Ceftaroline-resistant, daptomycin-tolerant, and heterogeneous vancomycin-intermediate methicillin-resistant Staphylococcus aureus causing infective endocarditis

We report a case of infective endocarditis (IE) caused by ceftaroline-resistant, daptomycin-tolerant, and heterogeneous vancomycin-intermediate methicillin-resistant S. aureus (MRSA). Resistance to ceftaroline emerged in the absence of drug exposure, and the E447K substitution in the active site of PBP2a previously associated with ceftaroline resistance was identified. Additionally, we present evidence of patient-to-patient transmission of the strain within the same unit. This case illustrates the difficulties in treating MRSA IE in the setting of a multidrug-resistant phenotype.

• Autores: Nigo, Masayuki; Diaz, Lorena; Carvajal Ortiz, Lina Paola; Tran, Truc T.; Rios, Rafael; panesso, diana; Garavito, Juan D.; Miller, William R.; Wanger, Audrey R.; Weinstock, George; Munita, Jose M.; Arias, César A.; Chambers, Henry
• Tipo de recurso: https://purl.org/coar/resource_type/c_6501
• Fecha de publicación: 2017
• Institución: Universidad El Bosque
• Repositorio: Repositorio U. El Bosque
• Idioma: eng
• OAI Identifier: oai:repositorio.unbosque.edu.co:20.500.12495/3423
• Acceso en línea: https://hdl.handle.net/20.500.12495/3423; https://doi.org/10.1128/aac.01235-16; https://repositorio.unbosque.edu.co
• Palabra clave: Farmacorresistencia bacteriana; Transmisión de enfermedad infecciosa; Insuficiencia del tratamiento; Staphylococcus aureus; Ceftaroline; Endocarditis.
• License: Acceso abierto