Síntesis y caracterización de nuevos compuestos de triamtereno con ZnCl2 y/o MnCl2: Evaluación del carácter fotosensibilizador y efectos cito y genotóxico.

ilustraciones, diagramas, tablas

Autores:: Coral Coral, Jhon Dario

Tipo de recurso:

Fecha de publicación:: 2022

Institución:: Universidad Nacional de Colombia

Repositorio:: Universidad Nacional de Colombia

Idioma:: spa

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repository_id_str
dc.title.spa.fl_str_mv	Síntesis y caracterización de nuevos compuestos de triamtereno con ZnCl2 y/o MnCl2: Evaluación del carácter fotosensibilizador y efectos cito y genotóxico.
dc.title.translated.eng.fl_str_mv	Synthesis and characterization of new triamterene compounds with ZnCl2 and/or MnCl2: Evaluation of photosensitizing character and cytotoxic and genotoxic effects.
title	Síntesis y caracterización de nuevos compuestos de triamtereno con ZnCl2 y/o MnCl2: Evaluación del carácter fotosensibilizador y efectos cito y genotóxico.
spellingShingle	Síntesis y caracterización de nuevos compuestos de triamtereno con ZnCl2 y/o MnCl2: Evaluación del carácter fotosensibilizador y efectos cito y genotóxico. 540 - Química y ciencias afines::547 - Química orgánica 570 - Biología::576 - Genética y evolución Fisicoquímica Chemistry, physical and theoretical Triamtereno Perfil de dilución Caracterización espectroscópica Estabilidad fotoquímica Ensayos citotóxicos y genotóxicos Hemólisis Síntesis de compuestos Triamterene Dilution profile spectroscopic characterization Photochemical stability Cytotoxic and genotoxic assays Synthesis of compounds Hemolysis
title_short	Síntesis y caracterización de nuevos compuestos de triamtereno con ZnCl2 y/o MnCl2: Evaluación del carácter fotosensibilizador y efectos cito y genotóxico.
title_full	Síntesis y caracterización de nuevos compuestos de triamtereno con ZnCl2 y/o MnCl2: Evaluación del carácter fotosensibilizador y efectos cito y genotóxico.
title_fullStr	Síntesis y caracterización de nuevos compuestos de triamtereno con ZnCl2 y/o MnCl2: Evaluación del carácter fotosensibilizador y efectos cito y genotóxico.
title_full_unstemmed	Síntesis y caracterización de nuevos compuestos de triamtereno con ZnCl2 y/o MnCl2: Evaluación del carácter fotosensibilizador y efectos cito y genotóxico.
title_sort	Síntesis y caracterización de nuevos compuestos de triamtereno con ZnCl2 y/o MnCl2: Evaluación del carácter fotosensibilizador y efectos cito y genotóxico.
dc.creator.fl_str_mv	Coral Coral, Jhon Dario
dc.contributor.advisor.none.fl_str_mv	Valencia Uribe, Gloria Cristina López Ortiz, Juan Bautista
dc.contributor.author.none.fl_str_mv	Coral Coral, Jhon Dario
dc.contributor.researchgroup.spa.fl_str_mv	Grupo de Investigación en Biotecnología Animal (Giba) Aplicaciones en Fotoquímica - GIAFOT
dc.subject.ddc.spa.fl_str_mv	540 - Química y ciencias afines::547 - Química orgánica 570 - Biología::576 - Genética y evolución
topic	540 - Química y ciencias afines::547 - Química orgánica 570 - Biología::576 - Genética y evolución Fisicoquímica Chemistry, physical and theoretical Triamtereno Perfil de dilución Caracterización espectroscópica Estabilidad fotoquímica Ensayos citotóxicos y genotóxicos Hemólisis Síntesis de compuestos Triamterene Dilution profile spectroscopic characterization Photochemical stability Cytotoxic and genotoxic assays Synthesis of compounds Hemolysis
dc.subject.lemb.none.fl_str_mv	Fisicoquímica Chemistry, physical and theoretical
dc.subject.proposal.spa.fl_str_mv	Triamtereno Perfil de dilución Caracterización espectroscópica Estabilidad fotoquímica Ensayos citotóxicos y genotóxicos Hemólisis Síntesis de compuestos
dc.subject.proposal.eng.fl_str_mv	Triamterene Dilution profile spectroscopic characterization Photochemical stability Cytotoxic and genotoxic assays Synthesis of compounds Hemolysis
description	ilustraciones, diagramas, tablas
publishDate	2022
dc.date.accessioned.none.fl_str_mv	2022-08-16T16:44:22Z
dc.date.available.none.fl_str_mv	2022-08-16T16:44:22Z
dc.date.issued.none.fl_str_mv	2022
dc.type.spa.fl_str_mv	Trabajo de grado - Maestría
dc.type.driver.spa.fl_str_mv	info:eu-repo/semantics/masterThesis
dc.type.version.spa.fl_str_mv	info:eu-repo/semantics/acceptedVersion
dc.type.content.spa.fl_str_mv	Text
dc.type.redcol.spa.fl_str_mv	http://purl.org/redcol/resource_type/TM
status_str	acceptedVersion
dc.identifier.uri.none.fl_str_mv	https://repositorio.unal.edu.co/handle/unal/81916
dc.identifier.instname.spa.fl_str_mv	Universidad Nacional de Colombia
dc.identifier.reponame.spa.fl_str_mv	Repositorio Institucional Universidad Nacional de Colombia
dc.identifier.repourl.spa.fl_str_mv	https://repositorio.unal.edu.co/
url	https://repositorio.unal.edu.co/handle/unal/81916 https://repositorio.unal.edu.co/
identifier_str_mv	Universidad Nacional de Colombia Repositorio Institucional Universidad Nacional de Colombia
dc.language.iso.spa.fl_str_mv	spa
language	spa
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dc.publisher.faculty.spa.fl_str_mv	Facultad de Ciencias
dc.publisher.place.spa.fl_str_mv	Medellín, Colombia
dc.publisher.branch.spa.fl_str_mv	Universidad Nacional de Colombia - Sede Medellín
institution	Universidad Nacional de Colombia
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spelling	Reconocimiento 4.0 Internacionalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Valencia Uribe, Gloria Cristina2b3f41a4e9f415ea8f35abd136606dcb600López Ortiz, Juan Bautista84a1edcef73863a1750a48b3e759313e600Coral Coral, Jhon Dariobbdab0212850adb4fe96b94a20eae619Grupo de Investigación en Biotecnología Animal (Giba)Aplicaciones en Fotoquímica - GIAFOT2022-08-16T16:44:22Z2022-08-16T16:44:22Z2022https://repositorio.unal.edu.co/handle/unal/81916Universidad Nacional de ColombiaRepositorio Institucional Universidad Nacional de Colombiahttps://repositorio.unal.edu.co/ilustraciones, diagramas, tablasEl triamtereno, un compuesto diurético de primera línea en algunos países incluido dentro del grupo de los ahorradores de potasio presenta poca solubilidad en agua. Con el propósito de mejorar este parámetro, y en consecuencia su disposición en el organismo, se sintetizaron dos nuevos compuestos en los que se modificó la estructura del TAT con manganeso y zinc, usando sus respectivos cloruros. La síntesis se llevó a cabo en solución agua:metanol. Estos compuestos fueron caracterizados a través de microscopía electrónica de barrido SEM y difracción de Rayos X en polvo. Adicionalmente, se observaron los perfiles de disolución en el tiempo en medio acuoso, evidenciando que este parámetro mejoró en los nuevos compuestos sintetizados. La caracterización de los nuevos compuestos se realizó a través de técnicas espectroscópicas como absorción UV-VIS, infrarrojo y raman. Los resultados obtenidos se contrastaron con termogramas y perfil de dilución. Se determinó el carácter fotosensibilizador del TAT y de los nuevos compuestos con Zn y Mn en medios alcohólicos. Se realizaron medidas de actinometría en estado estacionario que permitieron establecer el rendimiento cuántico de oxígeno molecular singulete generado por los nuevos compuestos. Adicionalmente, se realizaron medidas de rendimiento cuántico de fluorescencia, para aportar a la caracterización de los materiales, con miras al estudio posterior de sus aplicaciones como marcadores fluorescentes. La caracterización se completó con ensayos citotóxicos, genotóxicos y con prueba de hemolisis; con lo que fue posible demostrar el potencial antineoplásico de los nuevos compuestos sintetizados sobre la línea celular tumoral MCF-7. (Texto tomado de la fuente)Triamterene, a first line diuretic compound in some countries included in the group of potassium sparing compounds, presents poor solubility in water. In order to improve this parameter, and consequently its disposition in the organism, two new compounds were synthesized in which the TAT structure was modified with manganese and zinc, using their respective chlorides. The synthesis was carried out in water:methanol solution. These compounds were characterized by SEM scanning electron microscopy and powder X-ray diffraction. Additionally, the dissolution profiles over time in aqueous medium were observed, evidencing that this parameter improved in the new synthesized compounds. The characterization of the new compounds was carried out through spectroscopic techniques such as UV-VIS absorption, infrared and Raman. The results obtained were contrasted with thermograms and dilution profile. The photosensitizing character of TAT and the new compounds with Zn and Mn in alcoholic media was determined. Steady state actinometry measurements were performed to establish the singlet molecular oxygen quantum yield generated by the new compounds. Additionally, fluorescence quantum yield measurements were performed to contribute to the characterization of the materials, with a view to the subsequent study of their applications as fluorescent markers. The characterization was completed with cytotoxic, genotoxic and hemolysis assays; thus, it was possible to demonstrate the antineoplastic potential of the new compounds synthesized on the MCF-7 tumor cell line.MaestríaMagíster en Ciencias - QuímicaÁrea Curricular en Ciencias Naturalesviii, 113 páginasapplication/pdfspaUniversidad Nacional de ColombiaMedellín - Ciencias - Maestría en Ciencias - QuímicaEscuela de químicaFacultad de CienciasMedellín, ColombiaUniversidad Nacional de Colombia - Sede Medellín540 - Química y ciencias afines::547 - Química orgánica570 - Biología::576 - Genética y evoluciónFisicoquímicaChemistry, physical and theoreticalTriamterenoPerfil de diluciónCaracterización espectroscópicaEstabilidad fotoquímicaEnsayos citotóxicos y genotóxicosHemólisisSíntesis de compuestosTriamtereneDilution profilespectroscopic characterizationPhotochemical stabilityCytotoxic and genotoxic assaysSynthesis of compoundsHemolysisSíntesis y caracterización de nuevos compuestos de triamtereno con ZnCl2 y/o MnCl2: Evaluación del carácter fotosensibilizador y efectos cito y genotóxico.Synthesis and characterization of new triamterene compounds with ZnCl2 and/or MnCl2: Evaluation of photosensitizing character and cytotoxic and genotoxic effects.Trabajo de grado - Maestríainfo:eu-repo/semantics/masterThesisinfo:eu-repo/semantics/acceptedVersionTexthttp://purl.org/redcol/resource_type/TMAcuña Cueva, E. R., Faure, R., Illán Cabeza, N. A., Jiménez Pulido, S. B., Moreno Carretero, M. N., & Quirós Olozábal, M. (2003). Synthesis and characterization of several lumazine derivative complexes of Co(II), Ni(II), Cu(II), Cd(II), Pd(II) and Pt(II). X-ray structures of a mononuclear copper complex and a dinuclear cadmium complex. Inorganica Chimica Acta, 351(1), 356–362. https://doi.org/10.1016/S0020-1693(03)00172-5Amin, P. O., Muhammadsharif, F. F., Raza Saeed, S., Ketuly, K., & Sulaiman, K. (2021). The Effect of Donor- pi -Acceptor Unit on the Optoelectronic Parameters of Poly ( Triamterene-co-Terephthalate ): Betalain Dye Composite System. March. https://www.researchgate.net/publication/350342735_The_Effect_of_Donor-pi-Acceptor_Unit_on_the_Optoelectronic_Parameters_of_PolyTriamterene-co-TerephthalateBetalain_Dye_Composite_SystemBawa, Y. (2007). Solvent inclusion properties of Triamterene crystal forms and solubility differences between Roxithromycin polymorphic forms. 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Bioengineered, 12(1), 6703–6712. https://doi.org/10.1080/21655979.2021.1952366EstudiantesInvestigadoresMaestrosORIGINAL1085282761.2022.pdf1085282761.2022.pdfTesis de Maestria en Ciencias-Químicaapplication/pdf2219580https://repositorio.unal.edu.co/bitstream/unal/81916/3/1085282761.2022.pdfb12444ab3e81cce8c2058767af897963MD53LICENSElicense.txtlicense.txttext/plain; charset=utf-84074https://repositorio.unal.edu.co/bitstream/unal/81916/4/license.txt8153f7789df02f0a4c9e079953658ab2MD54THUMBNAIL1085282761.2022.pdf.jpg1085282761.2022.pdf.jpgGenerated Thumbnailimage/jpeg4458https://repositorio.unal.edu.co/bitstream/unal/81916/5/1085282761.2022.pdf.jpg7ca4b3e5e747a1690fb60ea4c952d51bMD55unal/81916oai:repositorio.unal.edu.co:unal/819162023-08-06 23:04:25.586Repositorio Institucional Universidad Nacional de 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EVESURBIFBPUiBMQSBTRUNSRVRBUsONQSBHRU5FUkFMLiAqTEEgVEVTSVMgQSBQVUJMSUNBUiBERUJFIFNFUiBMQSBWRVJTScOTTiBGSU5BTCBBUFJPQkFEQS4gCgpBbCBoYWNlciBjbGljIGVuIGVsIHNpZ3VpZW50ZSBib3TDs24sIHVzdGVkIGluZGljYSBxdWUgZXN0w6EgZGUgYWN1ZXJkbyBjb24gZXN0b3MgdMOpcm1pbm9zLiBTaSB0aWVuZSBhbGd1bmEgZHVkYSBzb2JyZSBsYSBsaWNlbmNpYSwgcG9yIGZhdm9yLCBjb250YWN0ZSBjb24gZWwgYWRtaW5pc3RyYWRvciBkZWwgc2lzdGVtYS4KClVOSVZFUlNJREFEIE5BQ0lPTkFMIERFIENPTE9NQklBIC0gw5psdGltYSBtb2RpZmljYWNpw7NuIDE5LzEwLzIwMjEK

Síntesis y caracterización de nuevos compuestos de triamtereno con ZnCl2 y/o MnCl2: Evaluación del carácter fotosensibilizador y efectos cito y genotóxico.

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