Caracterización demográfica e histopatológica de los pacientes pediátricos con trasplante renal llevados a biopsia en una institución de cuarto nivel de Bogotá Colombia

La mejor opción terapéutica para los pacientes con enfermedad renal crónica terminal es el trasplante, ya que mejora de manera importante la supervivencia, calidad de vida y reduce costos asociados a la atención a largo plazo. En el momento la mejor herramienta diagnostica para evaluar la evolución...

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Autores:
Zuluaga Giraldo, Yasmin Paola
Hernandez Verbel, Katherine
Benavides Viveros, Carlos Andres
Tipo de recurso:
https://purl.org/coar/resource_type/c_7a1f
Fecha de publicación:
2025
Institución:
Universidad El Bosque
Repositorio:
Repositorio U. El Bosque
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spa
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oai:repositorio.unbosque.edu.co:20.500.12495/15640
Acceso en línea:
https://hdl.handle.net/20.500.12495/15640
Palabra clave:
Enfermedad renal crónica
Trasplante renal
Biopsia renal
Disfunción del injerto renal
Chronic kidney disease
Kidney transplant
Kidney biopsy
Kidney graft dysfunction
WS 320
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id UNBOSQUE2_6e7e9ee0d9f615e0bcfbed33b5615302
oai_identifier_str oai:repositorio.unbosque.edu.co:20.500.12495/15640
network_acronym_str UNBOSQUE2
network_name_str Repositorio U. El Bosque
repository_id_str
dc.title.none.fl_str_mv Caracterización demográfica e histopatológica de los pacientes pediátricos con trasplante renal llevados a biopsia en una institución de cuarto nivel de Bogotá Colombia
dc.title.translated.none.fl_str_mv Demographic and histopathological characterization of pediatric kidney transplant patients undergoing biopsy at a fourth-level institution in Bogotá, Colombia
title Caracterización demográfica e histopatológica de los pacientes pediátricos con trasplante renal llevados a biopsia en una institución de cuarto nivel de Bogotá Colombia
spellingShingle Caracterización demográfica e histopatológica de los pacientes pediátricos con trasplante renal llevados a biopsia en una institución de cuarto nivel de Bogotá Colombia
Enfermedad renal crónica
Trasplante renal
Biopsia renal
Disfunción del injerto renal
Chronic kidney disease
Kidney transplant
Kidney biopsy
Kidney graft dysfunction
WS 320
title_short Caracterización demográfica e histopatológica de los pacientes pediátricos con trasplante renal llevados a biopsia en una institución de cuarto nivel de Bogotá Colombia
title_full Caracterización demográfica e histopatológica de los pacientes pediátricos con trasplante renal llevados a biopsia en una institución de cuarto nivel de Bogotá Colombia
title_fullStr Caracterización demográfica e histopatológica de los pacientes pediátricos con trasplante renal llevados a biopsia en una institución de cuarto nivel de Bogotá Colombia
title_full_unstemmed Caracterización demográfica e histopatológica de los pacientes pediátricos con trasplante renal llevados a biopsia en una institución de cuarto nivel de Bogotá Colombia
title_sort Caracterización demográfica e histopatológica de los pacientes pediátricos con trasplante renal llevados a biopsia en una institución de cuarto nivel de Bogotá Colombia
dc.creator.fl_str_mv Zuluaga Giraldo, Yasmin Paola
Hernandez Verbel, Katherine
Benavides Viveros, Carlos Andres
dc.contributor.advisor.none.fl_str_mv Hernandez Verbel, Katherine
dc.contributor.author.none.fl_str_mv Zuluaga Giraldo, Yasmin Paola
Hernandez Verbel, Katherine
Benavides Viveros, Carlos Andres
dc.contributor.orcid.none.fl_str_mv 0009-0006-7104-5742
dc.subject.none.fl_str_mv Enfermedad renal crónica
Trasplante renal
Biopsia renal
Disfunción del injerto renal
topic Enfermedad renal crónica
Trasplante renal
Biopsia renal
Disfunción del injerto renal
Chronic kidney disease
Kidney transplant
Kidney biopsy
Kidney graft dysfunction
WS 320
dc.subject.keywords.none.fl_str_mv Chronic kidney disease
Kidney transplant
Kidney biopsy
Kidney graft dysfunction
dc.subject.nlm.none.fl_str_mv WS 320
description La mejor opción terapéutica para los pacientes con enfermedad renal crónica terminal es el trasplante, ya que mejora de manera importante la supervivencia, calidad de vida y reduce costos asociados a la atención a largo plazo. En el momento la mejor herramienta diagnostica para evaluar la evolución clínica y la supervivencia de los injertos renales en pacientes con trasplantes es la biopsia del riñón trasplantado, la cual va a guiar el tratamiento y nos dará pronóstico de la función de este. Objetivo: Caracterizar histopatológicamente la población pediatrica con trasplante renal llevada a biopsia en la Fundación Cardio-Infantil entre el 2014 y 2024 Materiales y métodos Se realizo un estudio observacional de tipo descriptivo retrospectivo, con el fin de caracterizar socio demográficamente e histopatológicamente los niños sometidos a biopsia de riñón trasplantado. Se realizo en 53 pacientes en seguimiento entre los años 2014 y 2024 en la fundación cardio infantil. Se detalló a través de estadística descriptiva, con medidas de tendencia central y de dispersión, los resultados se mostraron en medidas de porcentaje, media y desviación estándar Resultados Se evaluaron variables sociodemográficas de los pacientes como la edad, sexo, IMC, encontrando qué la mediana de edad al momento de la biopsia fue de 13.7 años, con una distribución por sexo ligeramente mayor para el masculino (54.7 %). Más de la mitad de la población se clasificó como eutrófica (52.8 %). En cuanto a los hallazgos histopatológicos, el rechazo confirmado en sus diferentes formas fue la categoría más prevalente y la principal indicación de laboratorio para la realización de la biopsia fue la elevación de la creatinina Conclusión El rechazo al trasplante es una de las principales complicaciones encontradas en pacientes con trasplante renal y qué cursan con elevación de creatinina y/o uroanálisis inflamatoria, esta podría estar relacionada ha un deterioro progresivo e incluso irreversible de la función del injerto renal, por lo que este estudio aporta observaciones aportan elementos valiosos para la optimización del seguimiento
publishDate 2025
dc.date.accessioned.none.fl_str_mv 2025-08-04T19:29:15Z
dc.date.available.none.fl_str_mv 2025-08-04T19:29:15Z
dc.date.issued.none.fl_str_mv 2025-07
dc.type.coar.fl_str_mv http://purl.org/coar/resource_type/c_7a1f
dc.type.local.spa.fl_str_mv Tesis/Trabajo de grado - Monografía - Especialización
dc.type.coar.none.fl_str_mv https://purl.org/coar/resource_type/c_7a1f
dc.type.driver.none.fl_str_mv info:eu-repo/semantics/bachelorThesis
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dc.identifier.uri.none.fl_str_mv https://hdl.handle.net/20.500.12495/15640
dc.identifier.instname.spa.fl_str_mv instname:Universidad El Bosque
dc.identifier.reponame.spa.fl_str_mv reponame:Repositorio Institucional Universidad El Bosque
dc.identifier.repourl.none.fl_str_mv repourl:https://repositorio.unbosque.edu.co
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identifier_str_mv instname:Universidad El Bosque
reponame:Repositorio Institucional Universidad El Bosque
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dc.language.iso.fl_str_mv spa
language spa
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spelling Hernandez Verbel, KatherineZuluaga Giraldo, Yasmin PaolaHernandez Verbel, KatherineBenavides Viveros, Carlos Andres0009-0006-7104-57422025-08-04T19:29:15Z2025-08-04T19:29:15Z2025-07https://hdl.handle.net/20.500.12495/15640instname:Universidad El Bosquereponame:Repositorio Institucional Universidad El Bosquerepourl:https://repositorio.unbosque.edu.coLa mejor opción terapéutica para los pacientes con enfermedad renal crónica terminal es el trasplante, ya que mejora de manera importante la supervivencia, calidad de vida y reduce costos asociados a la atención a largo plazo. En el momento la mejor herramienta diagnostica para evaluar la evolución clínica y la supervivencia de los injertos renales en pacientes con trasplantes es la biopsia del riñón trasplantado, la cual va a guiar el tratamiento y nos dará pronóstico de la función de este. Objetivo: Caracterizar histopatológicamente la población pediatrica con trasplante renal llevada a biopsia en la Fundación Cardio-Infantil entre el 2014 y 2024 Materiales y métodos Se realizo un estudio observacional de tipo descriptivo retrospectivo, con el fin de caracterizar socio demográficamente e histopatológicamente los niños sometidos a biopsia de riñón trasplantado. Se realizo en 53 pacientes en seguimiento entre los años 2014 y 2024 en la fundación cardio infantil. Se detalló a través de estadística descriptiva, con medidas de tendencia central y de dispersión, los resultados se mostraron en medidas de porcentaje, media y desviación estándar Resultados Se evaluaron variables sociodemográficas de los pacientes como la edad, sexo, IMC, encontrando qué la mediana de edad al momento de la biopsia fue de 13.7 años, con una distribución por sexo ligeramente mayor para el masculino (54.7 %). Más de la mitad de la población se clasificó como eutrófica (52.8 %). En cuanto a los hallazgos histopatológicos, el rechazo confirmado en sus diferentes formas fue la categoría más prevalente y la principal indicación de laboratorio para la realización de la biopsia fue la elevación de la creatinina Conclusión El rechazo al trasplante es una de las principales complicaciones encontradas en pacientes con trasplante renal y qué cursan con elevación de creatinina y/o uroanálisis inflamatoria, esta podría estar relacionada ha un deterioro progresivo e incluso irreversible de la función del injerto renal, por lo que este estudio aporta observaciones aportan elementos valiosos para la optimización del seguimientoEspecialista en Nefrología PediátricaEspecializaciónThe best therapeutic option for patients with end-stage kidney disease is transplantation, as it significantly improves survival and quality of life and reduces costs associated with long-term care. Currently, the best diagnostic tool for evaluating the clinical course and survival of kidney grafts in transplant patients is a biopsy of the transplanted kidney, which will guide treatment and provide a prognosis for kidney function Objective: To histopathologically characterize the pediatric kidney transplant population biopsied at the Cardio-Infantil Foundation between 2014 and 2024. Materials and methods: A retrospective, descriptive, observational study was conducted to characterize the sociodemographic and histopathological characteristics of children who underwent kidney transplant biopsies. The study included 53 patients followed up between 2014 and 2024 at the Cardio-Infantil Foundation. Descriptive statistics were used, with measures of central tendency and dispersion. Results were presented as percentages, means, and standard deviations. Results: Sociodemographic variables of the patients were evaluated, such as age, sex, and BMI. The median age at the time of the biopsy was 13.7 years, with a slightly higher sex distribution for men (54.7%). More than half of the population was classified as eutrophic (52.8%). Regarding the histopathological findings, confirmed rejection in its different forms was the most prevalent category, and the main laboratory indication for performing the biopsy was elevated creatinine. Conclusion: Transplant rejection is one of the main complications found in kidney transplant patients who present with elevated creatinine and/or inflammatory urinalysis. This could be related to a progressive and even irreversible deterioration of kidney graft function. Therefore, this study provides observations that provide valuable elements for optimizing follow-up.application/pdfAttribution-ShareAlike 4.0 Internationalhttp://creativecommons.org/licenses/by-sa/4.0/Acceso abiertohttps://purl.org/coar/access_right/c_abf2http://purl.org/coar/access_right/c_abf2Enfermedad renal crónicaTrasplante renalBiopsia renalDisfunción del injerto renalChronic kidney diseaseKidney transplantKidney biopsyKidney graft dysfunctionWS 320Caracterización demográfica e histopatológica de los pacientes pediátricos con trasplante renal llevados a biopsia en una institución de cuarto nivel de Bogotá ColombiaDemographic and histopathological characterization of pediatric kidney transplant patients undergoing biopsy at a fourth-level institution in Bogotá, ColombiaEspecialización en Nefrología PediátricaUniversidad El BosqueFacultad de MedicinaTesis/Trabajo de grado - Monografía - Especializaciónhttps://purl.org/coar/resource_type/c_7a1fhttp://purl.org/coar/resource_type/c_7a1finfo:eu-repo/semantics/bachelorThesishttps://purl.org/coar/version/c_ab4af688f83e57aa1. 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