Impaired IL-23-dependent induction of IFN-g underlies mycobacterial disease in patients with inherited TYK2 deficiency

ABSTRACT: Human cells homozygous for rare loss-of-expression (LOE) TYK2 alleles have impaired, but not abolished, cellular responses to IFN-α/β (underlying viral diseases in the patients) and to IL-12 and IL-23 (underlying mycobacterial diseases). Cells homozygous for the common P1104A TYK2 allele h...

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Autores:

Arias Sierra, Andrés Augusto
Ogishi, Masato
Yang, Rui
Han, Ji Eun
Zhang, Peng
Rinchai, Darawan
Halpern, Joshua
Mulwa, Jeanette
Keating, Narelle
Chrabieh, Maya
Lainé, Candice
Seeleuthner, Yoann
Ramírez Alejo, Noé
Nekooie Marnany, Nioosha
Guennoun, Andrea
Muller Fleckenstein, Ingrid
Fleckenstein, Bernhard
Kilic, Sara S
Minegishi, Yoshiyuki
Ehl, Stephan
Kaiser-Labusch, Petra
Kendir-Demirkol, Yasemin
Rozenberg, Flore
Errami, Abderrahmane
Zhang, Shen Ying
Zhang, Qian
Bohlen, Jonathan
Philippot, Quentin
Puel, Anne
Jouanguy, Emmanuelle
Pourmoghaddas, Zahra
Bakhtiar, Shahrzad
Willasch, Andre M.
Horneff, Gerd
Llanora, Genevieve
Shek, Lynette P.
Chai, Louis Y A.
Tay, Sen Hee
Rahimi, Hamid H.
Mahdaviani, Seyed Alireza
Nepesov, Serdar
Bousfiha, Aziz A.
Erdeniz, Emine Hafize
Karbuz, Adem
Marr, Nico
Navarrete, Carmen
Adeli, Mehdi
Hammarstrom, Lennart
Abolhassani, Hassan
Parvaneh, Nima
Al Muhsen, Saleh
Alosaimi, Mohammed F.
Alsohime, Fahad
Nourizadeh, Maryam
Moin, Mostafa
Arnaout, Rand
Alshareef, Saad
El-Baghdadi, Jamila
Genel, Ferah
Sherkat, Roya
Kiykim, Ayça
Yücel, Esra
Keles, Sevgi
Bustamante, Jacinta
Abel, Laurent
Casanova, Jean Laurent
Boisson Dupuis, Stéphanie

Tipo de recurso:

Article of investigation

Fecha de publicación:

2022

Institución:

Universidad de Antioquia

Repositorio:

Repositorio UdeA

Idioma:

eng

OAI Identifier:

oai:bibliotecadigital.udea.edu.co:10495/40730

Acceso en línea:

https://hdl.handle.net/10495/40730

Palabra clave:

Interferon-gamma
Interferón gamma
Interleukin-23
Interleucina-23
Job Syndrome
Síndrome de Job
TYK2 Kinase
TYK2 Quinasa
https://id.nlm.nih.gov/mesh/D007371
https://id.nlm.nih.gov/mesh/D053759
https://id.nlm.nih.gov/mesh/D007589
https://id.nlm.nih.gov/mesh/D053634

Rights

openAccess

License

https://creativecommons.org/licenses/by/4.0/