Uso de PET SCAN en el estudio de la fiebre de origen desconocido, en una IPS de alta complejidad en Bogotá DC, Colombia

Fever of unknown origin (FUO) remains a frequent diagnostic challenge in clinical practice, particularly in high-complexity settings. Despite advances in diagnostic methodologies, a significant proportion of patients remain without a clear etiological diagnosis, delaying timely therapeutic intervent...

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Autores:
Centeno Padilla, Maria Jose
Montenegro Charry, Adolfo Alejandro
Tipo de recurso:
https://purl.org/coar/resource_type/c_7a1f
Fecha de publicación:
2025
Institución:
Universidad El Bosque
Repositorio:
Repositorio U. El Bosque
Idioma:
spa
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oai:repositorio.unbosque.edu.co:20.500.12495/15553
Acceso en línea:
https://hdl.handle.net/20.500.12495/15553
Palabra clave:
Fiebre de origen desconocido
Tomografía por Emisión de Positrones
Tomografía Computarizada
Biomarcadores
Diagnóstico por Imagen
Estudios Retrospectivos
Fever of Unknown Origin
Positron Emission Tomography
Computed Tomography
Biomarkers
Diagnostic Imaging
Retrospective Studies
WB 115
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Attribution-NonCommercial-ShareAlike 4.0 International
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oai_identifier_str oai:repositorio.unbosque.edu.co:20.500.12495/15553
network_acronym_str UNBOSQUE2
network_name_str Repositorio U. El Bosque
repository_id_str
dc.title.none.fl_str_mv Uso de PET SCAN en el estudio de la fiebre de origen desconocido, en una IPS de alta complejidad en Bogotá DC, Colombia
dc.title.translated.none.fl_str_mv Use of PET SCAN in the study of fever of unknown origin at a highly complex IPS in Bogotá DC, Colombia
title Uso de PET SCAN en el estudio de la fiebre de origen desconocido, en una IPS de alta complejidad en Bogotá DC, Colombia
spellingShingle Uso de PET SCAN en el estudio de la fiebre de origen desconocido, en una IPS de alta complejidad en Bogotá DC, Colombia
Fiebre de origen desconocido
Tomografía por Emisión de Positrones
Tomografía Computarizada
Biomarcadores
Diagnóstico por Imagen
Estudios Retrospectivos
Fever of Unknown Origin
Positron Emission Tomography
Computed Tomography
Biomarkers
Diagnostic Imaging
Retrospective Studies
WB 115
title_short Uso de PET SCAN en el estudio de la fiebre de origen desconocido, en una IPS de alta complejidad en Bogotá DC, Colombia
title_full Uso de PET SCAN en el estudio de la fiebre de origen desconocido, en una IPS de alta complejidad en Bogotá DC, Colombia
title_fullStr Uso de PET SCAN en el estudio de la fiebre de origen desconocido, en una IPS de alta complejidad en Bogotá DC, Colombia
title_full_unstemmed Uso de PET SCAN en el estudio de la fiebre de origen desconocido, en una IPS de alta complejidad en Bogotá DC, Colombia
title_sort Uso de PET SCAN en el estudio de la fiebre de origen desconocido, en una IPS de alta complejidad en Bogotá DC, Colombia
dc.creator.fl_str_mv Centeno Padilla, Maria Jose
Montenegro Charry, Adolfo Alejandro
dc.contributor.advisor.none.fl_str_mv Mendoza, Mario
Plata, Juan David
dc.contributor.author.none.fl_str_mv Centeno Padilla, Maria Jose
Montenegro Charry, Adolfo Alejandro
dc.contributor.orcid.none.fl_str_mv https://orcid.org/0000-0002-4561-7077
https://orcid.org/0009-0009-7295-5256
dc.subject.none.fl_str_mv Fiebre de origen desconocido
Tomografía por Emisión de Positrones
Tomografía Computarizada
Biomarcadores
Diagnóstico por Imagen
Estudios Retrospectivos
topic Fiebre de origen desconocido
Tomografía por Emisión de Positrones
Tomografía Computarizada
Biomarcadores
Diagnóstico por Imagen
Estudios Retrospectivos
Fever of Unknown Origin
Positron Emission Tomography
Computed Tomography
Biomarkers
Diagnostic Imaging
Retrospective Studies
WB 115
dc.subject.keywords.none.fl_str_mv Fever of Unknown Origin
Positron Emission Tomography
Computed Tomography
Biomarkers
Diagnostic Imaging
Retrospective Studies
dc.subject.nlm.none.fl_str_mv WB 115
description Fever of unknown origin (FUO) remains a frequent diagnostic challenge in clinical practice, particularly in high-complexity settings. Despite advances in diagnostic methodologies, a significant proportion of patients remain without a clear etiological diagnosis, delaying timely therapeutic interventions. The 18F-FDG-PET/CT has emerged as a valuable tool for identifying infectious, inflammatory, or neoplastic foci in these cases. However, its performance in the Colombian population has not been widely documented. A retrospective descriptive study was conducted to assess the utility of 18F-FDG-PET/CT in the diagnostic approach to patients with FUO hospitalized at a tertiary care institution in Bogotá, Colombia, between 2019 and 2023. A total of 38 patients were included, and clinical, laboratory, and imaging data were collected. Descriptive statistical analysis was performed, including frequencies, percentages, medians, and interquartile ranges. In 84.2% of cases, 18F-FDG-PET/CT contributed to guiding the diagnosis or identifying a probable underlying cause. In 28 patients (73.68%), the PET/CT findings were concordant with other diagnostic tests and the final diagnosis. In 16 cases (42.10%), PET/CT findings led to changes in clinical management or prompted additional targeted investigations. In conclusion, 18F-FDG-PET/CT proved to be a highly useful diagnostic tool in the evaluation of patients with FUO, particularly in those with inconclusive initial workups.
publishDate 2025
dc.date.accessioned.none.fl_str_mv 2025-07-29T15:17:44Z
dc.date.available.none.fl_str_mv 2025-07-29T15:17:44Z
dc.date.issued.none.fl_str_mv 2025-07
dc.type.coar.fl_str_mv http://purl.org/coar/resource_type/c_7a1f
dc.type.local.spa.fl_str_mv Tesis/Trabajo de grado - Monografía - Especialización
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dc.identifier.instname.spa.fl_str_mv instname:Universidad El Bosque
dc.identifier.reponame.spa.fl_str_mv reponame:Repositorio Institucional Universidad El Bosque
dc.identifier.repourl.none.fl_str_mv repourl:https://repositorio.unbosque.edu.co
url https://hdl.handle.net/20.500.12495/15553
identifier_str_mv instname:Universidad El Bosque
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language spa
dc.relation.references.none.fl_str_mv 1. Haidar G, Singh N. Fever of unknown origin. N Engl J Med [Internet]. 2022;386(5):463–77. Disponible en: http://dx.doi.org/10.1056/nejmra2111003
2. Rayan K. Fever of unknown origin. Med Clin North Am. 2024;108(1):79–92. Disponible en: https://doi.org/10.1016/j.mcna.2023.05.016
3. Mansi L. Eugene C, Lin A, Alavi A, editores. PET and PET/CT: A clinical guide. 3rd ed. New York: Thieme Medical Publishers; 2019. ISBN: 9781626231344. Eur J Nucl Med Mol Imaging [Internet]. 2019;46(8):1760–1. Disponible en: http://dx.doi.org/10.1007/s00259-019-04364-x
4. Sokoloff L, Reivich M, Kennedy C, et al. The [14C] deoxyglucose method for the measurement of local cerebral glucose utilization: theory, procedure, and normal values in the conscious and anesthetized albino rat. J Neurochem. 1977;28(5):897–916.
5. Rivero A, Zambrana JL, Pachón J. Fiebre de duración intermedia. Enferm Infecc Microbiol Clin [Internet].2003;21(3):147–52. Disponible en: http://dx.doi.org/10.1016/s0213-005x(03)72904-8
6. Wright WF, Mulders-Manders CM, Auwaerter PG, Bleeker-Rovers CP. Fever of unknown origin (FUO) - A call for new research standards and updated clinical management. Am J Med [Internet]. 2022;135(2):173–8. Disponible en: http://dx.doi.org/10.1016/j.amjmed.2021.07.038
7. Schonau V, Vogel K, Englbrecht M. The value of 18F-FDG-PET/CT in identifying the cause of fever of unknown origin (FUO) and inflammation of unknown origin (IUO): data from a prospective study. Ann Rheum Dis. 2018;77(1):70–77. Disponible en: http://dx.doi.org/10.1136/annrheumdis-2017-211687
8. Erdem H, Baymakova M, Alkan S, et al. Classical fever of unknown origin in 21 countries with different economic development: an international ID-IRI study. Eur J Clin Microbiol Infect Dis. 2023;42(4):387–398. doi:10.1007/s10096-023-04561-5.
9. Fusco FM, Pisapia R, Nardiello S, et al. Fever of unknown origin (FUO): which are the factors influencing the final diagnosis? A 2005–2015 systematic review. BMC Infect Dis. 2019;19(1):653. doi:10.1186/s12879-019-4285-8.
10. Torné Cachot J, Baucells Azcona JM, Blanch Falp J, Camell Ilari H. Classic fever of unknown origin: analysis of a cohort of 87 patients according to the definition with qualitative study criterion. Med Clin (Barc). 2021;156(5):206–213. doi:10.1016/j.medcli.2020.03.014.
11. Kubota, K., Tanaka, N., Miyata, Y., Ohtsu, H., Nakahara, T., Sakamoto, S., Kudo, T., Nishiyama, Y., Tateishi, U., Murakami, K., Nakamoto, Y., Taki, Y., Kaneta, T., Kawabe, J., Nagamachi, S., Kawano, T., Hatazawa, J., Mizutani, Y., Baba, S., Kirii, K., … Kobayakawa, M. (2021). Comparison of 18F-FDG PET/CT and 67Ga-SPECT for the diagnosis of fever of unknown origin: a multicenter prospective study in Japan. Annals of nuclear medicine, 35(1), 31–46. https://doi.org/10.1007/s12149-020-01533-z
12. Spernovasilis, N., Tsioutis, C., Markaki, L., Zafeiri, M., Soundoulounaki, S., & Gikas, A. (2020). Fever of unknown origin caused by infectious diseases in the era of migrant and refugee crisis. Travel medicine and infectious disease, 33, 101425. https://doi.org/10.1016/j.tmaid.2019.05.011
13. Kim, Y. S., Kim, K. R., Kang, J. M., Kim, J. M., & Kim, Y. J. (2017). Etiology and clinical characteristics of fever of unknown origin in children: a 15-year experience in a single center. Korean journal of pediatrics, 60(3), 77–85. https://doi.org/10.3345/kjp.2017.60.3.77
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institution Universidad El Bosque
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spelling Mendoza, MarioPlata, Juan DavidCenteno Padilla, Maria JoseMontenegro Charry, Adolfo Alejandrohttps://orcid.org/0000-0002-4561-7077https://orcid.org/0009-0009-7295-52562025-07-29T15:17:44Z2025-07-29T15:17:44Z2025-07https://hdl.handle.net/20.500.12495/15553instname:Universidad El Bosquereponame:Repositorio Institucional Universidad El Bosquerepourl:https://repositorio.unbosque.edu.coFever of unknown origin (FUO) remains a frequent diagnostic challenge in clinical practice, particularly in high-complexity settings. Despite advances in diagnostic methodologies, a significant proportion of patients remain without a clear etiological diagnosis, delaying timely therapeutic interventions. The 18F-FDG-PET/CT has emerged as a valuable tool for identifying infectious, inflammatory, or neoplastic foci in these cases. However, its performance in the Colombian population has not been widely documented. A retrospective descriptive study was conducted to assess the utility of 18F-FDG-PET/CT in the diagnostic approach to patients with FUO hospitalized at a tertiary care institution in Bogotá, Colombia, between 2019 and 2023. A total of 38 patients were included, and clinical, laboratory, and imaging data were collected. Descriptive statistical analysis was performed, including frequencies, percentages, medians, and interquartile ranges. In 84.2% of cases, 18F-FDG-PET/CT contributed to guiding the diagnosis or identifying a probable underlying cause. In 28 patients (73.68%), the PET/CT findings were concordant with other diagnostic tests and the final diagnosis. In 16 cases (42.10%), PET/CT findings led to changes in clinical management or prompted additional targeted investigations. In conclusion, 18F-FDG-PET/CT proved to be a highly useful diagnostic tool in the evaluation of patients with FUO, particularly in those with inconclusive initial workups.Fundacion Santa Fe de BogotaEspecialista en Medicina InternaEspecializaciónLa fiebre de origen desconocido (FOD) representa un desafío diagnóstico frecuente en la práctica clínica, especialmente en contextos de alta complejidad. A pesar de los avances en métodos diagnósticos, una proporción importante de pacientes permanece sin un diagnóstico etiológico claro, lo cual retrasa intervenciones terapéuticas oportunas. El 18F-FDG-PET/CT ha emergido como una herramienta útil para detectar focos infecciosos, inflamatorios o neoplásicos en estos casos. Sin embargo, su rendimiento en la población colombiana no ha sido ampliamente documentado. Se llevó a cabo un estudio descriptivo retrospectivo con el objetivo de describir la utilidad del 18F-FDG-PET/CT en el abordaje diagnóstico de pacientes con FOD hospitalizados en una institución de alta complejidad en Bogotá, Colombia, entre 2019 y 2023. Se incluyeron 38 pacientes, recolectando datos clínicos, paraclínicos y hallazgos de imagen. El análisis estadístico fue descriptivo, incluyendo frecuencias, porcentajes, medianas y rangos intercuartílicos. En el 84,2% de los casos, el 18F-FDG-PET/CT permitió orientar el diagnóstico o identificar una causa probable. En 28 pacientes (73,68%), los hallazgos fueron concordantes con estudios diagnósticos complementarios y con el diagnóstico final. En 16 casos (42,10%), los hallazgos del PET/CT generaron cambios en la conducta clínica o motivaron estudios adicionales dirigidos. En conclusión, el 18F-FDG-PET/CT demostró ser una herramienta de alta utilidad diagnóstica en pacientes con FOD, especialmente en aquellos con estudios iniciales no concluyentes.application/pdfAttribution-NonCommercial-ShareAlike 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-sa/4.0/Acceso abiertohttps://purl.org/coar/access_right/c_abf2http://purl.org/coar/access_right/c_abf2Fiebre de origen desconocidoTomografía por Emisión de PositronesTomografía ComputarizadaBiomarcadoresDiagnóstico por ImagenEstudios RetrospectivosFever of Unknown OriginPositron Emission TomographyComputed TomographyBiomarkersDiagnostic ImagingRetrospective StudiesWB 115Uso de PET SCAN en el estudio de la fiebre de origen desconocido, en una IPS de alta complejidad en Bogotá DC, ColombiaUse of PET SCAN in the study of fever of unknown origin at a highly complex IPS in Bogotá DC, ColombiaEspecialización en Medicina InternaUniversidad El BosqueFacultad de MedicinaTesis/Trabajo de grado - Monografía - Especializaciónhttps://purl.org/coar/resource_type/c_7a1fhttp://purl.org/coar/resource_type/c_7a1finfo:eu-repo/semantics/bachelorThesishttps://purl.org/coar/version/c_ab4af688f83e57aa1. Haidar G, Singh N. Fever of unknown origin. N Engl J Med [Internet]. 2022;386(5):463–77. Disponible en: http://dx.doi.org/10.1056/nejmra21110032. Rayan K. Fever of unknown origin. Med Clin North Am. 2024;108(1):79–92. Disponible en: https://doi.org/10.1016/j.mcna.2023.05.0163. Mansi L. Eugene C, Lin A, Alavi A, editores. PET and PET/CT: A clinical guide. 3rd ed. New York: Thieme Medical Publishers; 2019. ISBN: 9781626231344. Eur J Nucl Med Mol Imaging [Internet]. 2019;46(8):1760–1. Disponible en: http://dx.doi.org/10.1007/s00259-019-04364-x4. Sokoloff L, Reivich M, Kennedy C, et al. The [14C] deoxyglucose method for the measurement of local cerebral glucose utilization: theory, procedure, and normal values in the conscious and anesthetized albino rat. J Neurochem. 1977;28(5):897–916.5. Rivero A, Zambrana JL, Pachón J. Fiebre de duración intermedia. Enferm Infecc Microbiol Clin [Internet].2003;21(3):147–52. Disponible en: http://dx.doi.org/10.1016/s0213-005x(03)72904-86. Wright WF, Mulders-Manders CM, Auwaerter PG, Bleeker-Rovers CP. Fever of unknown origin (FUO) - A call for new research standards and updated clinical management. Am J Med [Internet]. 2022;135(2):173–8. Disponible en: http://dx.doi.org/10.1016/j.amjmed.2021.07.0387. Schonau V, Vogel K, Englbrecht M. The value of 18F-FDG-PET/CT in identifying the cause of fever of unknown origin (FUO) and inflammation of unknown origin (IUO): data from a prospective study. Ann Rheum Dis. 2018;77(1):70–77. Disponible en: http://dx.doi.org/10.1136/annrheumdis-2017-2116878. Erdem H, Baymakova M, Alkan S, et al. Classical fever of unknown origin in 21 countries with different economic development: an international ID-IRI study. Eur J Clin Microbiol Infect Dis. 2023;42(4):387–398. doi:10.1007/s10096-023-04561-5.9. Fusco FM, Pisapia R, Nardiello S, et al. Fever of unknown origin (FUO): which are the factors influencing the final diagnosis? A 2005–2015 systematic review. BMC Infect Dis. 2019;19(1):653. doi:10.1186/s12879-019-4285-8.10. Torné Cachot J, Baucells Azcona JM, Blanch Falp J, Camell Ilari H. Classic fever of unknown origin: analysis of a cohort of 87 patients according to the definition with qualitative study criterion. Med Clin (Barc). 2021;156(5):206–213. doi:10.1016/j.medcli.2020.03.014.11. Kubota, K., Tanaka, N., Miyata, Y., Ohtsu, H., Nakahara, T., Sakamoto, S., Kudo, T., Nishiyama, Y., Tateishi, U., Murakami, K., Nakamoto, Y., Taki, Y., Kaneta, T., Kawabe, J., Nagamachi, S., Kawano, T., Hatazawa, J., Mizutani, Y., Baba, S., Kirii, K., … Kobayakawa, M. (2021). Comparison of 18F-FDG PET/CT and 67Ga-SPECT for the diagnosis of fever of unknown origin: a multicenter prospective study in Japan. Annals of nuclear medicine, 35(1), 31–46. https://doi.org/10.1007/s12149-020-01533-z12. Spernovasilis, N., Tsioutis, C., Markaki, L., Zafeiri, M., Soundoulounaki, S., & Gikas, A. (2020). Fever of unknown origin caused by infectious diseases in the era of migrant and refugee crisis. Travel medicine and infectious disease, 33, 101425. https://doi.org/10.1016/j.tmaid.2019.05.01113. Kim, Y. S., Kim, K. R., Kang, J. M., Kim, J. M., & Kim, Y. J. (2017). Etiology and clinical characteristics of fever of unknown origin in children: a 15-year experience in a single center. 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