Histological revision of structures involved in the production of venomous secretions in Lonomia casanarensis (Lepidoptera: Saturniidae)

Lepidopteran insects of the genus Lonomia possess urticating spines as a defense mechanism during their larval stages. These spines, called scoli, contain toxins that can be harmful to humans because they can cause hemostatic disorders when injected into the bloodstream. Envenomation by Lonomia has...

Full description

Autores:
García Piñeros, Javier Andrés
Tipo de recurso:
Trabajo de grado de pregrado
Fecha de publicación:
2025
Institución:
Universidad de los Andes
Repositorio:
Séneca: repositorio Uniandes
Idioma:
eng
OAI Identifier:
oai:repositorio.uniandes.edu.co:1992/75824
Acceso en línea:
https://hdl.handle.net/1992/75824
Palabra clave:
Lonomia venomous caterpillars
Scoli histology
insect venom glands
Biología
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openAccess
License
Attribution 4.0 International
id UNIANDES2_f3bdbbcf03fe1ddf13ba566b96ac0550
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network_acronym_str UNIANDES2
network_name_str Séneca: repositorio Uniandes
repository_id_str
dc.title.eng.fl_str_mv Histological revision of structures involved in the production of venomous secretions in Lonomia casanarensis (Lepidoptera: Saturniidae)
title Histological revision of structures involved in the production of venomous secretions in Lonomia casanarensis (Lepidoptera: Saturniidae)
spellingShingle Histological revision of structures involved in the production of venomous secretions in Lonomia casanarensis (Lepidoptera: Saturniidae)
Lonomia venomous caterpillars
Scoli histology
insect venom glands
Biología
title_short Histological revision of structures involved in the production of venomous secretions in Lonomia casanarensis (Lepidoptera: Saturniidae)
title_full Histological revision of structures involved in the production of venomous secretions in Lonomia casanarensis (Lepidoptera: Saturniidae)
title_fullStr Histological revision of structures involved in the production of venomous secretions in Lonomia casanarensis (Lepidoptera: Saturniidae)
title_full_unstemmed Histological revision of structures involved in the production of venomous secretions in Lonomia casanarensis (Lepidoptera: Saturniidae)
title_sort Histological revision of structures involved in the production of venomous secretions in Lonomia casanarensis (Lepidoptera: Saturniidae)
dc.creator.fl_str_mv García Piñeros, Javier Andrés
dc.contributor.advisor.none.fl_str_mv González Rosas, Camila
Toro Vargas, Diana Marcela
dc.contributor.author.none.fl_str_mv García Piñeros, Javier Andrés
dc.contributor.researchgroup.none.fl_str_mv Facultad de Ciencias::Cimpat. Centro de Investigaciones en Microbiología y Parasitologia Tropical
dc.subject.keyword.eng.fl_str_mv Lonomia venomous caterpillars
Scoli histology
insect venom glands
topic Lonomia venomous caterpillars
Scoli histology
insect venom glands
Biología
dc.subject.themes.spa.fl_str_mv Biología
description Lepidopteran insects of the genus Lonomia possess urticating spines as a defense mechanism during their larval stages. These spines, called scoli, contain toxins that can be harmful to humans because they can cause hemostatic disorders when injected into the bloodstream. Envenomation by Lonomia has been a matter of public concern in countries where contact with these caterpillars poses a risk to the rural population, and while antivenoms exist, they are not readily available in rural areas. By identifying the structures that produce the venom, it may be possible to identify the structure that expresses the genes encoding the toxins and to develop a higher purity venom extract for antivenom production. The structures associated with the production of venom in the caterpillar have so far been described for one species of the genus: Lonomia obliqua. In the present work, histological techniques with epoxy resin were used to identify the structures associated with venom synthesis in the Colombian species Lonomia casanarensis. While the tissular morphology of Lonomia casanarensis was found to be very similar to that previously documented in Lonomia obliqua, a novel structure was found in the apical portion of the scoli; this gland-like structure may be associated with the production of the proteins present in the insect's venom and proposes a new perspective on the structures in which Lonomia produces it's venom.
publishDate 2025
dc.date.accessioned.none.fl_str_mv 2025-01-30T14:08:31Z
dc.date.available.none.fl_str_mv 2025-01-30T14:08:31Z
dc.date.issued.none.fl_str_mv 2025-01-29
dc.type.none.fl_str_mv Trabajo de grado - Pregrado
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dc.relation.references.none.fl_str_mv González, C., Ballesteros-Mejia, L., Díaz-Díaz, J., Toro-Vargas, D. M., Amarillo-Suarez, A. R., Gey, D., León, C., Tovar, E., Arias, M., Rivera, N., Buitrago, L. S., Pinto-Moraes, R. H., Sano Martins, I. S., Decaëns, T., González, M. A., Kitching, I. J., & Rougerie, R. (2023). Deadly and venomous Lonomia caterpillars are more than the two usual suspects. PLoS Neglected Tropical Diseases, 17(2), e0011063–e0011063. https://doi.org/10.1371/journal.pntd.0011063
Pinto, A. F., Berger, M., Reck Jr, J., Terra, R. M., & Guimarães, J. A. (2010). Lonomia obliqua venom: In vivo effects and molecular aspects associated with the hemorrhagic syndrome. Toxicon, 56(7), 1103-1112.
Arocha-Piñango, C. L., & Guerrero, B. (2002). Lonomia genus caterpillar envenomation: clinical and biological aspects. Pathophysiology of Haemostasis and Thrombosis, 31(3-6), 288-293.
Pineda, D., Amarillo, A., Becerra, J., & Montenegro, G. (2001). Síndrome hemorrágico por contacto con orugas del género Lonomia (Saturniidae) en Casanare, Colombia: informe de dos casos. Biomédica, 21(4), 328-332.
Lozano Morales, L. V. (2022). Proteomics and immunoproteomics of Lonomia casanarensis and Lonomia orientoandensis venoms. Universidad de los Andes.
Ricci-Silva, M. E., Valente, R. H., León, I. R., Tambourgi, D. V., Ramos, O. H. P., Perales, J., & Chudzinski-Tavassi, A. M. (2008). Immunochemical and proteomic technologies as tools for unravelling toxins involved in envenoming by accidental contact with Lonomia obliqua caterpillars. Toxicon (Oxford), 51(6), 1017–1028. https://doi.org/10.1016/j.toxicon.2008.01.013
Veiga, A. B. G., Ribeiro, J. M. C., Guimarães, J. A., & Francischetti, I. M. B. (2005). A catalog for the transcripts from the venomous structures of the caterpillar Lonomia obliqua: Identification of the proteins potentially involved in the coagulation disorder and hemorrhagic syndrome. Gene, 355, 11–27. https://doi.org/10.1016/j.gene.2005.05.002
Veiga, A. B. G., Blochtein, B., & Guimarães, J. A. (2001). Structures involved in production, secretion and injection of the venom produced by the caterpillar Lonomia obliqua (Lepidoptera, Saturniidae). Toxicon, 39(9), 1343-1351.
Spadacci-Morena, D. D., Soares, M. A. M., Moraes, R. H. P., Sano-Martins, I. S., & Sciani, J. M. (2016). The urticating apparatus in the caterpillar of Lonomia obliqua (Lepidoptera: Saturniidae). Toxicon, 119, 218-224.
Taylor, P., Salazar, E., Barrios, M., Salazar, A. M., Abad, M.-J., Urdanibia, I., Shealy, D., Arocha-Piñango, C. L., & Guerrero, B. (2016). Role of the inflammatory response in the hemorrhagic syndrome induced by the hemolymph of the caterpillar Lonomia achelous. Toxicon (Oxford), 121, 77–85. https://doi.org/10.1016/j.toxicon.2016.08.018
Mackessy, S. P. (2022). Venom production and secretion in reptiles. Journal of Experimental Biology, 225(7), jeb227348.
Schendel, V., Rash, L. D., Jenner, R. A., & Undheim, E. A. (2019). The diversity of venom: the importance of behavior and venom system morphology in understanding its ecology and evolution. Toxins, 11(11), 666.
Schwartz, E. F., Diego-Garcia, E., Rodríguez de la Vega, R. C., & Possani, L. D. (2007). Transcriptome analysis of the venom gland of the Mexican scorpion Hadrurus gertschi (Arachnida: Scorpiones). BMC genomics, 8, 1-12.
YAMAGUSHI, I. K. (1996). Development of an antivenom against toxins of Lonomia obliqua caterpillars. Toxicon, 34(9), 1045-1049.
Sarmiento, N. S., Arsanios, D. M., Muñoz, E. Q., & Sarmiento, C. S. (2018). Lonomic accident and allergic reaction to anti-lonomic serum: case report and literature review. International Journal of Current Research in Life Sciences, 7(05), 2052-2056.
Toro-Vargas, D. M., González, C., Rougerie, R., & Amarillo-Suárez, A. R. (2023). Characterization of morphological and biological aspects of venomous caterpillars of the genus Lonomia Walker (Lepidoptera: Saturniidae) in Colombia. Plos one, 18(5), e0285010.
Roat, T. C., Nocelli, R. C. F., & da Cruz Landim, C. (2006). The venom gland of queens of Apis mellifera (Hymenoptera, Apidae): morphology and secretory cycle. Micron (Oxford, England : 1993), 37(8), 717–723. https://doi.org/10.1016/j.micron.2006.03.00
Silva, L. M., Carvalho Botelho, A. C., Nacif-Pimenta, R., Martins, G. F., Alves, L. C., Brayner, F. A., Fortes-Dias, C. L., & Paolucci Pimenta, P. F. (2008). Structural analysis of the venom glands of the armed spider Phoneutria nigriventer (Keyserling, 1891): Microanatomy, fine structure and confocal observations. Toxicon (Oxford), 51(4), 693–706. https://doi.org/10.1016/j.toxicon.2007.12.009
Villas-Boas, I. M., Bonfá, G., & Tambourgi, D. V. (2018). Venomous caterpillars: From inoculation apparatus to venom composition and envenomation. Toxicon (Oxford), 153, 39–52. https://doi.org/10.1016/j.toxicon.2018.08.007
Matsuda, H., Yamada, T., Yoshida, M., & Nishimura, T. (2015). Flies without trehalose. The Journal of biological chemistry, 290(2), 1244–1255. https://doi.org/10.1074/jbc.M114.619411
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spelling González Rosas, Camilavirtual::22830-1Toro Vargas, Diana MarcelaGarcía Piñeros, Javier AndrésFacultad de Ciencias::Cimpat. Centro de Investigaciones en Microbiología y Parasitologia Tropical2025-01-30T14:08:31Z2025-01-30T14:08:31Z2025-01-29https://hdl.handle.net/1992/75824instname:Universidad de los Andesreponame:Repositorio Institucional Sénecarepourl:https://repositorio.uniandes.edu.co/Lepidopteran insects of the genus Lonomia possess urticating spines as a defense mechanism during their larval stages. These spines, called scoli, contain toxins that can be harmful to humans because they can cause hemostatic disorders when injected into the bloodstream. Envenomation by Lonomia has been a matter of public concern in countries where contact with these caterpillars poses a risk to the rural population, and while antivenoms exist, they are not readily available in rural areas. By identifying the structures that produce the venom, it may be possible to identify the structure that expresses the genes encoding the toxins and to develop a higher purity venom extract for antivenom production. The structures associated with the production of venom in the caterpillar have so far been described for one species of the genus: Lonomia obliqua. In the present work, histological techniques with epoxy resin were used to identify the structures associated with venom synthesis in the Colombian species Lonomia casanarensis. While the tissular morphology of Lonomia casanarensis was found to be very similar to that previously documented in Lonomia obliqua, a novel structure was found in the apical portion of the scoli; this gland-like structure may be associated with the production of the proteins present in the insect's venom and proposes a new perspective on the structures in which Lonomia produces it's venom.Pregrado10 páginasapplication/pdfengUniversidad de los AndesBiologíaFacultad de CienciasDepartamento de Ciencias BiológicasAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Histological revision of structures involved in the production of venomous secretions in Lonomia casanarensis (Lepidoptera: Saturniidae)Trabajo de grado - Pregradoinfo:eu-repo/semantics/bachelorThesisinfo:eu-repo/semantics/acceptedVersionhttp://purl.org/coar/resource_type/c_7a1fTexthttp://purl.org/redcol/resource_type/TPLonomia venomous caterpillarsScoli histologyinsect venom glandsBiologíaGonzález, C., Ballesteros-Mejia, L., Díaz-Díaz, J., Toro-Vargas, D. M., Amarillo-Suarez, A. R., Gey, D., León, C., Tovar, E., Arias, M., Rivera, N., Buitrago, L. S., Pinto-Moraes, R. H., Sano Martins, I. S., Decaëns, T., González, M. A., Kitching, I. J., & Rougerie, R. (2023). Deadly and venomous Lonomia caterpillars are more than the two usual suspects. PLoS Neglected Tropical Diseases, 17(2), e0011063–e0011063. https://doi.org/10.1371/journal.pntd.0011063Pinto, A. F., Berger, M., Reck Jr, J., Terra, R. M., & Guimarães, J. A. (2010). Lonomia obliqua venom: In vivo effects and molecular aspects associated with the hemorrhagic syndrome. Toxicon, 56(7), 1103-1112.Arocha-Piñango, C. L., & Guerrero, B. (2002). Lonomia genus caterpillar envenomation: clinical and biological aspects. Pathophysiology of Haemostasis and Thrombosis, 31(3-6), 288-293.Pineda, D., Amarillo, A., Becerra, J., & Montenegro, G. (2001). Síndrome hemorrágico por contacto con orugas del género Lonomia (Saturniidae) en Casanare, Colombia: informe de dos casos. Biomédica, 21(4), 328-332.Lozano Morales, L. V. (2022). Proteomics and immunoproteomics of Lonomia casanarensis and Lonomia orientoandensis venoms. Universidad de los Andes.Ricci-Silva, M. E., Valente, R. H., León, I. R., Tambourgi, D. V., Ramos, O. H. P., Perales, J., & Chudzinski-Tavassi, A. M. (2008). Immunochemical and proteomic technologies as tools for unravelling toxins involved in envenoming by accidental contact with Lonomia obliqua caterpillars. Toxicon (Oxford), 51(6), 1017–1028. https://doi.org/10.1016/j.toxicon.2008.01.013Veiga, A. B. G., Ribeiro, J. M. C., Guimarães, J. A., & Francischetti, I. M. B. (2005). A catalog for the transcripts from the venomous structures of the caterpillar Lonomia obliqua: Identification of the proteins potentially involved in the coagulation disorder and hemorrhagic syndrome. Gene, 355, 11–27. https://doi.org/10.1016/j.gene.2005.05.002Veiga, A. B. G., Blochtein, B., & Guimarães, J. A. (2001). Structures involved in production, secretion and injection of the venom produced by the caterpillar Lonomia obliqua (Lepidoptera, Saturniidae). Toxicon, 39(9), 1343-1351.Spadacci-Morena, D. D., Soares, M. A. M., Moraes, R. H. P., Sano-Martins, I. S., & Sciani, J. M. (2016). The urticating apparatus in the caterpillar of Lonomia obliqua (Lepidoptera: Saturniidae). Toxicon, 119, 218-224.Taylor, P., Salazar, E., Barrios, M., Salazar, A. M., Abad, M.-J., Urdanibia, I., Shealy, D., Arocha-Piñango, C. L., & Guerrero, B. (2016). Role of the inflammatory response in the hemorrhagic syndrome induced by the hemolymph of the caterpillar Lonomia achelous. Toxicon (Oxford), 121, 77–85. https://doi.org/10.1016/j.toxicon.2016.08.018Mackessy, S. P. (2022). Venom production and secretion in reptiles. Journal of Experimental Biology, 225(7), jeb227348.Schendel, V., Rash, L. D., Jenner, R. A., & Undheim, E. A. (2019). The diversity of venom: the importance of behavior and venom system morphology in understanding its ecology and evolution. Toxins, 11(11), 666.Schwartz, E. F., Diego-Garcia, E., Rodríguez de la Vega, R. C., & Possani, L. D. (2007). Transcriptome analysis of the venom gland of the Mexican scorpion Hadrurus gertschi (Arachnida: Scorpiones). BMC genomics, 8, 1-12.YAMAGUSHI, I. K. (1996). Development of an antivenom against toxins of Lonomia obliqua caterpillars. Toxicon, 34(9), 1045-1049.Sarmiento, N. S., Arsanios, D. M., Muñoz, E. Q., & Sarmiento, C. S. (2018). Lonomic accident and allergic reaction to anti-lonomic serum: case report and literature review. International Journal of Current Research in Life Sciences, 7(05), 2052-2056.Toro-Vargas, D. M., González, C., Rougerie, R., & Amarillo-Suárez, A. R. (2023). Characterization of morphological and biological aspects of venomous caterpillars of the genus Lonomia Walker (Lepidoptera: Saturniidae) in Colombia. Plos one, 18(5), e0285010.Roat, T. C., Nocelli, R. C. F., & da Cruz Landim, C. (2006). The venom gland of queens of Apis mellifera (Hymenoptera, Apidae): morphology and secretory cycle. Micron (Oxford, England : 1993), 37(8), 717–723. https://doi.org/10.1016/j.micron.2006.03.00Silva, L. M., Carvalho Botelho, A. C., Nacif-Pimenta, R., Martins, G. F., Alves, L. C., Brayner, F. A., Fortes-Dias, C. L., & Paolucci Pimenta, P. F. (2008). Structural analysis of the venom glands of the armed spider Phoneutria nigriventer (Keyserling, 1891): Microanatomy, fine structure and confocal observations. Toxicon (Oxford), 51(4), 693–706. https://doi.org/10.1016/j.toxicon.2007.12.009Villas-Boas, I. M., Bonfá, G., & Tambourgi, D. V. (2018). Venomous caterpillars: From inoculation apparatus to venom composition and envenomation. Toxicon (Oxford), 153, 39–52. https://doi.org/10.1016/j.toxicon.2018.08.007Matsuda, H., Yamada, T., Yoshida, M., & Nishimura, T. (2015). Flies without trehalose. 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