A Novel Mitochondria-Targeting Iron Chelator Neuroprotects Multimodally via HIF-1 Modulation Against a Mitochondrial Toxin in a Dopaminergic Cell Model of Parkinson’s Disease

Coumarins are plant-derived polyphenolic compounds belonging to the benzopyrones family, possessing wide-ranging pharmaceutical applications including cytoprotection, which may translate into therapeutic potential for multiple diseases, including Parkinson’s disease (PD). Here we demonstrate the neu...

Full description

Autores:

Fouché, Belinda
Turner, Stephanie
Gorham, Rebecca
Stephenson, Eloise J.
Gutbier, Simon
Elson, Joanna L.
García-Beltrán, Olimpo
Van Der Westhuizen, Francois H.
Pienaar, Ilse S.

Tipo de recurso:

Article of investigation

Fecha de publicación:

2023

Institución:

Universidad de Ibagué

Repositorio:

Repositorio Universidad de Ibagué

Idioma:

eng

OAI Identifier:

oai:repositorio.unibague.edu.co:20.500.12313/5572

Acceso en línea:

https://hdl.handle.net/20.500.12313/5572
https://link.springer.com/article/10.1007/s12035-022-03107-8

Palabra clave:

Mitocondría
Parkinson
Antioxidant
Iron chelation
Mitochondria; MPP+
Neuroprotection
Parkinson’s disease

Rights

closedAccess

License

http://purl.org/coar/access_right/c_14cb