Bacteriophage-antibiotic combinations for Enterococcus faecium with Varying Bacteriophage and Daptomycin Susceptibilities

Concerns regarding increased prevalence of daptomycin (DAP)-resistant strains necessitate novel therapies for Enterococcus faecium infections. Obligately lytic bacteriophages are viruses that target, infect, and kill bacterial cells. Limited studies have evaluated phage-antibiotic combinations against E. faecium After an initial screen of eight E. faecium strains, three strains with varying DAP/phage susceptibilities were selected for further experiments. Phage-to-strain specificity contributed to synergy with antibiotics by time-kill analyses and was associated with lower development of phage resistance.

• Autores: Morrisette, Taylor; Lev, Katherine L.; Kebriaei, Razieh; Abdul-Mutakabbir, Jacinda C.; Stamper, Kyle; Morales, Sandra; Lehman, Susan; Canfield, Gregory; Duerkop, Breck; Arias, César A.; Rybak, Michael Joseph
• Tipo de recurso: https://purl.org/coar/resource_type/c_6501
• Fecha de publicación: 2020
• Institución: Universidad El Bosque
• Repositorio: Repositorio U. El Bosque
• Idioma: eng
• OAI Identifier: oai:repositorio.unbosque.edu.co:20.500.12495/3914
• Acceso en línea: https://hdl.handle.net/20.500.12495/3914; https://doi.org/10.1128/aac.00993-20; https://repositorio.unbosque.edu.co
• Palabra clave: Bacteriophage-antibiotic combinations; Bacteriophages; Daptomycin; Enterococcus faecium
• License: Acceso abierto