoal Agents
Compuestos de Amonio Cuaternario
Quaternary Ammonium Compounds
Sales (Química)
Salts
Relación Estructura-Actividad
Structure-Activity Relationship
Células U937
Citotoxicidad
Cytotoxicity
U937 Cells
http://aims.fao.org/aos/agrovoc/c_34251
https://id.nlm.nih.gov/mesh/D007891
https://id.nlm.nih.gov/mesh/D007896
https://id.nlm.nih.gov/mesh/D064751
https://id.nlm.nih.gov/mesh/D000981
https://id.nlm.nih.gov/mesh/D000644
https://id.nlm.nih.gov/mesh/D012492
https://id.nlm.nih.gov/mesh/D013329
https://id.nlm.nih.gov/mesh/D020298

Rights

openAccess

License

http://creativecommons.org/licenses/by/2.5/co/