Noap: Un servicio innovador para el tratamiento de la Apnea Obstructiva del Sueño
La Apnea Obstructiva del Sueño (AOS) es una condición que afecta de forma significativa la calidad de vida de las personas y su entorno. Aunque su tratamiento gold standard, el CPAP (Continuous Positive Air Pressure) es muy efectivo, presenta un bajo índice de adherencia, lo que impide alcanzar un e...
- Autores:
-
Hosie Echeverri, Olivia
Ceballos Sarmiento, Hannah Vanessa
Castro Barrera, Paula Andrea
Vera Rincón, Javier Santiago
- Tipo de recurso:
- Trabajo de grado de pregrado
- Fecha de publicación:
- 2024
- Institución:
- Universidad de los Andes
- Repositorio:
- Séneca: repositorio Uniandes
- Idioma:
- spa
- OAI Identifier:
- oai:repositorio.uniandes.edu.co:1992/75357
- Acceso en línea:
- https://hdl.handle.net/1992/75357
- Palabra clave:
- Apnea Obstructiva del Sueño
Adherencia al tratamiento
Noap
Ingeniería
- Rights
- openAccess
- License
- Attribution 4.0 International
id |
UNIANDES2_df918fdf4bf141b052cfcc0437f316b6 |
---|---|
oai_identifier_str |
oai:repositorio.uniandes.edu.co:1992/75357 |
network_acronym_str |
UNIANDES2 |
network_name_str |
Séneca: repositorio Uniandes |
repository_id_str |
|
dc.title.none.fl_str_mv |
Noap: Un servicio innovador para el tratamiento de la Apnea Obstructiva del Sueño |
title |
Noap: Un servicio innovador para el tratamiento de la Apnea Obstructiva del Sueño |
spellingShingle |
Noap: Un servicio innovador para el tratamiento de la Apnea Obstructiva del Sueño Apnea Obstructiva del Sueño Adherencia al tratamiento Noap Ingeniería |
title_short |
Noap: Un servicio innovador para el tratamiento de la Apnea Obstructiva del Sueño |
title_full |
Noap: Un servicio innovador para el tratamiento de la Apnea Obstructiva del Sueño |
title_fullStr |
Noap: Un servicio innovador para el tratamiento de la Apnea Obstructiva del Sueño |
title_full_unstemmed |
Noap: Un servicio innovador para el tratamiento de la Apnea Obstructiva del Sueño |
title_sort |
Noap: Un servicio innovador para el tratamiento de la Apnea Obstructiva del Sueño |
dc.creator.fl_str_mv |
Hosie Echeverri, Olivia Ceballos Sarmiento, Hannah Vanessa Castro Barrera, Paula Andrea Vera Rincón, Javier Santiago |
dc.contributor.advisor.none.fl_str_mv |
Bigio Roitman, David |
dc.contributor.author.none.fl_str_mv |
Hosie Echeverri, Olivia Ceballos Sarmiento, Hannah Vanessa Castro Barrera, Paula Andrea Vera Rincón, Javier Santiago |
dc.contributor.jury.none.fl_str_mv |
Henríquez Martínez, Angie |
dc.subject.keyword.spa.fl_str_mv |
Apnea Obstructiva del Sueño Adherencia al tratamiento |
topic |
Apnea Obstructiva del Sueño Adherencia al tratamiento Noap Ingeniería |
dc.subject.keyword.none.fl_str_mv |
Noap |
dc.subject.themes.spa.fl_str_mv |
Ingeniería |
description |
La Apnea Obstructiva del Sueño (AOS) es una condición que afecta de forma significativa la calidad de vida de las personas y su entorno. Aunque su tratamiento gold standard, el CPAP (Continuous Positive Air Pressure) es muy efectivo, presenta un bajo índice de adherencia, lo que impide alcanzar un efecto terapéutico. El dispositivo en desuso representa un desperdicio de recursos y la prevalencia de síntomas y comorbilidades resulta en mayores costos para el sistema de salud. Así, es necesario encontrar una forma de aumentar la adherencia al tratamiento de los pacientes con AOS para evitar el gasto de recursos en pacientes no adherentes y enfocar la adopción del tratamiento en pacientes con baja y alta adherencia. Para esto, se propone un servicio que utiliza la personalización y el acompañamiento como fortalezas clave para facilitar la adopción a la terapia. Incluye noap especialista, una aplicación web diseñada para predecir la adherencia al tratamiento; noap dispositivo, un CPAP interactivo y de alta responsividad que se adapta a las necesidades del paciente; y noap paciente, una aplicación web enfocada en el seguimiento y acompañamiento durante todo el tratamiento. El servicio será implementado mediante suscripciones anuales ofrecidas a EPS e IPS en Colombia, integrando el dispositivo y las aplicaciones. En principio, se propone un método de venta directa para lograr acuerdos robustos con las entidades. Este modelo satisface las necesidades del paciente y reduce costos al sistema de salud mediante un enfoque terapéutico eficiente y un servicio adaptado al contexto del usuario. |
publishDate |
2024 |
dc.date.issued.none.fl_str_mv |
2024-12-12 |
dc.date.accessioned.none.fl_str_mv |
2025-01-13T14:52:26Z |
dc.date.available.none.fl_str_mv |
2025-01-13T14:52:26Z |
dc.type.none.fl_str_mv |
Trabajo de grado - Pregrado |
dc.type.driver.none.fl_str_mv |
info:eu-repo/semantics/bachelorThesis |
dc.type.version.none.fl_str_mv |
info:eu-repo/semantics/acceptedVersion |
dc.type.coar.none.fl_str_mv |
http://purl.org/coar/resource_type/c_7a1f |
dc.type.content.none.fl_str_mv |
Text |
dc.type.redcol.none.fl_str_mv |
http://purl.org/redcol/resource_type/TP |
format |
http://purl.org/coar/resource_type/c_7a1f |
status_str |
acceptedVersion |
dc.identifier.uri.none.fl_str_mv |
https://hdl.handle.net/1992/75357 |
dc.identifier.instname.none.fl_str_mv |
instname:Universidad de los Andes |
dc.identifier.reponame.none.fl_str_mv |
reponame:Repositorio Institucional Séneca |
dc.identifier.repourl.none.fl_str_mv |
repourl:https://repositorio.uniandes.edu.co/ |
url |
https://hdl.handle.net/1992/75357 |
identifier_str_mv |
instname:Universidad de los Andes reponame:Repositorio Institucional Séneca repourl:https://repositorio.uniandes.edu.co/ |
dc.language.iso.none.fl_str_mv |
spa |
language |
spa |
dc.relation.references.none.fl_str_mv |
J. M. Slowik, A. Sankari, and J. Collen, “Obstructive Sleep Apnea,” PubMed, 2022. https://www.ncbi.nlm.nih.gov/books/NBK459252/. “Entrevista #3,” Proyecto de Diseño, 2024, archivo: Encuentro_Cirugía_Maxilofacial.pptx A. V. Benjafield et al., “Estimation of the global prevalence and burden of obstructive sleep apnea: a literature-based analysis,” The Lancet Respiratory Medicine, vol. 7, no. 8. Elsevier BV, pp. 687–698, Aug. 2019. doi: 10.1016/s2213-2600(19)30198-5. L. Kline, “Clinical presentation and diagnosis of obstructive sleep apnea in adults,” UpToDate, 2024, [Online]. Available: https://www.uptodate.com/contents/clinical-presentation-and-diagnosis-of-obstructive-sleep-apnea-in-adults?search=obstructive sleep apnea&source=search_result&selectedTitle=1~150&usage_type=default&display_rank=1. P. Lévy et al., “Obstructive sleep apnoea syndrome,” Nature Reviews Disease Primers, vol. 1, no. 1. Springer Science and Business Media LLC, Jun. 25, 2015. doi: 10.1038/nrdp.2015.15. A. V. Benjafield et al., “Estimation of the global prevalence and burden of obstructive sleep apnea: a literature-based analysis,” The Lancet Respiratory Medicine, vol. 7, no. 8. Elsevier BV, pp. 687–698, Aug. 2019. doi: 10.1016/s2213-2600(19)30198-5. A. Malhotra, “Obstructive sleep apnea: Overview of management in adults,” UpToDate, 2024, [Online]. Available: https://www.uptodate.com/contents/obstructive-sleep-apnea-overview-of-management-in-adults?search=obstructive sleep apnea&source=search_result&selectedTitle=2~150&usage_type=default&display_rank=2#H10. M. R. Cowie and A. M. Gallagher, “Sleep Disordered Breathing and Heart Failure,” JACC: Heart Failure, vol. 5, no. 10. Elsevier BV, pp. 715–723, Oct. 2017. doi: 10.1016/j.jchf.2017.06.016. S. P. Patil, I. A. Ayappa, S. M. Caples, R. J. Kimoff, S. R. Patel, y C. G. Harrod, “Treatment of adult obstructive sleep apnea with positive airway pressure: An American academy of sleep medicine systematic review, meta-analysis, and GRADE assessment”, J. Clin. Sleep Med., vol. 15, núm. 02, pp. 301–334, 2019. P. Lévy et al., “Obstructive sleep apnoea syndrome,” Nature Reviews Disease Primers, vol. 1, no. 1. Springer Science and Business Media LLC, Jun. 25, 2015. doi: 10.1038/nrdp.2015.15. Y. Peker, H. Glantz, C. Eulenburg, K. Wegscheider, J. Herlitz, and E. Thunström, “Effect of positive airway pressure on cardiovascular outcomes in coronary artery disease patients with nonsleepy obstructive sleep apnea: The RICCADSA randomized controlled trial,” Am. J. Respir. Crit. Care Med., vol. 194, no. 5, 2016, doi: 10.1164/rccm.201601-0088OC. A. Malhotra, J. E. Orr, and R. L. Owens, “On the cutting edge of obstructive sleep apnoea: where next?,” The Lancet Respiratory Medicine, vol. 3, no. 5. Elsevier BV, pp. 397–403, May 2015. doi: 10.1016/s2213-2600(15)00051-x. E. Martinez-Ceron et al., “Effect of continuous positive airway pressure on glycemic control in patients with obstructive sleep apnea and type 2 diabetes a randomized clinical trial,” Am. J. Respir. Crit. Care Med., vol. 194, no. 4, 2016, doi: 10.1164/rccm.201510-1942OC. A. Malhotra, “Obstructive sleep apnea: Overview of management in adults,” UpToDate, 2024, [Online]. Available: https://www.uptodate.com/contents/obstructive-sleep-apnea-overview-of-management-in-adults?search=obstructive sleep apnea&source=search_result&selectedTitle=2~150&usage_type=default&display_rank=2#H10. O. Contal et al., “One-Year Adherence to Continuous Positive Airway Pressure With Telemonitoring in Sleep Apnea Hypopnea Syndrome: A Randomized Controlled Trial ,” Frontiers in Medicine , vol. 8. 2021, [Online]. Available: https://www.frontiersin.org/articles/10.3389/fmed.2021.626361. A. S. Jordan, D. G. McSharry, and A. Malhotra, “Adult obstructive sleep apnoea,” The Lancet, vol. 383, no. 9918. 2014, doi: 10.1016/S0140-6736(13)60734-5. “Encuesta #1” Proyecto de Diseño, 2024, archivo: Encuesta_APNEAS.pdf S. P. Patil, I. A. Ayappa, S. M. Caples, R. J. Kimoff, S. R. Patel, y C. G. Harrod, “Treatment of adult obstructive sleep apnea with positive airway pressure: An American academy of sleep medicine systematic review, meta-analysis, and GRADE assessment”, J. Clin. Sleep Med., vol. 15, núm. 02, pp. 301–334, 2019. J. L. Chang et al., “International Consensus Statement on Obstructive Sleep Apnea.,” Int. Forum Allergy Rhinol., vol. 13, no. 7, pp. 1061–1482, Jul. 2023, doi: 10.1002/alr.23079. Y. Kim, Y. S. Koo, H. Y. Lee, and S. Y. Lee, “Can Continuous positive airway pressure reduce the risk of stroke in obstructive sleep apnea patients? A systematic review and meta-Analysis,” PLoS One, vol. 11, no. 1, 2016, doi: 10.1371/journal.pone.0146317. D. Zhu et al., “Heated humidification did not improve compliance of positive airway pressure and subjective daytime sleepiness in obstructive sleep apnea syndrome: A meta-analysis,” PLoS One, vol. 13, no. 12, 2018, doi: 10.1371/journal.pone.0207994. Y. Peker, H. Glantz, C. Eulenburg, K. Wegscheider, J. Herlitz, and E. Thunström, “Effect of positive airway pressure on cardiovascular outcomes in coronary artery disease patients with nonsleepy obstructive sleep apnea: The RICCADSA randomized controlled trial,” Am. J. Respir. Crit. Care Med., vol. 194, no. 5, 2016, doi: 10.1164/rccm.201601-0088OC. “Entrevista #5,” Proyecto de Diseño, 2024, archivo: DraJaramillo.pptx L. S. Doherty, J. L. Kiely, V. Swan, and W. T. McNicholas, “Long-term effects of nasal continuous positive airway pressure therapy on cardiovascular outcomes in sleep apnea syndrome,” Chest, vol. 127, no. 6, 2005, doi: 10.1378/chest.127.6.2076. A. Tarasiuk, G. Reznor, S. Greenberg-Dotan, and H. Reuveni, “Financial Incentive Increases CPAP Acceptance in Patients from Low Socioeconomic Background,” PLoS ONE, vol. 7, no. 3. Public Library of Science (PLoS), p. e33178, Mar. 30, 2012. doi: 10.1371/journal.pone.0033178. E. Martinez-Ceron et al., “Effect of continuous positive airway pressure on glycemic control in patients with obstructive sleep apnea and type 2 diabetes a randomized clinical trial,” Am. J. Respir. Crit. Care Med., vol. 194, no. 4, 2016, doi: 10.1164/rccm.201510-1942OC. “Asistencia a la Jornada Neumológica en la Ciudad de Barranquilla el 15 de marzo de 2024” Proyecto de Diseño, 2024, archivo: Jornada_Neumologica.pptx. C. Navarro-Soriano et al., “TheHIPARCO-2 study: Long-term effect of continuous positive airway pressure on blood pressure in patients with resistant hypertension: Amulticenter prospective study,” J. Hypertens., vol. 39, no. 2, 2021, doi: 10.1097/HJH.0000000000002664. N. F. Watson, “Health care savings: The economic value of diagnostic and therapeutic care for obstructive sleep apnea,” Journal of Clinical Sleep Medicine, vol. 12, no. 8. 2016, doi: 10.5664/jcsm.6034. O. Contal et al., “One-Year Adherence to Continuous Positive Airway Pressure With Telemonitoring in Sleep Apnea Hypopnea Syndrome: A Randomized Controlled Trial ,” Frontiers in Medicine , vol. 8. 2021, [Online]. Available: https://www.frontiersin.org/articles/10.3389/fmed.2021.626361. E. M. Wickwire et al., “The Impact of Treatments for OSA on Monetized Health Economic Outcomes: A Systematic Review,” Chest, vol. 155, no. 5, 2019, doi: 10.1016/j.chest.2019.01.009. B. W. Rotenberg, D. Murariu, and K. P. Pang, “Trends in CPAP adherence over twenty years of data collection: A flattened curve,” J. Otolaryngol. - Head Neck Surg., vol. 45, no. 1, p. 43, Jan. 2016, doi: 10.1186/s40463-016-0156-0. H. O. Savage et al., “Development and validation of a novel non-contact monitor of nocturnal respiration for identifying sleep-disordered breathing in patients with heart failure,” ESC Hear. Fail., vol. 3, no. 3, 2016, doi: 10.1002/ehf2.12086. “Encuesta #1” Proyecto de Diseño, 2024, archivo: Encuesta_APNEAS.pdf “Entrevista #1,” Proyecto de Diseño, 2024, archivo: Susana_Montes.pptx G. Rapelli et al., “Improving CPAP adherence in adults with obstructive sleep apnea syndrome: A scoping review of motivational interventions,” Front. Psychol., vol. 14, 2023, [Online]. Available: Frontiers | Improving CPAP Adherence in Adults With Obstructive Sleep Apnea Syndrome: A Scoping Review of Motivational Interventions (frontiersin.org) A. M. May and J. E. Dalton, “Comparison of machine learning approaches for positive airway pressure adherence prediction in a veteran cohort,” Front. Sleep, vol. 3, 2024, doi: 10.3389/frsle.2024.1278086. J. L. Chang et al., “International Consensus Statement on Obstructive Sleep Apnea.,” Int. Forum Allergy Rhinol., vol. 13, no. 7, pp. 1061–1482, Jul. 2023, doi: 10.1002/alr.23079. K. Eguchi et al., “Investigation on factors related to poor CPAP adherence using machine learning: a pilot study,” Sci. Rep., vol. 12, no. 1, 2022, doi: 10.1038/s41598-022-21932-8. G. Scioscia et al., “Machine learning-based prediction of adherence to continuous positive airway pressure (CPAP) in obstructive sleep apnea (OSA),” Informatics Heal. Soc. Care, vol. 47, no. 3, 2022, doi: 10.1080/17538157.2021.1990300. E. L. Maschauer, D. M. Fairley, and R. L. Riha, “Does personality play a role in continuous positive airway pressure compliance?,” Breathe, vol. 13, no. 1. European Respiratory Society (ERS), pp. 32–43, Mar. 2017. doi: 10.1183/20734735.014916. J. Hua, H. Zhu, C. V. Orate-Pott, D. Shellenberger, D. Narayanaswamy, y N. A. Shetty, “Method and system for predicting adherence to a treatment”, 11804306, 31-oct-2023 N. Liu, S. De Souz, y O. Gromenko, “Prediction of respiratory therapy compliance”, 11508484B1, 22-nov-2022. D. F. Smith, C. P. Spiceland, L. C. Pringle, K. L. Mattare, J. R. Benke, and S. L. Ishman, “Financial incentive of home continuous positive airway pressure machine use in the inpatient hospital setting,” The Laryngoscope, vol. 124, no. 9. Wiley, pp. 2200–2204, May 30, 2014. doi: 10.1002/lary.24604. Y. Engelhard, M. Maalouf, y M. Chiu, “Devices, systems, and methods for adherence monitoring and patient interaction”, 11938265, 26-mar-2024. “Almohada Contour CPAP 2.0”. Oxigo. [En línea]. Disponible: https://www.oxigo.co/es/contour-almohada-cpap.html “ALMOHADA PARA APNEA DEL SUEÑO DEEPREST”, Oximedica. [En línea]. Disponible: https://oximedica.com/product/almohada-para-apnea-del-sueno-deeprest/ “MENTONERA SENCILLA DEEPREST”, Oximedica. [En línea]. Disponible: https://oximedica.com/product/mentonera-sencilla/ “Cojín Posicionador Contra La Apnea ZZOMA”. Apoyo Científico y Tecnológico para el Deporte, Biolaster. [En línea]. Disponible: https://www.biolaster.com/productos/cojin-posicionador-contra-la-apnea-zzoma/ “About Us”, VVFLY Electronics Co. [En línea]. Disponible: https://www.vvfly.cn/en/about.html マシュー・ロルフ・ハリントン, “Heat and moisture exchanger for patient interface”, JP:6891258:B2, 18-jun-2021. P. R. Kwok, R. Richard, K. Selvarajan, G. Richards, N. J. Reed, y L. Puckeridge, “Methods and apparatus for controlling mask leak in CPAP treatment”, 10342941, 09-jul-2019. A. Biener, C. Bayer, F. Komorowski, y B. C. Lang, “Patient interface”, 20170049984:A1, 23-feb-2017. T. T.-F. Fu y S. De Souza, “Auto-fit mask”, 20240082519:A1, 14-mar-2024. “Entrevista #2,” Proyecto de Diseño, 2024, archivo: JuanCarlos_Castro.pptx S. B. Lamberg, “Intraoral mandibular advancement device for treatment of sleep disorders”, 7730891, 08-jun-2010. L. Baratier y Y. Palomino, “Mandibular repositioning device”, 11576809, 14-feb-2023. M. R. Harrison y D. A. Kwiat, “Device and method for correcting obstructive sleep apnea”, 11779487, 10-oct-2023. J. E. Kovarik, “Method of treating snoring and obstructive sleep apnea”, 9445936, 20-sep-2016. “Resmed”, Resmed. [En línea]. Disponible: https://www.resmed.lat/ “AUTOCPAP”, Neumotec. [En línea]. Disponible: https://www.neumotec.com/categoria/autocpap/ “Simposio del Sueño Colsanitas,” Proyecto de Diseño, 2024, archivo: I_Simposio_de_Sueño.pptx C. Duhigg, The power of habits : why we do what we do in life and business. Hà Nội: Lao Động - Xã Hội, 2013. Stanford Byers Center For Biodesign, A Student Guide to BIODESIGN, Concepts of Screening and Selection. 2024. J. Tranquillo, J. Goldberg, y R. Allen, Biomedical engineering design. San Diego, CA, Estados Unidos de América: Academic Press, 2022. R. G. S. Andrade et al., “Nasal vs Oronasal CPAP for OSA Treatment: A Meta-Analysis,” Chest, vol. 153, no. 3, 2018, doi: 10.1016/j.chest.2017.10.044. S. Saraç, G. Ç. Afşar, Ö. Oruç, Ö. B. Topçuoğlu, C. Saltürk, and Y. Peker, “Impact of patient education on compliance with positive airway pressure treatment in obstructive sleep apnea,” Med. Sci. Monit., vol. 23, 2017, doi: 10.12659/MSM.902075. D. Zhu et al., “Heated humidification did not improve compliance of positive airway pressure and subjective daytime sleepiness in obstructive sleep apnea syndrome: A meta-analysis,” PLoS One, vol. 13, no. 12, 2018, doi: 10.1371/journal.pone.0207994. D. C. Dolan, R. Okonkwo, F. Gfullner, R. J. Hansbrough, R. J. Strobel, and L. Rosenthal, “Longitudinal comparison study of pressure relief (C-FlexTM) vs. CPAP in OSA patients,” Sleep Breath., vol. 13, no. 1, 2009, doi: 10.1007/s11325-008-0199-1. “Entrevista #10,” Proyecto de Diseño, 2024, archivo: DrLobelo.pptx D. L. Rose, Enchanted Objects: Design, Human Desire, and the Internet of Things. Scribner, 2014. J. A. A. De Dios and S. D. Brass, “New and unconventional treatments for obstructive sleep apnea.,” Neurotherapeutics, vol. 9, no. 4, pp. 702–709, Oct. 2012, doi: 10.1007/s13311-012-0146-5. C. E. Budin et al., “Therapeutic alternatives with CPAP in obstructive sleep apnea,” ValpoScholar, https://doi.org/10.22543/7674.62.P181189 (accessed Apr. 21, 2024). S. J. Kim et al., “Impact of number of medications and age on adherence to antihypertensive medications: A nationwide population-based study.,” Medicine (Baltimore)., vol. 98, no. 49, p. e17825, Dec. 2019, doi: 10.1097/MD.0000000000017825. B. Uchmanowicz, A. Chudiak, I. Uchmanowicz, J. Rosińczuk, and E. S. Froelicher, “Factors influencing adherence to treatment in older adults with hypertension,” Clin. Interv. Aging, vol. 13, 2018, doi: 10.2147/CIA.S182881. M. Sajatovic, F. C. Blow, H. C. Kales, M. Valenstein, D. Ganoczy, and R. V. Ignacio, “Age comparison of treatment adherence with antipsychotic medications among individuals with bipolar disorder,” Int. J. Geriatr. Psychiatry, vol. 22, no. 10, 2007, doi: 10.1002/gps.1777. S. R. Patel, J. P. Bakker, C. J. Stitt, M. S. Aloia, and S. M. Nouraie, “Age and Sex Disparities in Adherence to CPAP,” Chest, vol. 159, no. 1, pp. 382–389, 2021, doi: https://doi.org/10.1016/j.chest.2020.07.017. A. Prigent, C. Blanloeil, A.-L. Serandour, F. Barlet, F. Gagnadoux, and D. Jaffuel, “A biphasic effect of age on CPAP adherence: a cross-sectional study of 26,343 patients,” Respir. Res., vol. 24, no. 1, p. 234, 2023, doi: 10.1186/s12931-023-02543-x. A. Gabryelska, M. Sochal, B. Wasik, P. Szczepanowski, and P. Białasiewicz, “Factors Affecting Long-Term Compliance of CPAP Treatment—A Single Centre Experience,” J. Clin. Med., vol. 11, no. 1, 2022, doi: 10.3390/jcm11010139. J.-L. Pépin et al., “CPAP Therapy Termination Rates by OSA Phenotype: A French Nationwide Database Analysis,” J. Clin. Med., vol. 10, no. 5, 2021, doi: 10.3390/jcm10050936. E. S. Lau et al., “Sex, Permanent Drug Discontinuation, and Study Retention in Clinical Trials: Insights from the TIMI trials,” Circulation, vol. 143, no. 7, 2021, doi: 10.1161/CIRCULATIONAHA.120.052339. M. Manteuffel, S. Williams, W. Chen, R. R. Verbrugge, D. G. Pittman, and A. Steinkellner, “Influence of patient sex and gender on medication use, adherence, and prescribing alignment with guidelines.,” J. Womens. Health (Larchmt)., vol. 23, no. 2, pp. 112–119, Feb. 2014, doi: 10.1089/jwh.2012.3972. H. Woehrle, A. Graml, and G. Weinreich, “Age- and gender-dependent adherence with continuous positive airway pressure therapy,” Sleep Med., vol. 12, no. 10, pp. 1034–1036, 2011, doi: https://doi.org/10.1016/j.sleep.2011.05.008. A. M. Sawyer, N. S. Gooneratne, C. L. Marcus, D. Ofer, K. C. Richards, and T. E. Weaver, “A systematic review of CPAP adherence across age groups: Clinical and empiric insights for developing CPAP adherence interventions,” Sleep Med. Rev., vol. 15, no. 6, pp. 343–356, Dec. 2011, doi: 10.1016/J.SMRV.2011.01.003. M. Riachy, S. Najem, M. Iskandar, J. Choucair, I. Ibrahim, and G. Juvelikian, “Factors predicting CPAP adherence in obstructive sleep apnea syndrome,” Sleep and Breathing, vol. 21, no. 2, pp. 295–302, May 2017, doi: 10.1007/s11325-016-1408-y. M. Diaz-Abad, W. Chatila, M. R. Lammi, I. Swift, G. E. D’Alonzo, and S. L. Krachman, “Determinants of CPAP Adherence in Hispanics with Obstructive Sleep Apnea,” Sleep Disorders, vol. 2014, no. 1, p. 878213, Jan. 2014, doi: 10.1155/2014/878213. A. Palm et al., “Socioeconomic Factors and Adherence to CPAP: The Population-Based Course of Disease in Patients Reported to the Swedish CPAP Oxygen and Ventilator Registry Study,” Chest, vol. 160, no. 4, pp. 1481–1491, Oct. 2021, doi: 10.1016/j.chest.2021.04.064. B. Salepci et al., “CPAP Adherence of Patients With Obstructive Sleep Apnea,” Respiratory Care, vol. 58, no. 9, p. 1467, Sep. 2013, doi: 10.4187/respcare.02139. M. E. Billings and S. Redline, “Socioeconomic Differences in CPAP Adherence,” in CPAP Adherence: Factors and Perspectives, C. M. Shapiro, M. Gupta, and D. Zalai, Eds. Cham: Springer International Publishing, 2022, pp. 103–108. E. M. Wickwire, S. L. Jobe, L. M. Oldstone, S. M. Scharf, A. M. Johnson, and J. S. Albrecht, “Lower socioeconomic status and co-morbid conditions are associated with reduced continuous positive airway pressure adherence among older adult medicare beneficiaries with obstructive sleep apnea,” Sleep, vol. 43, no. 12, p. zsaa122, 2020, doi: 10.1093/sleep/zsaa122. D. Rosa et al., “Obstructive Sleep Apnea and Adherence to Continuous Positive Airway Pressure (CPAP) Treatment: Let’s Talk about Partners!,” Healthc. (Basel, Switzerland), vol. 10, no. 5, May 2022, doi: 10.3390/healthcare10050943. K. G. Baron, H. E. Gunn, L. F. Wolfe, and P. C. Zee, “Relationships and CPAP adherence among women with obstructive sleep apnea,” Sleep Sci. Pract., vol. 1, no. 1, p. 10, 2017, doi: 10.1186/s41606-017-0011-x. T. Gentina et al., “Marital quality, partner’s engagement and continuous positive airway pressure adherence in obstructive sleep apnea,” Sleep Med., vol. 55, pp. 56–61, 2019, doi: https://doi.org/10.1016/j.sleep.2018.12.009. F. Gagnadoux et al., “Influence of marital status and employment status on long-term adherence with continuous positive airway pressure in sleep apnea patients.,” PLoS One, vol. 6, no. 8, p. e22503, 2011, doi: 10.1371/journal.pone.0022503. M. Goosmann, A. M. Williams, K. Springer, and K. L. Yaremchuk, “The Impact of Marital Status and Race in Obstructive Sleep Apnea,” Ear, Nose Throat J., p. 01455613221120068, Aug. 2022, doi: 10.1177/01455613221120068. N. Laharnar et al., “Bed partner perception of CPAP therapy on relationship satisfaction and intimacy—A European perspective from the ESADA network,” J. Sleep Res., 2023, doi: 10.1111/jsr.14125. T. E. Weaver, “Best Predictors of Continuous Positive Airway Pressure Adherence,” Sleep Medicine Clinics, vol. 17, no. 4, pp. 587–595, Dec. 2022, doi: 10.1016/j.jsmc.2022.07.005. F. Baratta et al., “Long-term prediction of adherence to continuous positive air pressure therapy for the treatment of moderate/severe obstructive sleep apnea syndrome,” Sleep Medicine, vol. 43, pp. 66–70, Mar. 2018, doi: 10.1016/j.sleep.2017.09.032. N. McArdle, G. Devereux, H. Heidarnejad, H. M. Engleman, T. W. Mackay, and N. J. Douglas, “Long-term use of CPAP therapy for sleep apnea/hypopnea syndrome.,” Am J Respir Crit Care Med, vol. 159, no. 4 Pt 1, pp. 1108–1114, Apr. 1999, doi: 10.1164/ajrccm.159.4.9807111. Pływaczewski, R.; Bieleń, P.; Bednarek, M.; Jonczak, L.; Górecka, D.; Sliwiński, P. Influence of neck circumference and body mass index on obstructive sleep apnoea severity in males. Adv. Respir. Med. 2008, 76, 313–320. Ahbab, S.; Ataoğlu, H.E.; Tuna, M.; Karasulu, L.; Çetin, F.; Temiz, L.Ü.; Yenigün, M. Neck circumference, metabolic syndrome and obstructive sleep apnea syndrome; Evaluation of possible linkage. Med Sci. Monit. Int. Med J. Exp. Clin. Res. 2013, 19, 111. Katz, I.; Stradling, J.; Swtsky, A.; Zamel, N.; Hoffstein, V. Do Patients with Obstructive Sleep Apnea Have Thick Necks? 1, 2. Am. Rev. Respir. Dis. 1990, 141, 1228–1231. R. Budhiraja et al., “Early CPAP Use Identifies Subsequent Adherence to CPAP Therapy,” Sleep, vol. 30, no. 3, pp. 320–324, Mar. 2007, doi: 10.1093/sleep/30.3.320. S. Mihaicuta et al., “Analyzing Neck Circumference as an Indicator of CPAP Treatment Response in Obstructive Sleep Apnea with Network Medicine,” Diagnostics, vol. 11, no. 1, 2021, doi: 10.3390/diagnostics11010086. “Aval del Comité de Ética, Facultad de Ingeniería, Universidad de los Andes” Proyecto de Diseño, 2024, archivo: Aval_Uniandes.pdf “Protocolo Datos Clínicos y Demográficos” Proyecto de Diseño, 2024, archivo: SOLMED_Protocolo.pdf “Cronograma Datos Clínicos y Demográficos” Proyecto de Diseño, 2024, archivo: Cronograma.pdf “Presupuesto” Proyecto de Diseño, 2024, archivo: PresupuestoGeneral.pdf “Entrevista #8,” Proyecto de Diseño, 2024, archivo: Lina_Samper_Psicologia.pptx D. Pilat y S. Krastev, “The COM-B model for behavior change”, The Decision Lab. [En línea]. Disponible en: https://thedecisionlab.com/reference-guide/organizational-behavior/the-com-b-model-for-behavior-change. [Consultado: 03-jun-2024]. “Entrevista #9,” Proyecto de Diseño, 2024, archivo: Veronica_Marquez_Psicologia.pptx J. D. Doorley, F. R. Goodman, K. C. Kelso, y T. B. Kashdan, “Psychological flexibility: What we know, what we do not know, and what we think we know”, Soc. Personal. Psychol. Compass, vol. 14, núm. 12, pp. 1–11, 2020. R. C. Kamody et al., “Psychological flexibility among youth with type 1 diabetes: Relating patterns of acceptance, adherence, and stress to adaptation”, Behav. Med., vol. 44, núm. 4, pp. 271–279, 2018. E. Moitra y B. A. Gaudiano, “A psychological flexibility model of medication adherence in psychotic-spectrum disorders”, J. Contextual Behav. Sci., vol. 5, núm. 4, pp. 252–257, 2016. A. Harrison, W. Scott, L. Timmins, C. D. Graham, y A. M. Harrison, “Investigating the potentially important role of psychological flexibility in adherence to antiretroviral therapy in people living with HIV”, AIDS Care, vol. 33, núm. 3, pp. 337–346, 2021 Á. Menéndez-Aller, M. Cuesta, Á. Postigo, C. González-Nuevo, J. García-Fernández, y E. García-Cueto, “Validation of the Acceptance and Action Questionnaire-II in the general Spanish population”, Curr. Psychol., 2021. N. J. Williams et al., “The effects of social support and support types on continuous positive airway pressure use after 1 month of therapy among adults with obstructive sleep apnea”, 2024. D. C. Siebert, E. J. Mutran, y D. C. Reitzes, “Friendship and social support: the importance of role identity to aging adults”, Soc. Work, vol. 44, núm. 6, pp. 522–533, 1999. Center for Aging in Diverse Communities, “MOS SOCIAL SUPPORT SURVEY (MOS-SSS): SPANISH”, Ucsf.edu, 2020. [En línea]. Disponible en: https://cadc.ucsf.edu/sites/g/files/tkssra881/f/MOS%20Social%20Support%20Sorvey%20Spanish.pdf. [Consultado: 20-may-2024]. N. E. Londoño, H. Rogers, J.F. Castilla, S. Posada, N. Ochoa, D. Aguirre. (2012). Validación en Colombia del cuestionario MOS de apoyo social. International Journal of Psychological Research, 5(1), 142-150. G. Hawthorne, “Measuring social isolation in older adults: Development and initial validation of the friendship scale”, Soc. Indic. Res., vol. 77, núm. 3, pp. 521–548, 2006. S. Alfonsson, K. Johansson, J. Uddling, y T. Hursti, “Differences in motivation and adherence to a prescribed assignment after face-to-face and online psychoeducation: an experimental study”, BMC Psychol., vol. 5, núm. 1, p. 3, 2017. R. Radel, L. Pelletier, D. Pjevac, y B. Cheval, “The links between self-determined motivations and behavioral automaticity in a variety of real-life behaviors”, Motiv. Emot., vol. 41, núm. 4, pp. 443–454, 2017. J. Martín-Albo, J. L. Núñez, y J. G. Navarro, “Validation of the Spanish version of the Situational Motivation Scale (EMSI) in the educational context”, Span. J. Psychol., vol. 12, núm. 2, pp. 799–807, 2009. “Encuesta Recolección Variables Psicológicas” Proyecto de Diseño, 2024, archivo: Encuesta_Variables_Psicologicas.pdf A.-R. Blais and E. U. Weber, “A Domain-Specific Risk-Taking (DOSPERT) scale for adultpopulations,” Judgm. Decis. Mak., vol. 1, no. 1, pp. 33–47, 2006, doi: 10.1017/S1930297500000334. B. L. Barfoed et al., “Associations between patients’ risk attitude and their adherence to statin treatment– a population based questionnaire and register study,” BMC Fam. Pract., vol. 17, no. 1, p. 28, 2016, doi: 10.1186/s12875-016-0423-1. [74] J. Zhu, Y. Shi, J. Li, and Z. Zhang, “Role of risk attitude and time preference in preventive aspirin use adherence,” J. Eval. Clin. Pract., vol. 26, no. 3, 2020, doi: 10.1111/jep.13274. J. Zhu, Y. Shi, J. Li, and Z. Zhang, “Role of risk attitude and time preference in preventive aspirin use adherence,” J. Eval. Clin. Pract., vol. 26, no. 3, 2020, doi: 10.1111/jep.13274 N. Pelletier-Fleury et al., “Risk-seeking attitude in health and safety domain is associated with continuous positive airway pressure discontinuation in patients with obstructive sleep apnea- a multicenter prospective cohort study,” Sleep, vol. 44, no. 2, 2021, doi: 10.1093/sleep/zsaa156. P. Kasetti, N. F. Husain, T. C. Skinner, K. Asimakopoulou, J. Steier, and S. A. Sathyapala, “Personality traits and pre-treatment beliefs and cognitions predicting patient adherence to continuous positive airway pressure: A systematic review,” Sleep Medicine Reviews, vol. 74. 2024, doi: 10.1016/j.smrv.2024.101910. S. Olsen, S. Smith, T. Oei, and J. Douglas, “Health belief model predicts adherence to CPAP before experience with CPAP,” Eur. Respir. J., vol. 32, no. 3, 2008, doi: 10.1183/09031936.00127507. S. Okuboyejo, V. Mbarika, and N. Omoregbe, “The effect of self-efficacy and outcome expectation on medication adherence behavior.,” J. Public Health Africa, vol. 9, no. 3, p. 826, Dec. 2018, doi: 10.4081/jphia.2018.826. M. J. Martos-Méndez, “Self-efficacy and adherence to treatment: the mediating effects of social support,” J. Behav. Heal. Soc. Issues, vol. 7, no. 2, pp. 19–29, 2015, doi: https://doi.org/10.5460/jbhsi.v7.2.52889. S. Kojima et al., “Associations of self-efficacy and outcome expectancy with adherence to continuous positive airway pressure therapy in Japanese patients with obstructive sleep apnea,” Fujita Med. J., vol. 9, no. 2, 2023, doi: 10.20407/fmj.2022-015. R. Shaukat, Y. Gamal, A. Ali, and S. Mohamed, “Adherence to Positive Airway Pressure Therapy in Patients With Obstructive Sleep Apnea,” Cureus, 2022, doi: 10.7759/cureus.25946. D. M. Wallace, S. Shafazand, M. S. Aloia, and W. K. Wohlgemuth, “The association of age, insomnia, and self-efficacy with continuous positive airway pressure adherence in black, white, and Hispanic US veterans,” J. Clin. Sleep Med., vol. 9, no. 9, 2013, doi: 10.5664/jcsm.2988. T. Nguyen et al., “0571 Utilization of Self-Efficacy Measure of Sleep Apnea (SEMSA) questionnaire to Predict CPAP Adherence,” Sleep, vol. 46, no. Supplement_1, pp. A251–A251, 2023, doi: 10.1093/sleep/zsad077.0571. Mateus-Galeano EM, Céspedes-Cuevas VM. Validez y confiabilidad del instrumento "Medición de la autoeficacia percibida en apnea del sueño" - SEMSA. Versión en español. Aquichan. 2016;16(1):67-82. DOI: 10.5294/aqui.2016.16.1.8 “Protocolo Datos Psicológicos” Proyecto de Diseño, 2024, archivo: SOLMED_Protocolo2.pdf “Cronograma Datos Psicológicos” Proyecto de Diseño, 2024, archivo: Cronograma 2.xl Grau, J. Pensando en el usuario: la usabilidad. 2007. Anuario ThinkEPI, pp. 172 - 177. “Experimentaciones de diseño,” Proyecto de Diseño, 2024, archivo: Proceso_de_diseño.pptx “Encuesta de Usabilidad” Proyecto de Diseño, 2024, archivo: EncuestaUsabilidad.pdf “Entrevista #11,” Proyecto de Diseño, 2024, archivo: Camilo_Escobar.pptx “Entrevista #8,” Proyecto de Diseño, 2024, archivo: Pamela_Ramirez.pptx S. Alfonsson, K. Johansson, J. Uddling, y T. Hursti, “Differences in motivation and adherence to a prescribed assignment after face-to-face and online psychoeducation: an experimental study”, BMC Psychol., vol. 5, núm. 1, p. 3, 2017. J. L. Ortiz and D. Rosselli, “Adherence to Positive Airway Pressure Therapy in a Cohort of Colombian Patients with Obstructive Sleep Apnea Syndrome,” Sleep Sci., vol. 16, no. 2, 2023, doi: 10.1055/s-0043-1770799. Ministerio de Salud y Protección Social, “Boletines Poblacionales: Género - Mujeres, hombres y personas de los sectores sociales LGBTI”, Gov.co, 2020. [En línea]. Disponible en: https://www.minsalud.gov.co/sites/rid/Lists/BibliotecaDigital/RIDE/DE/PS/boletines-poblacionales-genero.pdf. [Consultado: 16-oct-2024]. S. Diaz, “Cifras de Kantar indicaron que la población estrato 1 en Colombia corresponde al 21%”, Diario La República, 15-mar-2022. [En línea]. Disponible en: https://www.larepublica.co/empresas/kantar-da-a-conocer-cifras-relevantes-en-el-marco-del-dia-mundial-del-consumidor-3322740. [Consultado: 16-oct-2024]. X, Valderrama-Penagos; KL, Dueñas-Quintero; KA, Guzmán-Ortiz. Descripción de la frecuencia de factores de mala adherencia en la terapia con presión positiva en la vía aérea (CPAP-BPAP-APAP) en pacientes con AOS pertenecientes al Hospital Militar Central de Colombia entre 2015-2020. Acta de Otorrinolaringología CCC. 2023;51(3):212-221 J. F. Z. Valencia, “Lo que implica para el país que 2,6 millones de personas vivan solas”, El Colombiano, 27-ago-2020. [En línea]. Disponible en: https://www.elcolombiano.com/colombia/retos-y-realidades-de-los-hogares-unipersonales-en-colombia-JG13515905. [Consultado: 16-oct-2024]. G. Ernst, M. Saban, y M. Schiavone, “Prevalencia y características de apneas obstructivas de sueño según gravedad”, Medicinabuenosaires.com. [En línea]. Disponible en: https://www.medicinabuenosaires.com/indices-de-2020/volumen-80-ano-2020-no-5-indice/prevalencia_apneas/. [Consultado: 16-oct-2024]. S. Pita Fernández, “Guía: Determinación del tamaño muestral - Fisterra”, 1996. [En línea]. Disponible en: https://www.fisterra.com/formacion/metodologia-investigacion/determinacion-tamano-muestral/. [Consultado: 23-sep-2024]. Departamento Administrativo Nacional de Estadística, “DANE - Proyecciones de población, Serie nacional de población por área, para el periodo 2020-2070”, Gov.co, 2023. [En línea]. Disponible en: https://www.dane.gov.co/index.php/estadisticas-por-tema/demografia-y-poblacion/proyecciones-de-poblacion. [Consultado: 23-sep-2024]. S. Bottia, H. Barrios-Bermúdez, y D. Rosselli, «Prevalencia de apnea de sueño en Colombia: un análisis de las bases de datos del Ministerio de Salud», Iatreia, vol. 37, n.º 1, jun. 2023. “Alertas Sanitarias,” Invima, https://app.invima.gov.co/alertas/dispositivos-medicos-invima?field_tipo_de_documento_value=1&field_a_o_value=4&page=34 (accessed Aug. 27, 2024). “Recognized Consensus Standards: Medical Devices,” Fda.gov, 2019. https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfstandards/detail.cfm?standard__identification_no=39510 (accessed Aug. 28, 2024). FDA, “Proposed Regulatory Framework for Modifications to Artificial Intelligence/Machine Learning (AI/ML)-Based Software as a Medical Device (SaMD) - Discussion Paper and Request for Feedback”, 2019. Accedido el 31 de agosto de 2024. [En línea]. Disponible: https://www.fda.gov/media/122535/download?attachment FDA. “Regulatory Controls”. U.S. Food and Drug Administration. Accedido el 1 de septiembre de 2024. [En línea]. Disponible: https://www.fda.gov/medical-devices/overview-device-regulation/regulatory-controls “ISO 80601-2-70:2020 Medical Electrical Equipment Part 2-70: Particular requirements for the basic safety and essential performance of Sleep ApnoEA Breathing therapy equipment,” ISO, 2018. https://www.iso.org/standard/75947.html “ISO 17510:2015 Medical devices — Sleep apnoea breathing therapy — Masks and application accessories,” ISO, 2015. https://www.iso.org/es/contents/data/standard/06/49/64910.html “ISO/CD TS 24971-2 Medical Devices — Guidance on the application of ISO 14971 Part 2: Machine Learning in Artificial Intelligence,” ISO. https://www.iso.org/standard/87600.html Universitat Oberta de Catalunya. (s/f). N-Fold Cross-Validation. Uoc.edu. Disponible en: https://datascience.recursos.uoc.edu/es/n-fold-cross-validation/ X. Huang, A. Khetan, M. Cvitkovic, and Z. S. Karnin, “TabTransformer: Tabular Data Modeling Using Contextual Embeddings,” CoRR, vol. abs/2012.0, 2020, [Online]. Available: [2012.06678] TabTransformer: Tabular Data Modeling Using Contextual Embeddings “Entrevista #12” Proyecto de Diseño, 2024, archivo: Christian_Perdomo.pptx “Taller de Vigilancia Tecnológica” Proyecto de Diseño, 2024, archivo: VigilanciaT_SOLMED_Equipo1.pptx P. Catalán et al., “Consistencia interna y validez de la versión española del cuestionario de calidad de vida específico para el síndrome de apnea del sueño: Sleep Apnoea Quality of Life Index,” Arch. Bronconeumol., vol. 48, no. 12, 2012, doi: 10.1016/j.arbres.2012.05.004. L. E. Lugo, H. I. García, and C. Gómez, “Confiabilidad del cuestionario de calidad de vida en salud SF-36 en Medellín, Colombia,” Rev. Fac. Nac. Salud Pública, vol. 24, no. 2, 2008, doi: 10.17533/udea.rfnsp.243. L. Zhou, J. Bao, I. M. A. Setiawan, A. Saptono, and B. Parmanto, “The mHealth App Usability Questionnaire (MAUQ): Development and Validation Study,” JMIR Mhealth Uhealth, vol. 7, no. 4, p. e11500, Apr. 2019, doi: 10.2196/11500. “mHealth App Usability Questionnaire (MAUQ) for Standalone mHealth Apps Used by Patients” Proyecto de Diseño, 2024, archivo: MAUQ_SPA_SusanaMontes.pdf Ministerio de la Protección Social, “DECRETO NÚMERO 4725 DE 2005”, 2005. [En línea]. Disponible en: https://www.invima.gov.co/sites/default/files/dispositivos-medicos/2023-10/DECRETO%204725%20DE%202005.pdf. International Medical Device Regulators Forum, "Software as a Medical Device (SaMD): Key Definitions," IMDRF/SaMD WG/N10FINAL:2013, 2013. Departamento Administrativo de la Función Pública, "Ley Estatutaria 1581 de 2012," 2012.. [Online]. Available: https://www.funcionpublica.gov.co/eva/gestornormativo/norma.php?i=49981. [Accessed: Dec. 7, 2024]. NQA, "ISO 13485 - Sistema de gestión de calidad para dispositivos médicos," [Online]. Available: https://www.nqa.com/es-co/certification/standards/iso-13485. [Accessed: Dec. 7, 2024]. ISO, "ISO 14971: Gestión de Riesgos para Dispositivos Médicos," [Online]. Available: https://www.iso.org/obp/ui#iso:std:iso:14971:ed-3:v1:es. [Accessed: Dec. 7, 2024]. Medical Electrical Equipment - Part 1: General Requirements for Basic Safety and Essential Performance. IEC 60601-1, 3.2ª edición, 2020. [Online]. Disponible en: https://www.intertek.es/equipos-medicos/seguridad-iec-60601/ International Organization for Standardization, "ISO 9001:2008 - Quality management systems — Requirements," ISO, Geneva, Switzerland, 2008. [Online]. Available: https://www.iso.org/standard/38421.html "ISO 27001 paso a paso - Implementación del SGSI," Norma ISO 27001, 2024. [En línea]. Disponible en: https://www.normaiso27001.es/. [Accedido: 7 de diciembre de 2024]. S. Blank and B. Dorf, Disciplined Entrepreneurship Workbook - DE Canvas, WILEY. "ModeloFinanciero," Proyecto de Diseño, 2024: archivo de Microsoft Excel: ModeloFinanciero_SOLMED_Equipo1.xlsx. N. González Mangado, C. J. Egea-Santaolalla, E. Chiner Vives, and O. Mediano, “Apnea obstructiva del sueño,” Open Respiratory Archives, Apr. 2020 "Plan Financiero," Proyecto de Diseño, 2024: archivo de Microsoft Excel: CalendarioPlanFinanciero.xlsx. “Sleep Apnea Devices Market Size | Global Industry Report, 2032”. Fortune Business Insights™ | Global Market Research Reports & Consulting, 2024. [En línea] Disponible en:https://www.fortunebusinessinsights.com/industry-reports/sleep-apnea-devices-market-100708 |
dc.rights.en.fl_str_mv |
Attribution 4.0 International |
dc.rights.uri.none.fl_str_mv |
http://creativecommons.org/licenses/by/4.0/ |
dc.rights.accessrights.none.fl_str_mv |
info:eu-repo/semantics/openAccess |
dc.rights.coar.none.fl_str_mv |
http://purl.org/coar/access_right/c_abf2 |
rights_invalid_str_mv |
Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ http://purl.org/coar/access_right/c_abf2 |
eu_rights_str_mv |
openAccess |
dc.format.extent.none.fl_str_mv |
52 páginas |
dc.format.mimetype.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Universidad de los Andes |
dc.publisher.program.none.fl_str_mv |
Ingeniería Biomédica |
dc.publisher.faculty.none.fl_str_mv |
Facultad de Ingeniería |
dc.publisher.department.none.fl_str_mv |
Departamento de Ingeniería Biomédica |
publisher.none.fl_str_mv |
Universidad de los Andes |
institution |
Universidad de los Andes |
bitstream.url.fl_str_mv |
https://repositorio.uniandes.edu.co/bitstreams/46ad1848-6bd8-4f96-acff-80ce669998af/download https://repositorio.uniandes.edu.co/bitstreams/fca2d534-8a08-4e36-abcd-0f3dcfedb40d/download https://repositorio.uniandes.edu.co/bitstreams/50758be4-73ef-4b10-b57a-84cf6af2c57b/download https://repositorio.uniandes.edu.co/bitstreams/b106ba65-2abd-4485-84ae-3eb1570dc4b9/download https://repositorio.uniandes.edu.co/bitstreams/b22b7023-d6bf-406a-af59-ba2d33a8f3c1/download https://repositorio.uniandes.edu.co/bitstreams/90c0c915-df9c-4427-9c38-57844175337b/download https://repositorio.uniandes.edu.co/bitstreams/1f7d4397-1b20-41a1-9f6a-806885bca0b1/download https://repositorio.uniandes.edu.co/bitstreams/979fde2d-c430-4527-8bff-a0e47656b314/download |
bitstream.checksum.fl_str_mv |
1cb1c825b5b6ccbb33463653cbbe8cb5 fd8166fccd84b0231ff16c0d84d90539 ae9e573a68e7f92501b6913cc846c39f 0175ea4a2d4caec4bbcc37e300941108 bc1b97cd43fefee2f8ac60a38607ebaa 69a195f678ad9e14b457097a8b9a8075 1a52cffc4f13ecdd87024041e087cb3c 340ec218f3c119503f6718d07922b642 |
bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 MD5 MD5 MD5 MD5 MD5 MD5 |
repository.name.fl_str_mv |
Repositorio institucional Séneca |
repository.mail.fl_str_mv |
adminrepositorio@uniandes.edu.co |
_version_ |
1831927833669140480 |
spelling |
Bigio Roitman, Davidvirtual::21989-1Hosie Echeverri, OliviaCeballos Sarmiento, Hannah VanessaCastro Barrera, Paula AndreaVera Rincón, Javier SantiagoHenríquez Martínez, Angie2025-01-13T14:52:26Z2025-01-13T14:52:26Z2024-12-12https://hdl.handle.net/1992/75357instname:Universidad de los Andesreponame:Repositorio Institucional Sénecarepourl:https://repositorio.uniandes.edu.co/La Apnea Obstructiva del Sueño (AOS) es una condición que afecta de forma significativa la calidad de vida de las personas y su entorno. Aunque su tratamiento gold standard, el CPAP (Continuous Positive Air Pressure) es muy efectivo, presenta un bajo índice de adherencia, lo que impide alcanzar un efecto terapéutico. El dispositivo en desuso representa un desperdicio de recursos y la prevalencia de síntomas y comorbilidades resulta en mayores costos para el sistema de salud. Así, es necesario encontrar una forma de aumentar la adherencia al tratamiento de los pacientes con AOS para evitar el gasto de recursos en pacientes no adherentes y enfocar la adopción del tratamiento en pacientes con baja y alta adherencia. Para esto, se propone un servicio que utiliza la personalización y el acompañamiento como fortalezas clave para facilitar la adopción a la terapia. Incluye noap especialista, una aplicación web diseñada para predecir la adherencia al tratamiento; noap dispositivo, un CPAP interactivo y de alta responsividad que se adapta a las necesidades del paciente; y noap paciente, una aplicación web enfocada en el seguimiento y acompañamiento durante todo el tratamiento. El servicio será implementado mediante suscripciones anuales ofrecidas a EPS e IPS en Colombia, integrando el dispositivo y las aplicaciones. En principio, se propone un método de venta directa para lograr acuerdos robustos con las entidades. Este modelo satisface las necesidades del paciente y reduce costos al sistema de salud mediante un enfoque terapéutico eficiente y un servicio adaptado al contexto del usuario.Pregrado52 páginasapplication/pdfspaUniversidad de los AndesIngeniería BiomédicaFacultad de IngenieríaDepartamento de Ingeniería BiomédicaAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Noap: Un servicio innovador para el tratamiento de la Apnea Obstructiva del SueñoTrabajo de grado - Pregradoinfo:eu-repo/semantics/bachelorThesisinfo:eu-repo/semantics/acceptedVersionhttp://purl.org/coar/resource_type/c_7a1fTexthttp://purl.org/redcol/resource_type/TPApnea Obstructiva del SueñoAdherencia al tratamientoNoapIngenieríaJ. M. Slowik, A. Sankari, and J. Collen, “Obstructive Sleep Apnea,” PubMed, 2022. https://www.ncbi.nlm.nih.gov/books/NBK459252/.“Entrevista #3,” Proyecto de Diseño, 2024, archivo: Encuentro_Cirugía_Maxilofacial.pptxA. V. Benjafield et al., “Estimation of the global prevalence and burden of obstructive sleep apnea: a literature-based analysis,” The Lancet Respiratory Medicine, vol. 7, no. 8. Elsevier BV, pp. 687–698, Aug. 2019. doi: 10.1016/s2213-2600(19)30198-5.L. Kline, “Clinical presentation and diagnosis of obstructive sleep apnea in adults,” UpToDate, 2024, [Online]. Available: https://www.uptodate.com/contents/clinical-presentation-and-diagnosis-of-obstructive-sleep-apnea-in-adults?search=obstructive sleep apnea&source=search_result&selectedTitle=1~150&usage_type=default&display_rank=1.P. Lévy et al., “Obstructive sleep apnoea syndrome,” Nature Reviews Disease Primers, vol. 1, no. 1. Springer Science and Business Media LLC, Jun. 25, 2015. doi: 10.1038/nrdp.2015.15.A. V. Benjafield et al., “Estimation of the global prevalence and burden of obstructive sleep apnea: a literature-based analysis,” The Lancet Respiratory Medicine, vol. 7, no. 8. Elsevier BV, pp. 687–698, Aug. 2019. doi: 10.1016/s2213-2600(19)30198-5.A. Malhotra, “Obstructive sleep apnea: Overview of management in adults,” UpToDate, 2024, [Online]. Available: https://www.uptodate.com/contents/obstructive-sleep-apnea-overview-of-management-in-adults?search=obstructive sleep apnea&source=search_result&selectedTitle=2~150&usage_type=default&display_rank=2#H10.M. R. Cowie and A. M. Gallagher, “Sleep Disordered Breathing and Heart Failure,” JACC: Heart Failure, vol. 5, no. 10. Elsevier BV, pp. 715–723, Oct. 2017. doi: 10.1016/j.jchf.2017.06.016.S. P. Patil, I. A. Ayappa, S. M. Caples, R. J. Kimoff, S. R. Patel, y C. G. Harrod, “Treatment of adult obstructive sleep apnea with positive airway pressure: An American academy of sleep medicine systematic review, meta-analysis, and GRADE assessment”, J. Clin. Sleep Med., vol. 15, núm. 02, pp. 301–334, 2019.P. Lévy et al., “Obstructive sleep apnoea syndrome,” Nature Reviews Disease Primers, vol. 1, no. 1. Springer Science and Business Media LLC, Jun. 25, 2015. doi: 10.1038/nrdp.2015.15.Y. Peker, H. Glantz, C. Eulenburg, K. Wegscheider, J. Herlitz, and E. Thunström, “Effect of positive airway pressure on cardiovascular outcomes in coronary artery disease patients with nonsleepy obstructive sleep apnea: The RICCADSA randomized controlled trial,” Am. J. Respir. Crit. Care Med., vol. 194, no. 5, 2016, doi: 10.1164/rccm.201601-0088OC.A. Malhotra, J. E. Orr, and R. L. Owens, “On the cutting edge of obstructive sleep apnoea: where next?,” The Lancet Respiratory Medicine, vol. 3, no. 5. Elsevier BV, pp. 397–403, May 2015. doi: 10.1016/s2213-2600(15)00051-x.E. Martinez-Ceron et al., “Effect of continuous positive airway pressure on glycemic control in patients with obstructive sleep apnea and type 2 diabetes a randomized clinical trial,” Am. J. Respir. Crit. Care Med., vol. 194, no. 4, 2016, doi: 10.1164/rccm.201510-1942OC.A. Malhotra, “Obstructive sleep apnea: Overview of management in adults,” UpToDate, 2024, [Online]. Available: https://www.uptodate.com/contents/obstructive-sleep-apnea-overview-of-management-in-adults?search=obstructive sleep apnea&source=search_result&selectedTitle=2~150&usage_type=default&display_rank=2#H10.O. Contal et al., “One-Year Adherence to Continuous Positive Airway Pressure With Telemonitoring in Sleep Apnea Hypopnea Syndrome: A Randomized Controlled Trial ,” Frontiers in Medicine , vol. 8. 2021, [Online]. Available: https://www.frontiersin.org/articles/10.3389/fmed.2021.626361.A. S. Jordan, D. G. McSharry, and A. Malhotra, “Adult obstructive sleep apnoea,” The Lancet, vol. 383, no. 9918. 2014, doi: 10.1016/S0140-6736(13)60734-5.“Encuesta #1” Proyecto de Diseño, 2024, archivo: Encuesta_APNEAS.pdfS. P. Patil, I. A. Ayappa, S. M. Caples, R. J. Kimoff, S. R. Patel, y C. G. Harrod, “Treatment of adult obstructive sleep apnea with positive airway pressure: An American academy of sleep medicine systematic review, meta-analysis, and GRADE assessment”, J. Clin. Sleep Med., vol. 15, núm. 02, pp. 301–334, 2019.J. L. Chang et al., “International Consensus Statement on Obstructive Sleep Apnea.,” Int. Forum Allergy Rhinol., vol. 13, no. 7, pp. 1061–1482, Jul. 2023, doi: 10.1002/alr.23079.Y. Kim, Y. S. Koo, H. Y. Lee, and S. Y. Lee, “Can Continuous positive airway pressure reduce the risk of stroke in obstructive sleep apnea patients? A systematic review and meta-Analysis,” PLoS One, vol. 11, no. 1, 2016, doi: 10.1371/journal.pone.0146317.D. Zhu et al., “Heated humidification did not improve compliance of positive airway pressure and subjective daytime sleepiness in obstructive sleep apnea syndrome: A meta-analysis,” PLoS One, vol. 13, no. 12, 2018, doi: 10.1371/journal.pone.0207994.Y. Peker, H. Glantz, C. Eulenburg, K. Wegscheider, J. Herlitz, and E. Thunström, “Effect of positive airway pressure on cardiovascular outcomes in coronary artery disease patients with nonsleepy obstructive sleep apnea: The RICCADSA randomized controlled trial,” Am. J. Respir. Crit. Care Med., vol. 194, no. 5, 2016, doi: 10.1164/rccm.201601-0088OC.“Entrevista #5,” Proyecto de Diseño, 2024, archivo: DraJaramillo.pptxL. S. Doherty, J. L. Kiely, V. Swan, and W. T. McNicholas, “Long-term effects of nasal continuous positive airway pressure therapy on cardiovascular outcomes in sleep apnea syndrome,” Chest, vol. 127, no. 6, 2005, doi: 10.1378/chest.127.6.2076.A. Tarasiuk, G. Reznor, S. Greenberg-Dotan, and H. Reuveni, “Financial Incentive Increases CPAP Acceptance in Patients from Low Socioeconomic Background,” PLoS ONE, vol. 7, no. 3. Public Library of Science (PLoS), p. e33178, Mar. 30, 2012. doi: 10.1371/journal.pone.0033178.E. Martinez-Ceron et al., “Effect of continuous positive airway pressure on glycemic control in patients with obstructive sleep apnea and type 2 diabetes a randomized clinical trial,” Am. J. Respir. Crit. Care Med., vol. 194, no. 4, 2016, doi: 10.1164/rccm.201510-1942OC.“Asistencia a la Jornada Neumológica en la Ciudad de Barranquilla el 15 de marzo de 2024” Proyecto de Diseño, 2024, archivo: Jornada_Neumologica.pptx.C. Navarro-Soriano et al., “TheHIPARCO-2 study: Long-term effect of continuous positive airway pressure on blood pressure in patients with resistant hypertension: Amulticenter prospective study,” J. Hypertens., vol. 39, no. 2, 2021, doi: 10.1097/HJH.0000000000002664.N. F. Watson, “Health care savings: The economic value of diagnostic and therapeutic care for obstructive sleep apnea,” Journal of Clinical Sleep Medicine, vol. 12, no. 8. 2016, doi: 10.5664/jcsm.6034.O. Contal et al., “One-Year Adherence to Continuous Positive Airway Pressure With Telemonitoring in Sleep Apnea Hypopnea Syndrome: A Randomized Controlled Trial ,” Frontiers in Medicine , vol. 8. 2021, [Online]. Available: https://www.frontiersin.org/articles/10.3389/fmed.2021.626361.E. M. Wickwire et al., “The Impact of Treatments for OSA on Monetized Health Economic Outcomes: A Systematic Review,” Chest, vol. 155, no. 5, 2019, doi: 10.1016/j.chest.2019.01.009.B. W. Rotenberg, D. Murariu, and K. P. Pang, “Trends in CPAP adherence over twenty years of data collection: A flattened curve,” J. Otolaryngol. - Head Neck Surg., vol. 45, no. 1, p. 43, Jan. 2016, doi: 10.1186/s40463-016-0156-0.H. O. Savage et al., “Development and validation of a novel non-contact monitor of nocturnal respiration for identifying sleep-disordered breathing in patients with heart failure,” ESC Hear. Fail., vol. 3, no. 3, 2016, doi: 10.1002/ehf2.12086.“Encuesta #1” Proyecto de Diseño, 2024, archivo: Encuesta_APNEAS.pdf“Entrevista #1,” Proyecto de Diseño, 2024, archivo: Susana_Montes.pptxG. Rapelli et al., “Improving CPAP adherence in adults with obstructive sleep apnea syndrome: A scoping review of motivational interventions,” Front. Psychol., vol. 14, 2023, [Online]. Available: Frontiers | Improving CPAP Adherence in Adults With Obstructive Sleep Apnea Syndrome: A Scoping Review of Motivational Interventions (frontiersin.org)A. M. May and J. E. Dalton, “Comparison of machine learning approaches for positive airway pressure adherence prediction in a veteran cohort,” Front. Sleep, vol. 3, 2024, doi: 10.3389/frsle.2024.1278086.J. L. Chang et al., “International Consensus Statement on Obstructive Sleep Apnea.,” Int. Forum Allergy Rhinol., vol. 13, no. 7, pp. 1061–1482, Jul. 2023, doi: 10.1002/alr.23079.K. Eguchi et al., “Investigation on factors related to poor CPAP adherence using machine learning: a pilot study,” Sci. Rep., vol. 12, no. 1, 2022, doi: 10.1038/s41598-022-21932-8.G. Scioscia et al., “Machine learning-based prediction of adherence to continuous positive airway pressure (CPAP) in obstructive sleep apnea (OSA),” Informatics Heal. Soc. Care, vol. 47, no. 3, 2022, doi: 10.1080/17538157.2021.1990300.E. L. Maschauer, D. M. Fairley, and R. L. Riha, “Does personality play a role in continuous positive airway pressure compliance?,” Breathe, vol. 13, no. 1. European Respiratory Society (ERS), pp. 32–43, Mar. 2017. doi: 10.1183/20734735.014916.J. Hua, H. Zhu, C. V. Orate-Pott, D. Shellenberger, D. Narayanaswamy, y N. A. Shetty, “Method and system for predicting adherence to a treatment”, 11804306, 31-oct-2023N. Liu, S. De Souz, y O. Gromenko, “Prediction of respiratory therapy compliance”, 11508484B1, 22-nov-2022.D. F. Smith, C. P. Spiceland, L. C. Pringle, K. L. Mattare, J. R. Benke, and S. L. Ishman, “Financial incentive of home continuous positive airway pressure machine use in the inpatient hospital setting,” The Laryngoscope, vol. 124, no. 9. Wiley, pp. 2200–2204, May 30, 2014. doi: 10.1002/lary.24604.Y. Engelhard, M. Maalouf, y M. Chiu, “Devices, systems, and methods for adherence monitoring and patient interaction”, 11938265, 26-mar-2024.“Almohada Contour CPAP 2.0”. Oxigo. [En línea]. Disponible: https://www.oxigo.co/es/contour-almohada-cpap.html“ALMOHADA PARA APNEA DEL SUEÑO DEEPREST”, Oximedica. [En línea]. Disponible: https://oximedica.com/product/almohada-para-apnea-del-sueno-deeprest/“MENTONERA SENCILLA DEEPREST”, Oximedica. [En línea]. Disponible: https://oximedica.com/product/mentonera-sencilla/“Cojín Posicionador Contra La Apnea ZZOMA”. Apoyo Científico y Tecnológico para el Deporte, Biolaster. [En línea]. Disponible: https://www.biolaster.com/productos/cojin-posicionador-contra-la-apnea-zzoma/“About Us”, VVFLY Electronics Co. [En línea]. Disponible: https://www.vvfly.cn/en/about.htmlマシュー・ロルフ・ハリントン, “Heat and moisture exchanger for patient interface”, JP:6891258:B2, 18-jun-2021.P. R. Kwok, R. Richard, K. Selvarajan, G. Richards, N. J. Reed, y L. Puckeridge, “Methods and apparatus for controlling mask leak in CPAP treatment”, 10342941, 09-jul-2019.A. Biener, C. Bayer, F. Komorowski, y B. C. Lang, “Patient interface”, 20170049984:A1, 23-feb-2017.T. T.-F. Fu y S. De Souza, “Auto-fit mask”, 20240082519:A1, 14-mar-2024.“Entrevista #2,” Proyecto de Diseño, 2024, archivo: JuanCarlos_Castro.pptxS. B. Lamberg, “Intraoral mandibular advancement device for treatment of sleep disorders”, 7730891, 08-jun-2010.L. Baratier y Y. Palomino, “Mandibular repositioning device”, 11576809, 14-feb-2023.M. R. Harrison y D. A. Kwiat, “Device and method for correcting obstructive sleep apnea”, 11779487, 10-oct-2023.J. E. Kovarik, “Method of treating snoring and obstructive sleep apnea”, 9445936, 20-sep-2016.“Resmed”, Resmed. [En línea]. Disponible: https://www.resmed.lat/“AUTOCPAP”, Neumotec. [En línea]. Disponible: https://www.neumotec.com/categoria/autocpap/“Simposio del Sueño Colsanitas,” Proyecto de Diseño, 2024, archivo: I_Simposio_de_Sueño.pptxC. Duhigg, The power of habits : why we do what we do in life and business. Hà Nội: Lao Động - Xã Hội, 2013.Stanford Byers Center For Biodesign, A Student Guide to BIODESIGN, Concepts of Screening and Selection. 2024.J. Tranquillo, J. Goldberg, y R. Allen, Biomedical engineering design. San Diego, CA, Estados Unidos de América: Academic Press, 2022.R. G. S. Andrade et al., “Nasal vs Oronasal CPAP for OSA Treatment: A Meta-Analysis,” Chest, vol. 153, no. 3, 2018, doi: 10.1016/j.chest.2017.10.044.S. Saraç, G. Ç. Afşar, Ö. Oruç, Ö. B. Topçuoğlu, C. Saltürk, and Y. Peker, “Impact of patient education on compliance with positive airway pressure treatment in obstructive sleep apnea,” Med. Sci. Monit., vol. 23, 2017, doi: 10.12659/MSM.902075.D. Zhu et al., “Heated humidification did not improve compliance of positive airway pressure and subjective daytime sleepiness in obstructive sleep apnea syndrome: A meta-analysis,” PLoS One, vol. 13, no. 12, 2018, doi: 10.1371/journal.pone.0207994.D. C. Dolan, R. Okonkwo, F. Gfullner, R. J. Hansbrough, R. J. Strobel, and L. Rosenthal, “Longitudinal comparison study of pressure relief (C-FlexTM) vs. CPAP in OSA patients,” Sleep Breath., vol. 13, no. 1, 2009, doi: 10.1007/s11325-008-0199-1.“Entrevista #10,” Proyecto de Diseño, 2024, archivo: DrLobelo.pptxD. L. Rose, Enchanted Objects: Design, Human Desire, and the Internet of Things. Scribner, 2014.J. A. A. De Dios and S. D. Brass, “New and unconventional treatments for obstructive sleep apnea.,” Neurotherapeutics, vol. 9, no. 4, pp. 702–709, Oct. 2012, doi: 10.1007/s13311-012-0146-5.C. E. Budin et al., “Therapeutic alternatives with CPAP in obstructive sleep apnea,” ValpoScholar, https://doi.org/10.22543/7674.62.P181189 (accessed Apr. 21, 2024).S. J. Kim et al., “Impact of number of medications and age on adherence to antihypertensive medications: A nationwide population-based study.,” Medicine (Baltimore)., vol. 98, no. 49, p. e17825, Dec. 2019, doi: 10.1097/MD.0000000000017825.B. Uchmanowicz, A. Chudiak, I. Uchmanowicz, J. Rosińczuk, and E. S. Froelicher, “Factors influencing adherence to treatment in older adults with hypertension,” Clin. Interv. Aging, vol. 13, 2018, doi: 10.2147/CIA.S182881.M. Sajatovic, F. C. Blow, H. C. Kales, M. Valenstein, D. Ganoczy, and R. V. Ignacio, “Age comparison of treatment adherence with antipsychotic medications among individuals with bipolar disorder,” Int. J. Geriatr. Psychiatry, vol. 22, no. 10, 2007, doi: 10.1002/gps.1777.S. R. Patel, J. P. Bakker, C. J. Stitt, M. S. Aloia, and S. M. Nouraie, “Age and Sex Disparities in Adherence to CPAP,” Chest, vol. 159, no. 1, pp. 382–389, 2021, doi: https://doi.org/10.1016/j.chest.2020.07.017.A. Prigent, C. Blanloeil, A.-L. Serandour, F. Barlet, F. Gagnadoux, and D. Jaffuel, “A biphasic effect of age on CPAP adherence: a cross-sectional study of 26,343 patients,” Respir. Res., vol. 24, no. 1, p. 234, 2023, doi: 10.1186/s12931-023-02543-x.A. Gabryelska, M. Sochal, B. Wasik, P. Szczepanowski, and P. Białasiewicz, “Factors Affecting Long-Term Compliance of CPAP Treatment—A Single Centre Experience,” J. Clin. Med., vol. 11, no. 1, 2022, doi: 10.3390/jcm11010139.J.-L. Pépin et al., “CPAP Therapy Termination Rates by OSA Phenotype: A French Nationwide Database Analysis,” J. Clin. Med., vol. 10, no. 5, 2021, doi: 10.3390/jcm10050936.E. S. Lau et al., “Sex, Permanent Drug Discontinuation, and Study Retention in Clinical Trials: Insights from the TIMI trials,” Circulation, vol. 143, no. 7, 2021, doi: 10.1161/CIRCULATIONAHA.120.052339.M. Manteuffel, S. Williams, W. Chen, R. R. Verbrugge, D. G. Pittman, and A. Steinkellner, “Influence of patient sex and gender on medication use, adherence, and prescribing alignment with guidelines.,” J. Womens. Health (Larchmt)., vol. 23, no. 2, pp. 112–119, Feb. 2014, doi: 10.1089/jwh.2012.3972.H. Woehrle, A. Graml, and G. Weinreich, “Age- and gender-dependent adherence with continuous positive airway pressure therapy,” Sleep Med., vol. 12, no. 10, pp. 1034–1036, 2011, doi: https://doi.org/10.1016/j.sleep.2011.05.008.A. M. Sawyer, N. S. Gooneratne, C. L. Marcus, D. Ofer, K. C. Richards, and T. E. Weaver, “A systematic review of CPAP adherence across age groups: Clinical and empiric insights for developing CPAP adherence interventions,” Sleep Med. Rev., vol. 15, no. 6, pp. 343–356, Dec. 2011, doi: 10.1016/J.SMRV.2011.01.003.M. Riachy, S. Najem, M. Iskandar, J. Choucair, I. Ibrahim, and G. Juvelikian, “Factors predicting CPAP adherence in obstructive sleep apnea syndrome,” Sleep and Breathing, vol. 21, no. 2, pp. 295–302, May 2017, doi: 10.1007/s11325-016-1408-y.M. Diaz-Abad, W. Chatila, M. R. Lammi, I. Swift, G. E. D’Alonzo, and S. L. Krachman, “Determinants of CPAP Adherence in Hispanics with Obstructive Sleep Apnea,” Sleep Disorders, vol. 2014, no. 1, p. 878213, Jan. 2014, doi: 10.1155/2014/878213.A. Palm et al., “Socioeconomic Factors and Adherence to CPAP: The Population-Based Course of Disease in Patients Reported to the Swedish CPAP Oxygen and Ventilator Registry Study,” Chest, vol. 160, no. 4, pp. 1481–1491, Oct. 2021, doi: 10.1016/j.chest.2021.04.064.B. Salepci et al., “CPAP Adherence of Patients With Obstructive Sleep Apnea,” Respiratory Care, vol. 58, no. 9, p. 1467, Sep. 2013, doi: 10.4187/respcare.02139.M. E. Billings and S. Redline, “Socioeconomic Differences in CPAP Adherence,” in CPAP Adherence: Factors and Perspectives, C. M. Shapiro, M. Gupta, and D. Zalai, Eds. Cham: Springer International Publishing, 2022, pp. 103–108.E. M. Wickwire, S. L. Jobe, L. M. Oldstone, S. M. Scharf, A. M. Johnson, and J. S. Albrecht, “Lower socioeconomic status and co-morbid conditions are associated with reduced continuous positive airway pressure adherence among older adult medicare beneficiaries with obstructive sleep apnea,” Sleep, vol. 43, no. 12, p. zsaa122, 2020, doi: 10.1093/sleep/zsaa122.D. Rosa et al., “Obstructive Sleep Apnea and Adherence to Continuous Positive Airway Pressure (CPAP) Treatment: Let’s Talk about Partners!,” Healthc. (Basel, Switzerland), vol. 10, no. 5, May 2022, doi: 10.3390/healthcare10050943.K. G. Baron, H. E. Gunn, L. F. Wolfe, and P. C. Zee, “Relationships and CPAP adherence among women with obstructive sleep apnea,” Sleep Sci. Pract., vol. 1, no. 1, p. 10, 2017, doi: 10.1186/s41606-017-0011-x.T. Gentina et al., “Marital quality, partner’s engagement and continuous positive airway pressure adherence in obstructive sleep apnea,” Sleep Med., vol. 55, pp. 56–61, 2019, doi: https://doi.org/10.1016/j.sleep.2018.12.009.F. Gagnadoux et al., “Influence of marital status and employment status on long-term adherence with continuous positive airway pressure in sleep apnea patients.,” PLoS One, vol. 6, no. 8, p. e22503, 2011, doi: 10.1371/journal.pone.0022503.M. Goosmann, A. M. Williams, K. Springer, and K. L. Yaremchuk, “The Impact of Marital Status and Race in Obstructive Sleep Apnea,” Ear, Nose Throat J., p. 01455613221120068, Aug. 2022, doi: 10.1177/01455613221120068.N. Laharnar et al., “Bed partner perception of CPAP therapy on relationship satisfaction and intimacy—A European perspective from the ESADA network,” J. Sleep Res., 2023, doi: 10.1111/jsr.14125.T. E. Weaver, “Best Predictors of Continuous Positive Airway Pressure Adherence,” Sleep Medicine Clinics, vol. 17, no. 4, pp. 587–595, Dec. 2022, doi: 10.1016/j.jsmc.2022.07.005.F. Baratta et al., “Long-term prediction of adherence to continuous positive air pressure therapy for the treatment of moderate/severe obstructive sleep apnea syndrome,” Sleep Medicine, vol. 43, pp. 66–70, Mar. 2018, doi: 10.1016/j.sleep.2017.09.032.N. McArdle, G. Devereux, H. Heidarnejad, H. M. Engleman, T. W. Mackay, and N. J. Douglas, “Long-term use of CPAP therapy for sleep apnea/hypopnea syndrome.,” Am J Respir Crit Care Med, vol. 159, no. 4 Pt 1, pp. 1108–1114, Apr. 1999, doi: 10.1164/ajrccm.159.4.9807111.Pływaczewski, R.; Bieleń, P.; Bednarek, M.; Jonczak, L.; Górecka, D.; Sliwiński, P. Influence of neck circumference and body mass index on obstructive sleep apnoea severity in males. Adv. Respir. Med. 2008, 76, 313–320.Ahbab, S.; Ataoğlu, H.E.; Tuna, M.; Karasulu, L.; Çetin, F.; Temiz, L.Ü.; Yenigün, M. Neck circumference, metabolic syndrome and obstructive sleep apnea syndrome; Evaluation of possible linkage. Med Sci. Monit. Int. Med J. Exp. Clin. Res. 2013, 19, 111.Katz, I.; Stradling, J.; Swtsky, A.; Zamel, N.; Hoffstein, V. Do Patients with Obstructive Sleep Apnea Have Thick Necks? 1, 2. Am. Rev. Respir. Dis. 1990, 141, 1228–1231.R. Budhiraja et al., “Early CPAP Use Identifies Subsequent Adherence to CPAP Therapy,” Sleep, vol. 30, no. 3, pp. 320–324, Mar. 2007, doi: 10.1093/sleep/30.3.320.S. Mihaicuta et al., “Analyzing Neck Circumference as an Indicator of CPAP Treatment Response in Obstructive Sleep Apnea with Network Medicine,” Diagnostics, vol. 11, no. 1, 2021, doi: 10.3390/diagnostics11010086.“Aval del Comité de Ética, Facultad de Ingeniería, Universidad de los Andes” Proyecto de Diseño, 2024, archivo: Aval_Uniandes.pdf“Protocolo Datos Clínicos y Demográficos” Proyecto de Diseño, 2024, archivo: SOLMED_Protocolo.pdf“Cronograma Datos Clínicos y Demográficos” Proyecto de Diseño, 2024, archivo: Cronograma.pdf“Presupuesto” Proyecto de Diseño, 2024, archivo: PresupuestoGeneral.pdf“Entrevista #8,” Proyecto de Diseño, 2024, archivo: Lina_Samper_Psicologia.pptxD. Pilat y S. Krastev, “The COM-B model for behavior change”, The Decision Lab. [En línea]. Disponible en: https://thedecisionlab.com/reference-guide/organizational-behavior/the-com-b-model-for-behavior-change. [Consultado: 03-jun-2024].“Entrevista #9,” Proyecto de Diseño, 2024, archivo: Veronica_Marquez_Psicologia.pptxJ. D. Doorley, F. R. Goodman, K. C. Kelso, y T. B. Kashdan, “Psychological flexibility: What we know, what we do not know, and what we think we know”, Soc. Personal. Psychol. Compass, vol. 14, núm. 12, pp. 1–11, 2020.R. C. Kamody et al., “Psychological flexibility among youth with type 1 diabetes: Relating patterns of acceptance, adherence, and stress to adaptation”, Behav. Med., vol. 44, núm. 4, pp. 271–279, 2018.E. Moitra y B. A. Gaudiano, “A psychological flexibility model of medication adherence in psychotic-spectrum disorders”, J. Contextual Behav. Sci., vol. 5, núm. 4, pp. 252–257, 2016.A. Harrison, W. Scott, L. Timmins, C. D. Graham, y A. M. Harrison, “Investigating the potentially important role of psychological flexibility in adherence to antiretroviral therapy in people living with HIV”, AIDS Care, vol. 33, núm. 3, pp. 337–346, 2021Á. Menéndez-Aller, M. Cuesta, Á. Postigo, C. González-Nuevo, J. García-Fernández, y E. García-Cueto, “Validation of the Acceptance and Action Questionnaire-II in the general Spanish population”, Curr. Psychol., 2021.N. J. Williams et al., “The effects of social support and support types on continuous positive airway pressure use after 1 month of therapy among adults with obstructive sleep apnea”, 2024.D. C. Siebert, E. J. Mutran, y D. C. Reitzes, “Friendship and social support: the importance of role identity to aging adults”, Soc. Work, vol. 44, núm. 6, pp. 522–533, 1999.Center for Aging in Diverse Communities, “MOS SOCIAL SUPPORT SURVEY (MOS-SSS): SPANISH”, Ucsf.edu, 2020. [En línea]. Disponible en: https://cadc.ucsf.edu/sites/g/files/tkssra881/f/MOS%20Social%20Support%20Sorvey%20Spanish.pdf. [Consultado: 20-may-2024].N. E. Londoño, H. Rogers, J.F. Castilla, S. Posada, N. Ochoa, D. Aguirre. (2012). Validación en Colombia del cuestionario MOS de apoyo social. International Journal of Psychological Research, 5(1), 142-150.G. Hawthorne, “Measuring social isolation in older adults: Development and initial validation of the friendship scale”, Soc. Indic. Res., vol. 77, núm. 3, pp. 521–548, 2006.S. Alfonsson, K. Johansson, J. Uddling, y T. Hursti, “Differences in motivation and adherence to a prescribed assignment after face-to-face and online psychoeducation: an experimental study”, BMC Psychol., vol. 5, núm. 1, p. 3, 2017.R. Radel, L. Pelletier, D. Pjevac, y B. Cheval, “The links between self-determined motivations and behavioral automaticity in a variety of real-life behaviors”, Motiv. Emot., vol. 41, núm. 4, pp. 443–454, 2017.J. Martín-Albo, J. L. Núñez, y J. G. Navarro, “Validation of the Spanish version of the Situational Motivation Scale (EMSI) in the educational context”, Span. J. Psychol., vol. 12, núm. 2, pp. 799–807, 2009.“Encuesta Recolección Variables Psicológicas” Proyecto de Diseño, 2024, archivo: Encuesta_Variables_Psicologicas.pdfA.-R. Blais and E. U. Weber, “A Domain-Specific Risk-Taking (DOSPERT) scale for adultpopulations,” Judgm. Decis. Mak., vol. 1, no. 1, pp. 33–47, 2006, doi: 10.1017/S1930297500000334.B. L. Barfoed et al., “Associations between patients’ risk attitude and their adherence to statin treatment– a population based questionnaire and register study,” BMC Fam. Pract., vol. 17, no. 1, p. 28, 2016, doi: 10.1186/s12875-016-0423-1. [74] J. Zhu, Y. Shi, J. Li, and Z. Zhang, “Role of risk attitude and time preference in preventive aspirin use adherence,” J. Eval. Clin. Pract., vol. 26, no. 3, 2020, doi: 10.1111/jep.13274.J. Zhu, Y. Shi, J. Li, and Z. Zhang, “Role of risk attitude and time preference in preventive aspirin use adherence,” J. Eval. Clin. Pract., vol. 26, no. 3, 2020, doi: 10.1111/jep.13274N. Pelletier-Fleury et al., “Risk-seeking attitude in health and safety domain is associated with continuous positive airway pressure discontinuation in patients with obstructive sleep apnea- a multicenter prospective cohort study,” Sleep, vol. 44, no. 2, 2021, doi: 10.1093/sleep/zsaa156.P. Kasetti, N. F. Husain, T. C. Skinner, K. Asimakopoulou, J. Steier, and S. A. Sathyapala, “Personality traits and pre-treatment beliefs and cognitions predicting patient adherence to continuous positive airway pressure: A systematic review,” Sleep Medicine Reviews, vol. 74. 2024, doi: 10.1016/j.smrv.2024.101910.S. Olsen, S. Smith, T. Oei, and J. Douglas, “Health belief model predicts adherence to CPAP before experience with CPAP,” Eur. Respir. J., vol. 32, no. 3, 2008, doi: 10.1183/09031936.00127507.S. Okuboyejo, V. Mbarika, and N. Omoregbe, “The effect of self-efficacy and outcome expectation on medication adherence behavior.,” J. Public Health Africa, vol. 9, no. 3, p. 826, Dec. 2018, doi: 10.4081/jphia.2018.826.M. J. Martos-Méndez, “Self-efficacy and adherence to treatment: the mediating effects of social support,” J. Behav. Heal. Soc. Issues, vol. 7, no. 2, pp. 19–29, 2015, doi: https://doi.org/10.5460/jbhsi.v7.2.52889.S. Kojima et al., “Associations of self-efficacy and outcome expectancy with adherence to continuous positive airway pressure therapy in Japanese patients with obstructive sleep apnea,” Fujita Med. J., vol. 9, no. 2, 2023, doi: 10.20407/fmj.2022-015.R. Shaukat, Y. Gamal, A. Ali, and S. Mohamed, “Adherence to Positive Airway Pressure Therapy in Patients With Obstructive Sleep Apnea,” Cureus, 2022, doi: 10.7759/cureus.25946.D. M. Wallace, S. Shafazand, M. S. Aloia, and W. K. Wohlgemuth, “The association of age, insomnia, and self-efficacy with continuous positive airway pressure adherence in black, white, and Hispanic US veterans,” J. Clin. Sleep Med., vol. 9, no. 9, 2013, doi: 10.5664/jcsm.2988.T. Nguyen et al., “0571 Utilization of Self-Efficacy Measure of Sleep Apnea (SEMSA) questionnaire to Predict CPAP Adherence,” Sleep, vol. 46, no. Supplement_1, pp. A251–A251, 2023, doi: 10.1093/sleep/zsad077.0571.Mateus-Galeano EM, Céspedes-Cuevas VM. Validez y confiabilidad del instrumento "Medición de la autoeficacia percibida en apnea del sueño" - SEMSA. Versión en español. Aquichan. 2016;16(1):67-82. DOI: 10.5294/aqui.2016.16.1.8“Protocolo Datos Psicológicos” Proyecto de Diseño, 2024, archivo: SOLMED_Protocolo2.pdf“Cronograma Datos Psicológicos” Proyecto de Diseño, 2024, archivo: Cronograma 2.xlGrau, J. Pensando en el usuario: la usabilidad. 2007. Anuario ThinkEPI, pp. 172 - 177.“Experimentaciones de diseño,” Proyecto de Diseño, 2024, archivo: Proceso_de_diseño.pptx“Encuesta de Usabilidad” Proyecto de Diseño, 2024, archivo: EncuestaUsabilidad.pdf“Entrevista #11,” Proyecto de Diseño, 2024, archivo: Camilo_Escobar.pptx“Entrevista #8,” Proyecto de Diseño, 2024, archivo: Pamela_Ramirez.pptxS. Alfonsson, K. Johansson, J. Uddling, y T. Hursti, “Differences in motivation and adherence to a prescribed assignment after face-to-face and online psychoeducation: an experimental study”, BMC Psychol., vol. 5, núm. 1, p. 3, 2017. J. L. Ortiz and D. Rosselli, “Adherence to Positive Airway Pressure Therapy in a Cohort of Colombian Patients with Obstructive Sleep Apnea Syndrome,” Sleep Sci., vol. 16, no. 2, 2023, doi: 10.1055/s-0043-1770799.Ministerio de Salud y Protección Social, “Boletines Poblacionales: Género - Mujeres, hombres y personas de los sectores sociales LGBTI”, Gov.co, 2020. [En línea]. Disponible en: https://www.minsalud.gov.co/sites/rid/Lists/BibliotecaDigital/RIDE/DE/PS/boletines-poblacionales-genero.pdf. [Consultado: 16-oct-2024].S. Diaz, “Cifras de Kantar indicaron que la población estrato 1 en Colombia corresponde al 21%”, Diario La República, 15-mar-2022. [En línea]. Disponible en: https://www.larepublica.co/empresas/kantar-da-a-conocer-cifras-relevantes-en-el-marco-del-dia-mundial-del-consumidor-3322740. [Consultado: 16-oct-2024].X, Valderrama-Penagos; KL, Dueñas-Quintero; KA, Guzmán-Ortiz. Descripción de la frecuencia de factores de mala adherencia en la terapia con presión positiva en la vía aérea (CPAP-BPAP-APAP) en pacientes con AOS pertenecientes al Hospital Militar Central de Colombia entre 2015-2020. Acta de Otorrinolaringología CCC. 2023;51(3):212-221J. F. Z. Valencia, “Lo que implica para el país que 2,6 millones de personas vivan solas”, El Colombiano, 27-ago-2020. [En línea]. Disponible en: https://www.elcolombiano.com/colombia/retos-y-realidades-de-los-hogares-unipersonales-en-colombia-JG13515905. [Consultado: 16-oct-2024].G. Ernst, M. Saban, y M. Schiavone, “Prevalencia y características de apneas obstructivas de sueño según gravedad”, Medicinabuenosaires.com. [En línea]. Disponible en: https://www.medicinabuenosaires.com/indices-de-2020/volumen-80-ano-2020-no-5-indice/prevalencia_apneas/. [Consultado: 16-oct-2024].S. Pita Fernández, “Guía: Determinación del tamaño muestral - Fisterra”, 1996. [En línea]. Disponible en: https://www.fisterra.com/formacion/metodologia-investigacion/determinacion-tamano-muestral/. [Consultado: 23-sep-2024].Departamento Administrativo Nacional de Estadística, “DANE - Proyecciones de población, Serie nacional de población por área, para el periodo 2020-2070”, Gov.co, 2023. [En línea]. Disponible en: https://www.dane.gov.co/index.php/estadisticas-por-tema/demografia-y-poblacion/proyecciones-de-poblacion. [Consultado: 23-sep-2024].S. Bottia, H. Barrios-Bermúdez, y D. Rosselli, «Prevalencia de apnea de sueño en Colombia: un análisis de las bases de datos del Ministerio de Salud», Iatreia, vol. 37, n.º 1, jun. 2023.“Alertas Sanitarias,” Invima, https://app.invima.gov.co/alertas/dispositivos-medicos-invima?field_tipo_de_documento_value=1&field_a_o_value=4&page=34 (accessed Aug. 27, 2024).“Recognized Consensus Standards: Medical Devices,” Fda.gov, 2019. https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfstandards/detail.cfm?standard__identification_no=39510 (accessed Aug. 28, 2024).FDA, “Proposed Regulatory Framework for Modifications to Artificial Intelligence/Machine Learning (AI/ML)-Based Software as a Medical Device (SaMD) - Discussion Paper and Request for Feedback”, 2019. Accedido el 31 de agosto de 2024. [En línea]. Disponible: https://www.fda.gov/media/122535/download?attachmentFDA. “Regulatory Controls”. U.S. Food and Drug Administration. Accedido el 1 de septiembre de 2024. [En línea]. Disponible: https://www.fda.gov/medical-devices/overview-device-regulation/regulatory-controls“ISO 80601-2-70:2020 Medical Electrical Equipment Part 2-70: Particular requirements for the basic safety and essential performance of Sleep ApnoEA Breathing therapy equipment,” ISO, 2018. https://www.iso.org/standard/75947.html“ISO 17510:2015 Medical devices — Sleep apnoea breathing therapy — Masks and application accessories,” ISO, 2015. https://www.iso.org/es/contents/data/standard/06/49/64910.html“ISO/CD TS 24971-2 Medical Devices — Guidance on the application of ISO 14971 Part 2: Machine Learning in Artificial Intelligence,” ISO. https://www.iso.org/standard/87600.htmlUniversitat Oberta de Catalunya. (s/f). N-Fold Cross-Validation. Uoc.edu. Disponible en: https://datascience.recursos.uoc.edu/es/n-fold-cross-validation/X. Huang, A. Khetan, M. Cvitkovic, and Z. S. Karnin, “TabTransformer: Tabular Data Modeling Using Contextual Embeddings,” CoRR, vol. abs/2012.0, 2020, [Online]. Available: [2012.06678] TabTransformer: Tabular Data Modeling Using Contextual Embeddings“Entrevista #12” Proyecto de Diseño, 2024, archivo: Christian_Perdomo.pptx“Taller de Vigilancia Tecnológica” Proyecto de Diseño, 2024, archivo: VigilanciaT_SOLMED_Equipo1.pptxP. Catalán et al., “Consistencia interna y validez de la versión española del cuestionario de calidad de vida específico para el síndrome de apnea del sueño: Sleep Apnoea Quality of Life Index,” Arch. Bronconeumol., vol. 48, no. 12, 2012, doi: 10.1016/j.arbres.2012.05.004.L. E. Lugo, H. I. García, and C. Gómez, “Confiabilidad del cuestionario de calidad de vida en salud SF-36 en Medellín, Colombia,” Rev. Fac. Nac. Salud Pública, vol. 24, no. 2, 2008, doi: 10.17533/udea.rfnsp.243.L. Zhou, J. Bao, I. M. A. Setiawan, A. Saptono, and B. Parmanto, “The mHealth App Usability Questionnaire (MAUQ): Development and Validation Study,” JMIR Mhealth Uhealth, vol. 7, no. 4, p. e11500, Apr. 2019, doi: 10.2196/11500.“mHealth App Usability Questionnaire (MAUQ) for Standalone mHealth Apps Used by Patients” Proyecto de Diseño, 2024, archivo: MAUQ_SPA_SusanaMontes.pdfMinisterio de la Protección Social, “DECRETO NÚMERO 4725 DE 2005”, 2005. [En línea]. Disponible en: https://www.invima.gov.co/sites/default/files/dispositivos-medicos/2023-10/DECRETO%204725%20DE%202005.pdf.International Medical Device Regulators Forum, "Software as a Medical Device (SaMD): Key Definitions," IMDRF/SaMD WG/N10FINAL:2013, 2013.Departamento Administrativo de la Función Pública, "Ley Estatutaria 1581 de 2012," 2012.. [Online]. Available: https://www.funcionpublica.gov.co/eva/gestornormativo/norma.php?i=49981. [Accessed: Dec. 7, 2024].NQA, "ISO 13485 - Sistema de gestión de calidad para dispositivos médicos," [Online]. Available: https://www.nqa.com/es-co/certification/standards/iso-13485. [Accessed: Dec. 7, 2024].ISO, "ISO 14971: Gestión de Riesgos para Dispositivos Médicos," [Online]. Available: https://www.iso.org/obp/ui#iso:std:iso:14971:ed-3:v1:es. [Accessed: Dec. 7, 2024].Medical Electrical Equipment - Part 1: General Requirements for Basic Safety and Essential Performance. IEC 60601-1, 3.2ª edición, 2020. [Online]. Disponible en: https://www.intertek.es/equipos-medicos/seguridad-iec-60601/International Organization for Standardization, "ISO 9001:2008 - Quality management systems — Requirements," ISO, Geneva, Switzerland, 2008. [Online]. Available: https://www.iso.org/standard/38421.html"ISO 27001 paso a paso - Implementación del SGSI," Norma ISO 27001, 2024. [En línea]. Disponible en: https://www.normaiso27001.es/. [Accedido: 7 de diciembre de 2024].S. Blank and B. Dorf, Disciplined Entrepreneurship Workbook - DE Canvas, WILEY."ModeloFinanciero," Proyecto de Diseño, 2024: archivo de Microsoft Excel: ModeloFinanciero_SOLMED_Equipo1.xlsx.N. González Mangado, C. J. Egea-Santaolalla, E. Chiner Vives, and O. Mediano, “Apnea obstructiva del sueño,” Open Respiratory Archives, Apr. 2020"Plan Financiero," Proyecto de Diseño, 2024: archivo de Microsoft Excel: CalendarioPlanFinanciero.xlsx.“Sleep Apnea Devices Market Size | Global Industry Report, 2032”. Fortune Business Insights™ | Global Market Research Reports & Consulting, 2024. [En línea] Disponible en:https://www.fortunebusinessinsights.com/industry-reports/sleep-apnea-devices-market-100708201821284202111125202111099202115854Publication7136bea3-d8a6-43c5-b5c9-6b4af41cf94cvirtual::21989-17136bea3-d8a6-43c5-b5c9-6b4af41cf94cvirtual::21989-1ORIGINALNoap: Un servicio innovador para el tratamiento de la Apnea Obstructiva del Sueño.pdfNoap: Un servicio innovador para el tratamiento de la Apnea Obstructiva del Sueño.pdfapplication/pdf11997994https://repositorio.uniandes.edu.co/bitstreams/46ad1848-6bd8-4f96-acff-80ce669998af/download1cb1c825b5b6ccbb33463653cbbe8cb5MD51Formato de autorización para el repositorio.pdfFormato de autorización para el repositorio.pdfHIDEapplication/pdf436793https://repositorio.uniandes.edu.co/bitstreams/fca2d534-8a08-4e36-abcd-0f3dcfedb40d/downloadfd8166fccd84b0231ff16c0d84d90539MD52LICENSElicense.txtlicense.txttext/plain; charset=utf-82535https://repositorio.uniandes.edu.co/bitstreams/50758be4-73ef-4b10-b57a-84cf6af2c57b/downloadae9e573a68e7f92501b6913cc846c39fMD53CC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-8908https://repositorio.uniandes.edu.co/bitstreams/b106ba65-2abd-4485-84ae-3eb1570dc4b9/download0175ea4a2d4caec4bbcc37e300941108MD54TEXTNoap: Un servicio innovador para el tratamiento de la Apnea Obstructiva del Sueño.pdf.txtNoap: Un servicio innovador para el tratamiento de la Apnea Obstructiva del Sueño.pdf.txtExtracted texttext/plain101677https://repositorio.uniandes.edu.co/bitstreams/b22b7023-d6bf-406a-af59-ba2d33a8f3c1/downloadbc1b97cd43fefee2f8ac60a38607ebaaMD55Formato de autorización para el repositorio.pdf.txtFormato de autorización para el repositorio.pdf.txtExtracted texttext/plain2117https://repositorio.uniandes.edu.co/bitstreams/90c0c915-df9c-4427-9c38-57844175337b/download69a195f678ad9e14b457097a8b9a8075MD57THUMBNAILNoap: Un servicio innovador para el tratamiento de la Apnea Obstructiva del Sueño.pdf.jpgNoap: Un servicio innovador para el tratamiento de la Apnea Obstructiva del Sueño.pdf.jpgGenerated Thumbnailimage/jpeg9211https://repositorio.uniandes.edu.co/bitstreams/1f7d4397-1b20-41a1-9f6a-806885bca0b1/download1a52cffc4f13ecdd87024041e087cb3cMD56Formato de autorización para el repositorio.pdf.jpgFormato de autorización para el repositorio.pdf.jpgGenerated Thumbnailimage/jpeg10991https://repositorio.uniandes.edu.co/bitstreams/979fde2d-c430-4527-8bff-a0e47656b314/download340ec218f3c119503f6718d07922b642MD581992/75357oai:repositorio.uniandes.edu.co:1992/753572025-01-15 03:16:53.331http://creativecommons.org/licenses/by/4.0/Attribution 4.0 Internationalopen.accesshttps://repositorio.uniandes.edu.coRepositorio institucional Sénecaadminrepositorio@uniandes.edu.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 |