Bioprospección de Urceolina caucana: caracterización metabolómica de compuestos lipídicos y fenólicos empleando HPLC-QTOF-MS para la identificación de nuevos compuestos bioactivos con potencial farmacéutico

La biodiversidad colombiana, una de las más grandes del mundo, ofrece una gran oportunidad parala bioprospección, que busca identificar compuestos bioactivos, en este caso específicamente conpotencial farmacéutico. Sin embargo, su uso y aprovechamiento aún enfrentan desafíosrelacionados con el conoc...

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Autores:
Tirone García, Angie Viviana
Hernández Useche, Juan David
Tipo de recurso:
Trabajo de grado de pregrado
Fecha de publicación:
2025
Institución:
Universidad de Ibagué
Repositorio:
Repositorio Universidad de Ibagué
Idioma:
spa
OAI Identifier:
oai:repositorio.unibague.edu.co:20.500.12313/5496
Acceso en línea:
https://hdl.handle.net/20.500.12313/5496
Palabra clave:
Compuestos bioactivos con potencial farmacéutico
Bioprospección de Urceolina caucana
Urceolina caucana
HPLC-QTOF-MS
Bioeconomía
Lípidos
Fenoles
Bioeconomy
Lipids
Phenols
Rights
openAccess
License
http://purl.org/coar/access_right/c_abf2
id UNIBAGUE2_a884da767abea512430a2bf787361e0e
oai_identifier_str oai:repositorio.unibague.edu.co:20.500.12313/5496
network_acronym_str UNIBAGUE2
network_name_str Repositorio Universidad de Ibagué
repository_id_str
dc.title.spa.fl_str_mv Bioprospección de Urceolina caucana: caracterización metabolómica de compuestos lipídicos y fenólicos empleando HPLC-QTOF-MS para la identificación de nuevos compuestos bioactivos con potencial farmacéutico
title Bioprospección de Urceolina caucana: caracterización metabolómica de compuestos lipídicos y fenólicos empleando HPLC-QTOF-MS para la identificación de nuevos compuestos bioactivos con potencial farmacéutico
spellingShingle Bioprospección de Urceolina caucana: caracterización metabolómica de compuestos lipídicos y fenólicos empleando HPLC-QTOF-MS para la identificación de nuevos compuestos bioactivos con potencial farmacéutico
Compuestos bioactivos con potencial farmacéutico
Bioprospección de Urceolina caucana
Urceolina caucana
HPLC-QTOF-MS
Bioeconomía
Lípidos
Fenoles
Bioeconomy
Lipids
Phenols
title_short Bioprospección de Urceolina caucana: caracterización metabolómica de compuestos lipídicos y fenólicos empleando HPLC-QTOF-MS para la identificación de nuevos compuestos bioactivos con potencial farmacéutico
title_full Bioprospección de Urceolina caucana: caracterización metabolómica de compuestos lipídicos y fenólicos empleando HPLC-QTOF-MS para la identificación de nuevos compuestos bioactivos con potencial farmacéutico
title_fullStr Bioprospección de Urceolina caucana: caracterización metabolómica de compuestos lipídicos y fenólicos empleando HPLC-QTOF-MS para la identificación de nuevos compuestos bioactivos con potencial farmacéutico
title_full_unstemmed Bioprospección de Urceolina caucana: caracterización metabolómica de compuestos lipídicos y fenólicos empleando HPLC-QTOF-MS para la identificación de nuevos compuestos bioactivos con potencial farmacéutico
title_sort Bioprospección de Urceolina caucana: caracterización metabolómica de compuestos lipídicos y fenólicos empleando HPLC-QTOF-MS para la identificación de nuevos compuestos bioactivos con potencial farmacéutico
dc.creator.fl_str_mv Tirone García, Angie Viviana
Hernández Useche, Juan David
dc.contributor.advisor.none.fl_str_mv Cortes, Charlotte Natalie
Ortiz Domínguez, Brandon Elí
dc.contributor.author.none.fl_str_mv Tirone García, Angie Viviana
Hernández Useche, Juan David
dc.contributor.jury.none.fl_str_mv Osorio Lopez, Edison Humberto
Florido Cuellar, Bilma Adela
dc.subject.armarc.none.fl_str_mv Compuestos bioactivos con potencial farmacéutico
Bioprospección de Urceolina caucana
topic Compuestos bioactivos con potencial farmacéutico
Bioprospección de Urceolina caucana
Urceolina caucana
HPLC-QTOF-MS
Bioeconomía
Lípidos
Fenoles
Bioeconomy
Lipids
Phenols
dc.subject.proposal.other.fl_str_mv Urceolina caucana
HPLC-QTOF-MS
dc.subject.proposal.spa.fl_str_mv Bioeconomía
Lípidos
Fenoles
dc.subject.proposal.eng.fl_str_mv Bioeconomy
Lipids
Phenols
description La biodiversidad colombiana, una de las más grandes del mundo, ofrece una gran oportunidad parala bioprospección, que busca identificar compuestos bioactivos, en este caso específicamente conpotencial farmacéutico. Sin embargo, su uso y aprovechamiento aún enfrentan desafíosrelacionados con el conocimiento limitado de los metabolitos específicos en especies nativas,como Urceolina caucana, y la necesidad de desarrollar metodologías eficientes para suidentificación y uso sostenible. El objetivo principal de este estudio fue realizar una caracterizaciónmetabolómica de los compuestos lipídicos y fenólicos presentes en U. caucana, empleando latécnica de HPLC-QTOF-MS, para identificar nuevos compuestos bioactivos con potencialfarmacéutico. Los objetivos específicos incluyeron obtener extractos de los metabolitos medianteextracción por ultrasonido, identificar los principales compuestos lipídicos y fenólicos en laespecie, y proponer posibles aplicaciones de estos metabolitos. La metodología consistió en laobtención de extractos y el análisis de estos mediante HPLC-QTOF-MS, una técnica avanzada quepermitió detectar y caracterizar un amplio perfil de metabolitos en la muestra. Los resultadosmostraron que U. caucana contiene una variedad significativa de compuestos lipídicos y fenólicos,muchos de los cuales tienen actividades biológicas relevantes y potencial en farmacología.Además, refuerzan el valor de la biodiversidad colombiana como fuente de nuevos compuestosbioactivos, subrayando la importancia de su aprovechamiento sostenible y responsable parafomentar la innovación y desarrollo.
publishDate 2025
dc.date.accessioned.none.fl_str_mv 2025-08-19T17:04:37Z
dc.date.available.none.fl_str_mv 2025-08-19T17:04:37Z
dc.date.issued.none.fl_str_mv 2025
dc.type.none.fl_str_mv Trabajo de grado - Pregrado
dc.type.coar.none.fl_str_mv http://purl.org/coar/resource_type/c_7a1f
dc.type.content.none.fl_str_mv Text
dc.type.driver.none.fl_str_mv info:eu-repo/semantics/bachelorThesis
dc.type.redcol.none.fl_str_mv http://purl.org/redcol/resource_type/TP
dc.type.version.none.fl_str_mv info:eu-repo/semantics/acceptedVersion
format http://purl.org/coar/resource_type/c_7a1f
status_str acceptedVersion
dc.identifier.citation.none.fl_str_mv Tirone García, A. V., & Hernández Useche, J. D. (2025). Bioprospección de Urceolina caucana: caracterización metabolómica de compuestos lipídicos y fenólicos empleando HPLC-QTOF-MS para la identificación de nuevos compuestos bioactivos con potencial farmacéutico. Universidad de Ibagué. https://hdl.handle.net/20.500.12313/5496
dc.identifier.uri.none.fl_str_mv https://hdl.handle.net/20.500.12313/5496
identifier_str_mv Tirone García, A. V., & Hernández Useche, J. D. (2025). Bioprospección de Urceolina caucana: caracterización metabolómica de compuestos lipídicos y fenólicos empleando HPLC-QTOF-MS para la identificación de nuevos compuestos bioactivos con potencial farmacéutico. Universidad de Ibagué. https://hdl.handle.net/20.500.12313/5496
url https://hdl.handle.net/20.500.12313/5496
dc.language.iso.none.fl_str_mv spa
language spa
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spelling Cortes, Charlotte Natalie29f49502-1027-47e8-be32-48e7c201a91d600Ortiz Domínguez, Brandon Elí79ab32b5-1885-431a-afbc-6eff518dda86-1Tirone García, Angie Viviana6f629210-b110-45ae-99e3-ae5360ab1f90-1Hernández Useche, Juan David9b92a88e-1321-45d2-ab05-5fac355805f5-1Osorio Lopez, Edison Humbertoa28240e4-ba7f-4632-9175-08073951f7f5-1Florido Cuellar, Bilma Adela28c1de04-8361-4d55-8a34-65bdf52344d4-12025-08-19T17:04:37Z2025-08-19T17:04:37Z2025La biodiversidad colombiana, una de las más grandes del mundo, ofrece una gran oportunidad parala bioprospección, que busca identificar compuestos bioactivos, en este caso específicamente conpotencial farmacéutico. Sin embargo, su uso y aprovechamiento aún enfrentan desafíosrelacionados con el conocimiento limitado de los metabolitos específicos en especies nativas,como Urceolina caucana, y la necesidad de desarrollar metodologías eficientes para suidentificación y uso sostenible. El objetivo principal de este estudio fue realizar una caracterizaciónmetabolómica de los compuestos lipídicos y fenólicos presentes en U. caucana, empleando latécnica de HPLC-QTOF-MS, para identificar nuevos compuestos bioactivos con potencialfarmacéutico. Los objetivos específicos incluyeron obtener extractos de los metabolitos medianteextracción por ultrasonido, identificar los principales compuestos lipídicos y fenólicos en laespecie, y proponer posibles aplicaciones de estos metabolitos. La metodología consistió en laobtención de extractos y el análisis de estos mediante HPLC-QTOF-MS, una técnica avanzada quepermitió detectar y caracterizar un amplio perfil de metabolitos en la muestra. Los resultadosmostraron que U. caucana contiene una variedad significativa de compuestos lipídicos y fenólicos,muchos de los cuales tienen actividades biológicas relevantes y potencial en farmacología.Además, refuerzan el valor de la biodiversidad colombiana como fuente de nuevos compuestosbioactivos, subrayando la importancia de su aprovechamiento sostenible y responsable parafomentar la innovación y desarrollo.Colombia's biodiversity, one of the largest in the world, offers a great opportunity forbioprospecting to identify bioactive compounds with pharmaceutical potential. However, their useand exploitation still face challenges related to the limited knowledge of specific metabolites innative species, such as Urceolina caucana, and the need to develop efficient methodologies fortheir identification and sustainable use. The main objective of this study was to perform ametabolomic characterization of lipid and phenolic compounds present in U. caucana, using theHPLC-QTOF-MS technique, to identify new bioactive compounds with pharmaceutical potential.The specific objectives included obtaining extracts of the metabolites by ultrasound extraction,identifying the main lipid and phenolic compounds in the species, and proposing possibleapplications of these metabolites. The methodology consisted of obtaining extracts and analyzingthem by HPLC-QTOF-MS, an advanced technique that allowed the detection and characterizationof a broad profile of metabolites in the sample. The results showed that U. caucana contains asignificant variety of lipid and phenolic compounds, many of which have relevant biologicalactivities and potential in pharmacology. They also reinforce the value of Colombian biodiversityas a source of new bioactive compounds, underlining the importance of their sustainable andresponsible use to foster innovation and development.PregradoBiologo ambientalTABLA DE CONTENIDO Introducción.....10 Descripción del proyecto.....10 1.1. Planteamiento del problema de investigación y justificación.....10 1.2. Marco teórico y estado del arte.....13 1.2.1. Bioprospección en Colombia.....13 1.2.2. Amaryllidaceae en Colombia.....15 1.2.3. Amaryllidoideae.....18 1.2.4. Urceolina caucana.....18 1.2.5. Compuestos fenólicos.....20 1.2.6. Compuestos lipídicos.....25 1.2.7. Metabolómica.....30 1.2.8. HPLC-QTOF-MS.....32 1.3. Objetivos.....34 1.3.1. Objetivo General.....34 1.3.2. Objetivos específicos.....34 1.4. Metodología.....34 1.4.1. OE1: Obtener los extractos de lípidos y fenoles mediante extracción con ultrasonido.....35 1.4.2. OE2: Identificar los principales compuestos lipídicos y fenólicos de U. caucana mediante HPLC-QTOF-MS.....37 1.4.3. OE3: Proponer las posibles aplicaciones de los compuestos identificados de U. caucana.....38 1.5. Resultados y Discusión.....39 1.5.1. OE1: Obtener los extractos de lípidos y fenoles mediante extracción con ultrasonido.....39 1.5.1.1. Actividad 1: Obtención del material vegetal.....39 1.5.1.2. Actividad 2: Extracción de Metabolitos.....40 1.5.2. OE2: Identificar los principales compuestos lipídicos y fenólicos de U. caucana mediante HPLC-QTOF-MS.....42 1.5.2.1. Actividad 1: Caracterización de compuestos.....42 1.5.2.2. Análisis de resultados de los compuestos fenólicos.....43 1.5.2.3. Análisis de resultados de los compuestos lipídicos.....48 1.5.3. OE3: Proponer las posibles aplicaciones de los compuestos identificados de U. caucana.....56 1.5.3.1. Actividad 1: Búsqueda información.....56 1.5.3.1.1. Compuestos fenólicos.....58 1.5.3.1.2. 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