Efficacy of omadacycline against multidrug-resistant enterococcus faecium strains in a mouse peritonitis model

Omadacycline (OMC) showed better in vitro potency than daptomycin (DAP) or vancomycin (VAN) against Vanr, Ampr, DAP-nonsusceptible, linezolid-resistant, cfr(B)1 Enterococcus faecium strains. In a mouse peritonitis model, OMC also showed significantly better animal survival during the study and at it...

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Autores:
Singh, Kavindra V.
Arias, Cesar A.
Tipo de recurso:
https://purl.org/coar/resource_type/c_6501
Fecha de publicación:
2021
Institución:
Universidad El Bosque
Repositorio:
Repositorio U. El Bosque
Idioma:
eng
OAI Identifier:
oai:repositorio.unbosque.edu.co:20.500.12495/7160
Acceso en línea:
https://hdl.handle.net/20.500.12495/7160
https://doi.org/10.1128/AAC.00709-21
Palabra clave:
E. faecium
Mouse peritonitis
Omadacycline
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License
Acceso abierto
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dc.title.spa.fl_str_mv Efficacy of omadacycline against multidrug-resistant enterococcus faecium strains in a mouse peritonitis model
dc.title.translated.spa.fl_str_mv Efficacy of omadacycline against multidrug-resistant enterococcus faecium strains in a mouse peritonitis model
title Efficacy of omadacycline against multidrug-resistant enterococcus faecium strains in a mouse peritonitis model
spellingShingle Efficacy of omadacycline against multidrug-resistant enterococcus faecium strains in a mouse peritonitis model
E. faecium
Mouse peritonitis
Omadacycline
title_short Efficacy of omadacycline against multidrug-resistant enterococcus faecium strains in a mouse peritonitis model
title_full Efficacy of omadacycline against multidrug-resistant enterococcus faecium strains in a mouse peritonitis model
title_fullStr Efficacy of omadacycline against multidrug-resistant enterococcus faecium strains in a mouse peritonitis model
title_full_unstemmed Efficacy of omadacycline against multidrug-resistant enterococcus faecium strains in a mouse peritonitis model
title_sort Efficacy of omadacycline against multidrug-resistant enterococcus faecium strains in a mouse peritonitis model
dc.creator.fl_str_mv Singh, Kavindra V.
Arias, Cesar A.
dc.contributor.author.none.fl_str_mv Singh, Kavindra V.
Arias, Cesar A.
dc.contributor.orcid.none.fl_str_mv Beral, Valerie E. [https://orcid.org/0000-0002-3581-9361]
dc.subject.keywords.spa.fl_str_mv E. faecium
Mouse peritonitis
Omadacycline
topic E. faecium
Mouse peritonitis
Omadacycline
description Omadacycline (OMC) showed better in vitro potency than daptomycin (DAP) or vancomycin (VAN) against Vanr, Ampr, DAP-nonsusceptible, linezolid-resistant, cfr(B)1 Enterococcus faecium strains. In a mouse peritonitis model, OMC also showed significantly better animal survival during the study and at its end than DAP or VAN with these E. faecium strains. However, OMC, DAP, and VAN showed comparable in vitro and in vivo efficacies against a non-vancomycin-resistant, tetracycline-resistant, DAP-susceptible E. faecium strain.
publishDate 2021
dc.date.issued.none.fl_str_mv 2021
dc.date.accessioned.none.fl_str_mv 2022-03-07T21:08:57Z
dc.date.available.none.fl_str_mv 2022-03-07T21:08:57Z
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dc.type.local.none.fl_str_mv Artículo de revista
dc.type.coar.none.fl_str_mv https://purl.org/coar/resource_type/c_6501
dc.type.driver.none.fl_str_mv info:eu-repo/semantics/article
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dc.identifier.issn.none.fl_str_mv 0066-4804
dc.identifier.uri.none.fl_str_mv https://hdl.handle.net/20.500.12495/7160
dc.identifier.doi.none.fl_str_mv https://doi.org/10.1128/AAC.00709-21
dc.identifier.instname.spa.fl_str_mv instname:Universidad El Bosque
dc.identifier.reponame.spa.fl_str_mv reponame:Repositorio Institucional Universidad El Bosque
dc.identifier.repourl.none.fl_str_mv repourl:https://repositorio.unbosque.edu.co
identifier_str_mv 0066-4804
instname:Universidad El Bosque
reponame:Repositorio Institucional Universidad El Bosque
repourl:https://repositorio.unbosque.edu.co
url https://hdl.handle.net/20.500.12495/7160
https://doi.org/10.1128/AAC.00709-21
dc.language.iso.none.fl_str_mv eng
language eng
dc.relation.ispartofseries.spa.fl_str_mv Antimicrobial Agents and Chemotherapy, 0066-4804, Vol 65, Num 9, 2021
dc.relation.uri.none.fl_str_mv https://journals.asm.org/doi/10.1128/AAC.00709-21
dc.rights.coar.fl_str_mv http://purl.org/coar/access_right/c_abf2
dc.rights.local.spa.fl_str_mv Acceso abierto
dc.rights.accessrights.none.fl_str_mv https://purl.org/coar/access_right/c_abf2
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dc.format.mimetype.none.fl_str_mv application/pdf
dc.publisher.spa.fl_str_mv American Society for Microbiology
dc.publisher.journal.spa.fl_str_mv Antimicrobial Agents and Chemotherapy
institution Universidad El Bosque
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spelling Singh, Kavindra V.Arias, Cesar A.Beral, Valerie E. [https://orcid.org/0000-0002-3581-9361]2022-03-07T21:08:57Z2022-03-07T21:08:57Z20210066-4804https://hdl.handle.net/20.500.12495/7160https://doi.org/10.1128/AAC.00709-21instname:Universidad El Bosquereponame:Repositorio Institucional Universidad El Bosquerepourl:https://repositorio.unbosque.edu.coapplication/pdfengAmerican Society for MicrobiologyAntimicrobial Agents and ChemotherapyAntimicrobial Agents and Chemotherapy, 0066-4804, Vol 65, Num 9, 2021https://journals.asm.org/doi/10.1128/AAC.00709-21Efficacy of omadacycline against multidrug-resistant enterococcus faecium strains in a mouse peritonitis modelEfficacy of omadacycline against multidrug-resistant enterococcus faecium strains in a mouse peritonitis modelArtículo de revistahttps://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1info:eu-repo/semantics/articlehttps://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/version/c_970fb48d4fbd8a85E. faeciumMouse peritonitisOmadacyclineOmadacycline (OMC) showed better in vitro potency than daptomycin (DAP) or vancomycin (VAN) against Vanr, Ampr, DAP-nonsusceptible, linezolid-resistant, cfr(B)1 Enterococcus faecium strains. In a mouse peritonitis model, OMC also showed significantly better animal survival during the study and at its end than DAP or VAN with these E. faecium strains. However, OMC, DAP, and VAN showed comparable in vitro and in vivo efficacies against a non-vancomycin-resistant, tetracycline-resistant, DAP-susceptible E. faecium strain.Acceso abiertohttps://purl.org/coar/access_right/c_abf2Acceso abiertohttp://purl.org/coar/access_right/c_abf2ORIGINALEfficacy of omadacycline against multidrug-resistant enterococcus faecium strains in a mouse peritonitis model.pdfEfficacy of omadacycline against multidrug-resistant enterococcus faecium strains in a mouse peritonitis model.pdfEfficacy of omadacycline against multidrug-resistant enterococcus faecium strains in a mouse peritonitis modelapplication/pdf453352https://pruebas-update-repositorio-unbosque.cloudbiteca.com/bitstreams/5ec66cf2-35da-4ae5-8249-85125dd78934/download1ba7c9be4d824a96ef353b8e9f03dea3MD51trueAnonymousREADLICENSElicense.txtlicense.txttext/plain; charset=utf-81748https://pruebas-update-repositorio-unbosque.cloudbiteca.com/bitstreams/9d8148ef-5c74-4359-a4b4-bd3653eea50a/download8a4605be74aa9ea9d79846c1fba20a33MD52falseAnonymousREADTHUMBNAILEfficacy of omadacycline against multidrug-resistant enterococcus faecium strains in a mouse peritonitis model.pdf.jpgEfficacy of omadacycline against multidrug-resistant enterococcus faecium strains in a mouse peritonitis model.pdf.jpgIM Thumbnailimage/jpeg11547https://pruebas-update-repositorio-unbosque.cloudbiteca.com/bitstreams/833e8b2c-e213-4adb-b5ea-b621036fe786/downloadfb5d720f03f0955d2ca8d8b1361cdd10MD53falseAnonymousREADTEXTEfficacy of omadacycline against multidrug-resistant enterococcus faecium strains in a mouse peritonitis model.pdf.txtEfficacy of omadacycline against multidrug-resistant enterococcus faecium strains in a mouse peritonitis model.pdf.txtExtracted texttext/plain26836https://pruebas-update-repositorio-unbosque.cloudbiteca.com/bitstreams/40a6bc94-281f-4808-92e1-37da8d986f26/download0d4b9b81f8af79a378dbec7f9e247cf6MD54falseAnonymousREAD20.500.12495/7160oai:pruebas-update-repositorio-unbosque.cloudbiteca.com:20.500.12495/71602024-02-07T03:02:45.095Zopen.accesshttps://pruebas-update-repositorio-unbosque.cloudbiteca.comRepositorio Institucional Universidad El Bosquebibliotecas@biteca.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