Protective Efect of the LRRK2 Kinase Inhibition in Human Fibroblasts Bearing the Genetic Variant GBA1 K198E: Implications for Parkinson’s Disease

Parkinson's disease (PD) is a chronic and progressive neurodegenerative disorder for which there are currently no curative therapies. Therefore, the need for innovative treatments for this illness is critical. The glucosylceramidase beta 1 (GBA1) and leucine-rich repeated kinase 2 (LRRK2) genes...

Full description

Autores:

Pérez Abshana, Laura Patricia
Mendívil Pérez, Miguel Ángel
Vélez Pardo, Carlos Alberto
Jiménez del Río, Marlene

Tipo de recurso:

Article of investigation

Fecha de publicación:

2025

Institución:

Universidad de Antioquia

Repositorio:

Repositorio UdeA

Idioma:

eng

OAI Identifier:

oai:bibliotecadigital.udea.edu.co:10495/46373

Acceso en línea:

https://hdl.handle.net/10495/46373

Palabra clave:

Autofagia - Efectos de los fármacos
Autophagy - Drug effects
Inhibidores de Proteínas Quinasas - Farmacología
Protein Kinase Inhibitors - Pharmacology
Glucosilceramidasa - Genética
Glucosylceramidase - Genetics
Fibroblastos
Fibroblasts
Proteína 2 Quinasa Serina - Treonina Rica en Repeticiones de Leucina
Leucine - Rich Repeat Serine - Threonine Protein Kinase-2
Lisosomas - Efectos de los fármacos
Lysosomes - Drug effects
Pirimidinas
Pyrimidines
Indazoles
Enfermedad de Parkinson
Parkinson disease
https://id.nlm.nih.gov/mesh/D001343
https://id.nlm.nih.gov/mesh/D047428
https://id.nlm.nih.gov/mesh/D005962
https://id.nlm.nih.gov/mesh/D005347
https://id.nlm.nih.gov/mesh/D000071158
https://id.nlm.nih.gov/mesh/D008247
http://id.nlm.nih.gov/mesh/D011743
http://id.nlm.nih.gov/mesh/D007191
ODS 3: Salud y bienestar. Garantizar una vida sana y promover el bienestar de todos a todas las edades

Rights

openAccess

License

http://creativecommons.org/licenses/by/4.0/