Pseudoirreversible slow-binding inhibition of trypanothione reductase by a protein-protein interaction disruptor

ABSTRACT: Background and purpose: Peptide P4 was described as a dimerization disruptor of trypanothione reductase (TryR), a homodimeric enzyme essential for survival of trypanosomatids. Determination of the true inhibitory constant (Ki ) for P4 was not achieved because reaction rates continuously de...

Full description

Autores:

Toro Londoño, Miguel Ángel
de Lucio, Héctor
Camarasa, María José
Velázquez, Sonsoles
Gago, Federico
Jiménez Ruiz, Antonio

Tipo de recurso:

Article of investigation

Fecha de publicación:

2020

Institución:

Universidad de Antioquia

Repositorio:

Repositorio UdeA

Idioma:

eng

OAI Identifier:

oai:bibliotecadigital.udea.edu.co:10495/44162

Acceso en línea:

https://hdl.handle.net/10495/44162

Palabra clave:

Dimerización
Dimerization
Inhibidores Enzimáticos
Enzyme Inhibitors
Leishmania infantum
NADH NADPH Oxidorreductasas
NADH, NADPH Oxidoreductases
Trypanosomatina
https://id.nlm.nih.gov/mesh/D019281
https://id.nlm.nih.gov/mesh/D004791
https://id.nlm.nih.gov/mesh/D018314
https://id.nlm.nih.gov/mesh/D009247
https://id.nlm.nih.gov/mesh/D014351

Rights

openAccess

License

https://creativecommons.org/licenses/by-nc-nd/2.5/co/