Combretastatin A-4: The Antitubulin Agent that Inspired the Design and Synthesis of Styrene and Spiroisatin Hybrids as Promising Cytotoxic, Antifungal and Antiviral Compounds

ABSTRACT: The design of a series of styrene and spiroisatin hybrids was based on the structure of combretastatin A-4 1. This library of 20 compounds were synthesized with the pharmacophoric units: 3,4,5-trimethoxy or/and 4-hydroxy-3-methoxy phenyl moities in their structure. Thereby, the libraries o...

Full description

Autores:

Tangarife Castaño, Verónica
Betancur Galvis, Liliana Amparo
Roa Linares, Vicky Constanza
Brand Miranda, Yaneth de Jesú
Kouznetsov, Vladimir
Puerto Galvis, sCarlos Eduardo

Tipo de recurso:

Article of investigation

Fecha de publicación:

2020

Institución:

Universidad de Antioquia

Repositorio:

Repositorio UdeA

Idioma:

eng

OAI Identifier:

oai:bibliotecadigital.udea.edu.co:10495/40306

Acceso en línea:

https://hdl.handle.net/10495/40306

Palabra clave:

Antifungal Agents
Antifúngicos
Antiviral Agents
Antivirales
Cytotoxins
Citotoxinas
https://id.nlm.nih.gov/mesh/D000935
https://id.nlm.nih.gov/mesh/D000998
https://id.nlm.nih.gov/mesh/D003603

Rights

openAccess

License

https://creativecommons.org/licenses/by/4.0/