Loss of SIRT2 leads to axonal degeneration and locomotor disability associated with redox and energy imbalance

ABSTRACT: Sirtuin 2 (SIRT2) is a member of a family of NAD+ -dependent histone deacetylases (HDAC) that play diverse roles in cellular metabolism and especially for aging process. SIRT2 is located in the nucleus, cytoplasm, and mitochondria, is highly expressed in the central nervous system (CNS), a...

Full description

Autores:

Ruiz Cortés, Zulma Tatiana
fourcade, Stéphane
Morató, Laia
Parameswaran, Janani
Ruiz, Montserrat
Jové, Ariona
Naudí, Alba
Martínez Redondo, Paloma
Dierssen, Mara
Ferrer, Isidre
Villarroya, Francesc
Pamplona, Reinald
Vaquero, Alejandro
Portero Otín, Manel
Pujol, Aurora

Tipo de recurso:

Article of investigation

Fecha de publicación:

2017

Institución:

Universidad de Antioquia

Repositorio:

Repositorio UdeA

Idioma:

eng

OAI Identifier:

oai:bibliotecadigital.udea.edu.co:10495/34420

Acceso en línea:

https://hdl.handle.net/10495/34420

Palabra clave:

Envejecimiento
Aging
Axones
Axons
ADN Mitocondrial
DNA, Mitochondrial
Metabolismo Energético
Energy Metabolism
Ratones
Mice
Ratones Endogámicos C57BL
Mice, Inbred C57BL
Ratones Noqueados
Mice, Knockout
Sirtuinas 2
Sirtuins 2
Enfermedades Neurodegenerativas
Neurodegenerative Diseases

Rights

openAccess

License

https://creativecommons.org/licenses/by/4.0/