Rapamycin Eyedrops Increased CD4+Foxp3+ Cells and Prevented Goblet Cell Loss in the Aged Ocular Surface

ABSTRACT: Inflammation and oxidative stress accompany aging. This study investigated the interplay between oxidative stress and inflammation in the lacrimal gland. C57BL/6 mice were used at 2 to 3, 12, and 24 months of age. Nuclear factor erythroid derived-2-related factor 2 (Nrf2)-/- and correspond...

Full description

Autores:

Trujillo Vargas, Claudia Milena
Kutlehria, Shallu
Hernández, Humberto
de Souza, Rodrigo G
Lee, Andrea
Yu, Zhiyuan
Pflugfelder, Stephen C
Singh, Mandip
de Paiva, Cintia S

Tipo de recurso:

Article of investigation

Fecha de publicación:

2020

Institución:

Universidad de Antioquia

Repositorio:

Repositorio UdeA

Idioma:

eng

OAI Identifier:

oai:bibliotecadigital.udea.edu.co:10495/40525

Acceso en línea:

https://hdl.handle.net/10495/40525

Palabra clave:

Aging
Envejecimiento
Autophagy-Related Protein-1 Homolog
Homólogo de la Proteína 1 Relacionada con la Autofagia
CD4 Antigens
Antígenos CD4
Cell Lineage
Linaje de la Célula
Conjunctiva
Conjuntiva
Cornea
Córnea
Disease Models, Animal
Modelos Animales de Enfermedad
Dry Eye Syndromes
Síndromes de Ojo Seco
Forkhead Transcription Factors
Factores de Transcripción Forkhead
Goblet Cells
Células Caliciformes
Inflammation
Inflamación
Interferon-gamma
Interferón gamma
Leukocyte Common Antigens
Antígenos Comunes de Leucocito
Ophthalmic Solutions
Soluciones Oftálmicas
Sirolimus
Sirolimus
Vascular Endothelial Growth Factor A
Factor A de Crecimiento Endotelial Vascular
https://id.nlm.nih.gov/mesh/D000375
https://id.nlm.nih.gov/mesh/D000071189
https://id.nlm.nih.gov/mesh/D015704
https://id.nlm.nih.gov/mesh/D019070
https://id.nlm.nih.gov/mesh/D003228
https://id.nlm.nih.gov/mesh/D003315
https://id.nlm.nih.gov/mesh/D004195
https://id.nlm.nih.gov/mesh/D015352
https://id.nlm.nih.gov/mesh/D051858
https://id.nlm.nih.gov/mesh/D020397
https://id.nlm.nih.gov/mesh/D007249
https://id.nlm.nih.gov/mesh/D007371
https://id.nlm.nih.gov/mesh/D017493
https://id.nlm.nih.gov/mesh/D009883
https://id.nlm.nih.gov/mesh/D020123
https://id.nlm.nih.gov/mesh/D042461

Rights

openAccess

License

https://creativecommons.org/licenses/by/4.0/