Synthesis, biological evaluation and structure-activity relationships of new quinoxaline derivatives as anti-Plasmodium falciparum agents
ABSTARCT: We report the synthesis and antimalarial activities of eighteen quinoxaline and quinoxaline 1,4-di-N-oxide derivatives, eight of which are completely novel. Compounds 1a and 2a were the most active against Plasmodium falciparum strains. Structure-activity relationships demonstrated the imp...
- Autores:
-
Pabón Vidal, Adriana Lucía
Gil, Ana Gloria
Galiano, Silvia
Perez Silanes, Silvia
Daharo, Eric
Monge, Antonio
Aldana, Ignacio
Burguete, Asunción
- Tipo de recurso:
- Article of investigation
- Fecha de publicación:
- 2014
- Institución:
- Universidad de Antioquia
- Repositorio:
- Repositorio UdeA
- Idioma:
- eng
- OAI Identifier:
- oai:bibliotecadigital.udea.edu.co:10495/11994
- Acceso en línea:
- http://hdl.handle.net/10495/11994
- Palabra clave:
- Antimalarial agents
Brimonidine Tartrate
Chalcone
Plasmodium falciparum
Quinoxaline
Tartrato de Brimonidina
- Rights
- openAccess
- License
- https://creativecommons.org/licenses/by/4.0/
| Summary: | ABSTARCT: We report the synthesis and antimalarial activities of eighteen quinoxaline and quinoxaline 1,4-di-N-oxide derivatives, eight of which are completely novel. Compounds 1a and 2a were the most active against Plasmodium falciparum strains. Structure-activity relationships demonstrated the importance of an enone moiety linked to the quinoxaline ring. Keywords: Plasmodium falciparum; antimalarial agents; quinoxaline; quinoxaline 1,4-di-N-oxide; chalcone |
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