Asociación entre la inducción del trabajo de parto con oxitocina sintética y el riesgo de depresión a los dos meses posparto: Una cohorte prospectiva

La depresión posparto (DPP) es una de las principales complicaciones de la salud mental materna, con consecuencias que trascienden el bienestar de la madre y afectan el desarrollo del recién nacido y la dinámica familiar (1). Se ha identificado como un factor de riesgo significativo para el maltrato...

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Autores:: Carrillo Mejía, María Lourdes

Tipo de recurso:

Fecha de publicación:: 2025

Institución:: Universidad Autónoma de Bucaramanga - UNAB

Repositorio:: Repositorio UNAB

Idioma:: spa

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network_acronym_str	UNAB2
network_name_str	Repositorio UNAB
repository_id_str
dc.title.spa.fl_str_mv	Asociación entre la inducción del trabajo de parto con oxitocina sintética y el riesgo de depresión a los dos meses posparto: Una cohorte prospectiva
dc.title.translated.spa.fl_str_mv	Association Between Labor Induction With Synthetic Oxytocin and the Risk of Depression Two Months Postpartum: A Prospective Cohort Study
title	Asociación entre la inducción del trabajo de parto con oxitocina sintética y el riesgo de depresión a los dos meses posparto: Una cohorte prospectiva
spellingShingle	Asociación entre la inducción del trabajo de parto con oxitocina sintética y el riesgo de depresión a los dos meses posparto: Una cohorte prospectiva Gynecology Obstetrics Medical sciences Health sciences Oxytocin Postpartum depression Mental depression Postpartum psychiatric disorders Puerperal psychosis Ginecología Ciencias médicas Depresión mental Trastornos psiquiátricos posparto Psicosis puerperal Ciencias de la salud Oxitocina Depresión posparto
title_short	Asociación entre la inducción del trabajo de parto con oxitocina sintética y el riesgo de depresión a los dos meses posparto: Una cohorte prospectiva
title_full	Asociación entre la inducción del trabajo de parto con oxitocina sintética y el riesgo de depresión a los dos meses posparto: Una cohorte prospectiva
title_fullStr	Asociación entre la inducción del trabajo de parto con oxitocina sintética y el riesgo de depresión a los dos meses posparto: Una cohorte prospectiva
title_full_unstemmed	Asociación entre la inducción del trabajo de parto con oxitocina sintética y el riesgo de depresión a los dos meses posparto: Una cohorte prospectiva
title_sort	Asociación entre la inducción del trabajo de parto con oxitocina sintética y el riesgo de depresión a los dos meses posparto: Una cohorte prospectiva
dc.creator.fl_str_mv	Carrillo Mejía, María Lourdes
dc.contributor.advisor.none.fl_str_mv	Castro Rueda, Vanesa Alexandra Quintero Roa, Eliana Maribel Ochoa Vera, Miguel Enrique
dc.contributor.author.none.fl_str_mv	Carrillo Mejía, María Lourdes
dc.contributor.cvlac.spa.fl_str_mv	Ochoa Vera, Miguel Enrique [898465] Quintero Roa, Eliana Maribel [0000802689]
dc.contributor.orcid.spa.fl_str_mv	Ochoa Vera, Miguel Enrique [0000-0002-4552-3388] Quintero Roa, Eliana Maribel [0000-0002-4355-384X]
dc.contributor.researchgate.spa.fl_str_mv	Ochoa Vera, Miguel Enrique [Miguel_Ochoa7]
dc.contributor.researchgroup.spa.fl_str_mv	Semilleros de Investigación UNAB
dc.contributor.apolounab.spa.fl_str_mv	Ochoa Vera, Miguel Enrique [miguel-enrique-ochoa-vera] Quintero Roa, Eliana Maribel [eliana-maribel-quintero-roa]
dc.contributor.linkedin.spa.fl_str_mv	Ochoa Vera, Miguel Enrique [miguel-enrique-ochoa-vera-ab1468100/]
dc.subject.keywords.spa.fl_str_mv	Gynecology Obstetrics Medical sciences Health sciences Oxytocin Postpartum depression Mental depression Postpartum psychiatric disorders Puerperal psychosis
topic	Gynecology Obstetrics Medical sciences Health sciences Oxytocin Postpartum depression Mental depression Postpartum psychiatric disorders Puerperal psychosis Ginecología Ciencias médicas Depresión mental Trastornos psiquiátricos posparto Psicosis puerperal Ciencias de la salud Oxitocina Depresión posparto
dc.subject.lemb.spa.fl_str_mv	Ginecología Ciencias médicas Depresión mental Trastornos psiquiátricos posparto Psicosis puerperal
dc.subject.proposal.spa.fl_str_mv	Ciencias de la salud Oxitocina Depresión posparto
description	La depresión posparto (DPP) es una de las principales complicaciones de la salud mental materna, con consecuencias que trascienden el bienestar de la madre y afectan el desarrollo del recién nacido y la dinámica familiar (1). Se ha identificado como un factor de riesgo significativo para el maltrato infantil y el deterioro del vínculo madre-hijo, lo que subraya la necesidad de su detección y manejo oportuno (2). Sin embargo, la identificación temprana de los síntomas depresivos sigue siendo un reto, en gran parte debido al desconocimiento de los factores de riesgo que predisponen a esta condición. Entre las múltiples intervenciones obstétricas realizadas durante el trabajo de parto, la administración de oxitocina sintética para la inducción o conducción del parto es una de las más frecuentes (3). Aunque su papel en la estimulación de las contracciones uterinas está bien establecido (4), su influencia en los procesos neurobiológicos que regulan el estado de ánimo y el comportamiento social ha generado inquietudes. La oxitocina endógena desempeña un papel clave en la modulación del apego materno, la reducción del estrés y la estabilidad emocional (3); en contraste, el uso exógeno de oxitocina sintética podría alterar estos procesos, interfiriendo con la regulación natural de la hormona y potencialmente aumentando el riesgo de trastornos del estado de ánimo en el puerperio (5). A pesar de que algunos estudios han explorado la relación entre esta intervención obstétrica y el bienestar psicológico materno, los hallazgos han sido inconsistentes. Mientras que algunas investigaciones sugieren una posible asociación entre el uso de oxitocina sintética y un mayor riesgo de DPP (6–8), otros han descrito a la oxitocina sintética como una factor protector (9). Esta incertidumbre pone de manifiesto la necesidad de estudios adicionales que permitan esclarecer esta relación y guíen mejores prácticas en la atención obstétrica. Este estudio busca evaluar la asociación entre la inducción del trabajo de parto con oxitocina sintética y el riesgo de desarrollar depresión a los dos meses posparto a través de un diseño de cohorte prospectiva. Además, se explorarán otros factores de riesgo asociados con la DPP con el objetivo de generar evidencia que contribuya a una atención obstétrica más informada y centrada en la salud mental materna.
publishDate	2025
dc.date.accessioned.none.fl_str_mv	2025-06-10T16:14:00Z
dc.date.available.none.fl_str_mv	2025-06-10T16:14:00Z
dc.date.issued.none.fl_str_mv	2025-05-19
dc.type.driver.none.fl_str_mv	info:eu-repo/semantics/masterThesis
dc.type.local.spa.fl_str_mv	Tesis
dc.type.hasversion.none.fl_str_mv	info:eu-repo/semantics/acceptedVersion
dc.type.redcol.none.fl_str_mv	http://purl.org/redcol/resource_type/TM
status_str	acceptedVersion
dc.identifier.uri.none.fl_str_mv	http://hdl.handle.net/20.500.12749/29557
dc.identifier.instname.spa.fl_str_mv	instname:Universidad Autónoma de Bucaramanga - UNAB
dc.identifier.reponame.spa.fl_str_mv	reponame:Repositorio Institucional UNAB
dc.identifier.repourl.spa.fl_str_mv	repourl:https://repository.unab.edu.co
url	http://hdl.handle.net/20.500.12749/29557
identifier_str_mv	instname:Universidad Autónoma de Bucaramanga - UNAB reponame:Repositorio Institucional UNAB repourl:https://repository.unab.edu.co
dc.language.iso.spa.fl_str_mv	spa
language	spa
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Rev Colomb Obstet Ginecol [Internet]. 2013;64(4):371–8. Available from: http://www.redalyc.org/articulo.oa?id=195229800003 Canaval G, Gonzalez M, Martinez L, Tovar M, Valencia C. Depresión postparto, apoyo social y calidad de vida en mujeres de Cali, Colombia. Colomb Med. 200AD;31. Ortiz R, Gallego C, Buitron E, Meneses Y, Muñoz N, Gonzales M. Prevalencia de tamiz positivo para Depresión Postparto en un Hospital de tercer nivel y posibles factores asociados. Rev Colomb Psiquiatr. 2016;45(4):253–61. Marles M, León Y, Solarte D. Depresión posparto: prevalencia y relación con la tipología y función familiar . Repertorio de Medicina y Cirugía FUCS. 2024;33:170– 7. Latorre J, Contreras L, Herrán O. Depresión posparto en una ciudad Colombiana. Factores de riesgo. Aten Primaria. 2006;37(6):332–8. Strapasson M, Ferreira C, Ramos J. Associations between postpartum depression and hypertensive disorders of pregnancy. International Journal of Gynecology and Obstetrics. 2018;143(3):367–73. Payne JL, Maguire J. Pathophysiological mechanisms implicated in postpartum depression. Vol. 52, Frontiers in Neuroendocrinology. Academic Press Inc.; 2019. p. 165–80. Doornbos B, Dijck-Brouwer DAJ, Kema IP, Tanke MAC, van Goor SA, Muskiet FAJ, et al. The development of peripartum depressive symptoms is associated with gene polymorphisms of MAOA, 5-HTT and COMT. Prog Neuropsychopharmacol Biol Psychiatry. 2009 Oct;33(7):1250–4. Bloch M, Daly RC, Rubinow DR. Endocrine Factors in the Etiology of Postpartum Depression. Compr Psychiatry. 2003;44(3):234–46. Arguz Cildir D, Ozbek A, Topuzoglu A, Orcin E, Janbakhishov CE. Association of prenatal attachment and early childhood emotional, behavioral, and developmental characteristics: A longitudinal study. Infant Ment Health J. 2020;41(4):517–29. Fasching PA, Faschingbauer F, Goecke TW, Engel A, Häberle L, Seifert A, et al. Genetic variants in the tryptophan hydroxylase 2 gene (TPH2) and depression during and after pregnancy. J Psychiatr Res. 2012;46(9):1109–17. Tye KM, Mirzabekov JJ, Warden Melissa R, Ferenczi EA, Tsai HC, Finkelstein J, et al. Dopamine neurons modulate neural encoding and expression of depression- related behaviour. Nature [Internet]. 2013;537–41. Available from: www.nature.com/reprints. Orejarena S. Trastornos afectivos posparto. MedUNAB. 2004;7:134–9. Pearlstein T, Howard M, Salisbury A, Zlotnick C. Postpartum depression. Am J Obstet Gynecol. 2009 Apr;200(4):357–64. Cox JL, Holden JM, Sagovsky R. Detection of Postnatal Depression: Development of the 10-item Edinburgh Postnatal Depression scale. British Journal of Psychiatry. 1987;150:782–6. National Institute for Health and Clinical Excellence (NICE). Antenatal and postnatal mental health: clinical management and service guidance [Internet]. 2014. Available from: www.nice.org.uk/guidance/cg192 Levis B, Negeri Z, Sun Y, Benedetti A, Thombs BD. Accuracy of the Edinburgh Postnatal Depression Scale (EPDS) for screening to detect major depression among pregnant and postpartum women: systematic review and meta-analysis of individual participant data. BMJ. 2020 Nov 11;m4022. Campo A, Ayola C, Peinado H, Amor M, Cogollo Z. Escala de Edinburgh para depresión posparto: consistencia interna y estructura factorial en mujeres embarazadas de Cartagena, Colombia. Rev Colomb Obstet Ginecol. 2007;58(•):277. Castañón CS, Pinto JL. Mejorando la pesquisa de depresión posparto a través de un instrumento de tamizaje, la escala de depresión posparto de Edimburgo. Rev Chil Obstet Ginecol. 2008;136:851–8. Cardone IA, Kim JJ, Gordon TEJ, Gordon SM, Silver RK. Psychosocial assessment by phone for high-scoring patients taking the Edinburgh Postnatal Depression Scale: Communication pathways and strategies. Arch Womens Ment Health. 2006;9(2):87–94. Quelopana Ana, Dimmit Jane. Validación del cuestionario “Postpartum depression screening scale” Versión en español en mujeres de Arica, Chile. Ciencia y enfermería XVI. 2010;37–47. Lara M, Navarrete L. Detección de depresión en mujeres embarazadas mexicanas con la CES-D. Salud Mental. 2012;35:57–62. Maldonado N, Castro R, Cardona P. Psychometric Properties of the Beck Depression Inventory-II (BDI-II) in Colombian University Students. Rev Colomb Psiquiatr. 2021; Guille C, Newman R, Fryml LD, Lifton CK, Epperson CN. Management of postpartum depression. Vol. 58, Journal of Midwifery and Women’s Health. John Wiley and Sons Inc.; 2013. p. 643–53. Massey SH, Schuette SA, Pournajafi-Nazarloo H, Wisner KL, Carter CS. Interaction of oxytocin level and past depression may predict postpartum depressive symptom severity. Arch Womens Ment Health. 2016;19(5):799–808. Hinshaw K, Simpson S, Cummings S, Hildreth A, Thornton J. A randomised controlled trial of early versus delayed oxytocin augmentation to treat primary dysfunctional labour in nulliparous women. BJOG. 2008;115(10):1289–96. Kroll-Desrosiers AR, Nephew BC, Babb JA, Guilarte-Walker Y, Moore Simas TA, Deligiannidis KM. Association of peripartum synthetic oxytocin administration and depressive and anxiety disorders within the first postpartum year. Depress Anxiety. 2017;34(2):137–46. Zúñiga E, Vásquez A, Forero jesica. GUÍA DE ATENCIÓN CLÍNICA PARA EL MANEJO INTRAHOSPITALARIO DE LA PACIENTE PROGRAMADA PARA CESÁREA. Bucaramanga; 2022. p. 29–30. Conde M, Acuña C. GUÍA DE ATENCIÓN CLÍNICA PARA EL MANEJO INTRAHOSPITALARIO DE LA PACIENTE PROGRAMADA PARA CESÁREA. Bucaramanga; 2018. p. 32–3. Gelvez L, Vásquez A, Forero J. GUÍA DE VIGILANCIA Y ATENCIÓN DEL TRABAJO PARTO Y PARTO NORMAL HOSPITAL LOCAL DEL NORTE – E.S.E ISABU, BUCARAMANGA, COLOMBIA. Bucaramanga ; 2023. p. 38–9. Chau V, Dryer R, Brunton R. Examining the relationship between maternal childhood abuse history and mother-infant bonding: The mediating roles of postpartum depression and maternal self-efficacy. Child Abuse Negl. 2023 Nov;145:106439. Kim YM, Oh R, Cho SH, June KJ, Lee JY, Cho HJ, et al. The association of women’s experience of abuse in childhood with depression during pregnancy and the role of emotional support as a moderator. PLoS One. 2023 Jul 26;18(7):e0289044. Brenner I, Ginzburg K, Golan A, Igawa MS, Lurie I, Reicher Y, et al. Peripartum dissociation, sense of control, postpartum posttraumatic stress disorder and emotional adjustment to motherhood in adult survivors of childhood maltreatment. Arch Womens Ment Health. 2024 Feb 18;27(1):127–36. Agnafors S, Bladh M, Svedin CG, Sydsjö G. Mental health in young mothers, single mothers and their children. BMC Psychiatry. 2019 Dec 11;19(1):112. Msipu Phiri T, Nyamaruze P, Akintola O. Perspectives about social support among unmarried pregnant university students in South Africa. PLoS One. 2023 Apr 24;18(4):e0284906. Austin AE, Sokol RL, Rowland C. Medicaid expansion and postpartum depressive symptoms: evidence from the 2009–2018 Pregnancy Risk Assessment Monitoring System survey. Ann Epidemiol. 2022 Apr;68:9–15. Eastwood JG, Jalaludin BB, Kemp LA, Phung HN, Barnett BE. Relationship of postnatal depressive symptoms to infant temperament, maternal expectations, social support and other potential risk factors: findings from a large Australian cross-sectional study. BMC Pregnancy Childbirth. 2012 Dec 12;12(1):148. Montgomery P, Bailey P, Purdon SJ, Snelling SJ, Kauppi C. Women with postpartum depression: “my husband” stories. BMC Nurs. 2009 Dec 5;8(1):8. Yim IS, Tanner Stapleton LR, Guardino CM, Hahn-Holbrook J, Dunkel Schetter C. Biological and Psychosocial Predictors of Postpartum Depression: Systematic Review and Call for Integration. Annu Rev Clin Psychol. 2015 Mar 28;11(1):99– 137. Mercier R, Garrett J, Thorp J, Siega-Riz A. Pregnancy intention and postpartum depression: secondary data analysis from a prospective cohort. BJOG. 2013 Aug 8;120(9):1116–22. Barber GA, Steinberg JR. The association between pregnancy intention, fertility treatment use, and postpartum depression. Soc Sci Med. 2022 Dec;314:115439. Gastaldon C, Solmi M, Correll CU, Barbui C, Schoretsanitis G. Risk factors of postpartum depression and depressive symptoms: umbrella review of current evidence from systematic reviews and meta-analyses of observational studies. The British Journal of Psychiatry. 2022 Oct 27;221(4):591–602.
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spelling	Castro Rueda, Vanesa Alexandraa8d2404c-7ea6-474b-9d3e-27c767c42b54Quintero Roa, Eliana Maribel9550cd86-659f-4c86-b86c-080b018199beOchoa Vera, Miguel Enriqueb2f66b1f-7691-4abf-a110-466c07955478Carrillo Mejía, María Lourdes6c6e966a-bb22-4b3b-b8e1-7703778b62cdOchoa Vera, Miguel Enrique [898465]Quintero Roa, Eliana Maribel [0000802689]Ochoa Vera, Miguel Enrique [0000-0002-4552-3388]Quintero Roa, Eliana Maribel [0000-0002-4355-384X]Ochoa Vera, Miguel Enrique [Miguel_Ochoa7]Semilleros de Investigación UNABOchoa Vera, Miguel Enrique [miguel-enrique-ochoa-vera]Quintero Roa, Eliana Maribel [eliana-maribel-quintero-roa]Ochoa Vera, Miguel Enrique [miguel-enrique-ochoa-vera-ab1468100/]Floridablanca (Santander, Colombia)Bucaramanga (Santander, Colombia)1 de agosto del 2022 y el 30 de abril del 2024UNAB Campus Bucaramanga2025-06-10T16:14:00Z2025-06-10T16:14:00Z2025-05-19http://hdl.handle.net/20.500.12749/29557instname:Universidad Autónoma de Bucaramanga - UNABreponame:Repositorio Institucional UNABrepourl:https://repository.unab.edu.coLa depresión posparto (DPP) es una de las principales complicaciones de la salud mental materna, con consecuencias que trascienden el bienestar de la madre y afectan el desarrollo del recién nacido y la dinámica familiar (1). Se ha identificado como un factor de riesgo significativo para el maltrato infantil y el deterioro del vínculo madre-hijo, lo que subraya la necesidad de su detección y manejo oportuno (2). Sin embargo, la identificación temprana de los síntomas depresivos sigue siendo un reto, en gran parte debido al desconocimiento de los factores de riesgo que predisponen a esta condición. Entre las múltiples intervenciones obstétricas realizadas durante el trabajo de parto, la administración de oxitocina sintética para la inducción o conducción del parto es una de las más frecuentes (3). Aunque su papel en la estimulación de las contracciones uterinas está bien establecido (4), su influencia en los procesos neurobiológicos que regulan el estado de ánimo y el comportamiento social ha generado inquietudes. La oxitocina endógena desempeña un papel clave en la modulación del apego materno, la reducción del estrés y la estabilidad emocional (3); en contraste, el uso exógeno de oxitocina sintética podría alterar estos procesos, interfiriendo con la regulación natural de la hormona y potencialmente aumentando el riesgo de trastornos del estado de ánimo en el puerperio (5). A pesar de que algunos estudios han explorado la relación entre esta intervención obstétrica y el bienestar psicológico materno, los hallazgos han sido inconsistentes. Mientras que algunas investigaciones sugieren una posible asociación entre el uso de oxitocina sintética y un mayor riesgo de DPP (6–8), otros han descrito a la oxitocina sintética como una factor protector (9). Esta incertidumbre pone de manifiesto la necesidad de estudios adicionales que permitan esclarecer esta relación y guíen mejores prácticas en la atención obstétrica. Este estudio busca evaluar la asociación entre la inducción del trabajo de parto con oxitocina sintética y el riesgo de desarrollar depresión a los dos meses posparto a través de un diseño de cohorte prospectiva. Además, se explorarán otros factores de riesgo asociados con la DPP con el objetivo de generar evidencia que contribuya a una atención obstétrica más informada y centrada en la salud mental materna.1. TÍTULO DEL PROYECTO........................................................................................................................... 4 2. RESUMEN............................................................................................................................................... 4 3. PLANTEAMIENTO DEL PROBLEMA .......................................................................................................... 5 4. MARCO TEÓRICO.................................................................................................................................... 7 4.1. OXITOCINA ENDÓGENA.................................................................................................................................. 7 4.2. OXITOCINA SINTÉTICA ................................................................................................................................... 9 4.2.1. Inducción del trabajo de parto....................................................................................................... 10. 4.2.2. Vías de interrupción del sistema oxitocinérgico natural ................................................................ 14 4.2.3. Efectos adversos de la oxitocina sintética relacionados con la depresión posparto ...................... 16 4.3. DEPRESIÓN POSPARTO................................................................................................................................. 18 4.3.1. Epidemiología mundial .................................................................................................................. 19 4.3.2. Epidemiología en Latinoamérica ................................................................................................... 20 4.3.3. Epidemiología en Colombia ........................................................................................................... 20 4.3.4. Factores de riesgo .......................................................................................................................... 21. 4.3.5. Fisiopatología ................................................................................................................................ 22 4.3.6. Presentación clínica ....................................................................................................................... 24 4.3.7. Instrumentos para evaluar la depresión posparto........................................................................ 25 4.3.8. Diagnóstico .................................................................................................................................... 28 5. ESTADO DEL ARTE ................................................................................................................................ 29 6. PREGUNTA DE INVESTIGACIÓN ............................................................................................................ 31 7. HIPÓTESIS ............................................................................................................................................ 31 8. OBJETIVOS..........................................................................................................................................31 8.1. OBJETIVO GENERAL .................................................................................................................................... 31 8.2. OBJETIVOS ESPECÍFICOS .............................................................................................................................. 31 9. METODOLOGÍA ................................................................................................................................... 32 9.1. TIPO DE ESTUDIO ....................................................................................................................................... 32 9.2. POBLACIÓN ............................................................................................................................................... 32 9.3. TAMAÑO DE LA MUESTRA............................................................................................................................ 32 9.4. CRITERIOS DE SELECCIÓN.............................................................................................................................. 32 9.4.1. Criteriosdeinclusión.....................................................................................................................32 9.4.2. Criteriosdeexclusión....................................................................................................................33 9.5. VARIABLES ................................................................................................................................................ 33 9.5.1. Variables independientes............................................................................................................... 33 9.5.2. Variablesdependientes.................................................................................................................35 9.6. INSTRUMENTO.........................................................................................................................................36 9.7. PROCEDIMIENTO DEL ESTUDIO/OBTENCIÓN DE LA INFORMACIÓN ........................................................................ 36 9.7.1. Primera fase.................................................................................................................................. 36 9.7.2. Segundafase.................................................................................................................................37 9.8 PLAN DE ANÁLISIS ................................................................................................................................ 39 9.9. CONSIDERACIONES ÉTICAS ........................................................................................................................... 40 10. RESULTADOS ...................................................................................................................................... 41 11. DISCUSIÓN ......................................................................................................................................... 51 12. CONCLUSIONES .................................................................................................................................. 57 13. RECOMENDACIONES .......................................................................................................................... 58 14. FORTALEZAS....................................................................................................................................... 58 15. LIMITACIONES.................................................................................................................................... 59 16. ANEXOS.............................................................................................................................................. 60 17. BIBLIOGRAFÍA .................................................................................................................................... 71EspecializaciónPostpartum depression (PPD) is one of the most common complications affecting maternal mental health, with consequences that extend beyond the mother's well-being to impact the newborn's development and overall family dynamics (1). It has been identified as a significant risk factor for child maltreatment and impaired mother-infant bonding, underscoring the importance of timely detection and management (2). However, the early identification of depressive symptoms remains a challenge, largely due to the limited understanding of the risk factors that predispose individuals to this condition. Among the various obstetric interventions performed during labor, the administration of synthetic oxytocin for labor induction or augmentation is one of the most frequent (3). While its role in stimulating uterine contractions is well established (4), concerns have emerged regarding its influence on the neurobiological processes that regulate mood and social behavior. Endogenous oxytocin plays a key role in modulating maternal attachment, reducing stress, and promoting emotional stability (3); in contrast, the exogenous administration of synthetic oxytocin may interfere with these natural processes, potentially disrupting hormonal regulation and increasing the risk of mood disorders during the postpartum period (5). Although several studies have investigated the relationship between this obstetric intervention and maternal psychological well-being, findings have been inconsistent. While some research suggests a possible association between synthetic oxytocin use and an increased risk of PPD (6–8), others have described synthetic oxytocin as a protective factor (9). This uncertainty highlights the need for further studies to clarify the nature of this relationship and inform best practices in obstetric care. The present study aims to evaluate the association between labor induction with synthetic oxytocin and the risk of developing postpartum depression at two months postpartum, using a prospective cohort design. Additionally, other risk factors associated with PPD will be explored, with the goal of generating evidence that supports more informed and mental health-centered obstetric care.Modalidad Presencialapplication/pdfspahttp://creativecommons.org/licenses/by-nc-nd/2.5/co/Abierto (Texto Completo)Atribución-NoComercial-SinDerivadas 2.5 Colombiahttp://purl.org/coar/access_right/c_abf2Asociación entre la inducción del trabajo de parto con oxitocina sintética y el riesgo de depresión a los dos meses posparto: Una cohorte prospectivaAssociation Between Labor Induction With Synthetic Oxytocin and the Risk of Depression Two Months Postpartum: A Prospective Cohort StudyEspecialista en Ginecología y ObstetriciaUniversidad Autónoma de Bucaramanga UNABFacultad Ciencias de la SaludEspecialización en Ginecología y ObstetriciaEGO-1385info:eu-repo/semantics/masterThesisTesisinfo:eu-repo/semantics/acceptedVersionhttp://purl.org/redcol/resource_type/TMGynecologyObstetricsMedical sciencesHealth sciencesOxytocinPostpartum depressionMental depressionPostpartum psychiatric disordersPuerperal psychosisGinecologíaCiencias médicasDepresión mentalTrastornos psiquiátricos pospartoPsicosis puerperalCiencias de la saludOxitocinaDepresión pospartoMoraes GP de A, Lorenzo L, Pontes GAR, Montenegro MC, Cantilino A. Triagem e diagnóstico de depressão pós-parto: Quando e como? Trends Psychiatry Psychother. 2017;39(1):54–61.Figueiredo B, Dias CC, Brandão S, Canário C, Nunes-Costa R. Breastfeeding and postpartum depression: State of the art review. J Pediatr (Rio J). 2013;89(4):332– 8.Bell AF, Erickson EN, Carter CS. Beyond labor: The role of natural and synthetic oxytocin in the transition to motherhood. J Midwifery Womens Health. 2014;59(1):35–42.Brunton Laurence, John Lazo, Keith Parker. Goodman & Gilman. Las bases farmacológicas de la Terapéutica. Undécima Edición. McGRAW-HILL, editor. 2007.Marin M, Olza I, Malalana A, González C, Costarelli V, Millán I, et al. Intrapartum synthetic oxytocin reduce the expression of primitive reflexes associated with breastfeeding. Breastfeeding Medicine. 2015 May 1;10(4):209–13.Gu V, Feeley N, Gold I, Hayton B, Robins S, Mackinnon A, et al. Intrapartum Synthetic Oxytocin and Its Effects on Maternal Well-Being at 2 Months Postpartum. Birth. 2016;43(1):28–35.Tichelman E, Warmink-Perdijk W, Henrichs J, Peters L, Schellevis FG, Berger MY, et al. Intrapartum synthetic oxytocin, behavioral and emotional problems in children, and the role of postnatal depressive symptoms, postnatal anxiety and mother-to-infant bonding: A Dutch prospective cohort study. Midwifery. 2021;100.Pesantes T. Inducción de labor de parto con oxitocina como factor de riesgo asociado a depresión puerperal en el Hospital Belén de Trujillo. [Trujillo, Perú]: UNIVERSIDAD PRIVADA ANTENOR ORREGO; 2018.Takács L, Seidlerová JM, Štěrbová Z, Čepický P, Havlíček J. The effects of intrapartum synthetic oxytocin on maternal postpartum mood: findings from a prospective observational study. Arch Womens Ment Health. 2019;22(4):485–91.Sharma V, Sharma P. Postpartum Depression: Diagnostic and Treatment Issues. Journal of Obstetrics and Gynaecology Canada. 2012;34(5):436–42.ACOG COMMITTEE OPINION Number 757 Committee on Obstetric Practice. ACOG Committee Opinion No. 757: Screening for Perinatal Depression. Obstetrics and Gynecology. 2018;132(5):e208–12.Martínez J, Jácome N. Depression in Pregnancy. Rev Colomb Psiquiatr. 2019;48(1):58–65.Wang Z, Liu J, Shuai H, Cai Z, Fu X, Liu Y, et al. Mapping global prevalence of depression among postpartum women. Transl Psychiatry. 2021;11(1).Ministerio de Salud y Protección Social. Encuesta Nacional de Demografía y Salud. Componente de Salud Sexual y Salud Reproductiva. 2015.Latorre J, Contreras L, García S, Arteaga J. La depresión postparto en madres adolescentes de Bucaramanga, Colombia. Rev Colomb Obstet Ginecol. 2006;57(3):156–62.Goodman SH, Gotlib IH. Risk for psychopathology in the children of depressed mothers: A developmental model for understanding mechanisms of transmission. Psychol Rev. 1999;106(3):458–90.Gimpl G, Fahrenholz F. The Oxytocin Receptor System: Structure, Function, and Regulation. Physiol Rev. 2001;81(2):629–83.Martin JA, Hamilton BE, Osterman MJK, Driscoll AK. Births: Final Data for 2019. Natl Vital Stat Rep. 2021;70(2):1–51.Miller S, Abalos E, Chamillard M, Ciapponi A, Colaci D, Comandé D, et al. Beyond too little, too late and too much, too soon: a pathway towards evidence-based, respectful maternity care worldwide. The Lancet. 2016;388(10056):2176–92.Contreras Y, Brito J, Araneda H, Manríquez Camilo, Fuentes Víctor, Parada Vicente. Exposición a oxitocina sintética intraparto y riesgo de depresión post parto. Rev Chil Obstet Ginecol. 2019;84(3):196–207.Uvnäs-Moberg K, Ekström-Bergström A, Berg M, Buckley S, Pajalic Z, Hadjigeorgiou E, et al. Maternal plasma levels of oxytocin during physiological childbirth - A systematic review with implications for uterine contractions and central actions of oxytocin. BMC Pregnancy Childbirth. 2019;19(1).Nucci M, Nakano AR, Teixeira LA. 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Asociación entre la inducción del trabajo de parto con oxitocina sintética y el riesgo de depresión a los dos meses posparto: Una cohorte prospectiva

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