Bacteriophage-antibiotic combinations for Enterococcus faecium with Varying Bacteriophage and Daptomycin Susceptibilities

Concerns regarding increased prevalence of daptomycin (DAP)-resistant strains necessitate novel therapies for Enterococcus faecium infections. Obligately lytic bacteriophages are viruses that target, infect, and kill bacterial cells. Limited studies have evaluated phage-antibiotic combinations again...

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Autores:
Morrisette, Taylor
Lev, Katherine L.
Kebriaei, Razieh
Abdul-Mutakabbir, Jacinda C.
Stamper, Kyle
Morales, Sandra
Lehman, Susan
Canfield, Gregory
Duerkop, Breck
Arias, César A.
Rybak, Michael Joseph
Tipo de recurso:
https://purl.org/coar/resource_type/c_6501
Fecha de publicación:
2020
Institución:
Universidad El Bosque
Repositorio:
Repositorio U. El Bosque
Idioma:
eng
OAI Identifier:
oai:repositorio.unbosque.edu.co:20.500.12495/3914
Acceso en línea:
https://hdl.handle.net/20.500.12495/3914
https://doi.org/10.1128/aac.00993-20
https://repositorio.unbosque.edu.co
Palabra clave:
Bacteriophage-antibiotic combinations
Bacteriophages
Daptomycin
Enterococcus faecium
Rights
License
Acceso abierto
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network_acronym_str UNBOSQUE2
network_name_str Repositorio U. El Bosque
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dc.title.spa.fl_str_mv Bacteriophage-antibiotic combinations for Enterococcus faecium with Varying Bacteriophage and Daptomycin Susceptibilities
dc.title.translated.spa.fl_str_mv Bacteriophage-antibiotic combinations for Enterococcus faecium with Varying Bacteriophage and Daptomycin Susceptibilities
title Bacteriophage-antibiotic combinations for Enterococcus faecium with Varying Bacteriophage and Daptomycin Susceptibilities
spellingShingle Bacteriophage-antibiotic combinations for Enterococcus faecium with Varying Bacteriophage and Daptomycin Susceptibilities
Bacteriophage-antibiotic combinations
Bacteriophages
Daptomycin
Enterococcus faecium
title_short Bacteriophage-antibiotic combinations for Enterococcus faecium with Varying Bacteriophage and Daptomycin Susceptibilities
title_full Bacteriophage-antibiotic combinations for Enterococcus faecium with Varying Bacteriophage and Daptomycin Susceptibilities
title_fullStr Bacteriophage-antibiotic combinations for Enterococcus faecium with Varying Bacteriophage and Daptomycin Susceptibilities
title_full_unstemmed Bacteriophage-antibiotic combinations for Enterococcus faecium with Varying Bacteriophage and Daptomycin Susceptibilities
title_sort Bacteriophage-antibiotic combinations for Enterococcus faecium with Varying Bacteriophage and Daptomycin Susceptibilities
dc.creator.fl_str_mv Morrisette, Taylor
Lev, Katherine L.
Kebriaei, Razieh
Abdul-Mutakabbir, Jacinda C.
Stamper, Kyle
Morales, Sandra
Lehman, Susan
Canfield, Gregory
Duerkop, Breck
Arias, César A.
Rybak, Michael Joseph
dc.contributor.author.none.fl_str_mv Morrisette, Taylor
Lev, Katherine L.
Kebriaei, Razieh
Abdul-Mutakabbir, Jacinda C.
Stamper, Kyle
Morales, Sandra
Lehman, Susan
Canfield, Gregory
Duerkop, Breck
Arias, César A.
Rybak, Michael Joseph
dc.subject.keywords.spa.fl_str_mv Bacteriophage-antibiotic combinations
Bacteriophages
Daptomycin
Enterococcus faecium
topic Bacteriophage-antibiotic combinations
Bacteriophages
Daptomycin
Enterococcus faecium
description Concerns regarding increased prevalence of daptomycin (DAP)-resistant strains necessitate novel therapies for Enterococcus faecium infections. Obligately lytic bacteriophages are viruses that target, infect, and kill bacterial cells. Limited studies have evaluated phage-antibiotic combinations against E. faecium After an initial screen of eight E. faecium strains, three strains with varying DAP/phage susceptibilities were selected for further experiments. Phage-to-strain specificity contributed to synergy with antibiotics by time-kill analyses and was associated with lower development of phage resistance.
publishDate 2020
dc.date.accessioned.none.fl_str_mv 2020-09-01T23:46:25Z
dc.date.available.none.fl_str_mv 2020-09-01T23:46:25Z
dc.date.issued.none.fl_str_mv 2020
dc.type.coar.fl_str_mv http://purl.org/coar/resource_type/c_2df8fbb1
dc.type.coarversion.fl_str_mv http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.local.none.fl_str_mv Artículo de revista
dc.type.coar.none.fl_str_mv https://purl.org/coar/resource_type/c_6501
dc.type.driver.none.fl_str_mv info:eu-repo/semantics/article
format https://purl.org/coar/resource_type/c_6501
dc.identifier.issn.none.fl_str_mv 1098-6596
dc.identifier.uri.none.fl_str_mv https://hdl.handle.net/20.500.12495/3914
dc.identifier.doi.none.fl_str_mv https://doi.org/10.1128/aac.00993-20
dc.identifier.instname.spa.fl_str_mv instname:Universidad El Bosque
dc.identifier.reponame.spa.fl_str_mv reponame:Repositorio Institucional Universidad El Bosque
dc.identifier.repourl.none.fl_str_mv https://repositorio.unbosque.edu.co
identifier_str_mv 1098-6596
instname:Universidad El Bosque
reponame:Repositorio Institucional Universidad El Bosque
url https://hdl.handle.net/20.500.12495/3914
https://doi.org/10.1128/aac.00993-20
https://repositorio.unbosque.edu.co
dc.language.iso.none.fl_str_mv eng
language eng
dc.relation.ispartofseries.spa.fl_str_mv Antimicrobial agents and chemotherapy, 1098-6596, Vol. 64, Nro. 9, 2020
dc.relation.uri.none.fl_str_mv https://aac.asm.org/content/64/9/e00993-20.abstract
dc.rights.coar.fl_str_mv http://purl.org/coar/access_right/c_abf2
dc.rights.local.spa.fl_str_mv Acceso abierto
dc.rights.accessrights.none.fl_str_mv https://purl.org/coar/access_right/c_abf2
Acceso abierto
dc.rights.creativecommons.none.fl_str_mv 2020-08-20
rights_invalid_str_mv Acceso abierto
https://purl.org/coar/access_right/c_abf2
2020-08-20
http://purl.org/coar/access_right/c_abf2
dc.format.mimetype.none.fl_str_mv application/pdf
dc.publisher.spa.fl_str_mv American Society for Microbiology
dc.publisher.journal.spa.fl_str_mv Antimicrobial agents and chemotherapy
institution Universidad El Bosque
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spelling Morrisette, TaylorLev, Katherine L.Kebriaei, RaziehAbdul-Mutakabbir, Jacinda C.Stamper, KyleMorales, SandraLehman, SusanCanfield, GregoryDuerkop, BreckArias, César A.Rybak, Michael Joseph2020-09-01T23:46:25Z2020-09-01T23:46:25Z20201098-6596https://hdl.handle.net/20.500.12495/3914https://doi.org/10.1128/aac.00993-20instname:Universidad El Bosquereponame:Repositorio Institucional Universidad El Bosquehttps://repositorio.unbosque.edu.coapplication/pdfengAmerican Society for MicrobiologyAntimicrobial agents and chemotherapyAntimicrobial agents and chemotherapy, 1098-6596, Vol. 64, Nro. 9, 2020https://aac.asm.org/content/64/9/e00993-20.abstractBacteriophage-antibiotic combinations for Enterococcus faecium with Varying Bacteriophage and Daptomycin SusceptibilitiesBacteriophage-antibiotic combinations for Enterococcus faecium with Varying Bacteriophage and Daptomycin SusceptibilitiesArtículo de revistahttps://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1info:eu-repo/semantics/articlehttp://purl.org/coar/version/c_970fb48d4fbd8a85Bacteriophage-antibiotic combinationsBacteriophagesDaptomycinEnterococcus faeciumConcerns regarding increased prevalence of daptomycin (DAP)-resistant strains necessitate novel therapies for Enterococcus faecium infections. Obligately lytic bacteriophages are viruses that target, infect, and kill bacterial cells. Limited studies have evaluated phage-antibiotic combinations against E. faecium After an initial screen of eight E. faecium strains, three strains with varying DAP/phage susceptibilities were selected for further experiments. Phage-to-strain specificity contributed to synergy with antibiotics by time-kill analyses and was associated with lower development of phage resistance.Acceso abiertohttps://purl.org/coar/access_right/c_abf2Acceso abierto2020-08-20http://purl.org/coar/access_right/c_abf2THUMBNAILMorrisette, T., Lev, K.L., Kebriaei, R._2020.jpgMorrisette, T., Lev, K.L., Kebriaei, R._2020.jpgimage/jpeg5775https://pruebas-update-repositorio-unbosque.cloudbiteca.com/bitstreams/ab297463-dbba-4656-8d79-87d0d87cb25b/download7210a811635d1799e7c05fee5d259be7MD53falseAnonymousREADLICENSElicense.txtlicense.txttext/plain; charset=utf-81748https://pruebas-update-repositorio-unbosque.cloudbiteca.com/bitstreams/5bad2c15-62da-4cb3-a0c4-1fa066471dc3/download8a4605be74aa9ea9d79846c1fba20a33MD52falseAnonymousREAD20.500.12495/3914oai:pruebas-update-repositorio-unbosque.cloudbiteca.com:20.500.12495/39142022-05-03T02:34:56.812Zmetadata.onlyhttps://pruebas-update-repositorio-unbosque.cloudbiteca.comRepositorio Institucional Universidad El Bosquebibliotecas@biteca.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