Dengue virus serological prevalence and seroconversion rates in children and adults in Medellin, Colombia : implications for vaccine introduction

ABSTRACT: Background: Dengue is an important public health problem worldwide. A vaccine has recently been licensed in some countries of Latin America and Asia. Recommendations for dengue vaccine introduction include endemicity and a high serological prevalence of dengue in the territories considering its introduction. Methods: A community-based survey was conducted to estimate dengue seroprevalence and age-specific seroconversion rates in a community in Medellin, Colombia, using a dengue serological test (IgG indirect ELISA). Residents were selected at random and were first screened for dengue infection; they were then followed over 2.5 years. Results: A total of 3684 individuals aged between 1 and 65 years participated in at least one survey. The overall dengue seroprevalence was 61%, and only 3.3% of seropositive subjects self-reported a past history of dengue. Among dengue virus (DENV)-naïve subjects with more than two visits (n=1002), the overall seroconversion rate was 8.7% (95% confidence interval 7.3-10.4) per 1000 person-months, over the study period. Overall, the mean age of DENV prevalent subjects was significantly higher than the mean age of seroconverted subjects. Specifically, DENV seropositivity over 70% was observed in participants over 21 years old. Serotype-specific plaque-reduction neutralization tests (PRNT) revealed that all four dengue serotypes were circulating, with DENV4 being most prevalent. Conclusions: These laboratory-based findings could inform dengue vaccine decisions, as they provide age-specific seroprevalence and seroconversion data, evidencing permanent and ongoing dengue transmission in the study area. This study provides evidence for the existing rates of secondary and heterotypic responses, presenting a challenge that must be addressed adequately by the new vaccine candidates

• Autores: Carabali, Mabel; Kyungah Lima, Jacqueline; Vélez, Diana Carolina; Trujillo Correa, Andrea Isabel; Egurrola Pedraza, Jorge Armando; Sung Lee, Kang; Kaufman, Jay S.; DaSilva, Luiz Jacinto; Vélez Bernal, Iván Darío; Osorio Benítez, Jorge Emilio
• Tipo de recurso: Article of investigation
• Fecha de publicación: 2017
• Institución: Universidad de Antioquia
• Repositorio: Repositorio UdeA
• Idioma: eng
• OAI Identifier: oai:bibliotecadigital.udea.edu.co:10495/27884
• Acceso en línea: http://hdl.handle.net/10495/27884
• Palabra clave: Dengue; Prevalence; Prevalencia; Seroconversion; Viral Load; Carga Viral; Child; Niño; Adult; Adulto; Colombia
• Rights: openAccess
• License: http://creativecommons.org/licenses/by-nc-nd/2.5/co/