Memory recovery through gene therapy with an antibody fragment selective for Aβ oligomers in a model of Alzheimer’s disease in rats

Strong evidence supports the hypothesis that synapse damage and memory impairment in early Alzheimer Disease (AD) might be due to synaptic failure caused by amyloid beta oligomers (AβOs). The preclinical efficacy of a single-chain variable fragment (scFv) antibody NUsc1 that selectively targets a su...

Full description

Autores:

Claudia Colettis, Natalia
Maria Victoria Oberholzer, Maria Victoria
Cercato, Magali
Habif, Martin
Clara Selles, Maria
Salas, Daniela
Sebollela, Adriano
Klein, William-L
Epstein, Alberto-L.
Salvetti, Anna
Ferreira, Sergio-T
Jerusalinsky, Diana

Tipo de recurso:

Article of journal

Fecha de publicación:

2023

Institución:

Corporación Universidad de la Costa

Repositorio:

REDICUC - Repositorio CUC

Idioma:

eng

OAI Identifier:

oai:repositorio.cuc.edu.co:11323/12927

Acceso en línea:

https://hdl.handle.net/11323/12927
https://repositorio.cuc.edu.co

Palabra clave:

LTM
Alzheimer’s Disease
Gene therapy
scFv
Single chain antibody fragmen
Aβ oligomer
Memoria de larga duración MLD
Enfermedad de Alzheimer
Terapia génica
scFv
Fragmento de anticuerpo de cadena simple
Oligómeros Aβ

Rights

openAccess

License

Atribución-NoComercial-SinDerivadas 4.0 Internacional (CC BY-NC-ND 4.0)