Synthesis and biological evaluation of combretastatin A-4 and three combretastatin-based hybrids

ABSTRACT: The syntheses of combretastatin A-4 from gallic acid and of three combretastatin-based hybrids are described. Starting from commercial gallic acid, thephosphonium salt (3,4,5-trimethoxybenzylphosphonium bromide) is synthesized and coupled, through a Wittig reaction, with several aldehydes,...

Full description

Autores:

Agudelo Goméz, Lee Solbay
Tangarife Castaño, Verónica
Betancur Galvis, Liliana Amparo
Zapata Londoño, María Bibiana
Pérez Guaita, David
González, Miguel

Tipo de recurso:

Article of investigation

Fecha de publicación:

2012

Institución:

Universidad de Antioquia

Repositorio:

Repositorio UdeA

Idioma:

eng

OAI Identifier:

oai:bibliotecadigital.udea.edu.co:10495/41216

Acceso en línea:

https://hdl.handle.net/10495/41216

Palabra clave:

Antifúngicos
Antifungal Agents
Antivirales
Antiviral Agents
Biología Molecular
Molecular Biology
Estilbenos
Stilbenes
https://id.nlm.nih.gov/mesh/D000935
https://id.nlm.nih.gov/mesh/D000998
https://id.nlm.nih.gov/mesh/D008967
https://id.nlm.nih.gov/mesh/D013267

Rights

openAccess

License

http://creativecommons.org/licenses/by-nc/2.5/co/