Nontherapeutic equivalence of a generic product of imipenem-cilastatin is caused more by chemical instability of the active pharmaceutical ingredient (imipenem) than by its substandard amount of cilastatin

ABSTRACT: The generic product had 30% lower concentration of cilastatin compared with the innovator of imipenem-cilastatin. Regarding the active pharmaceutical ingredient (imipenem), wefound no differences in MIC, MBC, concentration or potency or AUC, confirming equivalence in terms of in vitro acti...

Full description

Autores:

Agudelo Pérez, María
Rodríguez Jaramillo, Carlos Andrés
Zuluaga Salazar, Andrés Felipe
Vesga Meneses, Omar

Tipo de recurso:

Article of investigation

Fecha de publicación:

2019

Institución:

Universidad de Antioquia

Repositorio:

Repositorio UdeA

Idioma:

eng

OAI Identifier:

oai:bibliotecadigital.udea.edu.co:10495/23308

Acceso en línea:

http://hdl.handle.net/10495/23308

Palabra clave:

Combinación Cilastatina e Imipenem
Cilastatin, Imipenem Drug Combination
Equivalencia Terapéutica
Therapeutic Equivalency

Rights

openAccess

License

http://creativecommons.org/licenses/by/2.5/co/