Effects of short-term inhibition of Tetracyclines and Macrolides on specific methanogenic activity and swine biodegradability

Limited studies have examined kinetic models related to the impact of antibiotics on acetoclastic methanogenesis and swine wastewater biodegradability, which can be useful for improvement and correct operation of anaerobic systems. Many researchers have evaluated the inhibition on this main methane-...

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Autores:: Delgadillo-Mirquez L.
Gonzalez-Tineo P
Serrano D
Durán U

Tipo de recurso:: Article of investigation

Fecha de publicación:: 2022

Institución:: Universidad de Ibagué

Repositorio:: Repositorio Universidad de Ibagué

Idioma:: eng

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dc.title.eng.fl_str_mv	Effects of short-term inhibition of Tetracyclines and Macrolides on specific methanogenic activity and swine biodegradability
title	Effects of short-term inhibition of Tetracyclines and Macrolides on specific methanogenic activity and swine biodegradability
spellingShingle	Effects of short-term inhibition of Tetracyclines and Macrolides on specific methanogenic activity and swine biodegradability Antibióticos para usos veterinarios Metanogénesis acetoclástica Concentración inhibitoria media Aguas residuales de cerdos Efecto sinérgico Inhibición no competitiva Acetoclastic methanogenesis Antibiotics for veterinary uses Half-maximal inhibitory concentration Swine wastewater Synergistic effect Uncompetitive inhibition
title_short	Effects of short-term inhibition of Tetracyclines and Macrolides on specific methanogenic activity and swine biodegradability
title_full	Effects of short-term inhibition of Tetracyclines and Macrolides on specific methanogenic activity and swine biodegradability
title_fullStr	Effects of short-term inhibition of Tetracyclines and Macrolides on specific methanogenic activity and swine biodegradability
title_full_unstemmed	Effects of short-term inhibition of Tetracyclines and Macrolides on specific methanogenic activity and swine biodegradability
title_sort	Effects of short-term inhibition of Tetracyclines and Macrolides on specific methanogenic activity and swine biodegradability
dc.creator.fl_str_mv	Delgadillo-Mirquez L. Gonzalez-Tineo P Serrano D Durán U
dc.contributor.author.none.fl_str_mv	Delgadillo-Mirquez L. Gonzalez-Tineo P Serrano D Durán U
dc.subject.armarc.none.fl_str_mv	Antibióticos para usos veterinarios Metanogénesis acetoclástica Concentración inhibitoria media Aguas residuales de cerdos Efecto sinérgico Inhibición no competitiva
topic	Antibióticos para usos veterinarios Metanogénesis acetoclástica Concentración inhibitoria media Aguas residuales de cerdos Efecto sinérgico Inhibición no competitiva Acetoclastic methanogenesis Antibiotics for veterinary uses Half-maximal inhibitory concentration Swine wastewater Synergistic effect Uncompetitive inhibition
dc.subject.proposal.eng.fl_str_mv	Acetoclastic methanogenesis Antibiotics for veterinary uses Half-maximal inhibitory concentration Swine wastewater Synergistic effect Uncompetitive inhibition
description	Limited studies have examined kinetic models related to the impact of antibiotics on acetoclastic methanogenesis and swine wastewater biodegradability, which can be useful for improvement and correct operation of anaerobic systems. Many researchers have evaluated the inhibition on this main methane-producing pathway by antibiotics individually but in rare cases as a mix. Thus, two tetracyclines: oxytetracycline (OTC) and tetracycline (TCN) and one macrolide: tylosin (TYL) were used separately and in combination OTC+TCN+TYL (MIX) to evaluate their inhibition effects. Short-term inhibition assays are useful to evaluate the antibiotics impact detected on swine wastewater specific methanogenic activity (SMA) and biodegradability (BD) at different concentrations of antibiotics (15, 30 and 45 μg/mL); OTC and MIX showed the highest inhibition on SMA (78 and 76%, respectively) while the lower one was on methane production at 45 μg/mL of MIX (61%). The assays with swine wastewater showed that OTC and TCN had the highest inhibition on BD at 45 μg/mL, 71 and 51%, respectively. As expected, the maximum decrease in methane production (43.0% and 56.0%, respectively) occurred in the assays with the highest OTC and MIX concentrations, while TYL did not impact methane production in all assays. In specific activity, the results showed half- maximal half-maximal inhibitory OTC concentrations (3.8 and 2.8 μg/mL) in SMA and BD assays, respectively, while OTC recorded in methane production 4.5 and 54.2μg/mL in SMA and BD assays, respectively. These results indicate that antibiotics affect specific methanogenic activity and biodegradability more than methane production and inhibition was proposed as uncompetitive.
publishDate	2022
dc.date.issued.none.fl_str_mv	2022-08
dc.date.accessioned.none.fl_str_mv	2025-08-20T21:25:44Z
dc.date.available.none.fl_str_mv	2025-08-20T21:25:44Z
dc.type.none.fl_str_mv	Artículo de revista
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dc.identifier.citation.none.fl_str_mv	Delgadillo-Mirquez L., Delgadillo-Mirquez L., Serrano, D y Durán, U. (2022). Effects of short-term inhibition of Tetracyclines and Macrolides on specific methanogenic activity and swine biodegradability. Environmental Technology and Innovation, 27, 102574. DOI: 10.1016/j.eti.2022.102574
dc.identifier.doi.none.fl_str_mv	10.1016/j.eti.2022.102574
dc.identifier.uri.none.fl_str_mv	https://hdl.handle.net/20.500.12313/5502
identifier_str_mv	Delgadillo-Mirquez L., Delgadillo-Mirquez L., Serrano, D y Durán, U. (2022). Effects of short-term inhibition of Tetracyclines and Macrolides on specific methanogenic activity and swine biodegradability. Environmental Technology and Innovation, 27, 102574. DOI: 10.1016/j.eti.2022.102574 10.1016/j.eti.2022.102574
url	https://hdl.handle.net/20.500.12313/5502
dc.language.iso.none.fl_str_mv	eng
language	eng
dc.relation.citationstartpage.none.fl_str_mv	102574
dc.relation.citationvolume.none.fl_str_mv	27
dc.relation.ispartofjournal.none.fl_str_mv	Environmental Technology and Innovation
dc.relation.references.none.fl_str_mv	Ali Shah, F., Mahmood, Q., Maroof Shah, M., Pervez, A., Ahmad Asad, S., 2014. Microbial ecology of anaerobic digesters: The key players of anaerobiosis. Sci. World J. 2014, 183752. http://dx.doi.org/10.1155/2014/183752. Álvarez, J.A., Otero, L., Lema, J.M., Omil, F., 2010. The effect and fate of antibiotics during the anaerobic digestion of pig manure. Bioresour. Technol. 101, 8581–8586. http://dx.doi.org/10.1016/j.biortech.2010.06.075 Amin, M.M., Zilles, J.L., Greiner, J., Charbonneau, S., Raskin, L., Morgenroth, E., 2006. Influence of the antibiotic erythromycin on anaerobic treatment of a pharmaceutical wastewater. Environ. Sci. Technol. 40, 3971–3977. http://dx.doi.org/10.1021/es060428. Angenent, L.T., Mau, M., George, U., Zahn, J.A., Raskin, L., 2008. Effect of the presence of the antimicrobial tylosin in swine waste on anaerobic treatment. Water Res. 42, 2377–2384. http://dx.doi.org/10.1016/j.watres.2008.01.005 APHA, AWWA, WEF, 2015. Standard Methods for the Examination of Water and Wastewater. American Public Health Association, American Water Works Association, Water Environment Federation, Washington D.C. Aydin, S., Cetecioglu, Z., Arikan, O., Ince, B., Ozbayram, E.G., Ince, O., 2015. Inhibitory effects of antibiotic combinations on syntrophic bacteria, homoacetogens and methanogens. Chemosphere 120, 515–520. http://dx.doi.org/10.1016/j.chemosphere.2014.09.045. Bala, R., Gupta, G.K., Dasgupta, B.V., Mondal, M.K., 2019. Pretreatment optimisation and kinetics of batch anaerobic digestion of liquidised OFMSW treated with NaOH: Models verification with experimental data. J. Environ. Manag. 237, 313–321. http://dx.doi.org/10.1016/j.jenvman.2019.02.083. Barton, M.D., 2014. Impact of antibiotic use in the swine industry. Curr. Opin. Microbiol. 19, 9–15. http://dx.doi.org/10.1016/j.mib.2014.05.017. Cetecioglu, Z., Ince, B., Gros, M., Rodriguez-Mozaz, S., Barceló, D., Orhon, D., Ince, O., 2013. Chronic impact of tetracycline on the biodegradation of an organic substrate mixture under anaerobic conditions. Water Res. 47, 2959–2969. http://dx.doi.org/10.1016/j.watres.2013.02.053. Cetecioglu, Z., Orhon, D., 2017. Acute and chronic effects of antibiotics on deterioration of anaerobic substrate utilization. Curr. Org. Chem. 21, 1044–1053. http://dx.doi.org/10.2174/1385272821666170117095645. Chelliapan, S., Wilby, T., Sallis, P.J., Yuzir, A., 2011. Tolerance of the antibiotic tylosin on treatment performance of an up-flow anaerobic stage reactor (UASR). Water Sci. Technol. 63, 1599–1606. http://dx.doi.org/10.2166/wst.2011.222. Cheng, D.L., Ngo, H.H., Guo, W.S., Liu, Y.W., Zhou, J.L., Chang, S.W., Nguyen, D.D., Bui, X.T., Zhang, X.B., 2018. Bioprocessing for elimination antibiotics and hormones from swine wastewater. Sci. Total Environ. 621, 1664–1682. http://dx.doi.org/10.1016/j.scitotenv.2017.10.059 Du, L., Liu, W., 2012. Occurrence, fate, and ecotoxicity of antibiotics in agro-ecosystems: A review. Agron. Sustain. Dev. http://dx.doi.org/10.1007/ s13593-011-0062-9. Fountoulakis, M.S., Stamatelatou, K., Lyberatos, G., 2008. The effect of pharmaceuticals on the kinetics of methanogenesis and acetogenesis. Bioresour. Technol. 99, 7083–7090. http://dx.doi.org/10.1016/j.biortech.2008.01.008 García-Sánchez, L., Garzón-Zúñiga, M.A., Buelna, G., Moeller-Chávez, G.E., Noyola, A., Avilez-Flores, M., Estrada-Arriaga, E.B., 2013. Occurrence of tylosin in swine wastewater in Mexico. Water Sci. Technol. 68, http://dx.doi.org/10.2166/wst.2013.323 Griffin, M.O., Ceballos, G., Villarreal, F.J., 2011. Tetracycline compounds with non-antimicrobial organ protective properties: Possible mechanisms of action. Pharmacol. Res. 63, http://dx.doi.org/10.1016/j.phrs.2010.10.004 Heuer, H., Solehati, Q., Zimmerling, U., Kleineidam, K., Schloter, M., Müller, T., Focks, A., Thiele-Bruhn, S., Smalla, K., 2011. Accumulation of sulfonamide resistance genes in arable soils due to repeated application of manure containing sulfadiazine. Appl. Environ. Microbiol. 77, 2527–2530. http://dx.doi.org/10.1128/AEM.02577-10. Holm-Nielsen, J.B., Al Seadi, T., Oleskowicz-Popiel, P., 2009. The future of anaerobic digestion and biogas utilization. Bioresour. Technol. 100, http://dx.doi.org/10.1016/j.biortech.2008.12.046. Ji, J.Y., Xing, Y.J., Ma, Z.T., Zhang, M., Zheng, P., 2013. Acute toxicity of pharmaceutical wastewaters containing antibiotics to anaerobic digestion treatment. Chemosphere 91, 1094–1098. http://dx.doi.org/10.1016/j.chemosphere.2013.01.009. Jiang, Y., Banks, C., Zhang, Y., Heaven, S., Longhurst, P., 2018. Quantifying the percentage of methane formation via acetoclastic and syntrophic acetate oxidation pathways in anaerobic digesters. Waste Manage. 71, 749–756. http://dx.doi.org/10.1016/j.wasman.2017.04.005. Ke, X., Wang, C. yong, Li, R. dong, Zhang, Y., 2014. 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Veterinary antibiotics (VAs) contamination as a global agro-ecological issue: A critical view. Agric. Ecosyst. Env. http://dx.doi.org/10.1016/j.agee.2018.01.026. Loftin, K.A., Henny, C., Adams, C.D., Surampali, R., Mormile, M.R., 2005. Inhibition of microbial metabolism in anaerobic lagoons by selected sulfonamides, tetracyclines, lincomycin, and tylosin tartrate. Environ. Toxicol. Chem. 24, http://dx.doi.org/10.1897/04-093R.1. Lu, M., Niu, X., Liu, W., Zhang, J., Wang, J., Yang, J., Wang, W., Yang, Z., 2016. Biogas generation in anaerobic wastewater treatment under tetracycline antibiotic pressure. Sci. Rep. 6, http://dx.doi.org/10.1038/srep28336 Lu, X., Zhen, G., Liu, Y., Hojo, T., Estrada, A.L., Li, Y.Y., 2014. Long-term effect of the antibiotic cefalexin on methane production during waste activated sludge anaerobic digestion. Bioresour. Technol. 169, 644–651. http://dx.doi.org/10.1016/j.biortech.2014.07.056. Madison, J., 2008. Antibacterial drugs. In: Small Animal Clinical Pharmacology, second ed. Elsevier Ltd, http://dx.doi.org/10.1016/B978-0-7020-2858- 8.50010-5 Martín, M.A., Fernández, R., Gutiérrez, M.C., Siles, J.A., 2018. Thermophilic anaerobic digestion of pre-treated orange peel: Modelling of methane production. Process Saf. Environ. Prot. 117, 245–253. http://dx.doi.org/10.1016/j.psep.2018.05.008. Massé, D.I., Saady, N.M.C., Gilbert, Y., 2014. Potential of biological processes to eliminate antibiotics in livestock manure: An overview. Animals http://dx.doi.org/10.3390/ani4020146. Mitchell, S.M., Ullman, J.L., Teel, A.L., Watts, R.J., Frear, C., 2013. The effects of the antibiotics ampicillin, florfenicol, sulfamethazine, and tylosin on biogas production and their degradation efficiency during anaerobic digestion. Bioresour. Technol. 149, 244–252. http://dx.doi.org/10.1016/j. biortech.2013.09.048. Nguyen, D.D., Jeon, B.H., Jeung, J.H., Rene, E.R., Banu, J.R., Ravindran, B., Vu, C.M., Ngo, H.H., Guo, W., Chang, S.W., 2019. Thermophilic anaerobic digestion of model organic wastes: Evaluation of biomethane production and multiple kinetic models analysis. Bioresour. Technol. 280, 269–276. http://dx.doi.org/10.1016/j.biortech.2019.02.033. Oberoi, A.S., Jia, Y., Zhang, H., Khanal, S.K., Lu, H., 2019. Insights into the fate and removal of antibiotics in engineered biological treatment systems: A critical review. Environ. Sci. Technol. 53, http://dx.doi.org/10.1021/acs.est.9b01131. Reyes-Contreras, C., Vidal, G., 2015. Methanogenic toxicity evaluation of chlortetracycline hydrochloride. Electron. J. Biotechnol. 18, http://dx.doi.org/ 10.1016/j.ejbt.2015.09.009. Shi, J.C., Liao, X.D., Wu, Y.B., Liang, J.B., 2011. Effect of antibiotics on methane arising from anaerobic digestion of pig manure. Anim. Feed Sci. Technol. 166–167, 457–463. http://dx.doi.org/10.1016/j.anifeedsci.2011.04.033. 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From the application of antibiotics to antibiotic residues in liquid manures and digestates: A screening study in one European center of conventional pig husbandry. J. Environ. Manag. 177, 129–137. http://dx.doi.org/10.1016/j.jenvman. 2016.04.012. Xiao, L., Wang, Y., Lichtfouse, E., Li, Z., Kumar, P.S., Liu, J., Feng, D., Yang, Q., Liu, F., 2021. Effect of antibiotics on the microbial efficiency of anaerobic digestion of wastewater: A review. Front. Microbiol. http://dx.doi.org/10.3389/fmicb.2020.611613. Xiong, W., Sun, Y., Ding, X., Wang, M., Zeng, Z., 2015. Selective pressure of antibiotics on ARGs and bacterial communities in manure-polluted freshwater-sediment microcosms. Front. Microbiol. 6, http://dx.doi.org/10.3389/fmicb.2015.00194 Xu, T.J., Ting, Y.P., 2009. Fungal bioleaching of incineration fly ash: Metal extraction and modeling growth kinetics. Enzym. Microb. Technol. 44, 323–328. http://dx.doi.org/10.1016/j.enzmictec.2009.01.006. Yang, S., McDonald, J., Hai, F.I., Price, W.E., Khan, S.J., Nghiem, L.D., 2017. The fate of trace organic contaminants in sewage sludge during recuperative thickening anaerobic digestion. Bioresour. Technol. 240, http://dx.doi.org/10.1016/j.biortech.2017.02.020. Yin, F., Dong, H., Zhang, W., Zhu, Z., Shang, B., Wang, Y., 2019. Removal of combined antibiotic (florfenicol, tylosin and tilmicosin) during anaerobic digestion and their relative effect. Renew. Energy 139, 895–903. http://dx.doi.org/10.1016/j.renene.2019.03.001. Zhou, Q., Li, X., Wu, S., Zhong, Y., Yang, C., 2021. Enhanced strategies for antibiotic removal from swine wastewater in anaerobic digestion. Trends Biotechnol. http://dx.doi.org/10.1016/j.tibtech.2020.07.002. Zhou, L.J., Ying, G.G., Liu, S., Zhang, R.Q., Lai, H.J., Chen, Z.F., Pan, C.G., 2013. Excretion masses and environmental occurrence of antibiotics in typical swine and dairy cattle farms in China. Sci. 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spelling	Delgadillo-Mirquez L.6043e140-5f2a-45b9-b1c2-a328c753975b-1Gonzalez-Tineo P9bccb052-178d-43e8-a077-7de07289e3e4-1Serrano Dbdc7abfa-3c5f-40a7-9729-f8a1a715dd10-1Durán U59cc1f71-74cd-4eb4-b32e-0d56545204ce-12025-08-20T21:25:44Z2025-08-20T21:25:44Z2022-08Limited studies have examined kinetic models related to the impact of antibiotics on acetoclastic methanogenesis and swine wastewater biodegradability, which can be useful for improvement and correct operation of anaerobic systems. Many researchers have evaluated the inhibition on this main methane-producing pathway by antibiotics individually but in rare cases as a mix. Thus, two tetracyclines: oxytetracycline (OTC) and tetracycline (TCN) and one macrolide: tylosin (TYL) were used separately and in combination OTC+TCN+TYL (MIX) to evaluate their inhibition effects. Short-term inhibition assays are useful to evaluate the antibiotics impact detected on swine wastewater specific methanogenic activity (SMA) and biodegradability (BD) at different concentrations of antibiotics (15, 30 and 45 μg/mL); OTC and MIX showed the highest inhibition on SMA (78 and 76%, respectively) while the lower one was on methane production at 45 μg/mL of MIX (61%). The assays with swine wastewater showed that OTC and TCN had the highest inhibition on BD at 45 μg/mL, 71 and 51%, respectively. As expected, the maximum decrease in methane production (43.0% and 56.0%, respectively) occurred in the assays with the highest OTC and MIX concentrations, while TYL did not impact methane production in all assays. In specific activity, the results showed half- maximal half-maximal inhibitory OTC concentrations (3.8 and 2.8 μg/mL) in SMA and BD assays, respectively, while OTC recorded in methane production 4.5 and 54.2μg/mL in SMA and BD assays, respectively. These results indicate that antibiotics affect specific methanogenic activity and biodegradability more than methane production and inhibition was proposed as uncompetitive.application/pdfDelgadillo-Mirquez L., Delgadillo-Mirquez L., Serrano, D y Durán, U. (2022). Effects of short-term inhibition of Tetracyclines and Macrolides on specific methanogenic activity and swine biodegradability. Environmental Technology and Innovation, 27, 102574. DOI: 10.1016/j.eti.2022.10257410.1016/j.eti.2022.102574https://hdl.handle.net/20.500.12313/5502engElsevier B.V.Paises bajos10257427Environmental Technology and InnovationAli Shah, F., Mahmood, Q., Maroof Shah, M., Pervez, A., Ahmad Asad, S., 2014. Microbial ecology of anaerobic digesters: The key players of anaerobiosis. Sci. World J. 2014, 183752. http://dx.doi.org/10.1155/2014/183752.Álvarez, J.A., Otero, L., Lema, J.M., Omil, F., 2010. The effect and fate of antibiotics during the anaerobic digestion of pig manure. Bioresour. Technol. 101, 8581–8586. http://dx.doi.org/10.1016/j.biortech.2010.06.075Amin, M.M., Zilles, J.L., Greiner, J., Charbonneau, S., Raskin, L., Morgenroth, E., 2006. Influence of the antibiotic erythromycin on anaerobic treatment of a pharmaceutical wastewater. Environ. Sci. Technol. 40, 3971–3977. http://dx.doi.org/10.1021/es060428.Angenent, L.T., Mau, M., George, U., Zahn, J.A., Raskin, L., 2008. Effect of the presence of the antimicrobial tylosin in swine waste on anaerobic treatment. Water Res. 42, 2377–2384. http://dx.doi.org/10.1016/j.watres.2008.01.005APHA, AWWA, WEF, 2015. Standard Methods for the Examination of Water and Wastewater. American Public Health Association, American Water Works Association, Water Environment Federation, Washington D.C.Aydin, S., Cetecioglu, Z., Arikan, O., Ince, B., Ozbayram, E.G., Ince, O., 2015. Inhibitory effects of antibiotic combinations on syntrophic bacteria, homoacetogens and methanogens. 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This is an open access article under the CC BYinfo:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Atribución-NoComercial 4.0 Internacional (CC BY-NC 4.0)https://creativecommons.org/licenses/by-nc/4.0/https://www.sciencedirect.com/science/article/pii/S2352186422001596?pes=vor&utm_source=scopus&getft_integrator=scopusAntibióticos para usos veterinariosMetanogénesis acetoclásticaConcentración inhibitoria mediaAguas residuales de cerdosEfecto sinérgicoInhibición no competitivaAcetoclastic methanogenesisAntibiotics for veterinary usesHalf-maximal inhibitory concentrationSwine wastewaterSynergistic effectUncompetitive inhibitionEffects of short-term inhibition of Tetracyclines and Macrolides on specific methanogenic activity and swine biodegradabilityArtículo de revistahttp://purl.org/coar/resource_type/c_2df8fbb1http://purl.org/coar/version/c_970fb48d4fbd8a85Textinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionPublicationTEXTArtículo.pdf.txtArtículo.pdf.txtExtracted texttext/plain3749https://repositorio.unibague.edu.co/bitstreams/970fa954-2e5a-429f-a7fc-0a43f4f4b871/downloadbf590a0de67304d9fb069b448fbc7122MD53THUMBNAILArtículo.pdf.jpgArtículo.pdf.jpgIM Thumbnailimage/jpeg27317https://repositorio.unibague.edu.co/bitstreams/c81f5022-cd10-45f9-a149-1c5f8f2e1823/download1ca404000a7a16c49d43a0c683602a9cMD54ORIGINALArtículo.pdfArtículo.pdfapplication/pdf309964https://repositorio.unibague.edu.co/bitstreams/0ab903e4-89e6-46a2-bf2e-2b415379ab51/download092af8f5f592f9f67abc8e87219ef9d5MD52LICENSElicense.txtlicense.txttext/plain; charset=utf-8134https://repositorio.unibague.edu.co/bitstreams/b32ce87f-1acf-4c42-8f88-0c7f1c915e65/download2fa3e590786b9c0f3ceba1b9656b7ac3MD5120.500.12313/5502oai:repositorio.unibague.edu.co:20.500.12313/55022025-08-21 03:02:16.207https://creativecommons.org/licenses/by-nc/4.0/© 2022 The Authors. 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Effects of short-term inhibition of Tetracyclines and Macrolides on specific methanogenic activity and swine biodegradability

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