Factores asociados a dermatitis por radiación aguda en cáncer de mama en un Centro del Oriente Colombiano

El cáncer de mama es la neoplasia maligna más frecuente en mujeres. La radioterapia constituye un pilar terapéutico que mejora la supervivencia hasta en un 20% a 20 años, aunque puede generar efectos adversos, siendo la dermatitis por radiación (DPR) el más común, con una incidencia reportada de has...

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Autores:: Lozano Navarro, Laura Vanessa

Tipo de recurso:

Fecha de publicación:: 2025

Institución:: Universidad Autónoma de Bucaramanga - UNAB

Repositorio:: Repositorio UNAB

Idioma:: spa

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repository_id_str
dc.title.spa.fl_str_mv	Factores asociados a dermatitis por radiación aguda en cáncer de mama en un Centro del Oriente Colombiano
dc.title.translated.spa.fl_str_mv	Factors Associated with Acute Radiation Dermatitis in Breast Cancer at a Center in Eastern Colombia
title	Factores asociados a dermatitis por radiación aguda en cáncer de mama en un Centro del Oriente Colombiano
spellingShingle	Factores asociados a dermatitis por radiación aguda en cáncer de mama en un Centro del Oriente Colombiano Dermatology Medical sciences Health sciences Radiodermatitis Dermatitis Radiation dermatitis Radiotherapy Breast Neoplasms Medicine Medical radiology Blood irradiation Radiation Dermatología Ciencias médicas Medicina Radiología médica Irradiación de sangre Radiodermatitis Radiación Ciencias de la salud Radiodermatitis Dermatitis por radiación Dermatitis Radioterapia Cancer de mama
title_short	Factores asociados a dermatitis por radiación aguda en cáncer de mama en un Centro del Oriente Colombiano
title_full	Factores asociados a dermatitis por radiación aguda en cáncer de mama en un Centro del Oriente Colombiano
title_fullStr	Factores asociados a dermatitis por radiación aguda en cáncer de mama en un Centro del Oriente Colombiano
title_full_unstemmed	Factores asociados a dermatitis por radiación aguda en cáncer de mama en un Centro del Oriente Colombiano
title_sort	Factores asociados a dermatitis por radiación aguda en cáncer de mama en un Centro del Oriente Colombiano
dc.creator.fl_str_mv	Lozano Navarro, Laura Vanessa
dc.contributor.advisor.none.fl_str_mv	Reyes González, Adriana Moreno Jerez, Edgar Augusto
dc.contributor.author.none.fl_str_mv	Lozano Navarro, Laura Vanessa
dc.contributor.cvlac.spa.fl_str_mv	Reyes González, Adriana [0000126469] Moreno Jerez, Edgar Augusto [0001483571] Lozano Navarro, Laura Vanessa [0001726476]
dc.contributor.googlescholar.spa.fl_str_mv	Reyes González, Adriana [es&oi=ao]
dc.contributor.orcid.spa.fl_str_mv	Reyes González, Adriana [0000-0002-9852-9345] Moreno Jerez, Edgar Augusto [0009-0009-5871-9177]
dc.contributor.researchgate.spa.fl_str_mv	Lozano Navarro, Laura Vanessa [Laura_Vanessa_Lozano_Navarro]
dc.contributor.researchgroup.spa.fl_str_mv	Grupo de Investigación en Ciencias y Educación en Salud
dc.contributor.apolounab.spa.fl_str_mv	Reyes González, Adriana [adriana-lucia-reyes-gonzález] Moreno Jerez, Edgar Augusto [edgar-augusto-moreno-jerez/]
dc.subject.keywords.spa.fl_str_mv	Dermatology Medical sciences Health sciences Radiodermatitis Dermatitis Radiation dermatitis Radiotherapy Breast Neoplasms Medicine Medical radiology Blood irradiation Radiation
topic	Dermatology Medical sciences Health sciences Radiodermatitis Dermatitis Radiation dermatitis Radiotherapy Breast Neoplasms Medicine Medical radiology Blood irradiation Radiation Dermatología Ciencias médicas Medicina Radiología médica Irradiación de sangre Radiodermatitis Radiación Ciencias de la salud Radiodermatitis Dermatitis por radiación Dermatitis Radioterapia Cancer de mama
dc.subject.lemb.spa.fl_str_mv	Dermatología Ciencias médicas Medicina Radiología médica Irradiación de sangre Radiodermatitis Radiación
dc.subject.proposal.spa.fl_str_mv	Ciencias de la salud Radiodermatitis Dermatitis por radiación Dermatitis Radioterapia Cancer de mama
description	El cáncer de mama es la neoplasia maligna más frecuente en mujeres. La radioterapia constituye un pilar terapéutico que mejora la supervivencia hasta en un 20% a 20 años, aunque puede generar efectos adversos, siendo la dermatitis por radiación (DPR) el más común, con una incidencia reportada de hasta 90%. La DPR aguda puede variar desde eritema leve hasta necrosis, afectando la calidad de vida y, en casos graves, interrumpiendo el tratamiento. Su aparición depende de factores dosimétricos, técnicos e individuales. Este estudio tiene como objetivo evaluar los factores asociados a la incidencia de DPR en pacientes con cáncer de mama sometidas a radioterapia en un centro del oriente colombiano. Se realizó un estudio de cohorte prospectiva en pacientes con cáncer de mama tratadas con radioterapia adyuvante en dos centros (FOSCAL y FOSUNAB), entre junio y octubre de 2025. Se incluyeron mujeres mayores de 18 años sin radioterapia previa en el mismo campo. El tamaño muestral calculado fue 108 pacientes. El seguimiento tuvo una duración de cuatro semanas, con evaluación clínica semanal y registro de la severidad de DPR según la escala RTOG. El estudio fue aprobado por el comité́ de ética FOSCAL (No. 11196/2025). Resultados: La incidencia acumulada de DPR fue del 68.5%, predominando los casos grado 1 (63.0%) y grado 2 (5.6%); no se observaron casos grado 3 o 4. Las lesiones aparecieron a los 15 ± 5.8 días del inicio del tratamiento. En el análisis bivariado, ninguna variable clínica, sociodemográfica o de tratamiento mostró asociación estadísticamente significativa con la aparición de DPR (p > 0.05), aunque el fototipo mostró una tendencia protectora no significativa (RR=0.86; IC95% 0.71–1.05; p=0.14). En conclusión, La incidencia de DPR fue inferior a la reportada en otros centros. Las técnicas radioterapéuticas modernas y las estrategias preventivas personalizadas podrían contribuir a disminuir esta toxicidad. Se recomienda ampliar el tamaño muestral y realizar análisis dosimétricos para identificar factores de riesgo específicos.
publishDate	2025
dc.date.accessioned.none.fl_str_mv	2025-11-25T16:55:34Z
dc.date.available.none.fl_str_mv	2025-11-25T16:55:34Z
dc.date.issued.none.fl_str_mv	2025-11-25
dc.type.driver.none.fl_str_mv	info:eu-repo/semantics/masterThesis
dc.type.local.spa.fl_str_mv	Tesis
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identifier_str_mv	instname:Universidad Autónoma de Bucaramanga - UNAB reponame:Repositorio Institucional UNAB repourl:https://repository.unab.edu.co
dc.language.iso.spa.fl_str_mv	spa
language	spa
dc.relation.references.spa.fl_str_mv	Cavalcante LG, Domingues RAR, Junior B de O, Fernandes MAR, Pessoa EC, Abbade LPF. Incidence of radiodermatitis and factors associated with its severity in women with breast cancer: a cohort study. An Bras Dermatol. 2024 Jan 1;99(1):57–65. Hegedus F, Mathew LM, Schwartz RA. Radiation dermatitis: an overview. Vol. 56, International Journal of Dermatology. Blackwell Publishing Ltd; 2017. p. 909–14. Bontempo PDSM, Ciol MA, de Menêses AG, Simino GPR, Ferreira EB, dos Reis PED. Acute radiodermatitis in cancer patients: incidence and severity estimates. Revista da Escola de Enfermagem. 2021;55:1–8. Singh M, Alavi A, Wong R, Akita S. Radiodermatitis: A Review of Our Current Understanding. Vol. 17, American Journal of Clinical Dermatology. Springer International Publishing; 2016. p. 277–92. Protocolo de vigilancia en salud pública. Cáncer de mama y cuello uterino [Internet]. 2024 Aug. Available from: https://www.ins.gov.co/buscador- eventos/Lineamientos/Pro_C%C3%A1ncer%20de%20mama%20y%20cuello%20uterino %202024.pdf Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, et al. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA Cancer J Clin. 2021 May;71(3):209–49. Pi~ M, Laversanne M, Barrios E, De M, Cancela C, De Vries E, et al. An updated profile of the cancer burden, patterns and trends in Latin America and the Caribbean. 2022; Available from: https://doi.org/10.1016/j. Pardo C, Cendales R. Incidencia, mortalidad y prevalencia de Cáncer en Colombia [Internet]. 2012. Available from: www.cancer.gov.co/conozca-sobre-cancer-1/ Langlands FE, Horgan K, Ddodwell D, Smith L. Breast cancer subtypes: Response to radiotherapy and potential radiosensitisation. Vol. 86, British Journal of Radiology. 2013. Rübe CE, Freyter BM, Tewary G, Roemer K, Hecht M, Rübe C. Radiation Dermatitis: Radiation-Induced Effects on the Structural and Immunological Barrier Function of the Epidermis. Vol. 25, International Journal of Molecular Sciences. Multidisciplinary Digital Publishing Institute (MDPI); 2024. Beamer LC, Grant M. Longitudinal trends in skin-related and global quality of life among women with breast radiodermatitis: A pilot study. European Journal of Oncology Nursing. 2018 Apr 1;33:22–7. Bastos LJD, Lanzillotti RS, Brandão MAG, da Silva RC, Simões FV. Radiodermatitis: Severity, predictive factors and discontinuation of radiotherapy in patients with anal and rectal cancer. Revista da Escola de Enfermagem. 2022;56. Vieira LAC, Menêses AG de, Bontempo P de SM, Simino GPR, Ferreira EB, Guerra EN da S, et al. Incidence of radiodermatitis in breast cancer patients during hypofractionated radiotherapy. Revista da Escola de Enfermagem da USP. 2022;56. Jean L. Bolognia. Dermatología. Cuarta Edición. Vol. 1, Michael J. Veness y Shawn W. Richards. Elsevier; 2019. 2393–2403 p. De San U, De Guatemala C, De F, Médicas C, Mundial N, Esmeralda D, et al. A ESTUDIOS DE IMAGEN QUE EMITEN RADIACIÓN IONIZANTE A. 2022. Ryan JL. Ionizing Radiation: The Good, the Bad, and the Ugly. J Invest Dermatol [Internet]. 2012 [cited 2024 Dec 9];132(3 0 2):985. Available from: https://pmc.ncbi.nlm.nih.gov/articles/PMC3779131/ Schnur JB, Love B, Scheckner BL, Green S, Gabriella A, Montgomery GH. A systematic review of patient-rated measures of radiodermatitis in breast cancer radiotherapy. Vol. 34, American Journal of Clinical Oncology: Cancer Clinical Trials. 2011. p. 529–36. Solórzano L, Guzman JA, Arismendi N, Brito E. REACCIONES DERMATOLÓGICAS AGUDAS EN PACIENTES TRATADOS CON RADIOTERAPIA EXTERNA. SABER [Internet]. 2015 Mar;27(2):253–8. Available from: http://www.redalyc.org/articulo.oa?id=427742245006 Allali S, Kirova Y. Radiodermatitis and fibrosis in the context of breast radiation therapy: A critical review. Vol. 13, Cancers. MDPI; 2021. Pignol JP, Olivotto I, Rakovitch E, Gardner S, Sixel K, Beckham W, et al. A multicenter randomized trial of breast intensity-modulated radiation therapy to reduce acute radiation dermatitis. Journal of Clinical Oncology. 2008;26(13):2085–92. Krug D, Köder C, Häfner MF, Arians N, Harrabi SB, Koerber SA, et al. Acute toxicity of normofractionated intensity modulated radiotherapy with simultaneous integrated boost compared to three-dimensional conformal radiotherapy with sequential boost in the adjuvant treatment of breast cancer. Radiation Oncology. 2020 Dec 1;15(1). Huang CJ, Hou MF, Luo KH, Wei SY, Huang MY, Su SJ, et al. RTOG, CTCAE and WHO criteria for acute radiation dermatitis correlate with cutaneous blood flow measurements. Breast. 2015 Jun 1;24(3):230–6. Cancer Institute N. Common Terminology Criteria for Adverse Events (CTCAE) Common Terminology Criteria for Adverse Events (CTCAE) v5.0 [Internet]. 2017. Available from: https://www.meddra.org/ Kole AJ, Kole L, Moran MS. Acute radiation dermatitis in breast cancer patients: Challenges and solutions. Vol. 9, Breast Cancer: Targets and Therapy. Dove Medical Press Ltd.; 2017. p. 313–23. Shaitelman SF, Schlembach PJ, Arzu I, Ballo M, Bloom ES, Buchholz D, et al. Acute and short-term toxic effects of conventionally fractionated vs hypofractionated whole-breast irradiation : A randomized clinical trial. JAMA Oncol. 2015 Oct 1;1(7):931–41. Borrelli MR, Shen AH, Lee GK, Momeni A, Longaker MT, Wan DC. Radiation-Induced Skin Fibrosis: Pathogenesis, Current Treatment Options, and Emerging Therapeutics. Vol. 83, Annals of plastic surgery. NLM (Medline); 2019. p. S59–64. Guangmei D, Weishan H, Wenya L, Fasheng W, Jibing C. Evolution of radiation-induced dermatitis treatment. Clinical and Translational Oncology 2024 26:9 [Internet]. 2024 Apr 9 [cited 2024 Dec 10];26(9):2142–55. Available from: https://link.springer.com/article/10.1007/s12094-024-03460-1 Kost Y, Deutsch A, Mieczkowska K, Nazarian R, Muskat A, Hosgood HD, et al. Bacterial Decolonization for Prevention of Radiation Dermatitis: A Randomized Clinical Trial. JAMA Oncol [Internet]. 2023 Jul 20 [cited 2024 Dec 10];9(7):940. Available from: https://pmc.ncbi.nlm.nih.gov/articles/PMC10160991/ McQuestion M. Evidence-Based Skin Care Management in Radiation Therapy: Clinical Update. Semin Oncol Nurs. 2011 May 1;27(2):e1–17. Hymes SR, Strom EA, Fife C. Radiation dermatitis: Clinical presentation, pathophysiology, and treatment 2006. J Am Acad Dermatol [Internet]. 2006 Jan 1 [cited 2024 Dec 11];54(1):28–46. Available from: http://www.jaad.org/article/S0190962205027076/fulltext Ryan JL. Ionizing radiation: the good, the bad, and the ugly. J Invest Dermatol [Internet]. 2012 [cited 2024 Dec 11];132(3 Pt 2):985–93. Available from: https://pubmed.ncbi.nlm.nih.gov/22217743/ Wong RKS, Bensadoun RJ, Boers-Doets CB, Bryce J, Chan A, Epstein JB, et al. Clinical practice guidelines for the prevention and treatment of acute and late radiation reactions from the MASCC Skin Toxicity Study Group. Support Care Cancer [Internet]. 2013 [cited 2024 Dec 11];21(10):2933–48. Available from: https://pubmed.ncbi.nlm.nih.gov/23942595/ Kraus-Tiefenbacher U, Sfintizky A, Welzel G, Simeonova A, Sperk E, Siebenlist K, et al. Factors of influence on acute skin toxicity of breast cancer patients treated with standard three-dimensional conformal radiotherapy (3D-CRT) after breast conserving surgery (BCS) [Internet]. Vol. 7, Radiation Oncology. 2012. Available from: http://www.ro- journal.com/content/7/1/217 Borm KJ, Loos M, Oechsner M, Mayinger MC, Paepke D, Kiechle MB, et al. Acute radiodermatitis in modern adjuvant 3D conformal radiotherapy for breast cancer - The impact of dose distribution and patient related factors. Radiation Oncology. 2018 Nov 7;13(1). Huang EY, Ho MW, Wang YM. Dosimetric Correlation of Acute Radiation Dermatitis in Patients With Breast Cancer Undergoing Hypofractionated Proton Beam Therapy Using Pencil Beam Scanning. J Breast Cancer. 2024 Jun 1;27(3):187–200. Chen MF, Chen WC, Lai CH, Hung CH, Liu KC, Cheng YH. Predictive factors of radiation-induced skin toxicity in breast cancer patients [Internet]. 2010. Available from: http://www.biomedcentral.com/1471-2407/10/508 Liu D, Zheng Z, Zhang S, Zhu C, Zhang H, Zhou Y. Analysis of risk factors related to acute radiation dermatitis in breast cancer patients during radiotherapy. J Cancer Res Ther. 2022 Dec 1;18(7):1903–9. Kyei KA, Anim-Sampong S, Akoe EA, Daniels J, Obeng-Mensah T, Antwi WK, et al. Radiation-induced dermatitis among breast cancer patients undergoing adjuvant radiotherapy in Ghana. Transl Oncol. 2024 Aug 1;46. Sharp L, Johansson H, Hatschek T, Bergenmar M. Smoking as an independent risk factor for severe skin reactions due to adjuvant radiotherapy for breast cancer. Breast. 2013;22(5):634–8. Lee J, Park W, Choi DH, Huh SJ, Kim IR, Kang D, et al. Patient-reported symptoms of radiation dermatitis during breast cancer radiotherapy: a pilot study. Quality of Life Research. 2017 Jul 1;26(7):1713–9. Mikami K, Kitajima M, Noto Y, Itaki C, Fukushi Y, Hirota Y, et al. Long-term analysis of irradiated skin after breast-conserving surgery in breast cancer patients using noninvasive imaging. Aging Cancer. 2021 Dec 1;2(4):129–36. McLaughlin MF, Donoviel DB, Jones JA. Novel indications for commonly used medications as radiation protectants in spaceflight. Vol. 88, Aerospace Medicine and Human Performance. Aerospace Medical Association; 2017. p. 665–76. Holler V, Buard V, Gaugler MH, Guipaud O, Baudelin C, Sache A, et al. Pravastatin limits radiation-induced vascular dysfunction in the skin. Journal of Investigative Dermatology. 2009;129(5):1280–91. PEPE AL. Cáncer de mama. [Internet]. Vol. 4, Obstetricia y ginecología latino- americanas. 1946. p. 843–9. Available from: https://www.who.int/es/news- room/factsheets/detail/breast-cancer#:~:text=Quién está en riesgo&text=Aproximadamente%2C un 99%25 de los,se aplican a las mujeres.
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dc.coverage.spatial.spa.fl_str_mv	Floridablanca (Santander, Colombia)
dc.coverage.temporal.spa.fl_str_mv	Junio - Octubre 2025
dc.coverage.campus.spa.fl_str_mv	UNAB Campus Bucaramanga
dc.publisher.grantor.spa.fl_str_mv	Universidad Autónoma de Bucaramanga UNAB
dc.publisher.faculty.spa.fl_str_mv	Facultad Ciencias de la Salud
dc.publisher.program.spa.fl_str_mv	Especialización en Dermatología
dc.publisher.programid.none.fl_str_mv	EDER-356
institution	Universidad Autónoma de Bucaramanga - UNAB
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spelling	Reyes González, Adriana45f1d165-e5e5-4c82-8092-81e53475c6d7Moreno Jerez, Edgar Augusto02e5b79f-aa57-4265-8d74-709133e04fb9Lozano Navarro, Laura Vanessab7a1d4f6-bf22-4c3d-8faa-48ade7f66098Reyes González, Adriana [0000126469]Moreno Jerez, Edgar Augusto [0001483571]Lozano Navarro, Laura Vanessa [0001726476]Reyes González, Adriana [es&oi=ao]Reyes González, Adriana [0000-0002-9852-9345]Moreno Jerez, Edgar Augusto [0009-0009-5871-9177]Lozano Navarro, Laura Vanessa [Laura_Vanessa_Lozano_Navarro]Grupo de Investigación en Ciencias y Educación en SaludReyes González, Adriana [adriana-lucia-reyes-gonzález]Moreno Jerez, Edgar Augusto [edgar-augusto-moreno-jerez/]Floridablanca (Santander, Colombia)Junio - Octubre 2025UNAB Campus Bucaramanga2025-11-25T16:55:34Z2025-11-25T16:55:34Z2025-11-25http://hdl.handle.net/20.500.12749/32260instname:Universidad Autónoma de Bucaramanga - UNABreponame:Repositorio Institucional UNABrepourl:https://repository.unab.edu.coEl cáncer de mama es la neoplasia maligna más frecuente en mujeres. La radioterapia constituye un pilar terapéutico que mejora la supervivencia hasta en un 20% a 20 años, aunque puede generar efectos adversos, siendo la dermatitis por radiación (DPR) el más común, con una incidencia reportada de hasta 90%. La DPR aguda puede variar desde eritema leve hasta necrosis, afectando la calidad de vida y, en casos graves, interrumpiendo el tratamiento. Su aparición depende de factores dosimétricos, técnicos e individuales. Este estudio tiene como objetivo evaluar los factores asociados a la incidencia de DPR en pacientes con cáncer de mama sometidas a radioterapia en un centro del oriente colombiano. Se realizó un estudio de cohorte prospectiva en pacientes con cáncer de mama tratadas con radioterapia adyuvante en dos centros (FOSCAL y FOSUNAB), entre junio y octubre de 2025. Se incluyeron mujeres mayores de 18 años sin radioterapia previa en el mismo campo. El tamaño muestral calculado fue 108 pacientes. El seguimiento tuvo una duración de cuatro semanas, con evaluación clínica semanal y registro de la severidad de DPR según la escala RTOG. El estudio fue aprobado por el comité́ de ética FOSCAL (No. 11196/2025). Resultados: La incidencia acumulada de DPR fue del 68.5%, predominando los casos grado 1 (63.0%) y grado 2 (5.6%); no se observaron casos grado 3 o 4. Las lesiones aparecieron a los 15 ± 5.8 días del inicio del tratamiento. En el análisis bivariado, ninguna variable clínica, sociodemográfica o de tratamiento mostró asociación estadísticamente significativa con la aparición de DPR (p > 0.05), aunque el fototipo mostró una tendencia protectora no significativa (RR=0.86; IC95% 0.71–1.05; p=0.14). En conclusión, La incidencia de DPR fue inferior a la reportada en otros centros. Las técnicas radioterapéuticas modernas y las estrategias preventivas personalizadas podrían contribuir a disminuir esta toxicidad. Se recomienda ampliar el tamaño muestral y realizar análisis dosimétricos para identificar factores de riesgo específicos.Introducción ............................................................................................................... 9 Planteamiento del problema ...................................................................................... 9 Justificación ............................................................................................................. 12 Definición ........................................................................................................................13 Epidemiología ..................................................................................................................14 Fisiopatología...................................................................................................................15 Factores asociados ...........................................................................................................17 Manifestaciones clínicas y severidad.................................................................................19 Prevención y tratamiento .................................................................................................22 Pronóstico........................................................................................................................24 Estado del Arte......................................................................................................... 24 Pregunta e hipótesis de investigación ....................................................................... 31 Pregunta de investigación.................................................................................................31 Hipótesis de la investigación.............................................................................................31 Objetivos.................................................................................................................. 33 Objetivo General..............................................................................................................33 Objetivos específicos........................................................................................................33 Metodología ............................................................................................................ 33 Tipo de estudio ................................................................................................................33 Población.........................................................................................................................33 Criterios de inclusión ........................................................................................................33 Criterios de exclusión .......................................................................................................34 Cálculo de tamaño de muestra .........................................................................................34 Muestreo: ........................................................................................................................34 Recolección de la información ..........................................................................................35 Variables..........................................................................................................................36 Plan de análisis de datos...................................................................................................37 Consideraciones éticas.............................................................................................. 38 Resultados ............................................................................................................... 40 Discusión.................................................................................................................. 50 Conclusiones ............................................................................................................ 59 Referencias bibliográficas......................................................................................... 60 Anexos ..................................................................................................................... 67 Cronograma de actividades ...................................................................................... 73EspecializaciónBreast cancer is the most common malignant neoplasm in women. Radiotherapy is a therapeutic pillar that improves survival by up to 20% at 20 years, although it can cause adverse effects, the most common being radiation dermatitis (RD), with a reported incidence of up to 90%. Acute RD can range from mild erythema to necrosis, affecting quality of life and, in severe cases, interrupting treatment. Its onset depends on dosimetric, technical, and individual factors. This study aims to evaluate the factors associated with the incidence of RD in breast cancer patients undergoing radiotherapy at a center in eastern Colombia. A prospective cohort study was conducted in breast cancer patients treated with adjuvant radiotherapy at two centers (FOSCAL and FOSUNAB) between June and October 2025. Women over 18 years of age with no previous radiotherapy in the same field were included. The calculated sample size was 108 patients. Follow-up lasted four weeks, with weekly clinical evaluation and recording of the severity of RD according to the RTOG scale. The study was approved by the FOSCAL ethics committee (No. 11196/2025). Results: The cumulative incidence of RD was 68.5%, with grade 1 (63.0%) and grade 2 (5.6%) cases predominating; no grade 3 or 4 cases were observed. Lesions appeared 15 ± 5.8 days after the start of treatment. In the bivariate analysis, no clinical, sociodemographic, or treatment variable showed a statistically significant association with the onset of RD (p > 0.05), although skin type showed a non-significant protective trend (RR = 0.86; 95% CI 0.71–1.05; p = 0.14). In conclusion, the incidence of RD was lower than that reported in other centers. Modern radiotherapy techniques and personalized preventive strategies could contribute to reducing this toxicity. It is recommended to increase the sample size and perform dosimetric analyses to identify specific risk factors.Modalidad Presencialapplication/pdfspahttp://creativecommons.org/licenses/by-nc-nd/2.5/co/Abierto (Texto Completo)Atribución-NoComercial-SinDerivadas 2.5 Colombiahttp://purl.org/coar/access_right/c_abf2Factores asociados a dermatitis por radiación aguda en cáncer de mama en un Centro del Oriente ColombianoFactors Associated with Acute Radiation Dermatitis in Breast Cancer at a Center in Eastern ColombiaEspecialista en DermatologíaUniversidad Autónoma de Bucaramanga UNABFacultad Ciencias de la SaludEspecialización en DermatologíaEDER-356info:eu-repo/semantics/masterThesisTesisinfo:eu-repo/semantics/acceptedVersionhttp://purl.org/redcol/resource_type/TMDermatologyMedical sciencesHealth sciencesRadiodermatitisDermatitisRadiation dermatitisRadiotherapyBreast NeoplasmsMedicineMedical radiologyBlood irradiationRadiationDermatologíaCiencias médicasMedicinaRadiología médicaIrradiación de sangreRadiodermatitisRadiaciónCiencias de la saludRadiodermatitisDermatitis por radiaciónDermatitisRadioterapiaCancer de mamaCavalcante LG, Domingues RAR, Junior B de O, Fernandes MAR, Pessoa EC, Abbade LPF. 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Available from: https://www.who.int/es/news- room/factsheets/detail/breast-cancer#:~:text=Quién está en riesgo&text=Aproximadamente%2C un 99%25 de los,se aplican a las mujeres.https://apolo.unab.edu.co/en/persons/adriana-lucila-reyes-gonz%C3%A1lez/ORIGINALPROYECTO DE GRADO DPR con correciones.pdfPROYECTO DE GRADO DPR con correciones.pdfTesisapplication/pdf2402736https://repository.unab.edu.co/bitstream/20.500.12749/32260/1/PROYECTO%20DE%20GRADO%20DPR%20con%20correciones.pdfe5dd781a2087b584cc1e26a8ff139a79MD51open accessLicencia.pdfLicencia.pdfLicenciaapplication/pdf577554https://repository.unab.edu.co/bitstream/20.500.12749/32260/5/Licencia.pdf2c41ae146e7bf0c649993169b0d8cb69MD55metadata only accessLICENSElicense.txtlicense.txttext/plain; charset=utf-8829https://repository.unab.edu.co/bitstream/20.500.12749/32260/4/license.txt3755c0cfdb77e29f2b9125d7a45dd316MD54open accessTHUMBNAILPROYECTO DE GRADO DPR con correciones.pdf.jpgPROYECTO DE GRADO DPR con correciones.pdf.jpgIM Thumbnailimage/jpeg5530https://repository.unab.edu.co/bitstream/20.500.12749/32260/6/PROYECTO%20DE%20GRADO%20DPR%20con%20correciones.pdf.jpg62e2286d438786797762cbeb415f0dbcMD56open accessLicencia.pdf.jpgLicencia.pdf.jpgIM Thumbnailimage/jpeg12382https://repository.unab.edu.co/bitstream/20.500.12749/32260/7/Licencia.pdf.jpg5318732e6b06942f290485c74473a93cMD57metadata only access20.500.12749/32260oai:repository.unab.edu.co:20.500.12749/322602025-11-25 22:01:36.432open accessRepositorio Institucional \| Universidad Autónoma de Bucaramanga - UNABrepositorio@unab.edu.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

Factores asociados a dermatitis por radiación aguda en cáncer de mama en un Centro del Oriente Colombiano

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