A Neanderthal haplotype introgressed into the human genome confers protection against membranous nephropathy

ABSTRACT: Class 2 HLA and PLA2R1 alleles are exceptionally strong genetic risk factors for membranous nephropathy (MN), leading, through an unknown mechanism, to a targeted autoimmune response. Introgressed archaic haplotypes (introduced from an archaic human genome into the modern human genome) mig...

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Autores:

Arcos Burgos, Oscar Mauricio
Voinescu, Cătălin D.
Mozere, Monika
Genovese, Giulio
Downie, Mallory L
Gupta, Sanjana
Gale, Daniel P
Bockenhauer, Detlef
Kleta, Robert
Stanescu, Horia C

Tipo de recurso:

Article of investigation

Fecha de publicación:

2024

Institución:

Universidad de Antioquia

Repositorio:

Repositorio UdeA

Idioma:

eng

OAI Identifier:

oai:bibliotecadigital.udea.edu.co:10495/42271

Acceso en línea:

https://hdl.handle.net/10495/42271

Palabra clave:

Genoma Humano
Genome, Human
Estudio de Asociación del Genoma Completo
Genome-Wide Association Study
Insuficiencia Renal Crónica
Renal Insufficiency, Chronic
Glomerulonefritis Membranosa
Glomerulonephritis, Membranous
Síndrome Nefrótico
Nephrotic Syndrome
Haplotipos
Haplotypes
Hombre de Neandertal - genética
Neanderthals - genetics
Receptores de Fosfolipasa A2
Receptors, Phospholipase A2
https://id.nlm.nih.gov/mesh/D015894
https://id.nlm.nih.gov/mesh/D055106
https://id.nlm.nih.gov/mesh/D051436
https://id.nlm.nih.gov/mesh/D015433
https://id.nlm.nih.gov/mesh/D009404
https://id.nlm.nih.gov/mesh/D006239
https://id.nlm.nih.gov/mesh/D059125
https://id.nlm.nih.gov/mesh/D054507

Rights

openAccess

License

https://creativecommons.org/licenses/by/4.0/