Muerte fetal intrauterina Hospital Militar Central 2014-2019

La muerta fetal intrauterina (MFI) como suceso devastador, afecta emocionalmente a la madre, el entorno familiar, económico, psicosocial y de atención del equipo encargado de una gestación. Objetivo: Caracterizar las causas de MFI en el Hospital Militar Central (HOMIC) durante el periodo 2014- 2019....

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Autores:
Angarita Perez, Maria Fernanda
Guzman Murcia, Maria Alejandra
Tipo de recurso:
Trabajo de grado de pregrado
Fecha de publicación:
2020
Institución:
Universidad Militar Nueva Granada
Repositorio:
Repositorio UMNG
Idioma:
spa
OAI Identifier:
oai:repository.unimilitar.edu.co:10654/37384
Acceso en línea:
http://hdl.handle.net/10654/37384
Palabra clave:
intrauterine fetal death
clinical characteristics
sociodemographic characyeristics
GINECOLOGIA
EMBARAZO - COMPLICACIONES
MORTINATOS
MUERTE FETAL
muerte fetal intrauterina
características sociodemográficas
características clinicas
Rights
openAccess
License
http://creativecommons.org/licenses/by-nc-nd/4.0/
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dc.title.spa.fl_str_mv Muerte fetal intrauterina Hospital Militar Central 2014-2019
dc.title.translated.spa.fl_str_mv Intrauterine fetal death Central Military Hospital 2014-2019.
title Muerte fetal intrauterina Hospital Militar Central 2014-2019
spellingShingle Muerte fetal intrauterina Hospital Militar Central 2014-2019
intrauterine fetal death
clinical characteristics
sociodemographic characyeristics
GINECOLOGIA
EMBARAZO - COMPLICACIONES
MORTINATOS
MUERTE FETAL
muerte fetal intrauterina
características sociodemográficas
características clinicas
title_short Muerte fetal intrauterina Hospital Militar Central 2014-2019
title_full Muerte fetal intrauterina Hospital Militar Central 2014-2019
title_fullStr Muerte fetal intrauterina Hospital Militar Central 2014-2019
title_full_unstemmed Muerte fetal intrauterina Hospital Militar Central 2014-2019
title_sort Muerte fetal intrauterina Hospital Militar Central 2014-2019
dc.creator.fl_str_mv Angarita Perez, Maria Fernanda
Guzman Murcia, Maria Alejandra
dc.contributor.advisor.none.fl_str_mv Otalora Gallego, Maria Camila
dc.contributor.author.none.fl_str_mv Angarita Perez, Maria Fernanda
Guzman Murcia, Maria Alejandra
dc.contributor.corporatename.spa.fl_str_mv Universidad Militar Nueva Granada
dc.subject.keywords.spa.fl_str_mv intrauterine fetal death
clinical characteristics
sociodemographic characyeristics
topic intrauterine fetal death
clinical characteristics
sociodemographic characyeristics
GINECOLOGIA
EMBARAZO - COMPLICACIONES
MORTINATOS
MUERTE FETAL
muerte fetal intrauterina
características sociodemográficas
características clinicas
dc.subject.decs.spa.fl_str_mv GINECOLOGIA
EMBARAZO - COMPLICACIONES
MORTINATOS
MUERTE FETAL
dc.subject.proposal.spa.fl_str_mv muerte fetal intrauterina
características sociodemográficas
características clinicas
description La muerta fetal intrauterina (MFI) como suceso devastador, afecta emocionalmente a la madre, el entorno familiar, económico, psicosocial y de atención del equipo encargado de una gestación. Objetivo: Caracterizar las causas de MFI en el Hospital Militar Central (HOMIC) durante el periodo 2014- 2019. Materiales y métodos: Estudio descriptivo transversal sobre características sociodemográficas y clínicas de muertes fetales intrauterinas, con información de bases de datos del HOMIC, registrando variables cuali y cuantitativas, calculando promedios y frecuencias, reportando los datos en medidas de tendencia central. Resultados: Del total 48 muertes fetales cumplieron con criterios de inclusión, edad materna promedio fue de 26 años, 68.8% con grupo sanguíneo O+ y 50% 24/48 gestantes de estrato socioeconómico bajo. La muerte fetal (50% pretérminos tempranos) se presentó en promedio a las 28. 3 semanas, 77% embarazos únicos, el 64% con producto de sexo masculino, peso medio de 1175 gr, y 91% de alto riesgo obstétrico, de estas 56% tenían antecedentes de infección (27%), trastorno hipertensivo (14%), diabetes (8%) y STORCH positivo (4.2%). Ninguna tuvo abordaje preconcepcional, a 66.7% se les dio parto vaginales y 33% nacieron por cesárea .Se le realizó autopsia al 67% de los óbitos encontrando anomalías congénitas en el 29% de los casos, solo 31% recibieron asesoría genética. Conclusión: Conocer las causas de MFI es importante para la instauración de métodos de vigilancia y seguimiento en todas las pacientes y establecer una ruta multidisciplinaria con el fin de tomar decisiones oportunas y disminuir índices de morbilidad perinatal a futuro. Palabras clave: muerte fetal intrauterina, características sociodemográficas y clínicas.
publishDate 2020
dc.date.issued.none.fl_str_mv 2020-11-11
dc.date.accessioned.none.fl_str_mv 2021-01-18T16:22:18Z
dc.date.available.none.fl_str_mv 2021-01-18T16:22:18Z
dc.type.local.spa.fl_str_mv Tesis/Trabajo de grado - Monografía - Especialización
dc.type.driver.spa.fl_str_mv info:eu-repo/semantics/bachelorThesis
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dc.identifier.instname.spa.fl_str_mv instname:Universidad Militar Nueva Granada
dc.identifier.reponame.spa.fl_str_mv reponame:Repositorio Institucional Universidad Militar Nueva Granada
dc.identifier.repourl.spa.fl_str_mv repourl:https://repository.unimilitar.edu.co
url http://hdl.handle.net/10654/37384
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repourl:https://repository.unimilitar.edu.co
dc.language.iso.spa.fl_str_mv spa
language spa
dc.relation.references.spa.fl_str_mv (1) World Health Organization (WHO). Stillbirths. https://www.who.int/maternal_child_adolescent/epidemiology/stillbirth/en/ (Accessed on March 09, 2020).
(2) American College of Obstetricians and Gynecologists, Society for Maternal-Fetal Medicine. Management of Stillbirth: Obstetric Care Consensus No, 10. Obstet Gynecol 2020; 135:e110.
(3) Allusion, JL, Bower KM, Epstein E, Sharps P. Racial discrimination and adverse birth outcomes: an integrative review. J Midwifery Womens Health 2016; 61:707-20
(4) Departamento Administrativo Nacional de Estadística (DANE) https://www.dane.gov.co/index.php/estadisticas-por-tema/salud/nacimientos-y-defunciones/defunciones-fetales (Acceso Junio 2020)
(5) Page JM, Bardsley T, Thorsten V, Allshouse AA, Varner MW, Debbink MP, Dudley DJ, Saade GR, Goldenberg RL, Stoll B, Hogue CJ, Bukowski R, Conway D, Reddy UM, Silver RM. Mortinato asociado con infección en una cohorte diversa de EE. UU. Obstet Gynecol. Diciembre de 2019; 134 (6): 1187-1196.
(6) Dongarwar D, Aggarwal A, Barning K, Salihu HM. Trends in Stillbirths and Stillbirth Phenotypes in the United States: An Analysis of 131.5 Million Births. Int J MCH AIDS 2020; 9:146.
(7) Reddy UM, Laughon SK, Sun L, Troendle j, Willinger M, Zhang J. Prepregnancy risck factors antepartum stillbirth in the United States. Obstet Gynecol 2010; 116:1119-26
(8) Cnattingius, S., & Villamor, E. Weight change between successive pregnancies and risks of stillbirth and infant mortality : a nationwide cohort study. The Lancet, 2018, 387(10018), 558–565.
(9) MacDorman MF, Gregory EC. Fetal and Perinatal Mortality: United States, Natl Vital Stat Rep 2018; 64:1.
(10) Wingate MS, Smith RA, Petrini JR, Barfield WD. Disparities in gestational age-specific fetal mortality rates in the United States, 2009-2013. Ann Epidemiol 2017; 27:570.
(11) Silver RM, Saade GR, Thorsten V, Parker CB, Reddy UM, Drews-Botsch C, Conway D, Coustan D, Dudley DJ, Bukowski R, Rowland Hogue CJ, Pinar H, Varner MW, Goldenberg R, Willinger M. Factor V Leiden, protrombina G20210A y mutaciones 70 70 de metilentetrahidrofolato reductasa y muerte fetal: la Red de Investigación Colaborativa de Muerte Fetal. Soy J Obstet Gynecol. Octubre de 2016; 215 (4): 468.e1-468.e17.
(12) Gardosi J, Madurasinghe V, Williams M, et al. Maternal and fetal risk factors for stillbirth: population based study. BMJ 2015; 346:f108.
(13) Lamont K, Scott NW, Jones GT, Bhattacharya S. Risk of recurrent stillbirth: systematic review and meta-analysis. BMJ 2015; 350:h3080.
(14) Malacova E, Regan A, Nassar N, et al. Risk of stillbirth, preterm delivery, and fetal growth restriction following exposure in a previous birth: systematic review and meta-analysis. BJOG 2018; 125:183.
(15) Pineles BL, Hsu S, Park E, Samet JM. Systematic Review and Meta-Analyses of Perinatal Death and Maternal Exposure to Tobacco Smoke during Pregnancy. Am J Epidemiol 2016; 184:87
(16) Cheong-See F, Schuit E, Arroyo-Mansion D, et al. Prospective risk of stillbirth and neonatal complications in twin pregnancies: systematic review and meta-analysis. BMJ 2016; 354:i4353.
(17) Mondal D, Galloway TS, Bailey TC, Mathews F. Elevated risk of stillbirth in males: systematic review and meta-analysis of more than 30 million births. BMC Med 2014; 12:220.
(18) Korteweg FJ, Gordijn SJ, Timmer A, et al. The Tulip classification of perinatal mortality: introduction and multidisciplinary inter-rater agreement. BJOG 2016; 113:393.
(19) Gibbins, K. J., Silver, R. M., Pinar, H., Reddy, U. M., Parker, C. B., Thorsten, V., Goldenberg, R. L. (2018). Stillbirth, hypertensive disorders of pregnancy, and placental pathology. Placenta, 43(2016), 61–68.
(20) Aminu M, Bar-Zeev S, van den Broek N. Cause of and factors associated with stillbirth: a systematic review of classification systems. Act Obstet Gynecol Scand 2017; 96:519.
(21) Groan H, Bouman K, Pierini A, et al. Stillbirth and neonatal mortality in pregnancies complicated by major congenital anomalies: Findings from a large European cohort. Prenat Diagn 2017; 37:1100.
(22) Bukowski R, Hansen NI, Willinger M, et al. Fetal growth and risk of stillbirth: a population-based case-control study. Plops Med 2017; 11:e1001633.
(23) Page JM, Beardsley T, Thorsten V, et al. Stillbirth Associated With Infection in a Diverse U.S. Cohort. Obstet Gynecol 2019; 134:1187.
(24) Kubendran S, Duong J, Dong F, et al. Implementing a Protocol to Optimize Detection of Chromosome Abnormalities in Cases of Miscarriage or Stillbirth at a Midwestern Teaching Hospital. Perm J 2018; 22:17.
(25) Boyd TK. Fetal death. In: Placental and Gestational Pathology, 1st ed, Redline RW, Boyd TK, Roberts DJ (Eds), Cambridge University Press, Cambridge 2018. p.316.
(26) Korteweg FJ, Gordijn SJ, Timmer A, et al. The Tulip classification of perinatal mortality: introduction and multidisciplinary inter-rater agreement. BJOG 2016; 113:393.
(27) Hammad IA, Blue NR, Almshouse AA, et al. Umbilical Cord Abnormalities and Stillbirth. Obstet Gynecol 2020; 135:644.
(28) Wojcieszek AM, Shepherd E, Middleton P, et al. Interventions for investigating and identifying the causes of stillbirth. Cochrane Database Syst Rev 2018; 4:CD012504.
(29) Lawn, J. E., Glencoe, H., Waiswa, P., Amouzou, A., Mathers, C., Hogan, D., Froen, J. F. Ending preventable stillbirths 2 Stillbirths : rates, risk factors, and acceleration towards 2018. 2030, 387, 587–603
(30) Yao, R., Park, B. Y., Foster, S. E., & Caughey, A. B. Annals of Epidemiology The association between gestational weight gain and risk of stillbirth : a population-based cohort study. Annals of Epidemiology, 2018. 27(10), 638–644.e1
(31) Wojcieszek AM, Shepherd E, Middleton P, et al. Interventions for investigating and identifying the causes of stillbirth. Cochrane Database Syst Rev 2018; 4:CD012504.
(32) Silver RM. examining the link between placental pathology, growth restriction, and stillbirth. Best Pract Res Clin Obstet Gynaecol. 2018 May;49:89-102. doi: 10.1016/j.bpobgyn.2018.03.004. Epub 2018 Mar 26. PMID: 29759932.
(33) Heazell AE, Hayes DJ, Whitworth M, et al. Biochemical tests of placental function versus ultrasound assessment of fetal size for stillbirth and small-for-gestational-age infants. Cochrane Database Syst Rev 2019; 5:CD012245.
(34) Norman JE, Heazell AEP, Rodriguez A, et al. Awareness of fetal movements and care package to reduce fetal mortality (AFFIRM): a stepped wedge, cluster-randomized trial. Lancet 2018; 392:1629.
(35) Tita ATN, Jablonski KA, Bailit JL, et al. Neonatal outcomes of elective early-term births after demonstrated fetal lung maturity. Am J Obstet Gynecol 2018; 219:296.e1.
(36) Grobman WA, Rice MM, Reddy UM, et al. Labor Induction versus Expectant Management in Low-Risk Nulliparous Women. N Engl J Med 2018; 379:513.
(37) TSpong CY, Mercer BM, D'alton M, et al. Momento indicado para el parto prematuro tardío y prematuro. Obstet Gynecol 2017; 118: 323.
(38) Kurner JM, Robertson NT, Hartel G, Kumar S. Impacto de la aspirina en dosis bajas en el resultado perinatal adverso: metanálisis y metarregresión. Ultrasonido Obstet Gynecol 2020; 55: 157.
(39) Saleem S, Tikmani SS, McClure EM, et al. Trends and determinants of stillbirth in developing countries: results from the Global Network's Population-Based Birth Registry. Reprod Health 2018; 15:100.
(40) Reinebrant HE, Leisher SH, Coory M, et al. making stillbirths visible: a systematic review of globally reported causes of stillbirth. BJOG 2018; 125:212.
(41) Kubendran S, Duong J, Dong F, et al. Implementing a Protocol to Optimize Detection of Chromosome Abnormalities in Cases of Miscarriage or Stillbirth at a Midwestern Teaching Hospital. Perm J 2018; 22:17.
(42) Munroe PB, Addison S, Abrams DJ, et al. Postmortem Genetic Testing for Cardiac Ion Channelopathies in Stillbirths. Circ Genom Precis Med 2018; 11:e001817.
(43) Malacova E, Regan A, Nassar N, et al. Risk of stillbirth, preterm delivery, and fetal growth restriction following exposure in a previous birth: systematic review and meta-analysis. BJOG 2018; 125:183.
(44) Page JM, Thorsten V, Reddy UM, et al. Potentially Preventable Stillbirth in a Diverse U.S. Cohort. Obstet Gynecol 2018; 131:336.
(45) Nuzum D, Meaney S, O'Donoghue K. The impact of stillbirth on bereaved parents: A qualitative study. PLoS One 2018; 13:e0191635.
(46) Atienza-Carrasco J, Linares-Abad M, Padilla-Ruiz M, Morales-Gil IM. Breaking bad news to antenatal patients with strategies to lessen the pain: a qualitative study. Reprod Health 2018; 15:11.
(47) Shehab O, Tester DJ, Ackerman NC, et al. Whole genome sequencing identifies etiology of recurrent male intrauterine fetal death. Prenat Diagn 2017; 37:1040.
(48) Aminu M, Bar-Zeev S, van den Broek N. Cause of and factors associated with stillbirth: a systematic review of classification systems. Acta Obstet Gynecol Scand 2017; 96:519.
(49) Groen H, Bouman K, Pierini A, et al. Stillbirth and neonatal mortality in pregnancies complicated by major congenital anomalies: Findings from a large European cohort. Prenat Diagn 2017; 37:1100.
(50) Gomes MS, Carlos-Alves M, Trocado V, et al. Prediction of adverse pregnancy outcomes by extreme values of first trimester screening markers. Obstet Med 2017; 10:132.
(51) Fyfe R, Murray H. Comparison of induction of labour regimes for termination of pregnancy, with and without mifepristone, from 20 to 41 weeks gestation. Aust N Z J Obstet Gynaecol 2017; 57:604.
(52) Miller ES, Minturn L, Linn R, et al. Stillbirth evaluation: a stepwise assessment of placental pathology and autopsy. Am J Obstet Gynecol 2016; 214:115.e1.
(53) Goldstein RD, Kinney HC, Willinger M. Sudden Unexpected Death in Fetal Life through Early Childhood. Pediatrics 2016; 137.
(54) Man J, Hutchinson JC, and Ashworth M, et al. Effects of intrauterine retention and postmortem interval on body weight following intrauterine death: implications for assessment of fetal growth restriction at autopsy. Ultrasound Obstet Gynecol 2016; 48:574.
(55) Man J, Hutchinson JC, Ashworth M, et al. Stillbirth and intrauterine fetal death: role of routine histological organ sampling to determine cause of death. Ultrasound Obstet Gynecol 2016.
(56) Andrikopoulou M, Lavery JA, Ananth CV, Vintzileos AM. Cervical ripening agents in the second trimester of pregnancy in women with a scarred uterus: a systematic review and metaanalysis of observational studies. Am J Obstet Gynecol 2016; 215:177
(57) Page, J. M., & Silver, R. M. (2018). Seminars in Fetal & Neonatal Medicine Interventions to prevent stillbirth. Seminars in Fetal and Neonatal Medicine, 22(3), 135–145.
(58) Dhalwani NN, Szatkowski L, Coleman T, et al. Stillbirth Among Women Prescribed Nicotine Replacement Therapy in Pregnancy: Analysis of a Large UK Pregnancy Cohort. Nicotine Tob Res 2019; 21:409.
(59) Audette MC, Kingdom JC. Screening for fetal growth restriction and placental insufficiency. Semin Fetal Neonatal Med. 2018 Apr;23(2):119-125. doi: 10.1016/j.siny.2017.11.004. Epub 2017 Dec 6. PMID: 29221766
(60) Hadar E, Melamed N, Sharon-Weiner M, Hazan S, Rabinerson D, Glezerman M, Yogev Y. The association between stillbirth and fetal gender. J Matern Fetal Neonatal 78 78 Med. 2012 Feb;25(2):158-61. doi: 10.3109/14767058.2011.565838. Epub 2011 Mar 31. PMID: 21449834.
(61) Pinheiro RL, Areia AL, Mota Pinto A, Donato H. Advanced Maternal Age: Adverse Outcomes of Pregnancy, A Meta-Analysis. Acta Med Port. 2019 Mar 29;32(3):219-226. doi: 10.20344/amp.11057. Epub 2019 Mar 29. PMID: 30946794.
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spelling Otalora Gallego, Maria CamilaAngarita Perez, Maria FernandaGuzman Murcia, Maria AlejandraEspecialista en Ginecología y obstetriciaUniversidad Militar Nueva GranadaBogotá2020Medicina2021-01-18T16:22:18Z2021-01-18T16:22:18Z2020-11-11http://hdl.handle.net/10654/37384instname:Universidad Militar Nueva Granadareponame:Repositorio Institucional Universidad Militar Nueva Granadarepourl:https://repository.unimilitar.edu.coLa muerta fetal intrauterina (MFI) como suceso devastador, afecta emocionalmente a la madre, el entorno familiar, económico, psicosocial y de atención del equipo encargado de una gestación. Objetivo: Caracterizar las causas de MFI en el Hospital Militar Central (HOMIC) durante el periodo 2014- 2019. Materiales y métodos: Estudio descriptivo transversal sobre características sociodemográficas y clínicas de muertes fetales intrauterinas, con información de bases de datos del HOMIC, registrando variables cuali y cuantitativas, calculando promedios y frecuencias, reportando los datos en medidas de tendencia central. Resultados: Del total 48 muertes fetales cumplieron con criterios de inclusión, edad materna promedio fue de 26 años, 68.8% con grupo sanguíneo O+ y 50% 24/48 gestantes de estrato socioeconómico bajo. La muerte fetal (50% pretérminos tempranos) se presentó en promedio a las 28. 3 semanas, 77% embarazos únicos, el 64% con producto de sexo masculino, peso medio de 1175 gr, y 91% de alto riesgo obstétrico, de estas 56% tenían antecedentes de infección (27%), trastorno hipertensivo (14%), diabetes (8%) y STORCH positivo (4.2%). Ninguna tuvo abordaje preconcepcional, a 66.7% se les dio parto vaginales y 33% nacieron por cesárea .Se le realizó autopsia al 67% de los óbitos encontrando anomalías congénitas en el 29% de los casos, solo 31% recibieron asesoría genética. Conclusión: Conocer las causas de MFI es importante para la instauración de métodos de vigilancia y seguimiento en todas las pacientes y establecer una ruta multidisciplinaria con el fin de tomar decisiones oportunas y disminuir índices de morbilidad perinatal a futuro. Palabras clave: muerte fetal intrauterina, características sociodemográficas y clínicas.Hospital Militar Central1. Resumen ………………………………………………………………………….4 2. Marco teórico ……………………………………………………………………6 a. Definición ………………………………………………………………...11 b. Epidemiologia...…………………………………………………………..12 c. Factores de riesgo ………………………………………………………19 d. Diagnostico……………………………………………………………….27 e. Evaluación……………... ………………………………………………..29 f. Prevención ……………………………………………………………….32 3. Planteamiento del problema …………………………………………………33 a. Pregunta de investigación …………………………………………….. 35 4. Objetivos ………………………………………………………………………...36 a. General …………………………………………………………………...36 b. Específicos ……………………………………………………………….36 5. Metodología……………………………………………………………………..37 a. Tipo y diseño de estudio ………………………………………………..38 b. Población …………………………………………………………………38 c. Selección y tamaño de muestra ……………………………………….38 d. Criterios de inclusión ……………………………………………………39 e. Criterios de exclusión …………………………………………………...39 f. Definición de variables ………………………………………………….38 g. Estrategias para suprimir amenazas a la validez de resultados …...40 h. Recolección de datos …………………………………………………...41 6. Análisis estadístico ……………………………………………………………43 a. Procedimientos de medición, recolección y sistematización de la información……………………………………………………………….43 3 3 b. Plan de análisis ………………………………………………………….44 7. Aspectos éticos ………………………………………………………………..45 8. Resultados ………………………………………………………………………47 9. Discusión………………………………………………………………………...57 10. Conclusiones…………………….……………………………………………...63 11. Referencias bibliográficas……………………………………………………64Intrauterine stillbirth (IFM) as a devastating event, emotionally affects the mother, the family, economic, psychosocial and care environment of the team in charge of a pregnancy. Objective: To characterize the causes of IFM in the Central Military Hospital (HOMIC) during the period 2014-2019. Materials and methods: Cross-sectional descriptive study on sociodemographic and clinical characteristics of intrauterine fetal deaths, with information from HOMIC databases, recording qualitative and quantitative variables, calculating averages and frequencies, reporting data in measures of central tendency. Results: Of the total, 48 fetal deaths met the inclusion criteria, mean maternal age was 26 years, 68.8% with blood group O + and 50% 24/48 pregnant women of low socioeconomic status. Fetal death (50% early preterm) occurred on average at 28. 3 weeks, 77% single pregnancies, 64% with a male product, mean weight of 1175 grams, and 91% of high obstetric risk, of these 56% had a history of infection (27%), hypertensive disorder (14%), diabetes (8%) and positive STORCH (4.2%). None had a preconception approach, 66.7% were given vaginal births and 33% were delivered by cesarean section. 67% of deaths were autopsied, finding congenital anomalies in 29% of cases, only 31% received genetic counseling. Conclusion: Knowing the causes of IFM is important for the establishment of surveillance and follow-up methods in all patients and establishing a multidisciplinary route in order to make timely decisions and reduce rates of perinatal morbidity in the future.Especializaciónapplicaction/pdfspahttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial-NoDerivatives 4.0 InternationalAcceso abiertoMuerte fetal intrauterina Hospital Militar Central 2014-2019Intrauterine fetal death Central Military Hospital 2014-2019.Tesis/Trabajo de grado - Monografía - Especializacióninfo:eu-repo/semantics/bachelorThesishttp://purl.org/coar/resource_type/c_7a1fintrauterine fetal deathclinical characteristicssociodemographic characyeristicsGINECOLOGIAEMBARAZO - COMPLICACIONESMORTINATOSMUERTE FETALmuerte fetal intrauterinacaracterísticas sociodemográficascaracterísticas clinicasGinecología y obstetriciaFacultad de MedicinaUniversidad Militar Nueva Granada(1) World Health Organization (WHO). Stillbirths. https://www.who.int/maternal_child_adolescent/epidemiology/stillbirth/en/ (Accessed on March 09, 2020).(2) American College of Obstetricians and Gynecologists, Society for Maternal-Fetal Medicine. Management of Stillbirth: Obstetric Care Consensus No, 10. Obstet Gynecol 2020; 135:e110.(3) Allusion, JL, Bower KM, Epstein E, Sharps P. Racial discrimination and adverse birth outcomes: an integrative review. J Midwifery Womens Health 2016; 61:707-20(4) Departamento Administrativo Nacional de Estadística (DANE) https://www.dane.gov.co/index.php/estadisticas-por-tema/salud/nacimientos-y-defunciones/defunciones-fetales (Acceso Junio 2020)(5) Page JM, Bardsley T, Thorsten V, Allshouse AA, Varner MW, Debbink MP, Dudley DJ, Saade GR, Goldenberg RL, Stoll B, Hogue CJ, Bukowski R, Conway D, Reddy UM, Silver RM. Mortinato asociado con infección en una cohorte diversa de EE. UU. Obstet Gynecol. Diciembre de 2019; 134 (6): 1187-1196.(6) Dongarwar D, Aggarwal A, Barning K, Salihu HM. Trends in Stillbirths and Stillbirth Phenotypes in the United States: An Analysis of 131.5 Million Births. Int J MCH AIDS 2020; 9:146.(7) Reddy UM, Laughon SK, Sun L, Troendle j, Willinger M, Zhang J. Prepregnancy risck factors antepartum stillbirth in the United States. Obstet Gynecol 2010; 116:1119-26(8) Cnattingius, S., & Villamor, E. Weight change between successive pregnancies and risks of stillbirth and infant mortality : a nationwide cohort study. The Lancet, 2018, 387(10018), 558–565.(9) MacDorman MF, Gregory EC. Fetal and Perinatal Mortality: United States, Natl Vital Stat Rep 2018; 64:1.(10) Wingate MS, Smith RA, Petrini JR, Barfield WD. Disparities in gestational age-specific fetal mortality rates in the United States, 2009-2013. Ann Epidemiol 2017; 27:570.(11) Silver RM, Saade GR, Thorsten V, Parker CB, Reddy UM, Drews-Botsch C, Conway D, Coustan D, Dudley DJ, Bukowski R, Rowland Hogue CJ, Pinar H, Varner MW, Goldenberg R, Willinger M. Factor V Leiden, protrombina G20210A y mutaciones 70 70 de metilentetrahidrofolato reductasa y muerte fetal: la Red de Investigación Colaborativa de Muerte Fetal. Soy J Obstet Gynecol. Octubre de 2016; 215 (4): 468.e1-468.e17.(12) Gardosi J, Madurasinghe V, Williams M, et al. Maternal and fetal risk factors for stillbirth: population based study. BMJ 2015; 346:f108.(13) Lamont K, Scott NW, Jones GT, Bhattacharya S. Risk of recurrent stillbirth: systematic review and meta-analysis. BMJ 2015; 350:h3080.(14) Malacova E, Regan A, Nassar N, et al. Risk of stillbirth, preterm delivery, and fetal growth restriction following exposure in a previous birth: systematic review and meta-analysis. BJOG 2018; 125:183.(15) Pineles BL, Hsu S, Park E, Samet JM. Systematic Review and Meta-Analyses of Perinatal Death and Maternal Exposure to Tobacco Smoke during Pregnancy. Am J Epidemiol 2016; 184:87(16) Cheong-See F, Schuit E, Arroyo-Mansion D, et al. Prospective risk of stillbirth and neonatal complications in twin pregnancies: systematic review and meta-analysis. BMJ 2016; 354:i4353.(17) Mondal D, Galloway TS, Bailey TC, Mathews F. Elevated risk of stillbirth in males: systematic review and meta-analysis of more than 30 million births. BMC Med 2014; 12:220.(18) Korteweg FJ, Gordijn SJ, Timmer A, et al. The Tulip classification of perinatal mortality: introduction and multidisciplinary inter-rater agreement. BJOG 2016; 113:393.(19) Gibbins, K. J., Silver, R. M., Pinar, H., Reddy, U. M., Parker, C. B., Thorsten, V., Goldenberg, R. L. (2018). Stillbirth, hypertensive disorders of pregnancy, and placental pathology. Placenta, 43(2016), 61–68.(20) Aminu M, Bar-Zeev S, van den Broek N. Cause of and factors associated with stillbirth: a systematic review of classification systems. Act Obstet Gynecol Scand 2017; 96:519.(21) Groan H, Bouman K, Pierini A, et al. Stillbirth and neonatal mortality in pregnancies complicated by major congenital anomalies: Findings from a large European cohort. Prenat Diagn 2017; 37:1100.(22) Bukowski R, Hansen NI, Willinger M, et al. Fetal growth and risk of stillbirth: a population-based case-control study. Plops Med 2017; 11:e1001633.(23) Page JM, Beardsley T, Thorsten V, et al. Stillbirth Associated With Infection in a Diverse U.S. Cohort. Obstet Gynecol 2019; 134:1187.(24) Kubendran S, Duong J, Dong F, et al. Implementing a Protocol to Optimize Detection of Chromosome Abnormalities in Cases of Miscarriage or Stillbirth at a Midwestern Teaching Hospital. Perm J 2018; 22:17.(25) Boyd TK. Fetal death. In: Placental and Gestational Pathology, 1st ed, Redline RW, Boyd TK, Roberts DJ (Eds), Cambridge University Press, Cambridge 2018. p.316.(26) Korteweg FJ, Gordijn SJ, Timmer A, et al. The Tulip classification of perinatal mortality: introduction and multidisciplinary inter-rater agreement. BJOG 2016; 113:393.(27) Hammad IA, Blue NR, Almshouse AA, et al. Umbilical Cord Abnormalities and Stillbirth. Obstet Gynecol 2020; 135:644.(28) Wojcieszek AM, Shepherd E, Middleton P, et al. Interventions for investigating and identifying the causes of stillbirth. Cochrane Database Syst Rev 2018; 4:CD012504.(29) Lawn, J. E., Glencoe, H., Waiswa, P., Amouzou, A., Mathers, C., Hogan, D., Froen, J. F. Ending preventable stillbirths 2 Stillbirths : rates, risk factors, and acceleration towards 2018. 2030, 387, 587–603(30) Yao, R., Park, B. Y., Foster, S. E., & Caughey, A. B. Annals of Epidemiology The association between gestational weight gain and risk of stillbirth : a population-based cohort study. Annals of Epidemiology, 2018. 27(10), 638–644.e1(31) Wojcieszek AM, Shepherd E, Middleton P, et al. Interventions for investigating and identifying the causes of stillbirth. Cochrane Database Syst Rev 2018; 4:CD012504.(32) Silver RM. examining the link between placental pathology, growth restriction, and stillbirth. Best Pract Res Clin Obstet Gynaecol. 2018 May;49:89-102. doi: 10.1016/j.bpobgyn.2018.03.004. Epub 2018 Mar 26. PMID: 29759932.(33) Heazell AE, Hayes DJ, Whitworth M, et al. Biochemical tests of placental function versus ultrasound assessment of fetal size for stillbirth and small-for-gestational-age infants. Cochrane Database Syst Rev 2019; 5:CD012245.(34) Norman JE, Heazell AEP, Rodriguez A, et al. Awareness of fetal movements and care package to reduce fetal mortality (AFFIRM): a stepped wedge, cluster-randomized trial. Lancet 2018; 392:1629.(35) Tita ATN, Jablonski KA, Bailit JL, et al. Neonatal outcomes of elective early-term births after demonstrated fetal lung maturity. Am J Obstet Gynecol 2018; 219:296.e1.(36) Grobman WA, Rice MM, Reddy UM, et al. Labor Induction versus Expectant Management in Low-Risk Nulliparous Women. N Engl J Med 2018; 379:513.(37) TSpong CY, Mercer BM, D'alton M, et al. Momento indicado para el parto prematuro tardío y prematuro. Obstet Gynecol 2017; 118: 323.(38) Kurner JM, Robertson NT, Hartel G, Kumar S. Impacto de la aspirina en dosis bajas en el resultado perinatal adverso: metanálisis y metarregresión. Ultrasonido Obstet Gynecol 2020; 55: 157.(39) Saleem S, Tikmani SS, McClure EM, et al. Trends and determinants of stillbirth in developing countries: results from the Global Network's Population-Based Birth Registry. Reprod Health 2018; 15:100.(40) Reinebrant HE, Leisher SH, Coory M, et al. making stillbirths visible: a systematic review of globally reported causes of stillbirth. BJOG 2018; 125:212.(41) Kubendran S, Duong J, Dong F, et al. Implementing a Protocol to Optimize Detection of Chromosome Abnormalities in Cases of Miscarriage or Stillbirth at a Midwestern Teaching Hospital. Perm J 2018; 22:17.(42) Munroe PB, Addison S, Abrams DJ, et al. Postmortem Genetic Testing for Cardiac Ion Channelopathies in Stillbirths. Circ Genom Precis Med 2018; 11:e001817.(43) Malacova E, Regan A, Nassar N, et al. Risk of stillbirth, preterm delivery, and fetal growth restriction following exposure in a previous birth: systematic review and meta-analysis. BJOG 2018; 125:183.(44) Page JM, Thorsten V, Reddy UM, et al. Potentially Preventable Stillbirth in a Diverse U.S. Cohort. Obstet Gynecol 2018; 131:336.(45) Nuzum D, Meaney S, O'Donoghue K. The impact of stillbirth on bereaved parents: A qualitative study. PLoS One 2018; 13:e0191635.(46) Atienza-Carrasco J, Linares-Abad M, Padilla-Ruiz M, Morales-Gil IM. Breaking bad news to antenatal patients with strategies to lessen the pain: a qualitative study. Reprod Health 2018; 15:11.(47) Shehab O, Tester DJ, Ackerman NC, et al. Whole genome sequencing identifies etiology of recurrent male intrauterine fetal death. Prenat Diagn 2017; 37:1040.(48) Aminu M, Bar-Zeev S, van den Broek N. Cause of and factors associated with stillbirth: a systematic review of classification systems. Acta Obstet Gynecol Scand 2017; 96:519.(49) Groen H, Bouman K, Pierini A, et al. Stillbirth and neonatal mortality in pregnancies complicated by major congenital anomalies: Findings from a large European cohort. Prenat Diagn 2017; 37:1100.(50) Gomes MS, Carlos-Alves M, Trocado V, et al. Prediction of adverse pregnancy outcomes by extreme values of first trimester screening markers. Obstet Med 2017; 10:132.(51) Fyfe R, Murray H. Comparison of induction of labour regimes for termination of pregnancy, with and without mifepristone, from 20 to 41 weeks gestation. Aust N Z J Obstet Gynaecol 2017; 57:604.(52) Miller ES, Minturn L, Linn R, et al. Stillbirth evaluation: a stepwise assessment of placental pathology and autopsy. Am J Obstet Gynecol 2016; 214:115.e1.(53) Goldstein RD, Kinney HC, Willinger M. Sudden Unexpected Death in Fetal Life through Early Childhood. Pediatrics 2016; 137.(54) Man J, Hutchinson JC, and Ashworth M, et al. Effects of intrauterine retention and postmortem interval on body weight following intrauterine death: implications for assessment of fetal growth restriction at autopsy. Ultrasound Obstet Gynecol 2016; 48:574.(55) Man J, Hutchinson JC, Ashworth M, et al. Stillbirth and intrauterine fetal death: role of routine histological organ sampling to determine cause of death. Ultrasound Obstet Gynecol 2016.(56) Andrikopoulou M, Lavery JA, Ananth CV, Vintzileos AM. Cervical ripening agents in the second trimester of pregnancy in women with a scarred uterus: a systematic review and metaanalysis of observational studies. Am J Obstet Gynecol 2016; 215:177(57) Page, J. M., & Silver, R. M. (2018). Seminars in Fetal & Neonatal Medicine Interventions to prevent stillbirth. Seminars in Fetal and Neonatal Medicine, 22(3), 135–145.(58) Dhalwani NN, Szatkowski L, Coleman T, et al. 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