Scoping review: alteraciones neurocognitivas en trabajadores expuestos a plaguicidas

Resumen: Introducción: La exposición ocupacional a plaguicidas se ha correlacionado con alteraciones del sistema nervioso central dando lugar a enfermedades como la enfermedad de Parkinson y las demencias. Este estudio tuvo como objetivo identificar la evidencia existente sobre las alteraciones neur...

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Autores:
González Russi, Gyra Alejandra
Gómez Esteban, Natalia
Barrera Barrera , Julián David
Tipo de recurso:
https://purl.org/coar/resource_type/c_7a1f
Fecha de publicación:
2025
Institución:
Universidad El Bosque
Repositorio:
Repositorio U. El Bosque
Idioma:
spa
OAI Identifier:
oai:repositorio.unbosque.edu.co:20.500.12495/13931
Acceso en línea:
https://hdl.handle.net/20.500.12495/13931
Palabra clave:
Plaguicidas
Exposición ocupacional
Enfermedades del sistema nervioso
Enfermedad de Alzheimer
Enfermedad de Parkinson
658.38
Pesticides
Occupational exposure
Diseases of the central nervous system
Alzheimer's disease
Parkinson's disease
Rights
License
Attribution-NonCommercial-ShareAlike 4.0 International
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oai_identifier_str oai:repositorio.unbosque.edu.co:20.500.12495/13931
network_acronym_str UNBOSQUE2
network_name_str Repositorio U. El Bosque
repository_id_str
dc.title.none.fl_str_mv Scoping review: alteraciones neurocognitivas en trabajadores expuestos a plaguicidas
dc.title.translated.none.fl_str_mv Scoping review: neurocognitive disorders in workers exposed to pesticides
title Scoping review: alteraciones neurocognitivas en trabajadores expuestos a plaguicidas
spellingShingle Scoping review: alteraciones neurocognitivas en trabajadores expuestos a plaguicidas
Plaguicidas
Exposición ocupacional
Enfermedades del sistema nervioso
Enfermedad de Alzheimer
Enfermedad de Parkinson
658.38
Pesticides
Occupational exposure
Diseases of the central nervous system
Alzheimer's disease
Parkinson's disease
title_short Scoping review: alteraciones neurocognitivas en trabajadores expuestos a plaguicidas
title_full Scoping review: alteraciones neurocognitivas en trabajadores expuestos a plaguicidas
title_fullStr Scoping review: alteraciones neurocognitivas en trabajadores expuestos a plaguicidas
title_full_unstemmed Scoping review: alteraciones neurocognitivas en trabajadores expuestos a plaguicidas
title_sort Scoping review: alteraciones neurocognitivas en trabajadores expuestos a plaguicidas
dc.creator.fl_str_mv González Russi, Gyra Alejandra
Gómez Esteban, Natalia
Barrera Barrera , Julián David
dc.contributor.advisor.none.fl_str_mv López Michelena, Luis Ignacio
Giraldo Luna, Clara Margarita
dc.contributor.author.none.fl_str_mv González Russi, Gyra Alejandra
Gómez Esteban, Natalia
Barrera Barrera , Julián David
dc.contributor.orcid.none.fl_str_mv González Russi, Gyra Alejandra [0009-0003-4623-1357]
Gómez Esteban, Natalia [0009-0002-7386-6641]
Barrera Barrera, Julián David [0009-0003-3304-638X]
dc.subject.none.fl_str_mv Plaguicidas
Exposición ocupacional
Enfermedades del sistema nervioso
Enfermedad de Alzheimer
Enfermedad de Parkinson
topic Plaguicidas
Exposición ocupacional
Enfermedades del sistema nervioso
Enfermedad de Alzheimer
Enfermedad de Parkinson
658.38
Pesticides
Occupational exposure
Diseases of the central nervous system
Alzheimer's disease
Parkinson's disease
dc.subject.ddc.none.fl_str_mv 658.38
dc.subject.keywords.none.fl_str_mv Pesticides
Occupational exposure
Diseases of the central nervous system
Alzheimer's disease
Parkinson's disease
description Resumen: Introducción: La exposición ocupacional a plaguicidas se ha correlacionado con alteraciones del sistema nervioso central dando lugar a enfermedades como la enfermedad de Parkinson y las demencias. Este estudio tuvo como objetivo identificar la evidencia existente sobre las alteraciones neurocognitivas en trabajadores expuestos a plaguicidas. Metodología: Se realizó un scoping review en los motores de búsqueda PubMed, Clinical Key, SpringerLink, Web of Science y Elsevier. Las palabras claves fueron "Pesticides", “Cognitive Dysfunction", "Neurocognitive Disorders", "Neurological Disorders" y “Cognitive Function", y se incluyeron investigaciones publicadas entre 2019 y 2024. Los criterios de inclusión fueron delineados con las características de la población, el concepto y el contexto (PCC): trabajadores expuestos a plaguicidas, desarrollo de alteraciones neurocognitivas y exposición ocupacional a plaguicidas. Resultados: La revisión incluyó 20 artículos, destacando la asociación entre exposición ocupacional a plaguicidas y el desarrollo de enfermedades neurocognitivas como EA, EP y deterioro cognitivo. Varios plaguicidas tienen asociaciones estadísticamente significativas con las alteraciones neurocognitivas; además, existen varios factores de riesgo como el tiempo de exposición, frecuencia de aplicación y el uso insuficiente de EPP. La inhibición de enzimas como la AChE y la BChE se relaciona con déficits neurocognitivos. Conclusiones: La exposición ocupacional a plaguicidas se relaciona con el desarrollo de alteraciones neurocognitivas, principalmente la EP y la EA, además de afectar funciones cognitivas esenciales como la memoria y la atención. Se han identificado varios plaguicidas específicos que aumentan el riesgo de patologías neurocognitivas (clorpirifos, β-hexaclorociclohexano, diclorodifenildicloroetileno, paraquat, rotenona, diquat, 2,4,5-T y trifluralina). Sin embargo, todos los grupos de plaguicidas se han relacionado con la aparición de alteraciones neurocognitivas.
publishDate 2025
dc.date.accessioned.none.fl_str_mv 2025-02-12T13:05:09Z
dc.date.available.none.fl_str_mv 2025-02-12T13:05:09Z
dc.date.issued.none.fl_str_mv 2025-01
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dc.type.local.none.fl_str_mv Tesis/Trabajo de grado - Monografía - Especialización
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dc.type.driver.none.fl_str_mv info:eu-repo/semantics/bachelorThesis
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dc.identifier.instname.spa.fl_str_mv instname:Universidad El Bosque
dc.identifier.reponame.spa.fl_str_mv reponame:Repositorio Institucional Universidad El Bosque
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identifier_str_mv instname:Universidad El Bosque
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8. Flores-Gutierrez CA, Torres-Sanchez ED, Reyes-Uribe E, Torres-Jasso JH, Reyna-Villela MZ, Rojas-Bravo D, et al. The Association between Pesticide Exposure and the Development of Fronto-Temporal Dementia-Cum-Dissociative Disorders: A Review. Vol. 13, Brain Sciences; 2023.
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12. Tricco AC, Lillie E, Zarin W, O’Brien KK, Colquhoun H, Levac D, et al. PRISMA extension for scoping reviews (PRISMA-ScR): Checklist and explanation. Vol. 169, Annals of Internal Medicine. American College of Physicians; 2018. p. 467–73.
13. Schneider Medeiros M, P. Reddy S, P. Socal M, Schumacher-Schuh AF, Mello Rieder CR. Occupational pesticide exposure and the risk of death in patients with Parkinson’s disease: An observational study in southern Brazil. Environmental Health: A Global Access Science Source. 2020 Jun 17;19(1). DOI:10.1186/s12940-020-00624-8
14. Silvestre GCSB, Ferreira MJM, Figueiredo Sue EFMR, Silva CAL, Siqueira HH, Silva AMC. Parkinson disease and occupational and environmental exposure to pesticides in a region of intense agribusiness activity in Brazil: a case-control study. Journal of Occupational and Environmental Medicine. 2020 Dec 1;62(12):e732–7. DOI: 10.1097/JOM.0000000000002043
15. Perrin L, Spinosi J, Chaperon L, Kab S, Moisan F, Ebaz A. Pesticides expenditures by farming type and incidence of Parkinson disease in farmers: A French nationwide study. Environ Res [Internet]. 2021 Jun [cited 2024 Nov 16];197:111161. DOI: 10.1016/j.envres.2021.111161
16. Sturm ET, Castro C, Mendez-Colmenares A, Duffy J, Burzynska AAZ, Stallones L, et al. Risk Factors for Brain Health in Agricultural Work: A Systematic Review. Int J Environ Res Public Health [Internet]. 2022 Mar 13;19(6). Available from: http://www.ncbi.nlm.nih.gov/pubmed/35329061. DOI:10.3390/ijerph19063373
17. Brown EG, Goldman SM, Coffey CS, Siderowf A, Simuni T, Meng C, et al. Occupational Pesticide Exposure in Parkinson’s Disease Related to GBA and LRRK2 Variants. Journal of Intelligent and Fuzzy Systems. 2024 Jun 4;14(4):737–46 DOI: 10.3233/JPD-240015
18. de Graaf L, Boulanger M, Bureau M, Bouvier G, Meryet-Figuiere M, Tual S, et al. Occupational pesticide exposure, cancer and chronic neurological disorders: A systematic review of epidemiological studies in greenspace workers. Environ Res [Internet]. 2022 Jan 1 [cited 2024 Nov 16];203:111822. DOI10.1016/j.envres.2021.111822
19. Shrestha S, Parks CG, Umbach DM, Richards-Barber M, Hofmann JN, Chen H, et al. Pesticide use and incident Parkinson’s disease in a cohort of farmers and their spouses. Environmental Research. 2020 Dec 1;191. DOI: 10.1016/j.envres.2020.110186
20. Arab A, Mostafalou S. Neurotoxicity of pesticides in the context of CNS chronic diseases. Vol. 32, International Journal of Environmental Health Research; 2022. p. 2718–55. DOI: 10.1080/09603123.2021.1987396
21. Lini RS, Scanferla DTP, de Oliveira NG, Aguera RG, Santos T da S, Teixeira JJV, et al. Fungicides as a risk factor for the development of neurological diseases and disorders in humans: a systematic review. Vol. 54, Critical Reviews in Toxicology; 2024. p. 35–54. DOI: 10.1080/10408444.2024.2303481
22. Wongta A, Hongsibsong S, Xu ZL, Chantara S, Pattarawarapan M, Sapbamrer R, et al. The Relationship of Organophosphate Pesticide Exposure and Cognitive Decline Among Residents of an Agricultural Area in Northern Thailand. Journal of Health Research. 2023;37(6):372–9. DOI: 10.56808/2586-940X.1035
23. Rosales-Rimache J, Machado-Pereyra P, Bendezu-Quispe G. Relationship between Butyrylcholinesterase Activity and Cognitive Ability in Workers Exposed to Chlorpyrifos. Safety. 2023 Mar 1;9(1). DOI: 10.3390/safety9010012
24. Medehouenou TCM, Ayotte P, Carmichael PH, Kröger E, Verreault R, Lindsay J, et al. Exposure to polychlorinated biphenyls and organochlorine pesticides and risk of dementia, Alzheimer’s disease and cognitive decline in an older population: A prospective analysis from the Canadian Study of Health and Aging. Environmental Health: A Global Access Science Source. 2019 Jun 14;18(1). https://doi.org/10.1186/s12940-019-0494-2
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27. Pawestri IN, Sulistyaningsih E. Neurobehavioral performance of Indonesian farmers and its association with pesticide exposure: A cross-sectional study. Clinical Epidemiology and Global Health. 2021 Jul 1;11:100754. https://doi.org/10.1016/j.cegh.2021.100754
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30. Filippi I, Lucero P, Bonansea RI, Lerda D, Butinof M, Fernandez RA, et al. Validation of exposure indexes to pesticides through the analysis of exposure and effect biomarkers in ground pesticide applicators from Argentina. Heliyon. 2021 Sep 1;7(9). https://doi.org/10.1016/j.heliyon.2021.e07921
31. Amoatey P, Al-Mayahi A, Omidvarborna H, Baawain MS, Sulaiman H. Occupational exposure to pesticides and associated health effects among greenhouse farm workers. Vol. 27, Environmental Science and Pollution Research. Springer; 2020. p. 22251–70. https://doi.org/10.1007/s11356-020-08754-9
32. Ramírez-Santana M, Zúñiga-Venegas L, Corral S, Roeleveld N, Groenewoud H, van der Velden K, et al. Reduced neurobehavioral functioning in agricultural workers and rural inhabitants exposed to pesticides in northern Chile and its association with blood biomarkers inhibition. Environmental Health: A Global Access Science Source. 2020 Jul 22;19(1). https://doi.org/10.1186/s12940-020-00634-6
33. Campdelacreu J. Parkinson's disease and Alzheimer disease: environmental risk factors. Neurología. 2014 Nov; 29(9):541–9.
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35. Chondrogiorgi M, Tzoulaki I, Evangelou E, Ntritsos G, Tseretopoulou X, Pappa M, et al. Pesticide exposure and parkinsonism: A systematic review and meta-analysis. Parkinsonism Relat Disord [Internet]. 2016 Jan [cited 2024 Nov 16];22:e127–8. Available from: https://linkinghub.elsevier.com/retrieve/pii/S1353802015007403 2016;22.
36. Armenteros BFM. Enfermedad de Alzheimer y factores de riesgo ambientales. Rev Cuba Enf. 2017;33(1):159-172
37. Murray MT, Nowicki J. Alzheimer’s Disease. In: Textbook of Natural Medicine. 5th ed. Minnesota: Elsevier; 2020. p. 1090-1099.e3.
38. Mostafalou S, Abdollahi M. The link of organophosphorus pesticides with neurodegenerative and neurodevelopmental diseases based on evidence and mechanisms. Toxicology. 2018 Nov;409:44–52.
39. Ávila-Camargo A, Barreiro-Zambrano A, Sánchez-Calderón D, López-Michelena LI. Efectos cardiovasculares de la exposición ocupacional a pesticidas. Revista médica Risaralda [Internet]. 2024 Dec [cited 2024 Nov 6];30(1):107-118. DOI: https://doi.org/10.22517/25395203.25444.
40. López Michelena LI, Giraldo Luna CM, Yepes Boada A, Colmenares Ardila LF, Martínez Burgos M, Niño Bernal DC. Exposición a plaguicidas y desarrollo de leucemia en trabajadores del sector agrícola [Internet]. 2024 Dec [cited 2024 Nov 6]. Available from: https://repositorio.unbosque.edu.co/items/f8687996-78e3-4f2e-ae30-9f55a86a99bc
41. Toro-Osorio BM, Rojas-Rodríguez AE, Díaz-Zapata JA. Levels of serum cholinesterase in coffee growers from the caldas department, Colombia. Revista de Salud Publica. 2017 Jul 1;19(3):318–24.
42. Caro-Gamboa LJ, Forero-Castro M, Dallos-Baez AE. Cholinesterase inhibition as a biomarker for the surveillance of the occupationally exposed population to organophosphate pesticides. Ciencia Tecnología Agropecuaria. 2020 Jul 2;21(3).
43. Insecticide Resistance Action Committee. Insecticide Mode of Action Training slide deck IRAC MoA Workgroup [Internet]. 2019 [cited 2025 Jan 17]. Available from: https://irac-online.org/documents/tutorial-on-moa-mechanisms/?ext=pdf
44. Instituto Colombiano Agropecuario. Subgerencia de protección vegetal restricciones, prohibiciones y suspensión de registros de plaguicidas de uso agrícola en colombia [Internet]. Instituto Colombiano Agropecuario. 2021 [cited 2025 Jan 17]. Available from:https://www.ica.gov.co/getdoc/b2e5ff99-bd80-45e8-aa7a-e55f0b5b42dc/plaguicidas-prohibidos.aspx
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spelling López Michelena, Luis IgnacioGiraldo Luna, Clara MargaritaGonzález Russi, Gyra AlejandraGómez Esteban, NataliaBarrera Barrera , Julián DavidGonzález Russi, Gyra Alejandra [0009-0003-4623-1357]Gómez Esteban, Natalia [0009-0002-7386-6641]Barrera Barrera, Julián David [0009-0003-3304-638X]2025-02-12T13:05:09Z2025-02-12T13:05:09Z2025-01https://hdl.handle.net/20.500.12495/13931instname:Universidad El Bosquereponame:Repositorio Institucional Universidad El Bosquerepourl:https://repositorio.unbosque.edu.coResumen: Introducción: La exposición ocupacional a plaguicidas se ha correlacionado con alteraciones del sistema nervioso central dando lugar a enfermedades como la enfermedad de Parkinson y las demencias. Este estudio tuvo como objetivo identificar la evidencia existente sobre las alteraciones neurocognitivas en trabajadores expuestos a plaguicidas. Metodología: Se realizó un scoping review en los motores de búsqueda PubMed, Clinical Key, SpringerLink, Web of Science y Elsevier. Las palabras claves fueron "Pesticides", “Cognitive Dysfunction", "Neurocognitive Disorders", "Neurological Disorders" y “Cognitive Function", y se incluyeron investigaciones publicadas entre 2019 y 2024. Los criterios de inclusión fueron delineados con las características de la población, el concepto y el contexto (PCC): trabajadores expuestos a plaguicidas, desarrollo de alteraciones neurocognitivas y exposición ocupacional a plaguicidas. Resultados: La revisión incluyó 20 artículos, destacando la asociación entre exposición ocupacional a plaguicidas y el desarrollo de enfermedades neurocognitivas como EA, EP y deterioro cognitivo. Varios plaguicidas tienen asociaciones estadísticamente significativas con las alteraciones neurocognitivas; además, existen varios factores de riesgo como el tiempo de exposición, frecuencia de aplicación y el uso insuficiente de EPP. La inhibición de enzimas como la AChE y la BChE se relaciona con déficits neurocognitivos. Conclusiones: La exposición ocupacional a plaguicidas se relaciona con el desarrollo de alteraciones neurocognitivas, principalmente la EP y la EA, además de afectar funciones cognitivas esenciales como la memoria y la atención. Se han identificado varios plaguicidas específicos que aumentan el riesgo de patologías neurocognitivas (clorpirifos, β-hexaclorociclohexano, diclorodifenildicloroetileno, paraquat, rotenona, diquat, 2,4,5-T y trifluralina). Sin embargo, todos los grupos de plaguicidas se han relacionado con la aparición de alteraciones neurocognitivas.Especialista en Seguridad y Salud en el TrabajoEspecializaciónAbstract: Background: Occupational exposure to pesticides has been related with central nervous system alterations, leading to diseases such as Parkinson's disease and dementia. This study aimed to identify evidence on neurocognitive impairments in workers exposed to pesticides. Methodology: A scoping review was conducted using the searchers PubMed, Clinical Key, SpringerLink, Web of Science and Elsevier. The keywords used were "Pesticides," "Cognitive Dysfunction," "Neurocognitive Disorders," "Neurological Disorders," and "Cognitive Function," including studies published between 2019 and 2024. The inclusion criteria were defined considering population, concept, and context (PCC): workers exposed to pesticides, development of neurocognitive impairments and occupational exposure to pesticides. Results: The review included 20 articles that shows the association between occupational exposure to pesticides and the development of neurocognitive diseases such as AD, PD and cognitive impairment. Several pesticides have statistically significant associations with neurocognitive alterations; additionally, multiple risk factors were identified, including exposure duration, application frequency, and insufficient use of PPE. The inhibition of enzymes such as AChE and BChE is linked to neurocognitive deficits. Conclusions: Occupational exposure to pesticides is associated with the development of neurocognitive impairments, primarily PD and AD, affecting essential cognitive functions such as memory and attention. Several pesticides have been identified as a risk factor for neurocognitive disorders (chlorpyrifos, β-hexachlorocyclohexane, dichlorodiphenyldichloroethylene, paraquat, rotenone, diquat, 2,4,5-T, and trifluralin). However, all pesticide groups have been associated to the onset of neurocognitive alterations.application/pdfAttribution-NonCommercial-ShareAlike 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-sa/4.0/Acceso abiertohttps://purl.org/coar/access_right/c_abf2http://purl.org/coar/access_right/c_abf2PlaguicidasExposición ocupacionalEnfermedades del sistema nerviosoEnfermedad de AlzheimerEnfermedad de Parkinson658.38PesticidesOccupational exposureDiseases of the central nervous systemAlzheimer's diseaseParkinson's diseaseScoping review: alteraciones neurocognitivas en trabajadores expuestos a plaguicidasScoping review: neurocognitive disorders in workers exposed to pesticidesEspecialización en Seguridad y Salud en el TrabajoUniversidad El BosqueFacultad de MedicinaTesis/Trabajo de grado - Monografía - Especializaciónhttps://purl.org/coar/resource_type/c_7a1fhttp://purl.org/coar/resource_type/c_7a1finfo:eu-repo/semantics/bachelorThesishttps://purl.org/coar/version/c_ab4af688f83e57aa1. 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