Serum and urine electrolyte and nitrogenous waste product changes during the renal functional reserve test
Context: Renal functional reserve (RFR) refers to the kidney’s capability to increase its basal glomerular filtration rate (GFR) by at least 20 % after an adequate stimulus, such as a protein overload. As far as we know, no studies have yet reported the behavior of electrolyte excretion during the r...
- Autores:
-
Musso, Carlos
Juarez, Rossina
González-Torres, Henry Joseth
Capotondo, Mercedes
Terrasa, Sergio
Aroca-Martinez, Gustavo
- Tipo de recurso:
- Fecha de publicación:
- 2026
- Institución:
- Universidad Simón Bolívar
- Repositorio:
- Repositorio Digital USB
- Idioma:
- eng
- OAI Identifier:
- oai:bonga.unisimon.edu.co:20.500.12442/17357
- Acceso en línea:
- https://hdl.handle.net/20.500.12442/17357
http://doi.org/10.22265/acnef.13.1.818
https://revistanefrologia.org/index.php/rcn/article/view/818/1282
- Palabra clave:
- Reserva renal
Electrolitos
Fisiología renal
Riñón
Tasa de filtración glomerular
Estudios prospectivos
Renal reserve
Electrolytes
Renal physiology
Kidney
Glomerular filtration rate
Prospective studies
- Rights
- openAccess
- License
- Attribution-NonCommercial-NoDerivatives 4.0 International
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Serum and urine electrolyte and nitrogenous waste product changes during the renal functional reserve test |
| dc.title.translated.spa.fl_str_mv |
Cambios en los electrolitos séricos y urinarios y en los productos de desecho nitrogenados durante la prueba de reserva funcional renal |
| title |
Serum and urine electrolyte and nitrogenous waste product changes during the renal functional reserve test |
| spellingShingle |
Serum and urine electrolyte and nitrogenous waste product changes during the renal functional reserve test Reserva renal Electrolitos Fisiología renal Riñón Tasa de filtración glomerular Estudios prospectivos Renal reserve Electrolytes Renal physiology Kidney Glomerular filtration rate Prospective studies |
| title_short |
Serum and urine electrolyte and nitrogenous waste product changes during the renal functional reserve test |
| title_full |
Serum and urine electrolyte and nitrogenous waste product changes during the renal functional reserve test |
| title_fullStr |
Serum and urine electrolyte and nitrogenous waste product changes during the renal functional reserve test |
| title_full_unstemmed |
Serum and urine electrolyte and nitrogenous waste product changes during the renal functional reserve test |
| title_sort |
Serum and urine electrolyte and nitrogenous waste product changes during the renal functional reserve test |
| dc.creator.fl_str_mv |
Musso, Carlos Juarez, Rossina González-Torres, Henry Joseth Capotondo, Mercedes Terrasa, Sergio Aroca-Martinez, Gustavo |
| dc.contributor.author.none.fl_str_mv |
Musso, Carlos Juarez, Rossina González-Torres, Henry Joseth Capotondo, Mercedes Terrasa, Sergio Aroca-Martinez, Gustavo |
| dc.subject.spa.fl_str_mv |
Reserva renal Electrolitos Fisiología renal Riñón Tasa de filtración glomerular Estudios prospectivos |
| topic |
Reserva renal Electrolitos Fisiología renal Riñón Tasa de filtración glomerular Estudios prospectivos Renal reserve Electrolytes Renal physiology Kidney Glomerular filtration rate Prospective studies |
| dc.subject.keywords.eng.fl_str_mv |
Renal reserve Electrolytes Renal physiology Kidney Glomerular filtration rate Prospective studies |
| description |
Context: Renal functional reserve (RFR) refers to the kidney’s capability to increase its basal glomerular filtration rate (GFR) by at least 20 % after an adequate stimulus, such as a protein overload. As far as we know, no studies have yet reported the behavior of electrolyte excretion during the renal functional reserve test. Material and methods: A prospective study to evaluate serum and urinary changes in electrolytes, nitrogenous waste products, glucose, protein, and albumin during the renal functional reserve test in healthy young adults, evaluating their cimetidine-aided creatinine clearance and renal functional reserve test (Hellerstein). Results: There was a statistically significant increase in glomerular filtration rate (positive renal functional reserve) and serum glucose, as well as a significant reduction in serum values of nitrogen derivatives and electrolytes in 46 healthy young adult volunteers during the renal functional reserve test. Regarding the urinary fractional excretion of these substances, significant increases were observed for nitrogenous waste products and electrolytes, except for phosphorus, glucose, protein, and albumin urinary excretion, which suffered no change. Conclusion: The renal functional reserve significantly modified not only glomerular filtration rate but also nitrogenous waste products and electrolyte serum levels, as well as their urinary fractional excretion values in healthy young adults (mean age: 35 years). |
| publishDate |
2026 |
| dc.date.accessioned.none.fl_str_mv |
2026-02-13T15:07:30Z |
| dc.date.available.none.fl_str_mv |
2026-02-13T15:07:30Z |
| dc.date.issued.none.fl_str_mv |
2026 |
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http://purl.org/coar/version/c_970fb48d4fbd8a85 |
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http://purl.org/coar/resource_type/c_2df8fbb1 |
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info:eu-repo/semantics/article |
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Artículo científico |
| dc.identifier.citation.none.fl_str_mv |
Musso CG, Juarez R, Gonzalez-Torres H, Capotondo M, Terrasa S, Aroca-Martinez G. Serum and urine electrolyte and nitrogenous waste product changes during the renal functio- nal reserve test. Rev. Colomb. Nefrol. 2026; 13(1), e818. https://doi.org/10.22265/acnef.13.1.818 |
| dc.identifier.issn.none.fl_str_mv |
2500-5006 (Electrónico) 2389-7708 (Impreso) |
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https://hdl.handle.net/20.500.12442/17357 |
| dc.identifier.doi.none.fl_str_mv |
http://doi.org/10.22265/acnef.13.1.818 |
| dc.identifier.url.none.fl_str_mv |
https://revistanefrologia.org/index.php/rcn/article/view/818/1282 |
| identifier_str_mv |
Musso CG, Juarez R, Gonzalez-Torres H, Capotondo M, Terrasa S, Aroca-Martinez G. Serum and urine electrolyte and nitrogenous waste product changes during the renal functio- nal reserve test. Rev. Colomb. Nefrol. 2026; 13(1), e818. https://doi.org/10.22265/acnef.13.1.818 2500-5006 (Electrónico) 2389-7708 (Impreso) |
| url |
https://hdl.handle.net/20.500.12442/17357 http://doi.org/10.22265/acnef.13.1.818 https://revistanefrologia.org/index.php/rcn/article/view/818/1282 |
| dc.language.iso.none.fl_str_mv |
eng |
| language |
eng |
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Attribution-NonCommercial-NoDerivatives 4.0 International |
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http://purl.org/coar/access_right/c_abf2 |
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http://creativecommons.org/licenses/by-nc-nd/4.0/ |
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info:eu-repo/semantics/openAccess |
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Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ http://purl.org/coar/access_right/c_abf2 |
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openAccess |
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pdf |
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Asociación Colombiana de Nefrología e Hipertensión Arterial |
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Revista Colombiana de Nefrología Rev. Colomb. Nefrol. Vol. 13 No. 1 Año 2026 |
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Universidad Simón Bolívar |
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Musso, Carlos850d707e-a9ac-473b-99d3-87c77f6714a3600Juarez, Rossina29e22f36-59a9-41f6-bc09-388700b25751-1González-Torres, Henry Josethca0622ac-0709-4bba-a0b1-943d9bd63eb7600Capotondo, Mercedes2f3e274f-a247-4578-8a69-dc3b80a46d6b-1Terrasa, Sergiodf3776e1-0495-482b-8282-784b8b6a1de9600Aroca-Martinez, Gustavo29e7d2bf-e7cd-4f0b-a279-e34fe3d3b9166002026-02-13T15:07:30Z2026-02-13T15:07:30Z2026Musso CG, Juarez R, Gonzalez-Torres H, Capotondo M, Terrasa S, Aroca-Martinez G. Serum and urine electrolyte and nitrogenous waste product changes during the renal functio- nal reserve test. Rev. Colomb. Nefrol. 2026; 13(1), e818. https://doi.org/10.22265/acnef.13.1.8182500-5006 (Electrónico)2389-7708 (Impreso)https://hdl.handle.net/20.500.12442/17357http://doi.org/10.22265/acnef.13.1.818https://revistanefrologia.org/index.php/rcn/article/view/818/1282Context: Renal functional reserve (RFR) refers to the kidney’s capability to increase its basal glomerular filtration rate (GFR) by at least 20 % after an adequate stimulus, such as a protein overload. As far as we know, no studies have yet reported the behavior of electrolyte excretion during the renal functional reserve test. Material and methods: A prospective study to evaluate serum and urinary changes in electrolytes, nitrogenous waste products, glucose, protein, and albumin during the renal functional reserve test in healthy young adults, evaluating their cimetidine-aided creatinine clearance and renal functional reserve test (Hellerstein). Results: There was a statistically significant increase in glomerular filtration rate (positive renal functional reserve) and serum glucose, as well as a significant reduction in serum values of nitrogen derivatives and electrolytes in 46 healthy young adult volunteers during the renal functional reserve test. Regarding the urinary fractional excretion of these substances, significant increases were observed for nitrogenous waste products and electrolytes, except for phosphorus, glucose, protein, and albumin urinary excretion, which suffered no change. Conclusion: The renal functional reserve significantly modified not only glomerular filtration rate but also nitrogenous waste products and electrolyte serum levels, as well as their urinary fractional excretion values in healthy young adults (mean age: 35 years).Contexto: la reserva funcional renal (RFR) es la capacidad del riñón para aumentar su tasa de filtración glomerular basal (TFG) hasta al menos un 20 % tras un estímulo adecuado, como una sobrecarga proteica. Hasta donde sabemos, aún no se ha descrito qué ocurre con la excreción de electrolitos durante la prueba de reserva funcional renal. Material y métodos: estudio prospectivo para evaluar los cambios en los electrolitos séricos y urinarios, productos de desecho nitrogenados, glucosa, proteínas y albúmina durante la prueba de reserva funcional renal en adultos jóvenes sanos, evaluando su aclaramiento de creatinina con cimetidina y la prueba de reserva funcional renal (Hellerstein). Resultados: se observó un aumento estadísticamente significativo de la tasa de filtración glomerular (reserva funcional renal positiva) y de la glucosa sérica, así como una reducción significativa de los valores séricos de derivados nitrogenados y electrolitos en 46 voluntarios adultos jóvenes sanos durante la prueba de reserva funcional renal. En cuanto a la excreción fraccional urinaria de estas sustancias, se observó un aumento significativo de los productos de desecho nitrogenados y de los electrolitos, con excepción de la excreción urinaria del fósforo, la glucosa, las proteínas y la albúmina, la cual no presentó cambios. Conclusión: la reserva renal modificó significativamente no solo la tasa de filtración glomerular, sino también los niveles séricos de los productos de desecho nitrogenados y de los electrolitos, así como sus valores de excreción fraccional urinaria, en adultos jóvenes sanos (edad media: 35 años).pdfengAsociación Colombiana de Nefrología e Hipertensión ArterialAttribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Revista Colombiana de Nefrología Rev. Colomb. Nefrol.Vol. 13 No. 1 Año 2026Reserva renalElectrolitosFisiología renalRiñónTasa de filtración glomerularEstudios prospectivosRenal reserveElectrolytesRenal physiologyKidneyGlomerular filtration rateProspective studiesSerum and urine electrolyte and nitrogenous waste product changes during the renal functional reserve testCambios en los electrolitos séricos y urinarios y en los productos de desecho nitrogenados durante la prueba de reserva funcional renalinfo:eu-repo/semantics/articleArtículo científicohttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_2df8fbb1Bosch JP, Lew S, Glabman S, Lauer A. Renal hemodynamic changes in humans. Response to protein loading in normal and diseased kidneys. Am J Med. 1986;81(5):809–815. https:// doi.org/10.1016/0002-9343(86)90350-5Musso CG, Reynaldi J, Martinez B, Pierángelo A, Vilas M, Algranati L. Renal reserve in the oldest old. Int Urol Nephrol. 2011;43(1):253-256. https://doi.org/10.1007/s11255-010-9769-9Bosch JP, Saccaggi A, Lauer A, Ronco C, Belledonne M, Glabman S. Renal functional reserve in humans. Effect of protein intake on glomerular filtration rate. Am J Med. 1983;75(6):943–950. https://doi.org/10.1016/0002-9343(83)90873-2van Acker BA, Koomen GC, Koopman MG, de Waart DR, Arisz L. Creatinine clearance during cimetidine administration for measurement of glomerular filtration rate. Lancet. 1992;340(28):1326–1329. https://doi.org/10.1016/0140-6736(92)92502-7Musso CG, Vilas M. Water, electrolyte, and acid-base disorders in the elderly. In: Macias- Nunez JF, Jauregui J, Covic A, Musso CG, eds. Clinical Nephrogeriatrics. Springer. Cham;2019:43-62. https://doi.org/10.1007/978-3-030-18711-8 4Hellerstein S, Berenbom M, Erwin P, Wilson N, DiMaggio S. Measurement of renal functional reserve in children. Pediatr Nephrol. 2004;19:1132-1136. https://doi.org/10.1007/ s00467-004-1550-9Musso CG. Renal reserve test: Its methodology and significance. Saudi J Kidney Dis Transpl. 2011;22(5):990-993.Rodríguez-Iturbe B. The renal response to an acute protein load in man: Clinical perspective. Nephrol Dial Transplant. 1990;5(1):1–9. https://doi.org/10.1093/ndt/5.1.1Woods LL. Intrarenal mechanisms of renal reserve. Semin Nephrol. 1995;15(5):386–395.Capasso G, Mollica F, Saviano C, De Santo NG. Tubule effects of glomerular hyperfiltration: An integrated view. Semin Nephrol. 1995;15(5):419–425.King AJ. Nitric oxide and the renal hemodynamic response to proteins. Semin Nephrol. 1995;15(5):405–414.ter Wee PM, Tegzess AM, Donker Ab JM. Renal effects of intravenous amino acid administration in humans with and without renal disease: Hormonal correlates. Semin Nephrol. 1995;15(5):426–432.Musso CG, Fainstein I, Kaplan R, Macías-Núñez JF. Renal tubular function in the oldest old. Rev Esp Geriatr Gerontol. 2004;39(5):314-319. https://doi.org/10.1016/S0211-139X(04) 74980-XSede BarranquillaORIGINALPDF.pdfPDF.pdfapplication/pdf428784https://bonga.unisimon.edu.co/bitstreams/c1c604aa-6e9f-47c8-b3f1-03878f9b12f9/download5b1154832735f197c860e411d9e48946MD51CC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-8899https://bonga.unisimon.edu.co/bitstreams/90f3c35e-abb4-44cd-9e41-8839cc3ac060/download3b6ce8e9e36c89875e8cf39962fe8920MD52LICENSElicense.txtlicense.txttext/plain; charset=utf-8381https://bonga.unisimon.edu.co/bitstreams/a439484b-0e25-4687-8589-1db818e2e01e/download733bec43a0bf5ade4d97db708e29b185MD5320.500.12442/17357oai:bonga.unisimon.edu.co:20.500.12442/173572026-02-13 10:18:54.849http://creativecommons.org/licenses/by-nc-nd/4.0/Attribution-NonCommercial-NoDerivatives 4.0 Internationalopen.accesshttps://bonga.unisimon.edu.coRepositorio Digital Universidad Simón Bolívarrepositorio.digital@unisimon.edu.coPGEgcmVsPSJsaWNlbnNlIiBocmVmPSJodHRwOi8vY3JlYXRpdmVjb21tb25zLm9yZy9saWNlbnNlcy9ieS1uYy80LjAvIj48aW1nIGFsdD0iTGljZW5jaWEgQ3JlYXRpdmUgQ29tbW9ucyIgc3R5bGU9ImJvcmRlci13aWR0aDowO3dpZHRoOjEwMHB4OyIgc3JjPSJodHRwczovL2kuY3JlYXRpdmVjb21tb25zLm9yZy9sL2J5LW5jLzQuMC84OHgzMS5wbmciIC8+PC9hPjxici8+RXN0YSBvYnJhIGVzdMOhIGJham8gdW5hIDxhIHJlbD0ibGljZW5zZSIgaHJlZj0iaHR0cDovL2NyZWF0aXZlY29tbW9ucy5vcmcvbGljZW5zZXMvYnktbmMvNC4wLyI+TGljZW5jaWEgQ3JlYXRpdmUgQ29tbW9ucyBBdHJpYnVjacOzbi1Ob0NvbWVyY2lhbCA0LjAgSW50ZXJuYWNpb25hbDwvYT4u |