ARGONAUT II study of the in vitro activity of plazomicin against carbapenemase-producing klebsiella pneumoniae

Plazomicin was tested against 697 recently acquired carbapenem-resistant Klebsiella pneumoniae isolates from the Great Lakes region of the United States. Plazomicin MIC50 and MIC90 values were 0.25 and 1 mg/liter, respectively; 680 isolates (97.6%) were susceptible (MICs of ≤2 mg/liter), 9 (1.3%) intermediate (MICs of 4 mg/liter), and 8 (1.1%) resistant (MICs of >32 mg/liter). Resistance was associated with rmtF-, rmtB-, or armA-encoded 16S rRNA methyltransferases in all except 1 isolate.

• Autores: Jacobs, Michael R.; Good, Caryn E.; Hujer, Andrea M.; Abdelhamed, Ayman M.; Rhoads, Daniel; Hujer, Kristine M.; Rudin, Susan D.; Domitrovic, T. Nicholas J.; Connolly, Lynn E.; Krause, Kevin M.; Patel, Robin; Arias, Cesar A; Kreiswirth, Barry N.; Rojas, Laura J.; D'Souza, Roshan; King, C. Richard; Brinkac, Lauren M.; Nguyen, Kevin; Singh, Indresh; Fouts, Derrick E.; van Duin, David; Bonomo, Robert A.
• Tipo de recurso: https://purl.org/coar/resource_type/c_6501
• Fecha de publicación: 2020
• Institución: Universidad El Bosque
• Repositorio: Repositorio U. El Bosque
• Idioma: eng
• OAI Identifier: oai:repositorio.unbosque.edu.co:20.500.12495/3501
• Acceso en línea: https://hdl.handle.net/20.500.12495/3501; https://doi.org/10.1128/aac.00012-20; https://repositorio.unbosque.edu.co
• Palabra clave: Enterobacteriaceae resistentes a los carbapenémicos; Carbapenémicos; Proteínas asociadas a resistencia a múltiples medicamentos; Klebsiella; Antibiotic resistance; Carbapenemase
• License: Acceso abierto