A neurotrophin functioning with a Toll regulates structural plasticity in a dopaminergic circuit

Experience shapes the brain as neural circuits can be modified by neural stimulation or the lack of it. The molecular mechanisms underlying structural circuit plasticity and how plasticity modifies behaviour are poorly understood. Subjective experience requires dopamine, a neuromodulator that assign...

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Autores:
Jun Sun
Francisca Rojo-Cortes
Suzana Ulian-Benitez
Manuel G Forero
Guiyi Li
Deepanshu ND Singh
Xiaocui Wang
Sebastian Cachero
Marta Moreira
Dean Kavanagh
Gregory SXE Jefferis
Vincent Croset
Alicia Hidalgo
Tipo de recurso:
Article of investigation
Fecha de publicación:
2024
Institución:
Universidad de Ibagué
Repositorio:
Repositorio Universidad de Ibagué
Idioma:
eng
OAI Identifier:
oai:repositorio.unibague.edu.co:20.500.12313/6049
Acceso en línea:
https://elifesciences.org/articles/102222
https://hdl.handle.net/20.500.12313/6049
Palabra clave:
Neurotrofina
Función cerebral
Comportamiento cerebral
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openAccess
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Copyright Sun et al. T
id UNIBAGUE2_e215eaa8bfce2bfb35f8db9ce8cd40f0
oai_identifier_str oai:repositorio.unibague.edu.co:20.500.12313/6049
network_acronym_str UNIBAGUE2
network_name_str Repositorio Universidad de Ibagué
repository_id_str
dc.title.eng.fl_str_mv A neurotrophin functioning with a Toll regulates structural plasticity in a dopaminergic circuit
title A neurotrophin functioning with a Toll regulates structural plasticity in a dopaminergic circuit
spellingShingle A neurotrophin functioning with a Toll regulates structural plasticity in a dopaminergic circuit
Neurotrofina
Función cerebral
Comportamiento cerebral
title_short A neurotrophin functioning with a Toll regulates structural plasticity in a dopaminergic circuit
title_full A neurotrophin functioning with a Toll regulates structural plasticity in a dopaminergic circuit
title_fullStr A neurotrophin functioning with a Toll regulates structural plasticity in a dopaminergic circuit
title_full_unstemmed A neurotrophin functioning with a Toll regulates structural plasticity in a dopaminergic circuit
title_sort A neurotrophin functioning with a Toll regulates structural plasticity in a dopaminergic circuit
dc.creator.fl_str_mv Jun Sun
Francisca Rojo-Cortes
Suzana Ulian-Benitez
Manuel G Forero
Guiyi Li
Deepanshu ND Singh
Xiaocui Wang
Sebastian Cachero
Marta Moreira
Dean Kavanagh
Gregory SXE Jefferis
Vincent Croset
Alicia Hidalgo
dc.contributor.author.none.fl_str_mv Jun Sun
Francisca Rojo-Cortes
Suzana Ulian-Benitez
Manuel G Forero
Guiyi Li
Deepanshu ND Singh
Xiaocui Wang
Sebastian Cachero
Marta Moreira
Dean Kavanagh
Gregory SXE Jefferis
Vincent Croset
Alicia Hidalgo
dc.subject.armarc.none.fl_str_mv Neurotrofina
Función cerebral
Comportamiento cerebral
topic Neurotrofina
Función cerebral
Comportamiento cerebral
description Experience shapes the brain as neural circuits can be modified by neural stimulation or the lack of it. The molecular mechanisms underlying structural circuit plasticity and how plasticity modifies behaviour are poorly understood. Subjective experience requires dopamine, a neuromodulator that assigns a value to stimuli, and it also controls behaviour, including locomotion, learning, and memory. In Drosophila, Toll receptors are ideally placed to translate experience into structural brain change. Toll-6 is expressed in dopaminergic neurons (DANs), raising the intriguing possibility that Toll-6 could regulate structural plasticity in dopaminergic circuits. Drosophila neurotrophin-2 (DNT-2) is the ligand for Toll-6 and Kek-6, but whether it is required for circuit structural plasticity was unknown. Here, we show that DNT-2-expressing neurons connect with DANs, and they modulate each other. Loss of function for DNT-2 or its receptors Toll-6 and kinase-less Trk-like kek-6 caused DAN and synapse loss, impaired dendrite growth and connectivity, decreased synaptic sites, and caused locomotion deficits. In contrast, overexpressed DNT-2 increased DAN cell number, dendrite complexity, and promoted synaptogenesis. Neuronal activity modified DNT-2, increased synaptogenesis in DNT-2-positive neurons and DANs, and over-expression of DNT-2 did too. Altering the levels of DNT-2 or Toll-6 also modified dopamine-dependent behaviours, including locomotion and long-term memory. To conclude, a feedback loop involving dopamine and DNT-2 highlighted the circuits engaged, and DNT-2 with Toll-6 and Kek-6 induced structural plasticity in this circuit modifying brain function and behaviour.
publishDate 2024
dc.date.issued.none.fl_str_mv 2024
dc.date.accessioned.none.fl_str_mv 2025-11-27T16:31:55Z
dc.date.available.none.fl_str_mv 2025-11-27T16:31:55Z
dc.type.none.fl_str_mv Artículo de revista
dc.type.coar.none.fl_str_mv http://purl.org/coar/resource_type/c_2df8fbb1
dc.type.coarversion.none.fl_str_mv http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.content.none.fl_str_mv Text
dc.type.driver.none.fl_str_mv info:eu-repo/semantics/article
dc.type.version.none.fl_str_mv info:eu-repo/semantics/publishedVersion
format http://purl.org/coar/resource_type/c_2df8fbb1
status_str publishedVersion
dc.identifier.citation.none.fl_str_mv Sun, J., Rojo-Cortes, F., Ulian-Benitez, S., Forero, M., Li, G., Singh, D., Wang., X., Cachero. S., Moreira, M., Kavanagh, D., Jefferis, G., Croset, V. y Hidalgo, A. (2024). A neurotrophin functioning with a Toll regulates structural plasticity in a dopaminergic circuit. elife. https://elifesciences.org/articles/102222
dc.identifier.doi.none.fl_str_mv https://elifesciences.org/articles/102222
dc.identifier.eissn.none.fl_str_mv 2050084X
dc.identifier.uri.none.fl_str_mv https://hdl.handle.net/20.500.12313/6049
dc.identifier.url.none.fl_str_mv https://elifesciences.org/articles/102222
identifier_str_mv Sun, J., Rojo-Cortes, F., Ulian-Benitez, S., Forero, M., Li, G., Singh, D., Wang., X., Cachero. S., Moreira, M., Kavanagh, D., Jefferis, G., Croset, V. y Hidalgo, A. (2024). A neurotrophin functioning with a Toll regulates structural plasticity in a dopaminergic circuit. elife. https://elifesciences.org/articles/102222
2050084X
url https://elifesciences.org/articles/102222
https://hdl.handle.net/20.500.12313/6049
dc.language.iso.none.fl_str_mv eng
language eng
dc.relation.ispartofjournal.none.fl_str_mv Elife
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spelling Jun Sun3e6d84c1-ea87-40a6-8033-66ee19b57476-1Francisca Rojo-Cortes285b117e-bf23-4d6c-af3a-13311f233161-1Suzana Ulian-Benitezddd8ccf8-d8ed-48c5-913f-687b0a63ba80-1Manuel G Foreroaecfbbae-fbc7-455c-943a-18289b95331a-1Guiyi Lia6e2cceb-60d0-476d-ae96-e34a12f668d6-1Deepanshu ND Singh05afa134-7a3d-4760-a0ba-71e5bc6e1c25-1Xiaocui Wang557e98c6-8173-418a-bfa8-993c7bd029fb-1Sebastian Cachero970e2912-54b7-429a-bdf7-47211efe7680-1Marta Moreira22fb79e8-e779-4643-9712-853521ef2f05-1Dean Kavanaghe0051d00-e460-4753-ae95-58b9c142c812-1Gregory SXE Jefferis07bf157c-c535-41a9-b388-b53fc16d8b4b-1Vincent Croset41785fde-4d78-4a06-a888-9057fd0a9656-1Alicia Hidalgod439e77d-91f0-4506-b11b-8910ed3a96a8-12025-11-27T16:31:55Z2025-11-27T16:31:55Z2024Experience shapes the brain as neural circuits can be modified by neural stimulation or the lack of it. The molecular mechanisms underlying structural circuit plasticity and how plasticity modifies behaviour are poorly understood. Subjective experience requires dopamine, a neuromodulator that assigns a value to stimuli, and it also controls behaviour, including locomotion, learning, and memory. In Drosophila, Toll receptors are ideally placed to translate experience into structural brain change. Toll-6 is expressed in dopaminergic neurons (DANs), raising the intriguing possibility that Toll-6 could regulate structural plasticity in dopaminergic circuits. Drosophila neurotrophin-2 (DNT-2) is the ligand for Toll-6 and Kek-6, but whether it is required for circuit structural plasticity was unknown. Here, we show that DNT-2-expressing neurons connect with DANs, and they modulate each other. Loss of function for DNT-2 or its receptors Toll-6 and kinase-less Trk-like kek-6 caused DAN and synapse loss, impaired dendrite growth and connectivity, decreased synaptic sites, and caused locomotion deficits. In contrast, overexpressed DNT-2 increased DAN cell number, dendrite complexity, and promoted synaptogenesis. Neuronal activity modified DNT-2, increased synaptogenesis in DNT-2-positive neurons and DANs, and over-expression of DNT-2 did too. Altering the levels of DNT-2 or Toll-6 also modified dopamine-dependent behaviours, including locomotion and long-term memory. To conclude, a feedback loop involving dopamine and DNT-2 highlighted the circuits engaged, and DNT-2 with Toll-6 and Kek-6 induced structural plasticity in this circuit modifying brain function and behaviour.application/pdfSun, J., Rojo-Cortes, F., Ulian-Benitez, S., Forero, M., Li, G., Singh, D., Wang., X., Cachero. S., Moreira, M., Kavanagh, D., Jefferis, G., Croset, V. y Hidalgo, A. (2024). 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