La morfometría como método de ayuda para el diagnóstico del autismo

Una de las afecciones más graves que tiene una persona que padece de un TEA es la de no poder ser comprendido frente a los factores que socialmente lo incomodan y, el hecho de que esté sufriendo por esto trae en consecuencia, una angustia permanente por parte de sus familiares quienes estarán intent...

Full description

Autores:
Villate Baquero, Nicolas Santiago
Tipo de recurso:
Trabajo de grado de pregrado
Fecha de publicación:
2020
Institución:
Universidad Militar Nueva Granada
Repositorio:
Repositorio UMNG
Idioma:
spa
OAI Identifier:
oai:repository.unimilitar.edu.co:10654/36775
Acceso en línea:
http://hdl.handle.net/10654/36775
Palabra clave:
AUTISMO
AUTISMO - DIAGNOSTICO
MRI
ASD
Diagnosis
Structural Differences
Morphometry
Digital image processing
Brain
Autism
MRI
TEA
Autismo
Procesamiento digital de imágenes
Morfometría
Cerebro
Diferencias estructurales
Diagnóstico
Rights
openAccess
License
http://creativecommons.org/licenses/by-nc-nd/4.0/
id UNIMILTAR2_0ecf006b744140a5ce659513668fe1c2
oai_identifier_str oai:repository.unimilitar.edu.co:10654/36775
network_acronym_str UNIMILTAR2
network_name_str Repositorio UMNG
repository_id_str
dc.title.spa.fl_str_mv La morfometría como método de ayuda para el diagnóstico del autismo
dc.title.translated.spa.fl_str_mv Morphometry as a method of aid for the diagnosis of autism
title La morfometría como método de ayuda para el diagnóstico del autismo
spellingShingle La morfometría como método de ayuda para el diagnóstico del autismo
AUTISMO
AUTISMO - DIAGNOSTICO
MRI
ASD
Diagnosis
Structural Differences
Morphometry
Digital image processing
Brain
Autism
MRI
TEA
Autismo
Procesamiento digital de imágenes
Morfometría
Cerebro
Diferencias estructurales
Diagnóstico
title_short La morfometría como método de ayuda para el diagnóstico del autismo
title_full La morfometría como método de ayuda para el diagnóstico del autismo
title_fullStr La morfometría como método de ayuda para el diagnóstico del autismo
title_full_unstemmed La morfometría como método de ayuda para el diagnóstico del autismo
title_sort La morfometría como método de ayuda para el diagnóstico del autismo
dc.creator.fl_str_mv Villate Baquero, Nicolas Santiago
dc.contributor.advisor.none.fl_str_mv Velasco Toledo, Nelson Fernando
dc.contributor.author.none.fl_str_mv Villate Baquero, Nicolas Santiago
dc.subject.lemb.spa.fl_str_mv AUTISMO
AUTISMO - DIAGNOSTICO
topic AUTISMO
AUTISMO - DIAGNOSTICO
MRI
ASD
Diagnosis
Structural Differences
Morphometry
Digital image processing
Brain
Autism
MRI
TEA
Autismo
Procesamiento digital de imágenes
Morfometría
Cerebro
Diferencias estructurales
Diagnóstico
dc.subject.keywords.spa.fl_str_mv MRI
ASD
Diagnosis
Structural Differences
Morphometry
Digital image processing
Brain
Autism
dc.subject.proposal.spa.fl_str_mv MRI
TEA
Autismo
Procesamiento digital de imágenes
Morfometría
Cerebro
Diferencias estructurales
Diagnóstico
description Una de las afecciones más graves que tiene una persona que padece de un TEA es la de no poder ser comprendido frente a los factores que socialmente lo incomodan y, el hecho de que esté sufriendo por esto trae en consecuencia, una angustia permanente por parte de sus familiares quienes estarán intentando hacer lo que esté a su alcance para hacer sentir bien a su familiar afectado [4-5]. Adicionalmente, el diagnóstico de los TEA es complicado, dispendioso y no muy exacto, esto causa que día a día profesionales especializados busquen múltiples formas de facilitar y optimizar el proceso para llegar a dicho dictamen. Por ello, se busca con este trabajo proponer un método auxiliar que ayude a los profesionales de la salud a dictar juicios más objetivos y ágiles para así poder evitar un diagnóstico erróneo que pueda generar el despilfarro de dinero en estudios y medicamentos que posiblemente no ayuden al paciente
publishDate 2020
dc.date.accessioned.none.fl_str_mv 2020-11-10T00:46:55Z
dc.date.available.none.fl_str_mv 2020-11-10T00:46:55Z
dc.date.issued.none.fl_str_mv 2020-09-28
dc.type.local.spa.fl_str_mv Tesis/Trabajo de grado - Monografía - Pregrado
dc.type.driver.spa.fl_str_mv info:eu-repo/semantics/bachelorThesis
dc.type.coar.*.fl_str_mv http://purl.org/coar/resource_type/c_7a1f
format http://purl.org/coar/resource_type/c_7a1f
dc.identifier.uri.none.fl_str_mv http://hdl.handle.net/10654/36775
dc.identifier.instname.spa.fl_str_mv instname:Universidad Militar Nueva Granada
dc.identifier.reponame.spa.fl_str_mv reponame:Repositorio Institucional Universidad Militar Nueva Granada
dc.identifier.repourl.spa.fl_str_mv repourl:https://repository.unimilitar.edu.co
url http://hdl.handle.net/10654/36775
identifier_str_mv instname:Universidad Militar Nueva Granada
reponame:Repositorio Institucional Universidad Militar Nueva Granada
repourl:https://repository.unimilitar.edu.co
dc.language.iso.spa.fl_str_mv spa
language spa
dc.relation.references.spa.fl_str_mv [1] "Nueva Clasificación de los trastornos mentales", Sonepsyn.cl, 2014. [Online]. Available:https://www.sonepsyn.cl/revneuro/enero_marzo_2014/Suplemento_2014_1_Neuro_Psiq.pdf. [Accessed: 22- Apr- 2019].
[2] O. Castillero, "Las 10 principales pruebas para detectar el autismo", Psicologiaymente.com, 2015. [Online]. Available: https://psicologiaymente.com/clinica/pruebas-para-detectar-autismo. [Accessed:22- Apr- 2019].
[3] "¿Preocupado por el desarrollo?", Centers for Disease Control and Prevention, 2015. [Online]. Available: https://www.cdc.gov/spanish/especialesCDC/reaccionarpronto/. [Accessed: 22-Apr- 2019].
[4] B. Salud, "Causas, síntomas y tratamiento del autismo", Sanitas, 2017. [Online]. Available: https://www.sanitas.es/sanitas/seguros/es/particulares/biblioteca-de-salud/pediatria-infancia/autismo.html.[Accessed: 22- Apr- 2019].
[5] "Trastorno del espectro autista: MedlinePlus en español", Medlineplus.gov, 2018. [Online]. Available:https://medlineplus.gov/spanish/autismspectrumdisorder.html. [Accessed: 22-Apr- 2019].
[6] "Evaluación y diagnóstico | Trastornos del espectro autista", Cdc.gov, 2016. [Online]. Available: https://www.cdc.gov/ncbddd/spanish/autism/screening.html.[Accessed: 28- Apr- 2019].
[7] S. Ha, I. Sohn and N. Kim, "Characteristics of Brains in Autism Spectrum Disorder: Structure, Function and Connectivity across the Lifespan.", ncbi.nlm.nih.gov, 2015. [Online]. Available: https://pubmed.ncbi.nlm.nih.gov/26713076/. [Accessed: 28- Apr- 2019].
[8] M. Ismail, R. Keynton and M. Mostapha, "Studying Autism Spectrum Disorder with Structural and Diffusion Magnetic Resonance Imaging: A Survey.", ncbi.nlm.nih.gov, 2016. [Online]. Available: https://www.ncbi.nlm.nih.gov/pubmed/27242476. [Accessed: 28- Apr- 2019].
[9] "ICD 10 en línea, Volumen 1, Español", Ais.paho.org. [Online]. Available: http://ais.paho.org/classifications/Chapters/.[Accessed: 22- Apr- 2019].
[10] "Paidopsiquiatría", Psiquiatria.com, 2019. [Online]. Available: https://psiquiatria.com/glosario/paidopsiquiatria. [Accessed: 22- Apr- 2019].
[11] "¿Qué es un neurólogo infantil?", HealthyChildren.org, 2019. [Online]. Available: https://www.healthychildren.org/Spanish/family-life/health-management/pediatric-specialists/Paginas/what-is-a-child-neurologist.aspx. [Accessed: 22- Apr- 2019].
[12] P. Lam, "MRI Scans: Definition, uses, and procedure", Medical News Today, 2018. [Online]. Available: https://www.medicalnewstoday.com/articles/146309.php. [Accessed: 22- Apr- 2019].
[13] "Imagen por Resonancia Magnética (IRM) | National Institute of Biomedical Imaging and Bioengineering", Nibib.nih.gov, 2016. [Online]. Available: https://www.nibib.nih.gov/espanol/temas-cientificos/imagen-por-resonancia-magn%C3%A9tica-irm. [Accessed: 22- Apr- 2019].
[14] V. Siless, "FreeSurferWiki - Free Surfer Wiki", Surfer.nmr.mgh.harvard.edu, 2018. [Online]. Available: https://surfer.nmr.mgh.harvard.edu/fswiki. [Accessed: 28- Apr- 2019].
[15] M. Filippi, M. Rocca, O. Ciccarelli and N. De Stefano, "MRI criteria for the diagnosis of multiple sclerosis: MAGNIMS consensus guidelines", sciencedirect.com, 2016. [Online]. Available: https://www.sciencedirect.com/science/article/pii/S1474442215003932. [Accessed:28- Apr- 2019].
[16]D. Fraguas, L. Pina and C. Arango, "Progressive brain changes in children and adolescents with early-onset psychosis: A meta-analysis of longitudinal MRI studies", sciencedirect.com,2016.[Online].Available:https://www.sciencedirect.com/science/article/pii/S0920996414007543. [Accessed: 28- Apr- 2019].
[17] C. Tamnes and I. Agartz, "White Matter Microstructure in Early-Onset Schizophrenia: A Systematic Review of Diffusion Tensor Imaging Studies", sciencedirect.com, 2016. [Online]. Available: https://www.sciencedirect.com/science/article/abs/pii/S0890856716000381. [Accessed: 28- Apr- 2019].
[18] C. Falcon, A. Tucholka, G. Monté-Rubio and R. Cacciaglia, "Longitudinal structural cerebral changes related to core CSF biomarkers in preclinical Alzheimer's disease: A study of two independent datasets.", ncbi.nlm.nih.gov, 2018. [Online]. Available: https://www.ncbi.nlm.nih.gov/pubmed/30023169. [Accessed: 28- Apr- 2019].
[19] A. Al-Radaideh, A. I and A. H, "Cortical and Subcortical Morphometric and Iron Changes in Relapsing-Remitting Multiple Sclerosis and Their Association with White Matter T2 Lesion Load : A 3-Tesla Magnetic Resonance Imaging Study.", ncbi.nlm.nih.gov, 2019. [Online]. Available: https://www.ncbi.nlm.nih.gov/pubmed/29299614. [Accessed:28- Apr- 2019].
[20] A. Radziunas, V. Deltuva and A. Tamasauskas, "Brain MRI morphometric analysis in Parkinson's disease patients with sleep disturbances.", ncbi.nlm.nih.gov, 2018. [Online]. Available: https://www.ncbi.nlm.nih.gov/pubmed/29925331. [Accessed: 28- Apr- 2019].
[21] T. Gabrielsen, J. Anderson and K. Stephenson, "Functional MRI connectivity of children with autism and low verbal and cognitive performance.", ncbi.nlm.nih.gov, 2018. [Online]. Available: https://www.ncbi.nlm.nih.gov/pubmed/30603063. [Accessed: 28- Apr- 2019].
[22] A. Pagnozzi, E. Conti and S. Calderoni, "A systematic review of structural MRI biomarkers in autism spectrum disorder: A machine learning perspective.", ncbi.nlm.nih.gov, 2018. [Online]. Available: https://www.ncbi.nlm.nih.gov/pubmed/30172895. [Accessed: 28- Apr- 2019]
[23] D. Li, H. Karnath and X. Xu, "Candidate Biomarkers in Children with Autism Spectrum Disorder: A Review of MRI Studies.", ncbi.nlm.nih.gov, 2017. [Online]. Available: https://www.ncbi.nlm.nih.gov/pubmed/28283808. [Accessed: 28- Apr- 2019].
[24] A. Triglia, "Materia gris del cerebro: estructura y funciones", Psicologiaymente.com, 2017. [Online]. Available: https://psicologiaymente.com/neurociencias/materia-gris-cerebro. [Accessed: 22-Apr- 2019].
[25] "Sustancia blanca del cerebro: MedlinePlus enciclopedia médica", Medlineplus.gov, 2018. [Online]. Available: https://medlineplus.gov/spanish/ency/article/002344.htm. [Accessed: 22- Apr-2019].
[26] "Bayesian analysis of neuroimaging data in FSL. - PubMed - NCBI", Ncbi.nlm.nih.gov, 2010. [Online]. Available: https://www.ncbi.nlm.nih.gov/pubmed/19059349. [Accessed: 22- Apr- 2019].
[27] "SPM - Statistical Parametric Mapping", Fil.ion.ucl.ac.uk, 2018. [Online]. Available:https://www.fil.ion.ucl.ac.uk/spm/. [Accessed: 28- Apr- 2019].
[28] C. Guo, D. Ferreira and E. Westman, "Repeatability and reproducibility of FreeSurfer, FSL-SIENAX and SPM brain volumetric measurements and the effect of lesion filling in multiple sclerosis.", ncbi.nlm.nih.gov, 2019. [Online]. Available: https://www.ncbi.nlm.nih.gov/pubmed/30242503.[Accessed: 28- Apr- 2019].
[29] A. Trigilia, "Los 5 lóbulos del cerebro y sus distintas funciones", Psicologiaymente.com, 2018. [Online]. Available: https://psicologiaymente.com/neurociencias/lobulos-del-cerebro-funciones. [Accessed: 09- Apr- 2020].
[30] "¿Cómo es y cómo funciona nuestro cerebro?", Blog.fpmaragall.org, 2020. [Online]. Available: https://blog.fpmaragall.org/como-es-y-como-funciona-nuestro-cerebro. [Accessed: 08- Apr- 2020].
[31] L. Hirsch, "El cerebro y el sistema nervioso (para Adolecentes) - Nemours KidsHealth", Kidshealth.org, 2019. [Online]. Available: https://kidshealth.org/es/teens/brain-nervous-system-esp.html. [Accessed: 08- Apr- 2020].
[32] Ratey, John J. Cerebro: manual de instrucciones. 2003. Mondadori. [Accessed: 08- Apr- 2020].
[33] E. Jimenez, "Lóbulo cerebral - EcuRed", Ecured.cu, 2011. [Online]. Available: https://www.ecured.cu/L%C3%B3bulo_cerebral. [Accessed: 21- Apr- 2020].
[34] R. Lord, "asperger infantil", Asperger.es, 2017. [Online]. Available: https://www.asperger.es/sindrome_asperger_infancia_sintomas.html. [Accessed: 05- May- 2020].
[35] "La sinapsis (artículo) | Biología humana | Khan Academy", Khan Academy, 2018. [Online]. Available: https://es.khanacademy.org/science/biology/human-biology/neuron-nervous-system/a/the-synapse. [Accessed: 07- May- 2020].
[36] M. Mercadante and R. Van der Gaag, "Transtornos invasivos do desenvolvimento não-autísticos: síndrome de Rett, transtorno desintegrativo da infância e transtornos invasivos do desenvolvimento sem outra especificação", SciELO, 2006. [Online]. Available: https://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-44462006000500003. [Accessed: 18- Apr- 2020].
[37] "Anatomía y fisiología de los ganglios basales | NeuroWikia", Neurowikia.es, 2020. [Online]. Available: http://www.neurowikia.es/content/anatomia-y-fisiologia-de-los-ganglios-basales. [Accessed: 24- Apr- 2020].
[38] N. Kaneshiro, "Cuerpo calloso del cerebro: MedlinePlus enciclopedia médica illustración", Medlineplus.gov, 2018. [Online]. Available: https://medlineplus.gov/spanish/ency/esp_imagepages/8753.htm. [Accessed: 24- Apr- 2020].
[39] S. Sinha Dutta, "Funciones del hipocampo", News-Medical.net, 2019. [Online]. Available:https://www.news-medical.net/health/Hippocampus-Functions-(Spanish).aspx#2. [Accessed: 09- Sep- 2019].
[40] "Amígdala Cerebral - EcuRed", Ecured.cu, 2013. [Online]. Available: https://www.ecured.cu/Am%C3%ADgdala_Cerebral. [Accessed: 17- Sep- 2019].
[41] "Científicos revelan que anomalías del cerebro del feto pueden ser la causa del autismo", Autismo Madrid, 2014. [Online]. Available: https://autismomadrid.es/investigacion-2/cientificos-revelan-que-anomalias-del-cerebro-del-feto-pueden-ser-la-causa-del-autismo/. [Accessed: 24- Aug- 2019].
[42] "El Cerebro Humano", Sobre el cerebro humano - CogniFit, 2010. [Online]. Available: https://www.cognifit.com/es/cerebro. [Accessed: 15- Sep- 2019].
[43] C. Pardo, "The Neurobiology of Autism", Wiley Online Library, 2007. [Online]. Available: https://onlinelibrary.wiley.com/doi/full/10.1111/j.1750-3639.2007.00102.x. [Accessed: 10- Sep- 2019].
[44] "Diccionario de cáncer del NCI", Instituto Nacional del Cáncer, 2005. [Online]. Available: https://www.cancer.gov/espanol/publicaciones/diccionario/def/liquido-cefalorraquideo. [Accessed: 03- Aug- 2019].
[45] "Las Áreas Corticales:", Página web de neurofisiologia11, 2005. [Online]. Available: https://neurofisiologia11.jimdofree.com/%C3%A1reas-corticales/#:~:text=Las%20%C3%A1reas%20corticales%2C%20son%20lugares,y%20l%C3%ADmbico%20hay%20funciones%20asociadas. [Accessed: 06- Aug- 2019].
[46] I. Rovira, "Estructuras subcorticales del encéfalo: tipos y funciones", Psicologiaymente.com, 2013. [Online]. Available: https://psicologiaymente.com/neurociencias/estructuras-subcorticales#:~:text=El%20sistema%20o%20estructura%20subcortical,ventral%20de%20los%20ventr%C3%ADculos%20laterales. [Accessed: 20- Aug- 2019].
[47] M. Macias, "Etapas del neurodesarrollo", neuronas en crecimiento, 2015. [Online]. Available: https://neuropediatra.org/2015/12/16/etapas-del-neurodesarrollo/. [Accessed: 12- May- 2020].
[48] F. Ostrosky, "Desarrollo del cerebro", Portal.oas.org. [Online]. Available: http://portal.oas.org/LinkClick.aspx?fileticket=QSVgfnifmNc%3D&tabi. [Accessed: 08- May- 2020].
[49] E. Bowden and M. Jung-Beeman, "Aha! Insight experience correlates with solution activation in the right hemisphere", Psychonomic Bulletin & Review, vol. 10, no. 3, pp. 730-737, 2003. Available: https://pubmed.ncbi.nlm.nih.gov/14620371/. [Accessed 25 August 2019].
[50] B. Regader, "Hemisferios cerebrales: mitos y realidades", Psicologiaymente.com, 2017. [Online]. Available: https://psicologiaymente.com/neurociencias/hemisferios-cerebrales-mitos-realidades. [Accessed: 09- Feb- 2020].
[51] M. Jung-Beeman et al., "Neural Activity When People Solve Verbal Problems with Insight", PLoS Biology, vol. 2, no. 4, p. e97, 2004. Available: https://pubmed.ncbi.nlm.nih.gov/15094802/. [Accessed 7 July 2019].
[52] "Rayos X: MedlinePlus en español", Medlineplus.gov, 2010. [Online]. Available: https://medlineplus.gov/spanish/xrays.html. [Accessed: 13- Mar- 2020].
[53] "TAC: Tomografia Axial Computarizada", Fisterra.com, 2010. [Online]. Available: https://www.fisterra.com/Salud/3proceDT/tac.asp. [Accessed: 15- Mar- 2020].
[54] "Exámenes PET CT y RM: ¿Qué son y cómo usarlos en la medicina diagnóstica?", MV - Líder em Sistemas de Gestão de Saúde, 2016. [Online]. Available: http://www.mv.com.br/es/blog/examenes--pet-ct-y-rm---que-son-y-como-usarlos-en-la-medicina-diagnosticar. [Accessed: 10- Mar- 2020].
[55] A. Lopez, "Morfometría geométrica: el estudio de la forma y su aplicación en biología", Utm.mx, 2015. [Online]. Available: http://www.utm.mx/edi_anteriores/temas55/T55_2Nota_6.pdf. [Accessed: 28- Apr- 2019].
[56] I. Gielen, "Comparación de las técnicas de diagnóstico por imagen empleadas en la articulación con osteoartritis y su interpretación", Ddd.uab.cat, 2006. [Online]. Available: https://ddd.uab.cat/pub/clivetpeqani/11307064v26n2/11307064v26n2p137.pdf. [Accessed: 14- Mar- 2020].
[57] J. Levy, "Resonancia magnética: MedlinePlus enciclopedia médica", Medlineplus.gov, 2018. [Online]. Available: https://medlineplus.gov/spanish/ency/article/003335.htm. [Accessed: 22- Mar- 2020].
[58] A. Alegria Perez, "Principios fisicos de Resonancia Magnética", Es.slideshare.net, 2020. [Online]. Available: https://es.slideshare.net/RadiologiaHUP/principios-fisicos-de-resonancia-magnética. [Accessed: 24- Aug- 2020].
[59] A. Suarez and M. Vega, "Métodos morfométricos para detectar diferencias estructurales entre cerebros | Revista CENIC Ciencias Biológicas", Revista.cnic.edu.cu, 2019. [Online]. Available: https://revista.cnic.edu.cu/revistaCB/articulos/metodos-morfometricos-para-detectar-diferencias-estructurales-entre-cerebros. [Accessed: 22- Apr- 2019].
[60]J. Ashburner and K. Friston, "Voxel-Based Morphometry—The Methods", sciencedirect.com, 2002. [Online]. Available: https://www.sciencedirect.com/science/article/pii/S1053811900905822. [Accessed: 28- Apr- 2019].
[61] C. Peña, "Seguridad del paciente - Materiales de Contraste", Radiologyinfo.org, 2018. [Online]. Available: https://www.radiologyinfo.org/sp/info.cfm?pg=safety-contrast. [Accessed: 29- Mar- 2020].
[62] G. Luks, "Técnicas de Neuroimagen", Sites.google.com, 2015. [Online]. Available: https://sites.google.com/site/tecnicasdeneuroimagen/. [Accessed: 01- Apr- 2020].
[63] G. Bastarrika, "¿Qué es el TR?", Ecocardio.com. [Online]. Available: https://ecocardio.com/documentos/biblioteca-preguntas-basicas/preguntas-al-radiologo/919-que-es-tr.html. [Accessed: 28- Feb- 2020].
[64] D. Greve, "An Absolute Beginner’s Guide to Surface- and Voxel-based Morphometric Analysis", Cds.ismrm.org, 2011. [Online]. Available: https://cds.ismrm.org/protected/11MProceedings/files/ISMRM2011-8410.pdf. [Accessed: 22- Apr- 2020].
[65] R. Negrín, "La Morfología Funcional Deportiva. Su importancia en el currículo de la carrera de Cultura Física", Efdeportes.com, 2016. [Online]. Available: https://www.efdeportes.com/efd213/la-morfologia-funcional-deportiva-en-cultura-fisica.htm. [Accessed: 04- Nov- 2019].
[66] "Introducción a la evolución: Tipos de cambios en el desarrollo", Sesbe.org, 2020. [Online]. Available: https://www.sesbe.org/evosite/evo101/IIIC6dDevochange2.shtml.html. [Accessed: 05- Nov- 2019].
[67] M. Rodriguez, "Plasticidad fenotípica", Ugr.es, 2020. [Online]. Available: http://www.ugr.es/~jmgreyes/plasticidad.html. [Accessed: 06- Nov- 2019].
[68] "alometría – BioDic", Biodic.net, 2011. [Online]. Available: https://www.biodic.net/palabra/alometria/#.XvBaqmhKjIU. [Accessed: 07- Nov- 2019].
[69]”K-space (magnetic resonance imaging)", En.wikipedia.org, 2018. [Online]. Available: https://en.wikipedia.org/wiki/K-space_(magnetic_resonance_imaging). [Accessed: 10- Mar- 2020].
[70] V. Cutanda and d. Moratal, "Automatic Brain Morphometry and Volumetry Using SPM on Cognitively Impaired Patients", researchgate.net, 2015. [Online]. Available: https://www.researchgate.net/publication/276298355_Automatic_Brain_Morphometry_and_Volumetry_Using_SPM_on_Cognitively_Impaired_Patients. [Accessed: 30- Nov- 2019].
[71] A. BRUN and E. ENGLUND, "Regional pattern of degeneration in Alzheimer's disease: neuronal loss and histopathological grading", Histopathology, vol. 5, no. 5, pp. 549-564, 1981. Available: https://pubmed.ncbi.nlm.nih.gov/7286917/. [Accessed 18 October 2019].
[72] M. Raffino, "Geomorfología - Concepto, objeto de estudio, importancia y ramas", Concepto.de, 2020. [Online]. Available: https://concepto.de/geomorfologia/. [Accessed: 08- Nov- 2019].
[73] "Introduction - BET", Fsl.fmrib.ox.ac.uk. [Online]. Available: https://fsl.fmrib.ox.ac.uk/fslcourse/lectures/practicals/intro2/index.html. [Accessed: 10- Mar- 2020].
[74] S. Lorio and S. Fresard, "About the MNI space(s) – Lead-DBS", Lead-dbs.org, 2016. [Online]. Available: https://www.lead-dbs.org/about-the-mni-spaces/. [Accessed: 24- Mar- 2020].
[75] "Cómo funciona Transformar (cobertura)—Ayuda | ArcGIS for Desktop", Desktop.arcgis.com. [Online]. Available: http://desktop.arcgis.com/es/arcmap/10.3/tools/coverage-toolbox/how-transform-works.htm. [Accessed: 22- Mar- 2020].
[76] J. Andersson and M. Jenkinson, "FNIRT - FslWiki", Fsl.fmrib.ox.ac.uk, 2010. [Online]. Available: https://fsl.fmrib.ox.ac.uk/fsl/fslwiki/FNIRT. [Accessed: 23- Mar- 2020].
[77] J. Carpenter and S. Tribich, "Methods for Dummies Voxel-Based Morphometry (VBM) - ppt download", Slideplayer.com, 2016. [Online]. Available: https://slideplayer.com/slide/10495989/. [Accessed: 17- Mar- 2020].
[78] "Modelo lineal general: hipótesis y estimación", Ucm.es, 2013. [Online]. Available: https://www.ucm.es/data/cont/docs/518-2013-10-25-Tema_3_1_EctrGrado.pdf. [Accessed: 02- May- 2020].
[79] "¿Qué es ANOVA? - Minitab", Support.minitab.com, 2019. [Online]. Available: https://support.minitab.com/es-mx/minitab/19/help-and-how-to/statistical-modeling/anova/supporting-topics/basics/what-is-anova/#:~:text=Un%20an%C3%A1lisis%20de%20varianza%20(ANOVA,diferentes%20niveles%20de%20los%20factores. [Accessed: 04- May- 2020].
[80] A. Manera, M. Dadar, D. Collins and S. Ducharme, "Deformation based morphometry study of longitudinal MRI changes in behavioral variant frontotemporal dementia", NeuroImage: Clinical, vol. 24, p. 102079, 2019. Available: https://www.sciencedirect.com/science/article/pii/S2213158219304267. [Accessed 10 October 2019].
[81] C. Gaser, I. Nenadic, B. Buchsbaum, E. Hazlett and M. Buchsbaum, "Deformation-Based Morphometry and Its Relation to Conventional Volumetry of Brain Lateral Ventricles in MRI", NeuroImage, vol. 13, no. 6, pp. 1140-1145, 2001. Available: https://pubmed.ncbi.nlm.nih.gov/11352619/. [Accessed 10 October 2019].
[82] E. Meintjes et al., "A tensor-based morphometry analysis of regional differences in brain volume in relation to prenatal alcohol exposure", NeuroImage: Clinical, vol. 5, pp. 152-160, 2014. Available: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4097000/. [Accessed 12 October 2019].
[83] V. Rajagopalan et al., "Mapping directionality specific volume changes using tensor based morphometry: An application to the study of gyrogenesis and lateralization of the human fetal brain", NeuroImage, vol. 63, no. 2, pp. 947-958, 2012. Available: https://europepmc.org/article/PMC/3732053. [Accessed 13 October 2019].
[84] S. Smith, "Fast robust automated brain extraction", Human Brain Mapping, vol. 17, no. 3, pp. 143-155, 2002. Available: https://pubmed.ncbi.nlm.nih.gov/12391568/. [Accessed 19 April 2020].
[85] M. Jenkinson, M. Pechaud, and S. Smith. “BET2: MR-based estimation of brain, skull and scalp surfaces”. 2005. In Eleventh Annual Meeting of the Organization for Human Brain Mapping. [Accessed 19 April 2020].
[86] Zhang, Y. and Brady, M. and Smith, S. “Segmentation of brain MR images through a hidden Markov random field model and the expectation-maximization algorithm”. 2001. IEEE Trans Med Imag, 20(1):45-57. [Accessed 20 April 2020].
[87] M. Jenkinson and S.M. Smith. “A global optimisation method for robust affine registration of brain images”. 2001. Medical Image Analysis, 5(2):143-156. [Accessed 20 April 2020].
[88] N. Thomas, "FAST - FslWiki", Fsl.fmrib.ox.ac.uk, 2005. [Online]. Available: https://fsl.fmrib.ox.ac.uk/fsl/fslwiki/FAST. [Accessed: 26- Apr- 2019].
[89] M. Jenkinson and S.M. Smith. “A global optimisation method for robust affine registration of brain images”. 2001. Medical Image Analysis, 5(2):143-156. [Accessed: 26 April 2020].
[90] M. Jenkinson, "Fslutils - FslWiki", Fsl.fmrib.ox.ac.uk, 2020. [Online]. Available: https://fsl.fmrib.ox.ac.uk/fsl/fslwiki/Fslutils. [Accessed: 15- Apr- 2020].
[91] Makris N, Goldstein JM, Kennedy D, Hodge SM, Caviness VS, Faraone SV, Tsuang MT, Seidman LJ. “Disminución del volumen del lóbulo insular anterior izquierdo y total en la esquizofrenia”. 2006. Schizophr Res, vol. 83, pp. 155. [Accessed 19 May 2020].
[92] Frazier JA, Chiu S, Breeze JL, Makris N, Lange N, Kennedy DN, Herbert MR, Bent EK, Koneru VK, Dieterich ME, Hodge SM, Rauch SL, Grant PE, Cohen BM, Seidman LJ, Caviness VS, Biederman J . “Resonancia magnética cerebral estructural de los volúmenes límbico y talámico en el trastorno bipolar pediátrico”. 2005, vol. 7, pp. 1256. Soy J Psiquiatría.[Accessed 19 May 2020].
[93] S. Eickhoff et al., "A new SPM toolbox for combining probabilistic cytoarchitectonic maps and functional imaging data", NeuroImage, vol. 25, no. 4, pp. 1325-1335, 2005. Available: https://pubmed.ncbi.nlm.nih.gov/15850749/. [Accessed 3 June 2019].
[94] S. Eickhoff, S. Heim, K. Zilles and K. Amunts, "Testing anatomically specified hypotheses in functional imaging using cytoarchitectonic maps", NeuroImage, vol. 32, no. 2, pp. 570-582, 2006. Available: https://pubmed.ncbi.nlm.nih.gov/16781166/. [Accessed 4 June 2019].
[95] J. Talairach and P. Tournoux, "talairach.org | About", Talairach.org, 1988. [Online]. Available: https://www.talairach.org/about.html. [Accessed: 01- Jun- 2020].
[96] Di Martino, A. “Functional Connectomes Project International Neuroimaging Data-Sharing Initiative”. 2016. Available: http://fcon_1000.projects.nitrc.org/indi/abide/abide_I.html. [Accessed 16 January 2020].
[97] E. Courchesne et al., "Unusual brain growth patterns in early life in patients with autistic disorder: An MRI study", Neurology, vol. 57, no. 2, pp. 245-254, 2001. Available: https://n.neurology.org/content/57/2/245.short. [Accessed 16 June 2020].
[98] E. Courchesne, K. Campbell and S. Solso, "Brain growth across the life span in autism: Age-specific changes in anatomical pathology", Brain Research, vol. 1380, pp. 138-145, 2011. Available: https://www.sciencedirect.com/science/article/abs/pii/S0006899310021670. [Accessed 14 June 2020].
[99] I. Lobato, "ENTORNO PARA SEGMENTACIÓN DE IMÁGENES POR RESONANCIA MAGNÉTICA CEREBRALES", Diposit.ub.edu, 2013. [Online]. Available: http://diposit.ub.edu/dspace/bitstream/2445/48276/2/memoria.pdf. [Accessed: 06- Sep- 2019].
[100] L. Sucar, "Modelos Gráficos Probabilistas", Ccc.inaoep.mx, 2012. [Online]. Available: https://ccc.inaoep.mx/~esucar/Clases-mgp/pgm08-cam-2012.pdf. [Accessed: 06- Apr- 2020].
[101] T. Ortiz, "09-Variables latentes y algoritmo EM", Tereom.github.io, 2017. [Online]. Available: https://tereom.github.io/est-multivariada-15/09-EM.html#:~:text=El%20algoritmo%20de%20esperanza%2Dmaximizaci%C3%B3n,(%CE%B8(t)). [Accessed: 17- Apr- 2020].
[102] I. Gradštejn, Table of integrals, series, and products, 7th ed. New York: Acad. Press, 2000, pp. 1068-1069
[103] M. Jenkinson, "Atlases - FslWiki", Fsl.fmrib.ox.ac.uk. [Online]. Available: https://fsl.fmrib.ox.ac.uk/fsl/fslwiki/Atlases. [Accessed: 22- May- 2020].
[104] G. Seif, "The 5 Clustering Algorithms Data Scientists Need to Know", Medium, 2018. [Online]. Available: https://towardsdatascience.com/the-5-clustering-algorithms-data-scientists-need-to-know-a36d136ef68#:~:text=Clustering%20is%20a%20Machine%20Learning,the%20grouping%20of%20data%20points.&text=Clustering%20is%20a%20method%20of,analysis%20used%20in%20many%20fields. [Accessed: 29- May- 2020].
[105] C. Ákos Szabó et al., "Modeling the effective connectivity of the visual network in healthy and photosensitive, epileptic baboons", Brain Structure and Function, vol. 221, no. 4, pp. 2023-2033, 2015. Available: https://www.researchgate.net/publication/273324397_Modeling_the_effective_connectivity_of_the_visual_network_in_healthy_and_photosensitive_epileptic_baboons. [Accessed 12 October 2019].
[106] J. Anderson, K. Campbell, T. Amer, C. Grady and L. Hasher, "Timing is everything: Age differences in the cognitive control network are modulated by time of day.", Psychology and Aging, vol. 29, no. 3, pp. 648-657, 2014. Available: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4898963/. [Accessed 13 September 2019].
[107] C. Pradas, "Sistema límbico: partes, funciones y enfermedades - Con Fotos y Vídeo", psicologia-online.com, 2020. [Online]. Available: https://www.psicologia-online.com/sistema-limbico-partes-funciones-y-enfermedades-3824.html. [Accessed: 20- Jun- 2020].
[108] Andersson JLR, Jenkinson M, Smith S (2010) Non-linear registration, aka spatial normalisation. [Accessed 15 April 2020].
[109] J. Rodrigo, "T-test", Cienciadedatos.net, 2016. [Online]. Available: https://www.cienciadedatos.net/documentos/12_t-test. [Accessed: 08- Jun- 2020].
[110] M. Anderson and A. Winkler, "Randomise/Theory - FslWiki", Fsl.fmrib.ox.ac.uk, 2015. [Online]. Available: https://fsl.fmrib.ox.ac.uk/fsl/fslwiki/Randomise/Theory. [Accessed: 07- Jun- 2020].
[111] A. Winkler, G. Ridgway, M. Webster, S. Smith and T. Nichols, "Permutation inference for the general linear model", NeuroImage, vol. 92, pp. 381-397, 2014. Available: https://pubmed.ncbi.nlm.nih.gov/24530839/. [Accessed 25 October 2019].
[112] D. Amaral, C. Schumann and C. Nordahl, "Neuroanatomy of autism", Trends in Neurosciences, vol. 31, no. 3, pp. 137-145, 2008. Available: https://www.sciencedirect.com/science/article/abs/pii/S0166223608000386. [Accessed 15 June 2020].
[113] M. Atmaca, H. Yildirim, H. Ozdemir, E. Tezcan and A. Kursad Poyraz, "Volumetric MRI study of key brain regions implicated in obsessive–compulsive disorder", Progress in Neuro-Psychopharmacology and Biological Psychiatry, vol. 31, no. 1, pp. 46-52, 2007. Available: https://pubmed.ncbi.nlm.nih.gov/16859819/. [Accessed 15 June 2020].
[114] A. Hardan, S. Muddasani, M. Vemulapalli, M. Keshavan and N. Minshew, "An MRI Study of Increased Cortical Thickness in Autism", American Journal of Psychiatry, vol. 163, no. 7, pp. 1290-1292, 2006. Available: https://www.researchgate.net/publication/6969076_An_MRI_Study_of_Increased_Cortical_Thickness_in_Autism. [Accessed 17 June 2020].
[115] N. Hadjikhani, R. Joseph, J. Snyder and H. Tager-Flusberg, "Anatomical Differences in the Mirror Neuron System and Social Cognition Network in Autism", Cerebral Cortex, vol. 16, no. 9, pp. 1276-1282, 2005. Available: https://pubmed.ncbi.nlm.nih.gov/16306324/. [Accessed 13 June 2020].
[116] E. Aylward, N. Minshew, K. Field, B. Sparks and N. Singh, "Effects of age on brain volume and head circumference in autism", Neurology, vol. 59, no. 2, pp. 175-183, 2002. Available: https://pubmed.ncbi.nlm.nih.gov/12136053/. [Accessed 14 June 2020].
[117] E. Courchesne et al., "Unusual brain growth patterns in early life in patients with autistic disorder: An MRI study", Neurology, vol. 57, no. 2, pp. 245-254, 2001. Available: https://pubmed.ncbi.nlm.nih.gov/11468308/. [Accessed 16 June 2020].
[118] K. Stigler, B. McDonald, A. Anand, A. Saykin and C. McDougle, "Structural and functional magnetic resonance imaging of autism spectrum disorders", Brain Research, vol. 1380, pp. 146-161, 2011. Available: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3465665/. [Accessed 16 June 2020].
[119] H. Hazlett et al., "Magnetic Resonance Imaging and Head Circumference Study of Brain Size in Autism", Archives of General Psychiatry, vol. 62, no. 12, p. 1366, 2005. Available: https://www.researchgate.net/publication/7438347_Magnetic_Resonance_Imaging_and_Head_Circumference_Study_of_Brain_Size_in_Autism. [Accessed 17 June 2020].
[120] M. Herbert et al., "Dissociations of cerebral cortex, subcortical and cerebral white matter volumes in autistic boys", Brain, vol. 126, no. 5, pp. 1182-1192, 2003. Available: https://pubmed.ncbi.nlm.nih.gov/12690057/. [Accessed 16 June 2020].
[121] L. Lotspeich et al., "Investigation of Neuroanatomical Differences Between Autism and AspergerSyndrome", Archives of General Psychiatry, vol. 61, no. 3, p. 291, 2004. Available: https://pubmed.ncbi.nlm.nih.gov/14993117/. [Accessed 17 June 2020].
[122] C. Schumann, "The Amygdala Is Enlarged in Children But Not Adolescents with Autism; the Hippocampus Is Enlarged at All Ages", Journal of Neuroscience, vol. 24, no. 28, pp. 6392-6401, 2004. Available: https://pubmed.ncbi.nlm.nih.gov/15254095/. [Accessed 25 August 2020].
[123] C. Alvarez‐Jimenez, N. Múnera‐Garzón, M. Zuluaga, N. Velasco and E. Romero, "Autism spectrum disorder characterization in children by capturing local‐regional brain changes in MRI", Medical Physics, vol. 47, no. 1, pp. 119-131, 2019. Available: https://pubmed.ncbi.nlm.nih.gov/31682019/. [Accessed 18 June 2020].
[124] E. Candès and L. Demanet, "Curvelets and Fourier Integral Operators", Comptes Rendus Mathematique, vol. 336, no. 5, pp. 395-398, 2003. Available: https://www.sciencedirect.com/science/article/pii/S1631073X03000955. [Accessed 19 June 2020].
[125] S. Muñoz, "circunvolución cerebral [Neurocirugía Contemporánea]", Neurocirugiacontemporanea.com, 2017. [Online]. Available: http://neurocirugiacontemporanea.com/doku.php?id=circunvolucion_cerebral. [Accessed: 20- Jun- 2020].
[126] O. Castillero, "Corteza orbitofrontal: partes, funciones y características", Psicologiaymente.com, 2012. [Online]. Available: https://psicologiaymente.com/neurociencias/corteza-orbitofrontal. [Accessed: 20- Jun- 2020].
[127] D. McPherson, "planum polare | About memory", Memory-key.com, 2012. [Online]. Available: https://www.memory-key.com/category/regions/neocortex/temporal-lobe/superior-temporal-gyrus/planum-polare. [Accessed: 23- Jun- 2020].
[128] J. Cheng and M. Debowski, "Operculum | Radiology Reference Article | Radiopaedia.org", Radiopaedia.org, 2019. [Online]. Available: https://radiopaedia.org/articles/operculum. [Accessed: 24- Jun- 2020].
[129] J. Ottino-González, "How can I extract volume values (voxels, mm3?) for each individual on a particular cluster in FSL-VBM analysis?", ResearchGate, 2016. [Online]. Available: https://www.researchgate.net/post/How_can_I_extract_volume_values_voxels_mm3_for_each_individual_on_a_particular_cluster_in_FSL-VBM_analysis. [Accessed: 01- Jun- 2020].
dc.rights.uri.*.fl_str_mv http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.accessrights.spa.fl_str_mv info:eu-repo/semantics/openAccess
dc.rights.accessrights.*.fl_str_mv http://purl.org/coar/access_right/c_abf2
dc.rights.creativecommons.spa.fl_str_mv Attribution-NonCommercial-NoDerivatives 4.0 International
dc.rights.local.spa.fl_str_mv Acceso abierto
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-nd/4.0/
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 International
Acceso abierto
eu_rights_str_mv openAccess
dc.format.mimetype.spa.fl_str_mv applicaction/pdf
dc.coverage.sede.spa.fl_str_mv Calle 100
dc.publisher.program.spa.fl_str_mv Ingeniería en Mecatrónica
dc.publisher.faculty.spa.fl_str_mv Facultad de Ingeniería
dc.publisher.grantor.spa.fl_str_mv Universidad Militar Nueva Granada
institution Universidad Militar Nueva Granada
bitstream.url.fl_str_mv http://repository.unimilitar.edu.co/bitstream/10654/36775/2/license.txt
http://repository.unimilitar.edu.co/bitstream/10654/36775/1/VillateBaqueroNicolasSantiago2020.pdf
http://repository.unimilitar.edu.co/bitstream/10654/36775/3/VillateBaqueroNicolasSantiago2020.pdf.jpg
bitstream.checksum.fl_str_mv a609d7e369577f685ce98c66b903b91b
c59e5a25e606b5e173be723cffaf481a
75289fd5b6eeca3e47b57bf0fa1a6b89
bitstream.checksumAlgorithm.fl_str_mv MD5
MD5
MD5
repository.name.fl_str_mv Repositorio Institucional UMNG
repository.mail.fl_str_mv bibliodigital@unimilitar.edu.co
_version_ 1837098417389568000
spelling Velasco Toledo, Nelson FernandoVillate Baquero, Nicolas SantiagoIngeniero en Mecatrónica2020-11-10T00:46:55Z2020-11-10T00:46:55Z2020-09-28http://hdl.handle.net/10654/36775instname:Universidad Militar Nueva Granadareponame:Repositorio Institucional Universidad Militar Nueva Granadarepourl:https://repository.unimilitar.edu.coUna de las afecciones más graves que tiene una persona que padece de un TEA es la de no poder ser comprendido frente a los factores que socialmente lo incomodan y, el hecho de que esté sufriendo por esto trae en consecuencia, una angustia permanente por parte de sus familiares quienes estarán intentando hacer lo que esté a su alcance para hacer sentir bien a su familiar afectado [4-5]. Adicionalmente, el diagnóstico de los TEA es complicado, dispendioso y no muy exacto, esto causa que día a día profesionales especializados busquen múltiples formas de facilitar y optimizar el proceso para llegar a dicho dictamen. Por ello, se busca con este trabajo proponer un método auxiliar que ayude a los profesionales de la salud a dictar juicios más objetivos y ágiles para así poder evitar un diagnóstico erróneo que pueda generar el despilfarro de dinero en estudios y medicamentos que posiblemente no ayuden al pacienteOne of the most serious conditions that a person who suffers from an ASD has is that of not being able to be understood in the face of the factors that socially discomfort him and, the fact that he is suffering from this consequently brings permanent anguish on the part of their family members who will be trying to do what is in their power to make their affected family member feel good [4-5]. Additionally, the diagnosis of ASD is complicated, time consuming and not very exact, this causes that day by day specialized professionals look for multiple ways to facilitate and optimize the process to reach this opinion. Therefore, this work seeks to propose an auxiliary method that helps health professionals to make more objective and agile judgments in order to avoid a misdiagnosis that can generate the waste of money on studies and medicines that may not help the patient. patientPregradoapplicaction/pdfspahttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial-NoDerivatives 4.0 InternationalAcceso abiertoLa morfometría como método de ayuda para el diagnóstico del autismoMorphometry as a method of aid for the diagnosis of autismAUTISMOAUTISMO - DIAGNOSTICOMRIASDDiagnosisStructural DifferencesMorphometryDigital image processingBrainAutismMRITEAAutismoProcesamiento digital de imágenesMorfometríaCerebroDiferencias estructuralesDiagnósticoTesis/Trabajo de grado - Monografía - Pregradoinfo:eu-repo/semantics/bachelorThesishttp://purl.org/coar/resource_type/c_7a1fIngeniería en MecatrónicaFacultad de IngenieríaUniversidad Militar Nueva Granada[1] "Nueva Clasificación de los trastornos mentales", Sonepsyn.cl, 2014. [Online]. Available:https://www.sonepsyn.cl/revneuro/enero_marzo_2014/Suplemento_2014_1_Neuro_Psiq.pdf. [Accessed: 22- Apr- 2019].[2] O. Castillero, "Las 10 principales pruebas para detectar el autismo", Psicologiaymente.com, 2015. [Online]. Available: https://psicologiaymente.com/clinica/pruebas-para-detectar-autismo. [Accessed:22- Apr- 2019].[3] "¿Preocupado por el desarrollo?", Centers for Disease Control and Prevention, 2015. [Online]. Available: https://www.cdc.gov/spanish/especialesCDC/reaccionarpronto/. [Accessed: 22-Apr- 2019].[4] B. Salud, "Causas, síntomas y tratamiento del autismo", Sanitas, 2017. [Online]. Available: https://www.sanitas.es/sanitas/seguros/es/particulares/biblioteca-de-salud/pediatria-infancia/autismo.html.[Accessed: 22- Apr- 2019].[5] "Trastorno del espectro autista: MedlinePlus en español", Medlineplus.gov, 2018. [Online]. Available:https://medlineplus.gov/spanish/autismspectrumdisorder.html. [Accessed: 22-Apr- 2019].[6] "Evaluación y diagnóstico | Trastornos del espectro autista", Cdc.gov, 2016. [Online]. Available: https://www.cdc.gov/ncbddd/spanish/autism/screening.html.[Accessed: 28- Apr- 2019].[7] S. Ha, I. Sohn and N. Kim, "Characteristics of Brains in Autism Spectrum Disorder: Structure, Function and Connectivity across the Lifespan.", ncbi.nlm.nih.gov, 2015. [Online]. Available: https://pubmed.ncbi.nlm.nih.gov/26713076/. [Accessed: 28- Apr- 2019].[8] M. Ismail, R. Keynton and M. Mostapha, "Studying Autism Spectrum Disorder with Structural and Diffusion Magnetic Resonance Imaging: A Survey.", ncbi.nlm.nih.gov, 2016. [Online]. Available: https://www.ncbi.nlm.nih.gov/pubmed/27242476. [Accessed: 28- Apr- 2019].[9] "ICD 10 en línea, Volumen 1, Español", Ais.paho.org. [Online]. Available: http://ais.paho.org/classifications/Chapters/.[Accessed: 22- Apr- 2019].[10] "Paidopsiquiatría", Psiquiatria.com, 2019. [Online]. Available: https://psiquiatria.com/glosario/paidopsiquiatria. [Accessed: 22- Apr- 2019].[11] "¿Qué es un neurólogo infantil?", HealthyChildren.org, 2019. [Online]. Available: https://www.healthychildren.org/Spanish/family-life/health-management/pediatric-specialists/Paginas/what-is-a-child-neurologist.aspx. [Accessed: 22- Apr- 2019].[12] P. Lam, "MRI Scans: Definition, uses, and procedure", Medical News Today, 2018. [Online]. Available: https://www.medicalnewstoday.com/articles/146309.php. [Accessed: 22- Apr- 2019].[13] "Imagen por Resonancia Magnética (IRM) | National Institute of Biomedical Imaging and Bioengineering", Nibib.nih.gov, 2016. [Online]. Available: https://www.nibib.nih.gov/espanol/temas-cientificos/imagen-por-resonancia-magn%C3%A9tica-irm. [Accessed: 22- Apr- 2019].[14] V. Siless, "FreeSurferWiki - Free Surfer Wiki", Surfer.nmr.mgh.harvard.edu, 2018. [Online]. Available: https://surfer.nmr.mgh.harvard.edu/fswiki. [Accessed: 28- Apr- 2019].[15] M. Filippi, M. Rocca, O. Ciccarelli and N. De Stefano, "MRI criteria for the diagnosis of multiple sclerosis: MAGNIMS consensus guidelines", sciencedirect.com, 2016. [Online]. Available: https://www.sciencedirect.com/science/article/pii/S1474442215003932. [Accessed:28- Apr- 2019].[16]D. Fraguas, L. Pina and C. Arango, "Progressive brain changes in children and adolescents with early-onset psychosis: A meta-analysis of longitudinal MRI studies", sciencedirect.com,2016.[Online].Available:https://www.sciencedirect.com/science/article/pii/S0920996414007543. [Accessed: 28- Apr- 2019].[17] C. Tamnes and I. Agartz, "White Matter Microstructure in Early-Onset Schizophrenia: A Systematic Review of Diffusion Tensor Imaging Studies", sciencedirect.com, 2016. [Online]. Available: https://www.sciencedirect.com/science/article/abs/pii/S0890856716000381. [Accessed: 28- Apr- 2019].[18] C. Falcon, A. Tucholka, G. Monté-Rubio and R. Cacciaglia, "Longitudinal structural cerebral changes related to core CSF biomarkers in preclinical Alzheimer's disease: A study of two independent datasets.", ncbi.nlm.nih.gov, 2018. [Online]. Available: https://www.ncbi.nlm.nih.gov/pubmed/30023169. [Accessed: 28- Apr- 2019].[19] A. Al-Radaideh, A. I and A. H, "Cortical and Subcortical Morphometric and Iron Changes in Relapsing-Remitting Multiple Sclerosis and Their Association with White Matter T2 Lesion Load : A 3-Tesla Magnetic Resonance Imaging Study.", ncbi.nlm.nih.gov, 2019. [Online]. Available: https://www.ncbi.nlm.nih.gov/pubmed/29299614. [Accessed:28- Apr- 2019].[20] A. Radziunas, V. Deltuva and A. Tamasauskas, "Brain MRI morphometric analysis in Parkinson's disease patients with sleep disturbances.", ncbi.nlm.nih.gov, 2018. [Online]. Available: https://www.ncbi.nlm.nih.gov/pubmed/29925331. [Accessed: 28- Apr- 2019].[21] T. Gabrielsen, J. Anderson and K. Stephenson, "Functional MRI connectivity of children with autism and low verbal and cognitive performance.", ncbi.nlm.nih.gov, 2018. [Online]. Available: https://www.ncbi.nlm.nih.gov/pubmed/30603063. [Accessed: 28- Apr- 2019].[22] A. Pagnozzi, E. Conti and S. Calderoni, "A systematic review of structural MRI biomarkers in autism spectrum disorder: A machine learning perspective.", ncbi.nlm.nih.gov, 2018. [Online]. Available: https://www.ncbi.nlm.nih.gov/pubmed/30172895. [Accessed: 28- Apr- 2019][23] D. Li, H. Karnath and X. Xu, "Candidate Biomarkers in Children with Autism Spectrum Disorder: A Review of MRI Studies.", ncbi.nlm.nih.gov, 2017. [Online]. Available: https://www.ncbi.nlm.nih.gov/pubmed/28283808. [Accessed: 28- Apr- 2019].[24] A. Triglia, "Materia gris del cerebro: estructura y funciones", Psicologiaymente.com, 2017. [Online]. Available: https://psicologiaymente.com/neurociencias/materia-gris-cerebro. [Accessed: 22-Apr- 2019].[25] "Sustancia blanca del cerebro: MedlinePlus enciclopedia médica", Medlineplus.gov, 2018. [Online]. Available: https://medlineplus.gov/spanish/ency/article/002344.htm. [Accessed: 22- Apr-2019].[26] "Bayesian analysis of neuroimaging data in FSL. - PubMed - NCBI", Ncbi.nlm.nih.gov, 2010. [Online]. Available: https://www.ncbi.nlm.nih.gov/pubmed/19059349. [Accessed: 22- Apr- 2019].[27] "SPM - Statistical Parametric Mapping", Fil.ion.ucl.ac.uk, 2018. [Online]. Available:https://www.fil.ion.ucl.ac.uk/spm/. [Accessed: 28- Apr- 2019].[28] C. Guo, D. Ferreira and E. Westman, "Repeatability and reproducibility of FreeSurfer, FSL-SIENAX and SPM brain volumetric measurements and the effect of lesion filling in multiple sclerosis.", ncbi.nlm.nih.gov, 2019. [Online]. Available: https://www.ncbi.nlm.nih.gov/pubmed/30242503.[Accessed: 28- Apr- 2019].[29] A. Trigilia, "Los 5 lóbulos del cerebro y sus distintas funciones", Psicologiaymente.com, 2018. [Online]. Available: https://psicologiaymente.com/neurociencias/lobulos-del-cerebro-funciones. [Accessed: 09- Apr- 2020].[30] "¿Cómo es y cómo funciona nuestro cerebro?", Blog.fpmaragall.org, 2020. [Online]. Available: https://blog.fpmaragall.org/como-es-y-como-funciona-nuestro-cerebro. [Accessed: 08- Apr- 2020].[31] L. Hirsch, "El cerebro y el sistema nervioso (para Adolecentes) - Nemours KidsHealth", Kidshealth.org, 2019. [Online]. Available: https://kidshealth.org/es/teens/brain-nervous-system-esp.html. [Accessed: 08- Apr- 2020].[32] Ratey, John J. Cerebro: manual de instrucciones. 2003. Mondadori. [Accessed: 08- Apr- 2020].[33] E. Jimenez, "Lóbulo cerebral - EcuRed", Ecured.cu, 2011. [Online]. Available: https://www.ecured.cu/L%C3%B3bulo_cerebral. [Accessed: 21- Apr- 2020].[34] R. Lord, "asperger infantil", Asperger.es, 2017. [Online]. Available: https://www.asperger.es/sindrome_asperger_infancia_sintomas.html. [Accessed: 05- May- 2020].[35] "La sinapsis (artículo) | Biología humana | Khan Academy", Khan Academy, 2018. [Online]. Available: https://es.khanacademy.org/science/biology/human-biology/neuron-nervous-system/a/the-synapse. [Accessed: 07- May- 2020].[36] M. Mercadante and R. Van der Gaag, "Transtornos invasivos do desenvolvimento não-autísticos: síndrome de Rett, transtorno desintegrativo da infância e transtornos invasivos do desenvolvimento sem outra especificação", SciELO, 2006. [Online]. Available: https://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-44462006000500003. [Accessed: 18- Apr- 2020].[37] "Anatomía y fisiología de los ganglios basales | NeuroWikia", Neurowikia.es, 2020. [Online]. Available: http://www.neurowikia.es/content/anatomia-y-fisiologia-de-los-ganglios-basales. [Accessed: 24- Apr- 2020].[38] N. Kaneshiro, "Cuerpo calloso del cerebro: MedlinePlus enciclopedia médica illustración", Medlineplus.gov, 2018. [Online]. Available: https://medlineplus.gov/spanish/ency/esp_imagepages/8753.htm. [Accessed: 24- Apr- 2020].[39] S. Sinha Dutta, "Funciones del hipocampo", News-Medical.net, 2019. [Online]. Available:https://www.news-medical.net/health/Hippocampus-Functions-(Spanish).aspx#2. [Accessed: 09- Sep- 2019].[40] "Amígdala Cerebral - EcuRed", Ecured.cu, 2013. [Online]. Available: https://www.ecured.cu/Am%C3%ADgdala_Cerebral. [Accessed: 17- Sep- 2019].[41] "Científicos revelan que anomalías del cerebro del feto pueden ser la causa del autismo", Autismo Madrid, 2014. [Online]. Available: https://autismomadrid.es/investigacion-2/cientificos-revelan-que-anomalias-del-cerebro-del-feto-pueden-ser-la-causa-del-autismo/. [Accessed: 24- Aug- 2019].[42] "El Cerebro Humano", Sobre el cerebro humano - CogniFit, 2010. [Online]. Available: https://www.cognifit.com/es/cerebro. [Accessed: 15- Sep- 2019].[43] C. Pardo, "The Neurobiology of Autism", Wiley Online Library, 2007. [Online]. Available: https://onlinelibrary.wiley.com/doi/full/10.1111/j.1750-3639.2007.00102.x. [Accessed: 10- Sep- 2019].[44] "Diccionario de cáncer del NCI", Instituto Nacional del Cáncer, 2005. [Online]. Available: https://www.cancer.gov/espanol/publicaciones/diccionario/def/liquido-cefalorraquideo. [Accessed: 03- Aug- 2019].[45] "Las Áreas Corticales:", Página web de neurofisiologia11, 2005. [Online]. Available: https://neurofisiologia11.jimdofree.com/%C3%A1reas-corticales/#:~:text=Las%20%C3%A1reas%20corticales%2C%20son%20lugares,y%20l%C3%ADmbico%20hay%20funciones%20asociadas. [Accessed: 06- Aug- 2019].[46] I. Rovira, "Estructuras subcorticales del encéfalo: tipos y funciones", Psicologiaymente.com, 2013. [Online]. Available: https://psicologiaymente.com/neurociencias/estructuras-subcorticales#:~:text=El%20sistema%20o%20estructura%20subcortical,ventral%20de%20los%20ventr%C3%ADculos%20laterales. [Accessed: 20- Aug- 2019].[47] M. Macias, "Etapas del neurodesarrollo", neuronas en crecimiento, 2015. [Online]. Available: https://neuropediatra.org/2015/12/16/etapas-del-neurodesarrollo/. [Accessed: 12- May- 2020].[48] F. Ostrosky, "Desarrollo del cerebro", Portal.oas.org. [Online]. Available: http://portal.oas.org/LinkClick.aspx?fileticket=QSVgfnifmNc%3D&tabi. [Accessed: 08- May- 2020].[49] E. Bowden and M. Jung-Beeman, "Aha! Insight experience correlates with solution activation in the right hemisphere", Psychonomic Bulletin & Review, vol. 10, no. 3, pp. 730-737, 2003. Available: https://pubmed.ncbi.nlm.nih.gov/14620371/. [Accessed 25 August 2019].[50] B. Regader, "Hemisferios cerebrales: mitos y realidades", Psicologiaymente.com, 2017. [Online]. Available: https://psicologiaymente.com/neurociencias/hemisferios-cerebrales-mitos-realidades. [Accessed: 09- Feb- 2020].[51] M. Jung-Beeman et al., "Neural Activity When People Solve Verbal Problems with Insight", PLoS Biology, vol. 2, no. 4, p. e97, 2004. Available: https://pubmed.ncbi.nlm.nih.gov/15094802/. [Accessed 7 July 2019].[52] "Rayos X: MedlinePlus en español", Medlineplus.gov, 2010. [Online]. Available: https://medlineplus.gov/spanish/xrays.html. [Accessed: 13- Mar- 2020].[53] "TAC: Tomografia Axial Computarizada", Fisterra.com, 2010. [Online]. Available: https://www.fisterra.com/Salud/3proceDT/tac.asp. [Accessed: 15- Mar- 2020].[54] "Exámenes PET CT y RM: ¿Qué son y cómo usarlos en la medicina diagnóstica?", MV - Líder em Sistemas de Gestão de Saúde, 2016. [Online]. Available: http://www.mv.com.br/es/blog/examenes--pet-ct-y-rm---que-son-y-como-usarlos-en-la-medicina-diagnosticar. [Accessed: 10- Mar- 2020].[55] A. Lopez, "Morfometría geométrica: el estudio de la forma y su aplicación en biología", Utm.mx, 2015. [Online]. Available: http://www.utm.mx/edi_anteriores/temas55/T55_2Nota_6.pdf. [Accessed: 28- Apr- 2019].[56] I. Gielen, "Comparación de las técnicas de diagnóstico por imagen empleadas en la articulación con osteoartritis y su interpretación", Ddd.uab.cat, 2006. [Online]. Available: https://ddd.uab.cat/pub/clivetpeqani/11307064v26n2/11307064v26n2p137.pdf. [Accessed: 14- Mar- 2020].[57] J. Levy, "Resonancia magnética: MedlinePlus enciclopedia médica", Medlineplus.gov, 2018. [Online]. Available: https://medlineplus.gov/spanish/ency/article/003335.htm. [Accessed: 22- Mar- 2020].[58] A. Alegria Perez, "Principios fisicos de Resonancia Magnética", Es.slideshare.net, 2020. [Online]. Available: https://es.slideshare.net/RadiologiaHUP/principios-fisicos-de-resonancia-magnética. [Accessed: 24- Aug- 2020].[59] A. Suarez and M. Vega, "Métodos morfométricos para detectar diferencias estructurales entre cerebros | Revista CENIC Ciencias Biológicas", Revista.cnic.edu.cu, 2019. [Online]. Available: https://revista.cnic.edu.cu/revistaCB/articulos/metodos-morfometricos-para-detectar-diferencias-estructurales-entre-cerebros. [Accessed: 22- Apr- 2019].[60]J. Ashburner and K. Friston, "Voxel-Based Morphometry—The Methods", sciencedirect.com, 2002. [Online]. Available: https://www.sciencedirect.com/science/article/pii/S1053811900905822. [Accessed: 28- Apr- 2019].[61] C. Peña, "Seguridad del paciente - Materiales de Contraste", Radiologyinfo.org, 2018. [Online]. Available: https://www.radiologyinfo.org/sp/info.cfm?pg=safety-contrast. [Accessed: 29- Mar- 2020].[62] G. Luks, "Técnicas de Neuroimagen", Sites.google.com, 2015. [Online]. Available: https://sites.google.com/site/tecnicasdeneuroimagen/. [Accessed: 01- Apr- 2020].[63] G. Bastarrika, "¿Qué es el TR?", Ecocardio.com. [Online]. Available: https://ecocardio.com/documentos/biblioteca-preguntas-basicas/preguntas-al-radiologo/919-que-es-tr.html. [Accessed: 28- Feb- 2020].[64] D. Greve, "An Absolute Beginner’s Guide to Surface- and Voxel-based Morphometric Analysis", Cds.ismrm.org, 2011. [Online]. Available: https://cds.ismrm.org/protected/11MProceedings/files/ISMRM2011-8410.pdf. [Accessed: 22- Apr- 2020].[65] R. Negrín, "La Morfología Funcional Deportiva. Su importancia en el currículo de la carrera de Cultura Física", Efdeportes.com, 2016. [Online]. Available: https://www.efdeportes.com/efd213/la-morfologia-funcional-deportiva-en-cultura-fisica.htm. [Accessed: 04- Nov- 2019].[66] "Introducción a la evolución: Tipos de cambios en el desarrollo", Sesbe.org, 2020. [Online]. Available: https://www.sesbe.org/evosite/evo101/IIIC6dDevochange2.shtml.html. [Accessed: 05- Nov- 2019].[67] M. Rodriguez, "Plasticidad fenotípica", Ugr.es, 2020. [Online]. Available: http://www.ugr.es/~jmgreyes/plasticidad.html. [Accessed: 06- Nov- 2019].[68] "alometría – BioDic", Biodic.net, 2011. [Online]. Available: https://www.biodic.net/palabra/alometria/#.XvBaqmhKjIU. [Accessed: 07- Nov- 2019].[69]”K-space (magnetic resonance imaging)", En.wikipedia.org, 2018. [Online]. Available: https://en.wikipedia.org/wiki/K-space_(magnetic_resonance_imaging). [Accessed: 10- Mar- 2020].[70] V. Cutanda and d. Moratal, "Automatic Brain Morphometry and Volumetry Using SPM on Cognitively Impaired Patients", researchgate.net, 2015. [Online]. Available: https://www.researchgate.net/publication/276298355_Automatic_Brain_Morphometry_and_Volumetry_Using_SPM_on_Cognitively_Impaired_Patients. [Accessed: 30- Nov- 2019].[71] A. BRUN and E. ENGLUND, "Regional pattern of degeneration in Alzheimer's disease: neuronal loss and histopathological grading", Histopathology, vol. 5, no. 5, pp. 549-564, 1981. Available: https://pubmed.ncbi.nlm.nih.gov/7286917/. [Accessed 18 October 2019].[72] M. Raffino, "Geomorfología - Concepto, objeto de estudio, importancia y ramas", Concepto.de, 2020. [Online]. Available: https://concepto.de/geomorfologia/. [Accessed: 08- Nov- 2019].[73] "Introduction - BET", Fsl.fmrib.ox.ac.uk. [Online]. Available: https://fsl.fmrib.ox.ac.uk/fslcourse/lectures/practicals/intro2/index.html. [Accessed: 10- Mar- 2020].[74] S. Lorio and S. Fresard, "About the MNI space(s) – Lead-DBS", Lead-dbs.org, 2016. [Online]. Available: https://www.lead-dbs.org/about-the-mni-spaces/. [Accessed: 24- Mar- 2020].[75] "Cómo funciona Transformar (cobertura)—Ayuda | ArcGIS for Desktop", Desktop.arcgis.com. [Online]. Available: http://desktop.arcgis.com/es/arcmap/10.3/tools/coverage-toolbox/how-transform-works.htm. [Accessed: 22- Mar- 2020].[76] J. Andersson and M. Jenkinson, "FNIRT - FslWiki", Fsl.fmrib.ox.ac.uk, 2010. [Online]. Available: https://fsl.fmrib.ox.ac.uk/fsl/fslwiki/FNIRT. [Accessed: 23- Mar- 2020].[77] J. Carpenter and S. Tribich, "Methods for Dummies Voxel-Based Morphometry (VBM) - ppt download", Slideplayer.com, 2016. [Online]. Available: https://slideplayer.com/slide/10495989/. [Accessed: 17- Mar- 2020].[78] "Modelo lineal general: hipótesis y estimación", Ucm.es, 2013. [Online]. Available: https://www.ucm.es/data/cont/docs/518-2013-10-25-Tema_3_1_EctrGrado.pdf. [Accessed: 02- May- 2020].[79] "¿Qué es ANOVA? - Minitab", Support.minitab.com, 2019. [Online]. Available: https://support.minitab.com/es-mx/minitab/19/help-and-how-to/statistical-modeling/anova/supporting-topics/basics/what-is-anova/#:~:text=Un%20an%C3%A1lisis%20de%20varianza%20(ANOVA,diferentes%20niveles%20de%20los%20factores. [Accessed: 04- May- 2020].[80] A. Manera, M. Dadar, D. Collins and S. Ducharme, "Deformation based morphometry study of longitudinal MRI changes in behavioral variant frontotemporal dementia", NeuroImage: Clinical, vol. 24, p. 102079, 2019. Available: https://www.sciencedirect.com/science/article/pii/S2213158219304267. [Accessed 10 October 2019].[81] C. Gaser, I. Nenadic, B. Buchsbaum, E. Hazlett and M. Buchsbaum, "Deformation-Based Morphometry and Its Relation to Conventional Volumetry of Brain Lateral Ventricles in MRI", NeuroImage, vol. 13, no. 6, pp. 1140-1145, 2001. Available: https://pubmed.ncbi.nlm.nih.gov/11352619/. [Accessed 10 October 2019].[82] E. Meintjes et al., "A tensor-based morphometry analysis of regional differences in brain volume in relation to prenatal alcohol exposure", NeuroImage: Clinical, vol. 5, pp. 152-160, 2014. Available: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4097000/. [Accessed 12 October 2019].[83] V. Rajagopalan et al., "Mapping directionality specific volume changes using tensor based morphometry: An application to the study of gyrogenesis and lateralization of the human fetal brain", NeuroImage, vol. 63, no. 2, pp. 947-958, 2012. Available: https://europepmc.org/article/PMC/3732053. [Accessed 13 October 2019].[84] S. Smith, "Fast robust automated brain extraction", Human Brain Mapping, vol. 17, no. 3, pp. 143-155, 2002. Available: https://pubmed.ncbi.nlm.nih.gov/12391568/. [Accessed 19 April 2020].[85] M. Jenkinson, M. Pechaud, and S. Smith. “BET2: MR-based estimation of brain, skull and scalp surfaces”. 2005. In Eleventh Annual Meeting of the Organization for Human Brain Mapping. [Accessed 19 April 2020].[86] Zhang, Y. and Brady, M. and Smith, S. “Segmentation of brain MR images through a hidden Markov random field model and the expectation-maximization algorithm”. 2001. IEEE Trans Med Imag, 20(1):45-57. [Accessed 20 April 2020].[87] M. Jenkinson and S.M. Smith. “A global optimisation method for robust affine registration of brain images”. 2001. Medical Image Analysis, 5(2):143-156. [Accessed 20 April 2020].[88] N. Thomas, "FAST - FslWiki", Fsl.fmrib.ox.ac.uk, 2005. [Online]. Available: https://fsl.fmrib.ox.ac.uk/fsl/fslwiki/FAST. [Accessed: 26- Apr- 2019].[89] M. Jenkinson and S.M. Smith. “A global optimisation method for robust affine registration of brain images”. 2001. Medical Image Analysis, 5(2):143-156. [Accessed: 26 April 2020].[90] M. Jenkinson, "Fslutils - FslWiki", Fsl.fmrib.ox.ac.uk, 2020. [Online]. Available: https://fsl.fmrib.ox.ac.uk/fsl/fslwiki/Fslutils. [Accessed: 15- Apr- 2020].[91] Makris N, Goldstein JM, Kennedy D, Hodge SM, Caviness VS, Faraone SV, Tsuang MT, Seidman LJ. “Disminución del volumen del lóbulo insular anterior izquierdo y total en la esquizofrenia”. 2006. Schizophr Res, vol. 83, pp. 155. [Accessed 19 May 2020].[92] Frazier JA, Chiu S, Breeze JL, Makris N, Lange N, Kennedy DN, Herbert MR, Bent EK, Koneru VK, Dieterich ME, Hodge SM, Rauch SL, Grant PE, Cohen BM, Seidman LJ, Caviness VS, Biederman J . “Resonancia magnética cerebral estructural de los volúmenes límbico y talámico en el trastorno bipolar pediátrico”. 2005, vol. 7, pp. 1256. Soy J Psiquiatría.[Accessed 19 May 2020].[93] S. Eickhoff et al., "A new SPM toolbox for combining probabilistic cytoarchitectonic maps and functional imaging data", NeuroImage, vol. 25, no. 4, pp. 1325-1335, 2005. Available: https://pubmed.ncbi.nlm.nih.gov/15850749/. [Accessed 3 June 2019].[94] S. Eickhoff, S. Heim, K. Zilles and K. Amunts, "Testing anatomically specified hypotheses in functional imaging using cytoarchitectonic maps", NeuroImage, vol. 32, no. 2, pp. 570-582, 2006. Available: https://pubmed.ncbi.nlm.nih.gov/16781166/. [Accessed 4 June 2019].[95] J. Talairach and P. Tournoux, "talairach.org | About", Talairach.org, 1988. [Online]. Available: https://www.talairach.org/about.html. [Accessed: 01- Jun- 2020].[96] Di Martino, A. “Functional Connectomes Project International Neuroimaging Data-Sharing Initiative”. 2016. Available: http://fcon_1000.projects.nitrc.org/indi/abide/abide_I.html. [Accessed 16 January 2020].[97] E. Courchesne et al., "Unusual brain growth patterns in early life in patients with autistic disorder: An MRI study", Neurology, vol. 57, no. 2, pp. 245-254, 2001. Available: https://n.neurology.org/content/57/2/245.short. [Accessed 16 June 2020].[98] E. Courchesne, K. Campbell and S. Solso, "Brain growth across the life span in autism: Age-specific changes in anatomical pathology", Brain Research, vol. 1380, pp. 138-145, 2011. Available: https://www.sciencedirect.com/science/article/abs/pii/S0006899310021670. [Accessed 14 June 2020].[99] I. Lobato, "ENTORNO PARA SEGMENTACIÓN DE IMÁGENES POR RESONANCIA MAGNÉTICA CEREBRALES", Diposit.ub.edu, 2013. [Online]. Available: http://diposit.ub.edu/dspace/bitstream/2445/48276/2/memoria.pdf. [Accessed: 06- Sep- 2019].[100] L. Sucar, "Modelos Gráficos Probabilistas", Ccc.inaoep.mx, 2012. [Online]. Available: https://ccc.inaoep.mx/~esucar/Clases-mgp/pgm08-cam-2012.pdf. [Accessed: 06- Apr- 2020].[101] T. Ortiz, "09-Variables latentes y algoritmo EM", Tereom.github.io, 2017. [Online]. Available: https://tereom.github.io/est-multivariada-15/09-EM.html#:~:text=El%20algoritmo%20de%20esperanza%2Dmaximizaci%C3%B3n,(%CE%B8(t)). [Accessed: 17- Apr- 2020].[102] I. Gradštejn, Table of integrals, series, and products, 7th ed. New York: Acad. Press, 2000, pp. 1068-1069[103] M. Jenkinson, "Atlases - FslWiki", Fsl.fmrib.ox.ac.uk. [Online]. Available: https://fsl.fmrib.ox.ac.uk/fsl/fslwiki/Atlases. [Accessed: 22- May- 2020].[104] G. Seif, "The 5 Clustering Algorithms Data Scientists Need to Know", Medium, 2018. [Online]. Available: https://towardsdatascience.com/the-5-clustering-algorithms-data-scientists-need-to-know-a36d136ef68#:~:text=Clustering%20is%20a%20Machine%20Learning,the%20grouping%20of%20data%20points.&text=Clustering%20is%20a%20method%20of,analysis%20used%20in%20many%20fields. [Accessed: 29- May- 2020].[105] C. Ákos Szabó et al., "Modeling the effective connectivity of the visual network in healthy and photosensitive, epileptic baboons", Brain Structure and Function, vol. 221, no. 4, pp. 2023-2033, 2015. Available: https://www.researchgate.net/publication/273324397_Modeling_the_effective_connectivity_of_the_visual_network_in_healthy_and_photosensitive_epileptic_baboons. [Accessed 12 October 2019].[106] J. Anderson, K. Campbell, T. Amer, C. Grady and L. Hasher, "Timing is everything: Age differences in the cognitive control network are modulated by time of day.", Psychology and Aging, vol. 29, no. 3, pp. 648-657, 2014. Available: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4898963/. [Accessed 13 September 2019].[107] C. Pradas, "Sistema límbico: partes, funciones y enfermedades - Con Fotos y Vídeo", psicologia-online.com, 2020. [Online]. Available: https://www.psicologia-online.com/sistema-limbico-partes-funciones-y-enfermedades-3824.html. [Accessed: 20- Jun- 2020].[108] Andersson JLR, Jenkinson M, Smith S (2010) Non-linear registration, aka spatial normalisation. [Accessed 15 April 2020].[109] J. Rodrigo, "T-test", Cienciadedatos.net, 2016. [Online]. Available: https://www.cienciadedatos.net/documentos/12_t-test. [Accessed: 08- Jun- 2020].[110] M. Anderson and A. Winkler, "Randomise/Theory - FslWiki", Fsl.fmrib.ox.ac.uk, 2015. [Online]. Available: https://fsl.fmrib.ox.ac.uk/fsl/fslwiki/Randomise/Theory. [Accessed: 07- Jun- 2020].[111] A. Winkler, G. Ridgway, M. Webster, S. Smith and T. Nichols, "Permutation inference for the general linear model", NeuroImage, vol. 92, pp. 381-397, 2014. Available: https://pubmed.ncbi.nlm.nih.gov/24530839/. [Accessed 25 October 2019].[112] D. Amaral, C. Schumann and C. Nordahl, "Neuroanatomy of autism", Trends in Neurosciences, vol. 31, no. 3, pp. 137-145, 2008. Available: https://www.sciencedirect.com/science/article/abs/pii/S0166223608000386. [Accessed 15 June 2020].[113] M. Atmaca, H. Yildirim, H. Ozdemir, E. Tezcan and A. Kursad Poyraz, "Volumetric MRI study of key brain regions implicated in obsessive–compulsive disorder", Progress in Neuro-Psychopharmacology and Biological Psychiatry, vol. 31, no. 1, pp. 46-52, 2007. Available: https://pubmed.ncbi.nlm.nih.gov/16859819/. [Accessed 15 June 2020].[114] A. Hardan, S. Muddasani, M. Vemulapalli, M. Keshavan and N. Minshew, "An MRI Study of Increased Cortical Thickness in Autism", American Journal of Psychiatry, vol. 163, no. 7, pp. 1290-1292, 2006. Available: https://www.researchgate.net/publication/6969076_An_MRI_Study_of_Increased_Cortical_Thickness_in_Autism. [Accessed 17 June 2020].[115] N. Hadjikhani, R. Joseph, J. Snyder and H. Tager-Flusberg, "Anatomical Differences in the Mirror Neuron System and Social Cognition Network in Autism", Cerebral Cortex, vol. 16, no. 9, pp. 1276-1282, 2005. Available: https://pubmed.ncbi.nlm.nih.gov/16306324/. [Accessed 13 June 2020].[116] E. Aylward, N. Minshew, K. Field, B. Sparks and N. Singh, "Effects of age on brain volume and head circumference in autism", Neurology, vol. 59, no. 2, pp. 175-183, 2002. Available: https://pubmed.ncbi.nlm.nih.gov/12136053/. [Accessed 14 June 2020].[117] E. Courchesne et al., "Unusual brain growth patterns in early life in patients with autistic disorder: An MRI study", Neurology, vol. 57, no. 2, pp. 245-254, 2001. Available: https://pubmed.ncbi.nlm.nih.gov/11468308/. [Accessed 16 June 2020].[118] K. Stigler, B. McDonald, A. Anand, A. Saykin and C. McDougle, "Structural and functional magnetic resonance imaging of autism spectrum disorders", Brain Research, vol. 1380, pp. 146-161, 2011. Available: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3465665/. [Accessed 16 June 2020].[119] H. Hazlett et al., "Magnetic Resonance Imaging and Head Circumference Study of Brain Size in Autism", Archives of General Psychiatry, vol. 62, no. 12, p. 1366, 2005. Available: https://www.researchgate.net/publication/7438347_Magnetic_Resonance_Imaging_and_Head_Circumference_Study_of_Brain_Size_in_Autism. [Accessed 17 June 2020].[120] M. Herbert et al., "Dissociations of cerebral cortex, subcortical and cerebral white matter volumes in autistic boys", Brain, vol. 126, no. 5, pp. 1182-1192, 2003. Available: https://pubmed.ncbi.nlm.nih.gov/12690057/. [Accessed 16 June 2020].[121] L. Lotspeich et al., "Investigation of Neuroanatomical Differences Between Autism and AspergerSyndrome", Archives of General Psychiatry, vol. 61, no. 3, p. 291, 2004. Available: https://pubmed.ncbi.nlm.nih.gov/14993117/. [Accessed 17 June 2020].[122] C. Schumann, "The Amygdala Is Enlarged in Children But Not Adolescents with Autism; the Hippocampus Is Enlarged at All Ages", Journal of Neuroscience, vol. 24, no. 28, pp. 6392-6401, 2004. Available: https://pubmed.ncbi.nlm.nih.gov/15254095/. [Accessed 25 August 2020].[123] C. Alvarez‐Jimenez, N. Múnera‐Garzón, M. Zuluaga, N. Velasco and E. Romero, "Autism spectrum disorder characterization in children by capturing local‐regional brain changes in MRI", Medical Physics, vol. 47, no. 1, pp. 119-131, 2019. Available: https://pubmed.ncbi.nlm.nih.gov/31682019/. [Accessed 18 June 2020].[124] E. Candès and L. Demanet, "Curvelets and Fourier Integral Operators", Comptes Rendus Mathematique, vol. 336, no. 5, pp. 395-398, 2003. Available: https://www.sciencedirect.com/science/article/pii/S1631073X03000955. [Accessed 19 June 2020].[125] S. Muñoz, "circunvolución cerebral [Neurocirugía Contemporánea]", Neurocirugiacontemporanea.com, 2017. [Online]. Available: http://neurocirugiacontemporanea.com/doku.php?id=circunvolucion_cerebral. [Accessed: 20- Jun- 2020].[126] O. Castillero, "Corteza orbitofrontal: partes, funciones y características", Psicologiaymente.com, 2012. [Online]. Available: https://psicologiaymente.com/neurociencias/corteza-orbitofrontal. [Accessed: 20- Jun- 2020].[127] D. McPherson, "planum polare | About memory", Memory-key.com, 2012. [Online]. Available: https://www.memory-key.com/category/regions/neocortex/temporal-lobe/superior-temporal-gyrus/planum-polare. [Accessed: 23- Jun- 2020].[128] J. Cheng and M. Debowski, "Operculum | Radiology Reference Article | Radiopaedia.org", Radiopaedia.org, 2019. [Online]. Available: https://radiopaedia.org/articles/operculum. [Accessed: 24- Jun- 2020].[129] J. Ottino-González, "How can I extract volume values (voxels, mm3?) for each individual on a particular cluster in FSL-VBM analysis?", ResearchGate, 2016. [Online]. Available: https://www.researchgate.net/post/How_can_I_extract_volume_values_voxels_mm3_for_each_individual_on_a_particular_cluster_in_FSL-VBM_analysis. [Accessed: 01- Jun- 2020].Calle 100LICENSElicense.txtlicense.txttext/plain; charset=utf-83420http://repository.unimilitar.edu.co/bitstream/10654/36775/2/license.txta609d7e369577f685ce98c66b903b91bMD52ORIGINALVillateBaqueroNicolasSantiago2020.pdfVillateBaqueroNicolasSantiago2020.pdfTrabajo de gradoapplication/pdf2834458http://repository.unimilitar.edu.co/bitstream/10654/36775/1/VillateBaqueroNicolasSantiago2020.pdfc59e5a25e606b5e173be723cffaf481aMD51THUMBNAILVillateBaqueroNicolasSantiago2020.pdf.jpgVillateBaqueroNicolasSantiago2020.pdf.jpgIM Thumbnailimage/jpeg5355http://repository.unimilitar.edu.co/bitstream/10654/36775/3/VillateBaqueroNicolasSantiago2020.pdf.jpg75289fd5b6eeca3e47b57bf0fa1a6b89MD5310654/36775oai:repository.unimilitar.edu.co:10654/367752020-12-01 01:19:16.304Repositorio Institucional UMNGbibliodigital@unimilitar.edu.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

Publicaciones similares