Early Islet Damage After Direct Exposure of Pig Islets to Blood:Has Humoral Immunity Been Underestimated?

Currently, islet transplantation as a cell therapeutic option for type 1 diabetes occurs via islet injection into the portal vein. Direct contact between islets and blood is a pathophysiological “provocation” that results in the instant blood-mediated inflammatory reaction (IBMIR) and is associated...

Full description

Autores:

Trucco, Massimo
Bottino, Rita
Echeverri Junca, Gabriel Jaime
Van der Windt, Dirk J.
Marigliano, Marco
He, Jing
Votyakova, Tatyana V.
Ekser, Burcin
Ayares, David
Lakkis, Fadi G.
Cooper, David K. C.

Tipo de recurso:

Article of investigation

Fecha de publicación:

2012

Institución:

Universidad ICESI

Repositorio:

Repositorio ICESI

Idioma:

eng

OAI Identifier:

oai:repository.icesi.edu.co:10906/81202

Acceso en línea:

http://openurl.ingenta.com/content/xref?genre=article&issn=0963-6897&volume=21&issue=8&spage=1791
http://journals.sagepub.com/doi/pdf/10.3727/096368912X653011
http://hdl.handle.net/10906/81202
http://dx.doi.org/10.3727/096368912X653011

Palabra clave:

Anticuerpos
Inmunidad humoral
Ciencias socio biomédicas
Medical sciences
Xenotrasplantes
Trasplante de islotes

Rights

openAccess

License

https://creativecommons.org/licenses/by-nc-nd/4.0/