The Production of Reactive Oxygen Species Is a Universal Action Mechanism of Amphotericin B against Pathogenic Yeasts and Contributes to the Fungicidal Effect of This Drug

ABSTRACT: Amphotericin B (AMB) is an antifungal drug that binds to ergosterol and forms pores at the cell membrane, causing the loss of ions. In addition, AMB induces the accumulation of reactive oxygen species (ROS), and although these molecules have multiple deleterious effects on fungal cells, th...

Full description

Autores:

Mesa Arango, Ana Cecilia
Trevijano Contador, Nuria
Román, Elvira
Sánchez Fresneda, Ruth
Casas, Celia
Herrero, Enrique
Argüelles, Juan Carlos
Pla, Jesus
Cuenca Estrella, Manuel
Zaragosa, Oscar

Tipo de recurso:

Article of investigation

Fecha de publicación:

2014

Institución:

Universidad de Antioquia

Repositorio:

Repositorio UdeA

Idioma:

eng

OAI Identifier:

oai:bibliotecadigital.udea.edu.co:10495/26423

Acceso en línea:

http://hdl.handle.net/10495/26423

Palabra clave:

Anfotericina B
Amphotericin B
Antifúngicos
Antifungal Agents
Candidiasis
Criptococosis
Cryptococcosis
Farmacorresistencia Fúngica
Drug Resistance, Fungal
Ergosterol
Estrés Oxidativo
Oxidative Stress
Consumo de Oxígeno
Oxygen Consumption
Especies Reactivas de Oxígeno
Reactive Oxygen Species

Rights

openAccess

License

https://creativecommons.org/licenses/by/4.0/