NNT mediates redox-dependent pigmentation via a UVB- and MITF-independent mechanism

ABSTRACT: Ultraviolet (UV) light and incompletely understood genetic and epigenetic variations determine skin color. Here we describe an UV- and microphthalmia-associated transcription factor (MITF)-independent mechanism of skin pigmentation. Targeting the mitochondrial redox-regulating enzyme nicot...

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Autores:

Bedoya Berrío, Gabriel de Jesús
Ruíz Linares, Andrés
Rachmin, Inbal
Adhikari, Kaustubh
Pardo, Luba M.
Lee, Ju Hee
McConnell, Alicia M.
Kato, Shinichiro
Fan, Shaohua
Kawakami, Akinori
Suita, Yusuke
Wakamatsu, Kazumasa
Igras, Vivien
Zhang, Jianming
Navarro, Paula P
Makhlouta Lugo, Camila
R Noonan, Haley
Christie, Kathleen A.
Itin, Kaspar
Mujahid, Nisma
Lo, Jennifer V.
Hyun Won, Chong
Evans, Conor L.
Yu Weng, Qing
Wang, Hequn
Osseiran, Sam
Lovas, Alyssa
Németh, István
Cozzio, Antonio
Navarini, Alexander A.
Hsiao, Jennifer J.
Nguyen, Nhu
Kemény, Lajos V.
Iliopoulos, Othon
Berking, Carola
Ruzicka, Thomas
Gonzalez-José, Rolando
Bortolini, Maria Cátira
Canizales Quinteros, Samuel
Acuna Alonso, Víctor
Gallo, Carla
Poletti, Giovanni
Rothhammer, Francisco
Ito, Shosuke
Schiaffino, Maria Vittoria
Chao, Luke H.
Kleinstiver, Benjamin P.
Tishkoff, Sarah
Zon, Leonard I.
Nijsten, Tamar
Allouche, Jennifer
Fisher, David E
Roider, Elisabeth

Tipo de recurso:

Article of investigation

Fecha de publicación:

2021

Institución:

Universidad de Antioquia

Repositorio:

Repositorio UdeA

Idioma:

eng

OAI Identifier:

oai:bibliotecadigital.udea.edu.co:10495/41091

Acceso en línea:

https://hdl.handle.net/10495/41091

Palabra clave:

Cell Line
Línea Celular
Cohort Studies
Estudios de Cohortes
Cyclic AMP
AMP Cíclico
DNA Damage
Daño del ADN
Enzyme Inhibitors
Inhibidores Enzimáticos
Genetic Predisposition to Disease
Predisposición Genética a la Enfermedad
Melanocytes
Melanocitos
Melanosomes
Melanosomas
Mice, Inbred C57BL
Ratones Endogámicos C57BL
Microphthalmia-Associated Transcription Factor
Factor de Transcripción Asociado a Microftalmía
Mitochondria
Mitocondria
Monophenol Monooxygenase
Monofenol Monooxigenasa
NADP Transhydrogenases
NADP Transhidrogenasas
Oxidation-Reduction
Oxidación-Reducción
Polymorphism, Single Nucleotide
Polimorfismo de Nucleótido Simple
Proteasome Endopeptidase Complex
Complejo de la Endopetidasa Proteasomal
Proteolysis
Proteólisis
RNA, Messenger
ARN Mensajero
Skin Pigmentation
Pigmentación de la Piel
Ubiquitin
Ultraviolet Rays
Rayos Ultravioletas
Ubiquitina
https://id.nlm.nih.gov/mesh/D002460
https://id.nlm.nih.gov/mesh/D015331
https://id.nlm.nih.gov/mesh/D000242
https://id.nlm.nih.gov/mesh/D004249
https://id.nlm.nih.gov/mesh/D004791
https://id.nlm.nih.gov/mesh/D020022
https://id.nlm.nih.gov/mesh/D008544
https://id.nlm.nih.gov/mesh/D020460
https://id.nlm.nih.gov/mesh/D008810
https://id.nlm.nih.gov/mesh/D051739
https://id.nlm.nih.gov/mesh/D008928
https://id.nlm.nih.gov/mesh/D014442
https://id.nlm.nih.gov/mesh/D009250
https://id.nlm.nih.gov/mesh/D010084
https://id.nlm.nih.gov/mesh/D020641
https://id.nlm.nih.gov/mesh/D046988
https://id.nlm.nih.gov/mesh/D059748
https://id.nlm.nih.gov/mesh/D012333
https://id.nlm.nih.gov/mesh/D012880
https://id.nlm.nih.gov/mesh/D025801
https://id.nlm.nih.gov/mesh/D014466

Rights

openAccess

License

http://creativecommons.org/licenses/by-nc/2.5/co/