Factores asociados a ingreso a UCI en pacientes con IRAG por SARS CoV-2 durante la pandemia en hospitales colombianos

ilustraciones, gráficas, tablas

Autores:: Ortega Quintero, Adriana Paola

Tipo de recurso:

Fecha de publicación:: 2023

Institución:: Universidad Nacional de Colombia

Repositorio:: Universidad Nacional de Colombia

Idioma:: spa

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dc.title.spa.fl_str_mv	Factores asociados a ingreso a UCI en pacientes con IRAG por SARS CoV-2 durante la pandemia en hospitales colombianos
dc.title.translated.eng.fl_str_mv	Factors associated with ICU admission in patients with SARS CoV-2 during the pandemic in Colombian hospitals
title	Factores asociados a ingreso a UCI en pacientes con IRAG por SARS CoV-2 durante la pandemia en hospitales colombianos
spellingShingle	Factores asociados a ingreso a UCI en pacientes con IRAG por SARS CoV-2 durante la pandemia en hospitales colombianos 610 - Medicina y salud::616 - Enfermedades SARS-CoV-2 Measures of Association, Exposure, Risk or Outcome Síndrome Respiratorio Agudo Grave Medidas de Asociación, Exposición, Riesgo o Desenlace Factores de riesgo UCI Risk factors COVID 19 Intensive Care Unit
title_short	Factores asociados a ingreso a UCI en pacientes con IRAG por SARS CoV-2 durante la pandemia en hospitales colombianos
title_full	Factores asociados a ingreso a UCI en pacientes con IRAG por SARS CoV-2 durante la pandemia en hospitales colombianos
title_fullStr	Factores asociados a ingreso a UCI en pacientes con IRAG por SARS CoV-2 durante la pandemia en hospitales colombianos
title_full_unstemmed	Factores asociados a ingreso a UCI en pacientes con IRAG por SARS CoV-2 durante la pandemia en hospitales colombianos
title_sort	Factores asociados a ingreso a UCI en pacientes con IRAG por SARS CoV-2 durante la pandemia en hospitales colombianos
dc.creator.fl_str_mv	Ortega Quintero, Adriana Paola
dc.contributor.advisor.none.fl_str_mv	Cortés Luna, Jorge Alberto
dc.contributor.author.none.fl_str_mv	Ortega Quintero, Adriana Paola
dc.contributor.datacollector.none.fl_str_mv	Gómez Rodriguez Rosario Sánchez González Sandra
dc.contributor.researcher.none.fl_str_mv	Villalobos Díaz Maxi Fayibe Morantes Caballero Jairo Alberto
dc.subject.ddc.spa.fl_str_mv	610 - Medicina y salud::616 - Enfermedades
topic	610 - Medicina y salud::616 - Enfermedades SARS-CoV-2 Measures of Association, Exposure, Risk or Outcome Síndrome Respiratorio Agudo Grave Medidas de Asociación, Exposición, Riesgo o Desenlace Factores de riesgo UCI Risk factors COVID 19 Intensive Care Unit
dc.subject.decs.eng.fl_str_mv	SARS-CoV-2 Measures of Association, Exposure, Risk or Outcome
dc.subject.decs.spa.fl_str_mv	Síndrome Respiratorio Agudo Grave Medidas de Asociación, Exposición, Riesgo o Desenlace
dc.subject.proposal.spa.fl_str_mv	Factores de riesgo UCI
dc.subject.proposal.eng.fl_str_mv	Risk factors COVID 19 Intensive Care Unit
description	ilustraciones, gráficas, tablas
publishDate	2023
dc.date.accessioned.none.fl_str_mv	2023-02-07T13:31:02Z
dc.date.available.none.fl_str_mv	2023-02-07T13:31:02Z
dc.date.issued.none.fl_str_mv	2023-02-03
dc.type.spa.fl_str_mv	Trabajo de grado - Especialidad Médica
dc.type.driver.spa.fl_str_mv	info:eu-repo/semantics/masterThesis
dc.type.version.spa.fl_str_mv	info:eu-repo/semantics/acceptedVersion
dc.type.content.spa.fl_str_mv	Text
dc.type.redcol.spa.fl_str_mv	http://purl.org/redcol/resource_type/TM
status_str	acceptedVersion
dc.identifier.uri.none.fl_str_mv	https://repositorio.unal.edu.co/handle/unal/83346
dc.identifier.instname.spa.fl_str_mv	Universidad Nacional de Colombia
dc.identifier.reponame.spa.fl_str_mv	Repositorio Institucional Universidad Nacional de Colombia
dc.identifier.repourl.spa.fl_str_mv	https://repositorio.unal.edu.co/
url	https://repositorio.unal.edu.co/handle/unal/83346 https://repositorio.unal.edu.co/
identifier_str_mv	Universidad Nacional de Colombia Repositorio Institucional Universidad Nacional de Colombia
dc.language.iso.spa.fl_str_mv	spa
language	spa
dc.relation.references.spa.fl_str_mv	Instituto Nacional de Salud. Protocolo de Vigilancia en Salud Pública - Infección Respiratoria Aguda (IRA). 2018. https://www.ins.gov.co/BibliotecaDigital/PRO-Infección-respiratoria-aguda Zhu N, Zhang D, Wang W, Li X, Yang Bo, Song J et al. A novel coronavirus from patients with pneumonia in China, 2019. N Engl J Med. 2020;382:727-733 Cucinotta D, Vanelli M. WHO declares COVID-19 a Pandemic. Acta Biomed. 2020;91:157-160 Wu Z, McGoogan JM. Characteristics of and important lessons from the Coronavirus Disease 2019 (COVID-19) outbreak in China: Summary of a Report of 72314 Cases from the Chinese center for disease control and prevention. JAMA. 2020;323:1239-1242 Bhargava A, Fukushima E, Levine M, Zhao W, Tanveer F, Szpunar S et al. Predictors for Severe COVID-19 Infection. Clin infect Dis. 2020;71(8):1962-1968 Zhou F, Yu T, Ronghui D, Fan G, Liu Y, Liu Z et al, Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. Lancet. 2020;395:1054-1962 Zhang J, Yu Miao, Tong Song, Liu LY, Tang LV. Predictive factors for disease progression in hospitalized patients with coronavirus disease 2019 in Wuhan, China. J Clin Virol. 2020;127:104392 Wang D, Hu B, Hu C. Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus–Infected Pneumonia in Wuhan, China. JAMA. 2020;323(11):1061-1069 Liu W, Tao ZW, Wang L, Yuan ML, Liu K, Zhou L et al. Analysis of factors associated with disease outcomes in hospitalized patients with 2019 novel coronavirus disease. Chin Med J (Engl). 2020;133(9):1032-1038 Bergman J, Ballin M, Nordström A, Nordström P. Risk factors for COVID-19 diagnosis, hospitalization, and subsequent all-cause mortality in Sweden: a nationwide study. Eur J Epidemiol. 2021;36(3):287–298 Petrilli CM, Jones SA, Yang J, Rajagopalan H, O’Donnell L, Chernyak Y, et al. Factors associated with hospital admission and critical illness among 5279 people with coronavirus disease 2019 in New York City: prospective cohort study. BMJ. 2020;m1966 Murthy S, Archambault PM, Atique A, Carrier FM, Cheng MP, Codan C, et al. Characteristics and outcomes of patients with COVID-19 admitted to hospital and intensive care in the first phase of the pandemic in Canada: a national cohort study. CMAJ Open. 2021;9(1):E181–8 Zhou P, Yang XL, Wang XG, Hu B, Zhang L, Zhang W et al. A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature. 2020;579(7798):270-273 Eurosurveillance Editorial Team. Note from the editors: World Health Organization declares novel coronavirus (2019-nCoV) sixth public health emergency of international concern. Euro. Surveill. 2020;25(5):200131e Coronaviridae Study Group of the International Committee on Taxonomy of Viruses. The species severe acute respiratory syndrome-related coronavirus: classifying 2019-nCoV and naming it SARS-CoV-2. Nat Microbiol. 2020;5(4):536-544 Fisher D, Heymann, D. Q&A: the novel coronavirus outbreak causing COVID-19. BMC Med. 2020;18(1):57 Jin Y, Yang H, Ji W, Wu W, Chen S, Zhang W, et al. Virology, epidemiology, pathogenesis, and control of covid-19. Viruses. 2020;12(4):1–17 Chan JF, Kok KH, Zhu Z, Chu H, To K, Yuan S, et al. Genomic characterization of the 2019 novel human-pathogenic coronavirus isolated from a patient with atypical pneumonia after visiting Wuhan. Emerg. Microbes Infect. 2020;9(1):221-236 Wang C, Horby P, Hayden F, Gao G. A novel coronavirus outbreak of global health concern. Lancet. 2020;395(10223):470-473 Holmes E, Goldstein S, Rasmusen A, Robertson D, Christoph A, Wertheim J, et al. The origins of SARS CoV 2: A critical Review. Cell 2021;184(19):4848-4856 Deslandes A, Berti V, Tandjaoui-Lambotte Y, Alloui C, Zahar JR, Brichler, et al. SARS-CoV-2 was already spreading in France in late December 2019. Int J Antimicrob Agents. 2020;55(6):106006 Lotfi M, Rezaei N. SARS-CoV-2: A comprehensive review from pathogenicity of the virus to clinical consequences. J Med Virol. 2020;92(10):1864-1874 Hu B, Guo H, Zhou P, Shi ZL. Characteristics of SARS-CoV-2 and COVID-19. Nat Rev Microbiol. 2021;19(3):141-154 King AM, Adams MJ, Carstens EB, Lefkowitz EJ (eds). Virus Taxonomy: Ninth Report of the International Committee on Taxonomy of Viruses. Elsevier Inc. 2012; 223–228 Fan Y, Zhao K, Shi ZL, Zhou P. Bat Coronaviruses in China. Viruses. 2019;11(3):210 He F, Deng Y, Li W. Coronavirus disease 2019: What we know?. J Med Virol. 2020;92(7):719-725 Ruan Q, Yang K, Wang W, Jiang L, Song J. Clinical predictors of mortality due to COVID-19 based on an analysis of data of 150 patients from Wuhan, China. Intensive Care Med. 2020;46(5):846-848 Eastin C, Eastin T. Clinical Characteristics of Coronavirus Disease 2019 in China: Guan W, Ni Z, Hu Y, et al. N Engl J Med. 2020. J Emerg Med. 2020;58(4):711-712 Saavedra Trujillo CH. Resumen: Consenso colombiano de atención, diagnóstico y manejo de la infección por SARS-COV-2/COVID-19 en establecimientos de atención de la salud - Recomendaciones basadas en consenso de expertos e informadas en la evidencia. Infectio. 2020;24:3 (S1):1-153 Ministerio de salud y protección social de Colombia. Lineamientos para el uso de pruebas diagnósticas de sars-cov-2 (Covid-19) en Colombia ministerio de salud y protección social Bogotá. Agosto de 2022. 2022:1–23 Garrow, J.S, Webster, J. Quetelet’s index (W/H2) as a measure of fatness. Int.J.Obes.1985: 9(2):147–153 ARDS Definition Task Force, Ranieri VM, Rubenfeld GD, Thompson BT, Ferguson ND, Caldwell E, Fan E, et al. Acute respiratory distress syndrome: The Berlin definition. JAMA. 2012 Jun 20; 307(23):2526–2533 Singer M, Deutschman CS, Seymour CW, Shankar-Hari M, Annane D, Bauer M, et al. The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3) JAMA. 2016 Feb 23; 315(8): 801–810 Konstantinides SV, Meyer G, Becattini C, Bueno H, Geersing GJ, Harjola VP, et al. ESC Guidelines for the diagnosis and management of acute pulmonary embolism developed in collaboration with the European Respiratory Society (ERS). Eur Heart J. 2020;41(4):543-603 Castro MC, Gurzenda S, Macário EM, França GVA. Characteristics, outcomes and risk factors for mortality of 522 167 patients hospitalised with COVID-19 in Brazil: a retrospective cohort study. BMJ Open. 2021; 11(5): e049089 Salje H, Tran Kiem C, Lefrancq N, Courtejoie N, Bosetti P, Paireau J, et al. Estimating the burden of SARS-CoV- 2 in France. Science. 2020; 369 (6500):208–211 Grasselli G, Pesenti A, Cecconi M. Critical care utilization for the COVID-19 outbreak in Lombardy, Italy: early experience and forecast during an emergency response. JAMA. 2020;323(16):1545-1546 Graselli G, Zangrillo A, Zanella A, Antonelli M, Cabrini L, Castelli A, et al. Baseline Characteristics and Outcomes of 1591 Patients Infected With SARS-CoV-2 Admitted to ICUs of the Lombardy Region, Italy. JAMA. 2020; 323(16):1574-1581 Sifuentes-Osorio J, Angulo-Guerrero O, De Anda-Jáuregui G, Díaz-De-León-Santiago JL, Hernández-Lemus E, Benítez-Pérez H et al. Probability of hospitalisation and death among COVID-19 patients with comorbidity during outbreaks occurring in Mexico City. J Glob Health. 2022;12:05038 Zeiser F, Donida B, da Costa CA, Ramos GO, Scherer JN, Barcellos NT, et al. First and second COVID-19 waves in Brazil: A crosssectional study of patients’ characteristics related to hospitalization and in-hospital mortality. Lancet Reg Health Am. 2022;6:100107 Henríquez A, Accini J, Baquero H, Molina F, Rey A, Ángel VE, et al. Clinical features and prognostic factors of adults with COVID-19 admitted to intensive care units in Colombia: A multicentre retrospective study during the first wave of the pandemic. Acta Colombiana de Cuidado Intensivo. 2022;22(2):95–9 Izcovich A, Ragusa MA, Tortosa F, Lavena Marzio MA, Agnoletti C, Bengolea A, et al. Prognostic factors for severity and mortality in patients infected with COVID-19: A systematic review. PLoS One. 2020;15(11): e0241955 Booth A, Reed AB, Ponzo S, Yassaee A, Aral M, Plans D, et al. Population risk factors for severe disease and mortality in COVID- 19: A global systematic review and meta-analysis. PLoS ONE. 2021;16(3):e0247461 Docherty AB, Harrison EM, Green CA, Hardwick HE, Pius R, Norman L, et al. Features of 20 133 UK patients in hospital with covid-19 using the ISARIC WHO Clinical Characterisation Protocol: prospective observational cohort study. BMJ. 2020;369:m1985 Hang W, Tipih T, Makoah N, Vermeulen J, Goedhals D, Sempa J, et al. Comorbidities in SARS-CoV-2 Patients: a Systematic Review and Meta-Analysis. mBio. 2021; 12(1): e03647-20 Yu W, Rohli K, Yang S, Jia P. Impact of obesity on Covid19 patients. J Diabetes Complications. 202;35(3):107817 Lofti M, Rezai N. SARS-CoV-2: A comprehensive review from pathogenicity of the virus to clinical consequences. J Med Virol. 2020; 92(10): 1864-1874 Wang JG, Hur J, Hong KS, Lee W, Ahn JH. Prognostic accuracy of the SIRS, qSOFA, and NEWS for early detection of clinical deterioration in SARS-CoV-2 infected patients. J Korean Med Sci. 2020; 35(25): e234 Borges L, Pithon T, Curi R, Hatanaka E. COVID-19 and Neutrophils: The Relationship between Hyperinflammation and Neutrophil Extracellular Traps. Mediators Inflamm. 2020; 2020:8829674. Yao Y, Cao J, Wang Q, Shi Q, Liu K, Luo Z, et al. D-dimer as a biomarker for disease severity and mortality in COVID-19 patients: a case control study. J Intensive Care. 2020;8:49 Sieswerda E, de Boer M, Bonten M, Boersman W, Jonkers R, Aleva R et al. Recommendations for antibacterial therapy in adults with COVID-19 - an evidence based guideline. Clin Microbiol Infect. 2021;27(1):61-66 Du Y, Tu L, Zhu P, Mu M, Wang R, Yang P et al. Clinical Features of 85 Fatal Cases of COVID-19 from Wuhan. A Retrospective Observational Study. Am J Respir Crit Care Med. 2020; 201(11):1372-1379 Langford B, So M, Raybardhan S, Leung V, Westwood D, MacFadden D et al. Bacterial co-infection and secondary infection in patients with COVID-19: a living rapid review and meta-analysis. Clin Microbiol Infect. 2020; 26(12):1622-1629
dc.rights.spa.fl_str_mv	Derechos reservados al autor, 2023
dc.rights.coar.fl_str_mv	http://purl.org/coar/access_right/c_abf2
dc.rights.license.spa.fl_str_mv	Reconocimiento 4.0 Internacional
dc.rights.uri.spa.fl_str_mv	http://creativecommons.org/licenses/by/4.0/
dc.rights.accessrights.spa.fl_str_mv	info:eu-repo/semantics/openAccess
rights_invalid_str_mv	Reconocimiento 4.0 Internacional Derechos reservados al autor, 2023 http://creativecommons.org/licenses/by/4.0/ http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv	openAccess
dc.format.extent.spa.fl_str_mv	63 páginas
dc.format.mimetype.spa.fl_str_mv	application/pdf
dc.coverage.country.none.fl_str_mv	Colombia
dc.publisher.spa.fl_str_mv	Universidad Nacional de Colombia
dc.publisher.program.spa.fl_str_mv	Bogotá - Medicina - Especialidad en Medicina Interna
dc.publisher.faculty.spa.fl_str_mv	Facultad de Medicina
dc.publisher.place.spa.fl_str_mv	Bogotá, Colombia
dc.publisher.branch.spa.fl_str_mv	Universidad Nacional de Colombia - Sede Bogotá
institution	Universidad Nacional de Colombia
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spelling	Reconocimiento 4.0 InternacionalDerechos reservados al autor, 2023http://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Cortés Luna, Jorge Alberto0c464a67eb12c6c3cc5db2876f58accdOrtega Quintero, Adriana Paola2c55d7223cddd3ff35e1db892833a29cGómez Rodriguez RosarioSánchez González SandraVillalobos Díaz Maxi FayibeMorantes Caballero Jairo Alberto2023-02-07T13:31:02Z2023-02-07T13:31:02Z2023-02-03https://repositorio.unal.edu.co/handle/unal/83346Universidad Nacional de ColombiaRepositorio Institucional Universidad Nacional de Colombiahttps://repositorio.unal.edu.co/ilustraciones, gráficas, tablasIntroducción: Los pacientes con COVID-19 presentan un espectro clínico variable y su severidad está influenciada por factores de riesgo individuales. Identificarlos de manera oportuna permite predecir formas graves de la enfermedad. Objetivo: Determinar los factores asociados al ingreso a unidad de cuidados intensivos (UCI) en pacientes hospitalizados por COVID-19 durante las primeras 2 olas de la epidemia en Colombia. Materiales y métodos: Estudio de cohorte multicéntrico, retrospectivo en pacientes hospitalizados por COVID-19 en instituciones prestadoras de salud de Bogotá y Girardot, Colombia. Se incluyeron adultos con diagnóstico confirmado de marzo de 2020 a enero de 2021. Se describieron las características sociodemográficas clínicas y paraclínicas de la población y se establecieron las variables independientes que predecían el ingreso a la UCI mediante un modelo de regresión logística multivariada. Resultados: Se incluyeron 1160 pacientes con una edad media de 55 años, 59.7% fueron hombres y 426 pacientes (37.7%) ingresaron a UCI. Los factores asociados a ingreso a UCI fueron edad (OR 1,25, 95%IC: 1,14-1,37 por cada década de vida), sobrepeso (OR 2,82, 95%IC: 1,98-4,02) y obesidad (OR 2,97, 95%IC: 2,03-4,37), antecedente cardiovascular valvular (OR 6,46, 95%IC: 1,84-27,48) hipotensión (OR 2,35, 95%IC: 1,40-3,97), presencia de SIRS (OR 2,03, 95%IC: 1,50-2,74), disnea (OR 1,52, 95%IC:1,09-2.14), requerimiento de oxígeno (OR 2,64, 95%IC: 1,67-4,30 por cada incremento 1% de FiO2), neutrofilia (OR 1,09, 95%IC: 1,05-1,13 por cada 1000 cel/ml), elevación del dímero D (OR: 1,09, 95%IC: 1,03-1,18 por cada 1000 ng/ml), compromiso multilobar (OR 2,19, 95%IC: 1,58-3,07) y consolidación pulmonar (OR 1,52, 95%IC: 1,13-2,04). La mortalidad intrahospitalaria fue de 14,4% (166 pacientes). Conclusión: En esta cohorte de pacientes hospitalizados por COVID-19, el 36,72% ingresaron a UCI, encontrando como principales predictores la edad, obesidad, antecedente de valvulopatía, hipotensión, presencia de SIRS y compromiso pulmonar multilobar. (Texto tomado de la fuente)Background: Patients with COVID-19 present a variable clinical spectrum and its severity is influenced by the presence of risk factors. Identifying them in a timely manner makes it possible to predict severe forms of the disease. Aim: To determine the factors associated with ICU admission in patients hospitalized for COVID-19 during the first 2 waves of the epidemic in Colombia Material and method: Retrospective multicenter cohort study in patients hospitalized for COVID-19 in health care institutions in Bogotá and Girardot, Colombia. Adults with a confirmed diagnosis from March 2020 to January 2021 were included. The clinical and paraclinical sociodemographic characteristics of the population were described and the independent variables that predicted admission to the ICU were obtained using a multivariate logistic regression model. Results: 1160 patients were included: mean age was 55 years, 59,7% were men, and 436 patients (36,7%) were admitted to the ICU. The factors associated with admission to the ICU were age (OR 1,25, 95%CI: 1,14-1,37 for each decade of life), overweight (OR 2,82, 95%CI: 1,98-4,02) and obesity (OR 2,97, 95%CI: 2,03-4,37), antecedent valvular cardiovascular disease (OR 6.46, 95%CI: 1.84-27.48), hypotension (OR 2,35, 95%CI: 1,40-3,97), presence of SIRS (OR 2,03, 95%CI: 1,50-2,74), dyspnea (OR 1,52, 95%CI: 1,09-2,14), oxygen requirement (OR 2,64, 95%CI: 1,67-4,30 for each 1% increase in FiO2), neutrophilia (OR 1,09, 95%CI: 1,05-1,13 for each 1000 cells/ml), elevated D-dimer (OR 1,09, 95%CI: 1,03 - 1,18 per 1000 ng/ml) multilobar involvement (OR 2,19, 95%CI: 1,58-3,07) and pulmonary consolidation (OR 1,52, 95%CI: 1,13-2,04). In-hospital mortality was 14,4% (166 patients). Conclusion: In this cohort of patients hospitalized for COVID-19, 36,72% were admitted to the ICU, finding age, obesity, a history of valve disease, hypotension, presence of SIRS, and multilobar pulmonary involvement as the main predictors.Especialidades MédicasEspecialista en Medicina InternaEstudio epidemiológico, observacional, de cohorte analítico retrospectivo, multicéntrico, en pacientes adultos con diagnóstico confirmado de infección por covid19 que cumplan con los criterios de IRAG establecidos por el Ministerio de Salud según su última revisión (agosto 2010); hospitalizados en instituciones de salud de Bogotá y Girardot - Colombia de marzo de 2020 a enero de 2021. Se describieron las características sociodemográficas clínicas y paraclínicas de la población y se establecieron las variables independientes que predecían el ingreso a la UCI mediante un modelo de regresión logística multivariada.Infectología63 páginasapplication/pdfspaUniversidad Nacional de ColombiaBogotá - Medicina - Especialidad en Medicina InternaFacultad de MedicinaBogotá, ColombiaUniversidad Nacional de Colombia - Sede Bogotá610 - Medicina y salud::616 - EnfermedadesSARS-CoV-2Measures of Association, Exposure, Risk or OutcomeSíndrome Respiratorio Agudo GraveMedidas de Asociación, Exposición, Riesgo o DesenlaceFactores de riesgoUCIRisk factorsCOVID 19Intensive Care UnitFactores asociados a ingreso a UCI en pacientes con IRAG por SARS CoV-2 durante la pandemia en hospitales colombianosFactors associated with ICU admission in patients with SARS CoV-2 during the pandemic in Colombian hospitalsTrabajo de grado - Especialidad Médicainfo:eu-repo/semantics/masterThesisinfo:eu-repo/semantics/acceptedVersionTexthttp://purl.org/redcol/resource_type/TMColombiaInstituto Nacional de Salud. Protocolo de Vigilancia en Salud Pública - Infección Respiratoria Aguda (IRA). 2018. https://www.ins.gov.co/BibliotecaDigital/PRO-Infección-respiratoria-agudaZhu N, Zhang D, Wang W, Li X, Yang Bo, Song J et al. A novel coronavirus from patients with pneumonia in China, 2019. N Engl J Med. 2020;382:727-733Cucinotta D, Vanelli M. WHO declares COVID-19 a Pandemic. Acta Biomed. 2020;91:157-160Wu Z, McGoogan JM. Characteristics of and important lessons from the Coronavirus Disease 2019 (COVID-19) outbreak in China: Summary of a Report of 72314 Cases from the Chinese center for disease control and prevention. JAMA. 2020;323:1239-1242Bhargava A, Fukushima E, Levine M, Zhao W, Tanveer F, Szpunar S et al. Predictors for Severe COVID-19 Infection. Clin infect Dis. 2020;71(8):1962-1968Zhou F, Yu T, Ronghui D, Fan G, Liu Y, Liu Z et al, Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. Lancet. 2020;395:1054-1962Zhang J, Yu Miao, Tong Song, Liu LY, Tang LV. Predictive factors for disease progression in hospitalized patients with coronavirus disease 2019 in Wuhan, China. J Clin Virol. 2020;127:104392Wang D, Hu B, Hu C. Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus–Infected Pneumonia in Wuhan, China. JAMA. 2020;323(11):1061-1069Liu W, Tao ZW, Wang L, Yuan ML, Liu K, Zhou L et al. Analysis of factors associated with disease outcomes in hospitalized patients with 2019 novel coronavirus disease. Chin Med J (Engl). 2020;133(9):1032-1038Bergman J, Ballin M, Nordström A, Nordström P. Risk factors for COVID-19 diagnosis, hospitalization, and subsequent all-cause mortality in Sweden: a nationwide study. Eur J Epidemiol. 2021;36(3):287–298Petrilli CM, Jones SA, Yang J, Rajagopalan H, O’Donnell L, Chernyak Y, et al. Factors associated with hospital admission and critical illness among 5279 people with coronavirus disease 2019 in New York City: prospective cohort study. BMJ. 2020;m1966Murthy S, Archambault PM, Atique A, Carrier FM, Cheng MP, Codan C, et al. Characteristics and outcomes of patients with COVID-19 admitted to hospital and intensive care in the first phase of the pandemic in Canada: a national cohort study. CMAJ Open. 2021;9(1):E181–8Zhou P, Yang XL, Wang XG, Hu B, Zhang L, Zhang W et al. A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature. 2020;579(7798):270-273Eurosurveillance Editorial Team. Note from the editors: World Health Organization declares novel coronavirus (2019-nCoV) sixth public health emergency of international concern. Euro. Surveill. 2020;25(5):200131eCoronaviridae Study Group of the International Committee on Taxonomy of Viruses. 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Clin Microbiol Infect. 2020; 26(12):1622-1629InvestigadoresPúblico generalLICENSElicense.txtlicense.txttext/plain; charset=utf-85879https://repositorio.unal.edu.co/bitstream/unal/83346/1/license.txteb34b1cf90b7e1103fc9dfd26be24b4aMD51ORIGINAL1098742304.2023.pdf1098742304.2023.pdfTrabajo de grado de Especialidad en Medicina Internaapplication/pdf690981https://repositorio.unal.edu.co/bitstream/unal/83346/2/1098742304.2023.pdfcfff20a96731f22ba97869fcc76d55edMD52THUMBNAIL1098742304.2023.pdf.jpg1098742304.2023.pdf.jpgGenerated Thumbnailimage/jpeg4994https://repositorio.unal.edu.co/bitstream/unal/83346/3/1098742304.2023.pdf.jpg972bb6dea0ffd75412e703b87c28e04cMD53unal/83346oai:repositorio.unal.edu.co:unal/833462023-08-15 23:04:34.289Repositorio Institucional Universidad Nacional de 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Factores asociados a ingreso a UCI en pacientes con IRAG por SARS CoV-2 durante la pandemia en hospitales colombianos

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