Colombia. Ministerio de Salud y Protección Social (MinSalud). SABE Colombia 2015: Estudio Nacional de Salud, Bienestar y Envejecimiento. Bogotá D.C.: MinSalud; 2015.

El fluido lagrimal se caracteriza por ser una mezcla de moléculas que incluye proteínas, lípidos, metabolitos, entre otros; estas moléculas juegan un papel importante en la fisiopatología de distintas enfermedades, por lo cual las lágrimas han sido de gran interés para la comunidad científica en la...

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Autores:: Duran Cristiano, Sandra Carolina
Gómez-Molina, Andrea

Tipo de recurso:: https://purl.org/coar/resource_type/c_6501

Fecha de publicación:: 2020

Institución:: Universidad El Bosque

Repositorio:: Repositorio U. El Bosque

Idioma:: spa

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repository_id_str
dc.title.spa.fl_str_mv	Colombia. Ministerio de Salud y Protección Social (MinSalud). SABE Colombia 2015: Estudio Nacional de Salud, Bienestar y Envejecimiento. Bogotá D.C.: MinSalud; 2015.
dc.title.translated.spa.fl_str_mv	Tear film biomarkers and its clinical application
title	Colombia. Ministerio de Salud y Protección Social (MinSalud). SABE Colombia 2015: Estudio Nacional de Salud, Bienestar y Envejecimiento. Bogotá D.C.: MinSalud; 2015.
spellingShingle	Colombia. Ministerio de Salud y Protección Social (MinSalud). SABE Colombia 2015: Estudio Nacional de Salud, Bienestar y Envejecimiento. Bogotá D.C.: MinSalud; 2015. Lágrima Biomarcador Proteína Epigenética Superficie ocular Tear Biomarker Protein Epigenetic Ocular Surface
title_short	Colombia. Ministerio de Salud y Protección Social (MinSalud). SABE Colombia 2015: Estudio Nacional de Salud, Bienestar y Envejecimiento. Bogotá D.C.: MinSalud; 2015.
title_full	Colombia. Ministerio de Salud y Protección Social (MinSalud). SABE Colombia 2015: Estudio Nacional de Salud, Bienestar y Envejecimiento. Bogotá D.C.: MinSalud; 2015.
title_fullStr	Colombia. Ministerio de Salud y Protección Social (MinSalud). SABE Colombia 2015: Estudio Nacional de Salud, Bienestar y Envejecimiento. Bogotá D.C.: MinSalud; 2015.
title_full_unstemmed	Colombia. Ministerio de Salud y Protección Social (MinSalud). SABE Colombia 2015: Estudio Nacional de Salud, Bienestar y Envejecimiento. Bogotá D.C.: MinSalud; 2015.
title_sort	Colombia. Ministerio de Salud y Protección Social (MinSalud). SABE Colombia 2015: Estudio Nacional de Salud, Bienestar y Envejecimiento. Bogotá D.C.: MinSalud; 2015.
dc.creator.fl_str_mv	Duran Cristiano, Sandra Carolina Gómez-Molina, Andrea
dc.contributor.author.none.fl_str_mv	Duran Cristiano, Sandra Carolina Gómez-Molina, Andrea
dc.contributor.orcid.none.fl_str_mv	Duran Cristiano, Sandra Carolina[0000-0002-5366-8552]
dc.subject.spa.fl_str_mv	Lágrima Biomarcador Proteína Epigenética Superficie ocular
topic	Lágrima Biomarcador Proteína Epigenética Superficie ocular Tear Biomarker Protein Epigenetic Ocular Surface
dc.subject.keywords.spa.fl_str_mv	Tear Biomarker Protein Epigenetic Ocular Surface
description	El fluido lagrimal se caracteriza por ser una mezcla de moléculas que incluye proteínas, lípidos, metabolitos, entre otros; estas moléculas juegan un papel importante en la fisiopatología de distintas enfermedades, por lo cual las lágrimas han sido de gran interés para la comunidad científica en la búsqueda de biomarcadores y en el desarrollo de estrategias terapéuticas para enfermedades sistémicas y oculares. La poca invasividad y el bajo riesgo al obtener la lágrima la convierten en una interesante muestra en comparación con algunos fluidos corporales que pueden ser mucho más costosos y molestos para su obtención. Lo anterior ha sido demostrado en diversos estudios que sugieren estrategias para obtener la muestra e indican un posterior análisis mediante avanzadas técnicas de biología molecular y celular, entre ellas los análisis ómicos, que han logrado una mejor caracterización lagrimal.Los análisis ómicos han contribuido en la identificación diferencial de distintas moléculas que pueden desempeñar un papel importante en el diagnóstico, seguimiento y/o tratamiento de enfermedades oculares y sistémicas. Por tanto, el propósito del presente artículo fue describir las diferentes características del fluido lagrimal, así como los posibles candidatos de biomarcadores de patologías oculares y sistémicas reportados
publishDate	2020
dc.date.issued.none.fl_str_mv	2020-07-22
dc.date.accessioned.none.fl_str_mv	2021-05-06T13:47:10Z
dc.date.available.none.fl_str_mv	2021-05-06T13:47:10Z
dc.type.coar.fl_str_mv	http://purl.org/coar/resource_type/c_2df8fbb1
dc.type.coarversion.fl_str_mv	http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.local.spa.fl_str_mv	Artículo de revista
dc.type.coar.none.fl_str_mv	https://purl.org/coar/resource_type/c_6501
dc.type.driver.none.fl_str_mv	info:eu-repo/semantics/article
dc.type.coarversion.none.fl_str_mv	https://purl.org/coar/version/c_970fb48d4fbd8a85
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dc.identifier.issn.none.fl_str_mv	2322-9462
dc.identifier.uri.none.fl_str_mv	https://hdl.handle.net/20.500.12495/5817
dc.identifier.doi.none.fl_str_mv	DOI: https://doi.org/10.18270/rsb.v10i1.2787
dc.identifier.instname.spa.fl_str_mv	instname:Universidad El Bosque
dc.identifier.reponame.spa.fl_str_mv	reponame:Repositorio Institucional Universidad El Bosque
dc.identifier.repourl.none.fl_str_mv	repourl:https://repositorio.unbosque.edu.co
identifier_str_mv	2322-9462 DOI: https://doi.org/10.18270/rsb.v10i1.2787 instname:Universidad El Bosque reponame:Repositorio Institucional Universidad El Bosque repourl:https://repositorio.unbosque.edu.co
url	https://hdl.handle.net/20.500.12495/5817
dc.language.iso.none.fl_str_mv	spa
language	spa
dc.relation.ispartofseries.spa.fl_str_mv	Rev. salud. bosque /ISSN 2322-946 / Volumen 10 /ene. - jun . de 2020 / Número 1/ Págs. 53-6
dc.relation.uri.none.fl_str_mv	https://revistasaludbosque.unbosque.edu.co/index.php/RSB/article/view/2787
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spelling	Duran Cristiano, Sandra CarolinaGómez-Molina, AndreaDuran Cristiano, Sandra Carolina[0000-0002-5366-8552]2021-05-06T13:47:10Z2021-05-06T13:47:10Z2020-07-222322-9462https://hdl.handle.net/20.500.12495/5817DOI: https://doi.org/10.18270/rsb.v10i1.2787instname:Universidad El Bosquereponame:Repositorio Institucional Universidad El Bosquerepourl:https://repositorio.unbosque.edu.coEl fluido lagrimal se caracteriza por ser una mezcla de moléculas que incluye proteínas, lípidos, metabolitos, entre otros; estas moléculas juegan un papel importante en la fisiopatología de distintas enfermedades, por lo cual las lágrimas han sido de gran interés para la comunidad científica en la búsqueda de biomarcadores y en el desarrollo de estrategias terapéuticas para enfermedades sistémicas y oculares. La poca invasividad y el bajo riesgo al obtener la lágrima la convierten en una interesante muestra en comparación con algunos fluidos corporales que pueden ser mucho más costosos y molestos para su obtención. Lo anterior ha sido demostrado en diversos estudios que sugieren estrategias para obtener la muestra e indican un posterior análisis mediante avanzadas técnicas de biología molecular y celular, entre ellas los análisis ómicos, que han logrado una mejor caracterización lagrimal.Los análisis ómicos han contribuido en la identificación diferencial de distintas moléculas que pueden desempeñar un papel importante en el diagnóstico, seguimiento y/o tratamiento de enfermedades oculares y sistémicas. Por tanto, el propósito del presente artículo fue describir las diferentes características del fluido lagrimal, así como los posibles candidatos de biomarcadores de patologías oculares y sistémicas reportadosThe lacrimal fluid is characterized by a mixture of molecules from proteins, lipids, metabolites among others, which play an important role in the pathophysiology of different diseases, for which it has been of great interest in the scientific community for the search of biomarkers and development of therapeutic strategies in systemic and eye diseases. The lower invasiveness and risk when obtaining the tear, makes it an interesting sample compared to some bodily fluids that can be much more expensive and annoying to obtain. The above has been demonstrated through various studies in which they suggest different strategies to obtain the sample and its subsequent analysis using techniques of molecular and cellular biology among them advanced molecular technology such as those such as omic analyses, which have achieved a better lacrimal characterization. These analyses have contributed to the differential identification of different molecules that may play an important role in the diagno-sis, monitoring and/or treatment of eye and systemic diseases. The purpose of this article is to describe the different characteristics of the tear fluid as well as the possible candidates for biomarkers of mainly reported eye and systemic pathologiesapplication/pdfspaRev. salud. bosque /ISSN 2322-946 / Volumen 10 /ene. - jun . de 2020 / Número 1/ Págs. 53-6https://revistasaludbosque.unbosque.edu.co/index.php/RSB/article/view/2787Craig JP, Nichols KK, Akpek EK, Caffery B, Dua HS, Joo CK, et al. 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D OI: 10.1155/ 2015/ 573681de Freitas-Campos C, Cole N, Van Dyk D, Walsh BJ, Diakos P, Almeida D, et al. Proteomic analysis of dog tears for potential cancer markers. Vol. 85, Research in Veteri-nary Science. 2008. p. 349-52.Lanza NL, Valenzuela F, Perez VL, Galor A. The Matrix Metalloproteinase 9 Point-of-Care Test in Dry Eye. Ocul Sur f. 2016;14(2):189-95. DOI: 10.1016/j.jtos.2015.10.004.Sambursky R. Presence or absence of ocular surface in-flammation directs clinical and therapeutic management of dry eye. Clin Ophthalmol. 2016;10:2337-43. DOI: 10.2147/OP TH.S121256.Atribución-NoComercial-CompartirIgual 4.0 Internacionalhttps://creativecommons.org/licenses/by-nc-sa/4.0/Acceso abiertohttps://purl.org/coar/access_right/c_abf2http://purl.org/coar/access_right/c_abf2LágrimaBiomarcadorProteínaEpigenéticaSuperficie ocularTearBiomarkerProteinEpigeneticOcular SurfaceColombia. Ministerio de Salud y Protección Social (MinSalud). SABE Colombia 2015: Estudio Nacional de Salud, Bienestar y Envejecimiento. Bogotá D.C.: MinSalud; 2015.Tear film biomarkers and its clinical applicationArtículo de revistahttps://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1info:eu-repo/semantics/articlehttps://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/version/c_970fb48d4fbd8a85Revista Salud BosqueTHUMBNAILPORTADA1.png.jpgPORTADA1.png.jpgIM Thumbnailimage/jpeg10157https://pruebas-update-repositorio-unbosque.cloudbiteca.com/bitstreams/68c8ef75-806c-4ba7-a30f-12b5874a8ca5/downloadfd2d0b7c3530c00d848d335e03ee892aMD54falseAnonymousREADORIGINALPORTADA1.pngPORTADA1.pngimage/png3332705https://pruebas-update-repositorio-unbosque.cloudbiteca.com/bitstreams/0d2ff925-d1e3-4726-9386-e3cdf0200a17/downloadfa3a3ff48a85e891f20aded428e1410aMD51trueAnonymousREADCC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-81031https://pruebas-update-repositorio-unbosque.cloudbiteca.com/bitstreams/032e7af4-4ca9-4712-94c3-cf1a73998689/download934f4ca17e109e0a05eaeaba504d7ce4MD52falseAnonymousREADLICENSElicense.txtlicense.txttext/plain; charset=utf-81748https://pruebas-update-repositorio-unbosque.cloudbiteca.com/bitstreams/8e1cc3cb-028d-4135-87de-0f3836d8b1b3/download8a4605be74aa9ea9d79846c1fba20a33MD53falseAnonymousREAD20.500.12495/5817oai:pruebas-update-repositorio-unbosque.cloudbiteca.com:20.500.12495/58172021-05-07T03:03:33.914Zhttps://creativecommons.org/licenses/by-nc-sa/4.0/Atribución-NoComercial-CompartirIgual 4.0 Internacionalopen.accesshttps://pruebas-update-repositorio-unbosque.cloudbiteca.comRepositorio Institucional Universidad El Bosquebibliotecas@biteca.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

Colombia. Ministerio de Salud y Protección Social (MinSalud). SABE Colombia 2015: Estudio Nacional de Salud, Bienestar y Envejecimiento. Bogotá D.C.: MinSalud; 2015.

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