Use of preclinical data for selection of a phase II/III dose for evernimicin and identification of a preclinical MIC breakpoint

ABSTRACT: One of the most challenging issues in the design of phase II/III clinical trials of antimicrobial agents is dose selection. The choice is often based on preclinical data from pharmacokinetic (PK) studies with animals and healthy volunteers but is rarely linked directly to the target organi...

Full description

Autores:

Vesga Meneses, Omar
Preston, S. L.
Hardalo, C.
Hare, R.
Banfield, C.
Andes, D.
Drusano, G. L.
Craig, W. A.

Tipo de recurso:

Article of investigation

Fecha de publicación:

2001

Institución:

Universidad de Antioquia

Repositorio:

Repositorio UdeA

Idioma:

eng

OAI Identifier:

oai:bibliotecadigital.udea.edu.co:10495/44543

Acceso en línea:

https://hdl.handle.net/10495/44543

Palabra clave:

Aminoglicósidos
Aminoglycosides
Antibacterianos
Anti-Bacterial Agents
Resistencia a la Meticilina
Methicillin Resistance
Método de Montecarlo
Monte Carlo Method
Oligosacáridos
Oligosaccharides
Área Bajo la Curva
Area Under Curve
Bacterias Grampositivas
Gram-Positive Bacteria
Infecciones Bacterianas
Bacterial Infections
Pruebas de Sensibilidad Microbiana
Microbial Sensitivity Tests
Staphylococcus aureus
Unión Proteica
Protein Binding
https://id.nlm.nih.gov/mesh/D008826
https://id.nlm.nih.gov/mesh/D009010
https://id.nlm.nih.gov/mesh/D009844
https://id.nlm.nih.gov/mesh/D011485
https://id.nlm.nih.gov/mesh/D016106
https://id.nlm.nih.gov/mesh/D000617
https://id.nlm.nih.gov/mesh/D000900
https://id.nlm.nih.gov/mesh/D019540vvvvvvvvvvvvvvvvvvvvvvvvvvvvvvvvvvvvvvvvvvvvvvvvvvvvvvvvvvvvvvvvvvvv
https://id.nlm.nih.gov/mesh/D001424
https://id.nlm.nih.gov/mesh/D006094

Rights

openAccess

License

http://creativecommons.org/licenses/by/2.5/co/