Venomic, transcriptomic, and bioactivity analyses of pamphobeteus verdolaga venom reveal complex disulfide-rich peptides that modulate calcium channels

ABSTRACT: Pamphobeteus verdolaga is a recently described Theraphosidae spider from the Andean region of Colombia. Previous reports partially characterized its venom profile. In this study, we conducted a detailed analysis that includes reversed-phase high-performance liquid chromatography (rp-HPLC),...

Full description

Autores:

Estrada Gómez, Sebastián
Vargas Muñoz, Leidy Johana
Quintana Castillo, Juan Carlos
Caldas Cardoso, Fernanda
Arenas Gómez, Claudia Marcela
Pineda, Sandy Steffany
Saldarriaga Córdoba, Mónica María

Tipo de recurso:

Article of investigation

Fecha de publicación:

2019

Institución:

Universidad de Antioquia

Repositorio:

Repositorio UdeA

Idioma:

eng

OAI Identifier:

oai:bibliotecadigital.udea.edu.co:10495/40661

Acceso en línea:

https://hdl.handle.net/10495/40661

Palabra clave:

Secuencia de Aminoácidos
Amino Acid Sequence
Bloqueadores de los Canales de Calcio - aislamiento & purificación
Calcium Channel Blockers - isolation & purification
Bloqueadores de los Canales de Calcio - farmacología
Calcium Channel Blockers - pharmacology
Canales de Calcio - metabolismo
Calcium Channels - metabolism
Línea Celular Tumoral
Cell Line, Tumor
Disulfuros - aislamiento & purificación
Disulfides - isolation & purification
Disulfuros - farmacología
Disulfides - pharmacology
Anotación de Secuencia Molecular
Molecular Sequence Annotation
Péptidos
Peptides
Alineación de Secuencia
Sequence Alignment
Venenos de Araña - química
Spider Venoms - chemistry
Venenos de Araña - genética
Spider Venoms - genetics
Arañas - genética
Spiders - genetics
Transcriptoma - genética
Transcriptome - genetics
https://id.nlm.nih.gov/mesh/D000595
https://id.nlm.nih.gov/mesh/D002121
https://id.nlm.nih.gov/mesh/D015220
https://id.nlm.nih.gov/mesh/D045744
https://id.nlm.nih.gov/mesh/D004220
https://id.nlm.nih.gov/mesh/D058977
https://id.nlm.nih.gov/mesh/D010455
https://id.nlm.nih.gov/mesh/D016415
https://id.nlm.nih.gov/mesh/D013111
https://id.nlm.nih.gov/mesh/D013112
https://id.nlm.nih.gov/mesh/D059467

Rights

openAccess

License

http://creativecommons.org/licenses/by/2.5/co/