Tanycytes of the hypothalamic median eminence form a diet-responsive neurogenic niche.

ABSTRACT:Adult hypothalamic neurogenesis has been recently reported, but the cell of origin and function of these newborn neurons are unknown. We utilize genetic fate mapping to show that median eminence tanycytes generate newborn neurons; blocking this neurogenesis alters weight and metabolic activ...

Full description

Autores:
Miranda Angulo, Ana Lucia
Lee, Daniel A.
Bedont, Joseph L.
Pak, Thomas
Wang, Hong
Song, Juan
Takiar, Vani
Charubhumi, Vanessa
Balordi, Francesca
Takebayashi, Hirohide
Aja, Susan
Ford, Eric
Fishell, Gordon
Blackshaw, Seth
Tipo de recurso:
Article of investigation
Fecha de publicación:
2012
Institución:
Universidad de Antioquia
Repositorio:
Repositorio UdeA
Idioma:
eng
OAI Identifier:
oai:bibliotecadigital.udea.edu.co:10495/36725
Acceso en línea:
https://hdl.handle.net/10495/36725
Palabra clave:
Neurogénesis
Hipotálamo
Hypothalamus
Peso corporal
Body Weight
Bromodesoxiuridina
Bromodeoxyuridine
Dieta alta en grases
Diet hight fat
Eminencia Media
Median Eminence
Ratones endogámicos C57BL
Mice, Inbred C57BL
Receptores de estrógeno
Receptors, Estrogen
Tamoxifeno
Tamoxifen
Rights
openAccess
License
http://creativecommons.org/licenses/by/2.5/co/
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network_acronym_str UDEA2
network_name_str Repositorio UdeA
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dc.title.spa.fl_str_mv Tanycytes of the hypothalamic median eminence form a diet-responsive neurogenic niche.
title Tanycytes of the hypothalamic median eminence form a diet-responsive neurogenic niche.
spellingShingle Tanycytes of the hypothalamic median eminence form a diet-responsive neurogenic niche.
Neurogénesis
Hipotálamo
Hypothalamus
Peso corporal
Body Weight
Bromodesoxiuridina
Bromodeoxyuridine
Dieta alta en grases
Diet hight fat
Eminencia Media
Median Eminence
Ratones endogámicos C57BL
Mice, Inbred C57BL
Receptores de estrógeno
Receptors, Estrogen
Tamoxifeno
Tamoxifen
title_short Tanycytes of the hypothalamic median eminence form a diet-responsive neurogenic niche.
title_full Tanycytes of the hypothalamic median eminence form a diet-responsive neurogenic niche.
title_fullStr Tanycytes of the hypothalamic median eminence form a diet-responsive neurogenic niche.
title_full_unstemmed Tanycytes of the hypothalamic median eminence form a diet-responsive neurogenic niche.
title_sort Tanycytes of the hypothalamic median eminence form a diet-responsive neurogenic niche.
dc.creator.fl_str_mv Miranda Angulo, Ana Lucia
Lee, Daniel A.
Bedont, Joseph L.
Pak, Thomas
Wang, Hong
Song, Juan
Takiar, Vani
Charubhumi, Vanessa
Balordi, Francesca
Takebayashi, Hirohide
Aja, Susan
Ford, Eric
Fishell, Gordon
Blackshaw, Seth
dc.contributor.author.none.fl_str_mv Miranda Angulo, Ana Lucia
Lee, Daniel A.
Bedont, Joseph L.
Pak, Thomas
Wang, Hong
Song, Juan
Takiar, Vani
Charubhumi, Vanessa
Balordi, Francesca
Takebayashi, Hirohide
Aja, Susan
Ford, Eric
Fishell, Gordon
Blackshaw, Seth
dc.contributor.researchgroup.spa.fl_str_mv Grupo de Investigación en Psiquiatría GIPSI
dc.subject.decs.none.fl_str_mv Neurogénesis
Hipotálamo
Hypothalamus
Peso corporal
Body Weight
Bromodesoxiuridina
Bromodeoxyuridine
Dieta alta en grases
Diet hight fat
Eminencia Media
Median Eminence
Ratones endogámicos C57BL
Mice, Inbred C57BL
Receptores de estrógeno
Receptors, Estrogen
Tamoxifeno
Tamoxifen
topic Neurogénesis
Hipotálamo
Hypothalamus
Peso corporal
Body Weight
Bromodesoxiuridina
Bromodeoxyuridine
Dieta alta en grases
Diet hight fat
Eminencia Media
Median Eminence
Ratones endogámicos C57BL
Mice, Inbred C57BL
Receptores de estrógeno
Receptors, Estrogen
Tamoxifeno
Tamoxifen
description ABSTRACT:Adult hypothalamic neurogenesis has been recently reported, but the cell of origin and function of these newborn neurons are unknown. We utilize genetic fate mapping to show that median eminence tanycytes generate newborn neurons; blocking this neurogenesis alters weight and metabolic activity in adult mice. These findings describe a previously unreported neurogenic niche within the mammalian hypothalamus with important implications for metabolism.
publishDate 2012
dc.date.issued.none.fl_str_mv 2012
dc.date.accessioned.none.fl_str_mv 2023-10-02T14:26:15Z
dc.date.available.none.fl_str_mv 2023-10-02T14:26:15Z
dc.type.spa.fl_str_mv Artículo de investigación
dc.type.coar.spa.fl_str_mv http://purl.org/coar/resource_type/c_2df8fbb1
dc.type.redcol.spa.fl_str_mv https://purl.org/redcol/resource_type/ART
dc.type.coarversion.spa.fl_str_mv http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.driver.spa.fl_str_mv info:eu-repo/semantics/article
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dc.identifier.citation.spa.fl_str_mv Lee DA, Bedont JL, Pak T, Wang H, Song J, Miranda-Angulo A, Takiar V, Charubhumi V, Balordi F, Takebayashi H, Aja S, Ford E, Fishell G, Blackshaw S. Tanycytes of the hypothalamic median eminence form a diet-responsive neurogenic niche. Nat Neurosci. 2012 Mar 25;15(5):700-2. doi: 10.1038/nn.3079. PMID: 22446882; PMCID: PMC3380241.
dc.identifier.issn.none.fl_str_mv 1097-6256
dc.identifier.uri.none.fl_str_mv https://hdl.handle.net/10495/36725
dc.identifier.doi.none.fl_str_mv 10.1038/nn.3079
dc.identifier.eissn.none.fl_str_mv 1546-1726
identifier_str_mv Lee DA, Bedont JL, Pak T, Wang H, Song J, Miranda-Angulo A, Takiar V, Charubhumi V, Balordi F, Takebayashi H, Aja S, Ford E, Fishell G, Blackshaw S. Tanycytes of the hypothalamic median eminence form a diet-responsive neurogenic niche. Nat Neurosci. 2012 Mar 25;15(5):700-2. doi: 10.1038/nn.3079. PMID: 22446882; PMCID: PMC3380241.
1097-6256
10.1038/nn.3079
1546-1726
url https://hdl.handle.net/10495/36725
dc.language.iso.spa.fl_str_mv eng
language eng
dc.relation.ispartofjournalabbrev.spa.fl_str_mv Nat. Neurosci.
dc.relation.citationendpage.spa.fl_str_mv 11
dc.relation.citationissue.spa.fl_str_mv 5
dc.relation.citationstartpage.spa.fl_str_mv 1
dc.relation.citationvolume.spa.fl_str_mv 15
dc.relation.ispartofjournal.spa.fl_str_mv Nature Neuroscience
dc.rights.uri.*.fl_str_mv http://creativecommons.org/licenses/by/2.5/co/
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dc.publisher.spa.fl_str_mv Nature Research
dc.publisher.place.spa.fl_str_mv Nueva York, Estados Unidos
institution Universidad de Antioquia
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spelling Miranda Angulo, Ana LuciaLee, Daniel A.Bedont, Joseph L.Pak, ThomasWang, HongSong, JuanTakiar, VaniCharubhumi, VanessaBalordi, FrancescaTakebayashi, HirohideAja, SusanFord, EricFishell, GordonBlackshaw, SethGrupo de Investigación en Psiquiatría GIPSI2023-10-02T14:26:15Z2023-10-02T14:26:15Z2012Lee DA, Bedont JL, Pak T, Wang H, Song J, Miranda-Angulo A, Takiar V, Charubhumi V, Balordi F, Takebayashi H, Aja S, Ford E, Fishell G, Blackshaw S. Tanycytes of the hypothalamic median eminence form a diet-responsive neurogenic niche. Nat Neurosci. 2012 Mar 25;15(5):700-2. doi: 10.1038/nn.3079. PMID: 22446882; PMCID: PMC3380241.1097-6256https://hdl.handle.net/10495/3672510.1038/nn.30791546-1726ABSTRACT:Adult hypothalamic neurogenesis has been recently reported, but the cell of origin and function of these newborn neurons are unknown. We utilize genetic fate mapping to show that median eminence tanycytes generate newborn neurons; blocking this neurogenesis alters weight and metabolic activity in adult mice. These findings describe a previously unreported neurogenic niche within the mammalian hypothalamus with important implications for metabolism.COL002914711application/pdfengNature ResearchNueva York, Estados Unidoshttp://creativecommons.org/licenses/by/2.5/co/https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Tanycytes of the hypothalamic median eminence form a diet-responsive neurogenic niche.Artículo de investigaciónhttp://purl.org/coar/resource_type/c_2df8fbb1https://purl.org/redcol/resource_type/ARThttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionNeurogénesisHipotálamoHypothalamusPeso corporalBody WeightBromodesoxiuridinaBromodeoxyuridineDieta alta en grasesDiet hight fatEminencia MediaMedian EminenceRatones endogámicos C57BLMice, Inbred C57BLReceptores de estrógenoReceptors, EstrogenTamoxifenoTamoxifenNat. 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