Synthesis, biological evaluation and structure-activity relationships of new quinoxaline derivatives as anti-Plasmodium falciparum agents

ABSTARCT: We report the synthesis and antimalarial activities of eighteen quinoxaline and quinoxaline 1,4-di-N-oxide derivatives, eight of which are completely novel. Compounds 1a and 2a were the most active against Plasmodium falciparum strains. Structure-activity relationships demonstrated the imp...

Full description

Autores:

Pabón Vidal, Adriana Lucía
Gil, Ana Gloria
Galiano, Silvia
Perez Silanes, Silvia
Daharo, Eric
Monge, Antonio
Aldana, Ignacio
Burguete, Asunción

Tipo de recurso:

Article of investigation

Fecha de publicación:

2014

Institución:

Universidad de Antioquia

Repositorio:

Repositorio UdeA

Idioma:

eng

OAI Identifier:

oai:bibliotecadigital.udea.edu.co:10495/11994

Acceso en línea:

http://hdl.handle.net/10495/11994

Palabra clave:

Antimalarial agents
Brimonidine Tartrate
Chalcone
Plasmodium falciparum
Quinoxaline
Tartrato de Brimonidina

Rights

openAccess

License

https://creativecommons.org/licenses/by/4.0/