Synthesis, characterization and biological evaluation of rare earth complexes against tropical diseases Leishmaniasis, Malaria and Trypanosomiasis
RESUMEN: Complejos lantánidos de Y(III), Ce(III), Nd(III), Sm(III) e Yb(III) con ligandos 4-R-cinamato y 4-R-fenilacetato (R = Cl, CH3O-) fueron sintetizados y caracterizados empleando análisis elemental, conductancia molar, mediciones espectroscópicas (infrarrojo, UV-Vis) y análisis térmico. La eva...
- Autores:
-
Aragón Muriel, Alberto
Muñoz, July
Polo Cerón, Dorian
Robledo Restrepo, Sara María
Upegui Zapata, Yulieth Alexandra
- Tipo de recurso:
- Article of investigation
- Fecha de publicación:
- 2016
- Institución:
- Universidad de Antioquia
- Repositorio:
- Repositorio UdeA
- Idioma:
- eng
- OAI Identifier:
- oai:bibliotecadigital.udea.edu.co:10495/31652
- Acceso en línea:
- https://hdl.handle.net/10495/31652
http://erevistas.saber.ula.ve/index.php/avancesenquimica/article/view/7863
- Palabra clave:
- Elementos de la Serie de los Lantanoides
Lanthanoid Series Elements
Plasmodium falciparum
Leishmania panamensis
Trypanosoma cruzi
Citotoxicidad
Cytotoxicity
http://aims.fao.org/aos/agrovoc/c_34251
- Rights
- openAccess
- License
- https://creativecommons.org/licenses/by-nc-sa/4.0/
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Synthesis, characterization and biological evaluation of rare earth complexes against tropical diseases Leishmaniasis, Malaria and Trypanosomiasis |
| title |
Synthesis, characterization and biological evaluation of rare earth complexes against tropical diseases Leishmaniasis, Malaria and Trypanosomiasis |
| spellingShingle |
Synthesis, characterization and biological evaluation of rare earth complexes against tropical diseases Leishmaniasis, Malaria and Trypanosomiasis Elementos de la Serie de los Lantanoides Lanthanoid Series Elements Plasmodium falciparum Leishmania panamensis Trypanosoma cruzi Citotoxicidad Cytotoxicity http://aims.fao.org/aos/agrovoc/c_34251 |
| title_short |
Synthesis, characterization and biological evaluation of rare earth complexes against tropical diseases Leishmaniasis, Malaria and Trypanosomiasis |
| title_full |
Synthesis, characterization and biological evaluation of rare earth complexes against tropical diseases Leishmaniasis, Malaria and Trypanosomiasis |
| title_fullStr |
Synthesis, characterization and biological evaluation of rare earth complexes against tropical diseases Leishmaniasis, Malaria and Trypanosomiasis |
| title_full_unstemmed |
Synthesis, characterization and biological evaluation of rare earth complexes against tropical diseases Leishmaniasis, Malaria and Trypanosomiasis |
| title_sort |
Synthesis, characterization and biological evaluation of rare earth complexes against tropical diseases Leishmaniasis, Malaria and Trypanosomiasis |
| dc.creator.fl_str_mv |
Aragón Muriel, Alberto Muñoz, July Polo Cerón, Dorian Robledo Restrepo, Sara María Upegui Zapata, Yulieth Alexandra |
| dc.contributor.author.none.fl_str_mv |
Aragón Muriel, Alberto Muñoz, July Polo Cerón, Dorian Robledo Restrepo, Sara María Upegui Zapata, Yulieth Alexandra |
| dc.contributor.researchgroup.spa.fl_str_mv |
Programa de Estudio y Control de Enfermedades Tropicales (PECET) |
| dc.subject.decs.none.fl_str_mv |
Elementos de la Serie de los Lantanoides Lanthanoid Series Elements Plasmodium falciparum Leishmania panamensis Trypanosoma cruzi |
| topic |
Elementos de la Serie de los Lantanoides Lanthanoid Series Elements Plasmodium falciparum Leishmania panamensis Trypanosoma cruzi Citotoxicidad Cytotoxicity http://aims.fao.org/aos/agrovoc/c_34251 |
| dc.subject.agrovoc.none.fl_str_mv |
Citotoxicidad Cytotoxicity |
| dc.subject.agrovocuri.none.fl_str_mv |
http://aims.fao.org/aos/agrovoc/c_34251 |
| description |
RESUMEN: Complejos lantánidos de Y(III), Ce(III), Nd(III), Sm(III) e Yb(III) con ligandos 4-R-cinamato y 4-R-fenilacetato (R = Cl, CH3O-) fueron sintetizados y caracterizados empleando análisis elemental, conductancia molar, mediciones espectroscópicas (infrarrojo, UV-Vis) y análisis térmico. La evaluación de la actividad citotóxica en células U-937 mostró que los complejos lantánidos no son tóxicos contra esta línea romonocítica humana. Todos los compuestos sintetizados fueron examinados para su actividad in vitro contra tres parásitos protozoarios: Leishmania panamensis, Plasmodium falciparum y Trypanosoma cruzi. El complejo de Ce(III) con ligando 4-metoxicinamato, a 20 µg/ml, redujo la infección en 22 % y puede considerarse moderadamente activo contra L. panamensis. Todos los complejos seleccionados demostraron actividad anti-parasitaria contra T. cruzi. |
| publishDate |
2016 |
| dc.date.issued.none.fl_str_mv |
2016 |
| dc.date.accessioned.none.fl_str_mv |
2022-11-01T16:19:20Z |
| dc.date.available.none.fl_str_mv |
2022-11-01T16:19:20Z |
| dc.type.spa.fl_str_mv |
Artículo de investigación |
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http://purl.org/coar/resource_type/c_2df8fbb1 |
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https://purl.org/redcol/resource_type/ART |
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info:eu-repo/semantics/article |
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info:eu-repo/semantics/publishedVersion |
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http://purl.org/coar/resource_type/c_2df8fbb1 |
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1856-5301 |
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https://hdl.handle.net/10495/31652 |
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http://erevistas.saber.ula.ve/index.php/avancesenquimica/article/view/7863 |
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1856-5301 |
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https://hdl.handle.net/10495/31652 http://erevistas.saber.ula.ve/index.php/avancesenquimica/article/view/7863 |
| dc.language.iso.spa.fl_str_mv |
eng |
| language |
eng |
| dc.relation.citationendpage.spa.fl_str_mv |
61 |
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2 |
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53 |
| dc.relation.citationvolume.spa.fl_str_mv |
11 |
| dc.relation.ispartofjournal.spa.fl_str_mv |
Avances en Química |
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https://creativecommons.org/licenses/by-nc-sa/4.0/ |
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Universidad de Los Andes, Facultad de Ciencias |
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Mérida, Venezuela |
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Universidad de Antioquia |
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Aragón Muriel, AlbertoMuñoz, JulyPolo Cerón, DorianRobledo Restrepo, Sara MaríaUpegui Zapata, Yulieth AlexandraPrograma de Estudio y Control de Enfermedades Tropicales (PECET)2022-11-01T16:19:20Z2022-11-01T16:19:20Z20161856-5301https://hdl.handle.net/10495/31652http://erevistas.saber.ula.ve/index.php/avancesenquimica/article/view/7863RESUMEN: Complejos lantánidos de Y(III), Ce(III), Nd(III), Sm(III) e Yb(III) con ligandos 4-R-cinamato y 4-R-fenilacetato (R = Cl, CH3O-) fueron sintetizados y caracterizados empleando análisis elemental, conductancia molar, mediciones espectroscópicas (infrarrojo, UV-Vis) y análisis térmico. La evaluación de la actividad citotóxica en células U-937 mostró que los complejos lantánidos no son tóxicos contra esta línea romonocítica humana. Todos los compuestos sintetizados fueron examinados para su actividad in vitro contra tres parásitos protozoarios: Leishmania panamensis, Plasmodium falciparum y Trypanosoma cruzi. El complejo de Ce(III) con ligando 4-metoxicinamato, a 20 µg/ml, redujo la infección en 22 % y puede considerarse moderadamente activo contra L. panamensis. Todos los complejos seleccionados demostraron actividad anti-parasitaria contra T. cruzi.ABSTRACT:The lanthanide complexes Y(III), Ce(III), Nd(III), Sm(III) and Yb(III) with 4-R-cinnamate and 4-R-phenylacetate (R = Cl, CH3O-) ligands have been synthesized and characterized using elemental analysis, molar conductance, spectroscopic measurements (IR, UV-Vis spectra) and thermal analysis. The evaluation of cytotoxic activity in U-937 cells has revealed that lanthanide complexes are not toxic against this human promonocytic line. All synthesized compounds have been screened for in vitro activity against three parasitic protozoa: Leishmania panamensis, Plasmodium falciparum and Trypanosoma cruzi. The Ce(III) complex with the 4-methoxycinnamate ligand at 20 µg/ml reduces infection by 22 % and may be considered moderately active against L. panamensis. All of the selected complexes demonstrate anti-parasitic activity against T. cruzi.COL00150999application/pdfengUniversidad de Los Andes, Facultad de CienciasMérida, Venezuelahttps://creativecommons.org/licenses/by-nc-sa/4.0/http://creativecommons.org/licenses/by-nc-sa/2.5/co/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Synthesis, characterization and biological evaluation of rare earth complexes against tropical diseases Leishmaniasis, Malaria and TrypanosomiasisArtículo de investigaciónhttp://purl.org/coar/resource_type/c_2df8fbb1https://purl.org/redcol/resource_type/ARThttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionElementos de la Serie de los LantanoidesLanthanoid Series ElementsPlasmodium falciparumLeishmania panamensisTrypanosoma cruziCitotoxicidadCytotoxicityhttp://aims.fao.org/aos/agrovoc/c_342516125311Avances en QuímicaPublicationORIGINALAlbertoAragón_2016_SynthesisCharacterizationBiological.pdfAlbertoAragón_2016_SynthesisCharacterizationBiological.pdfAtículo de investigaciónapplication/pdf545330https://bibliotecadigital.udea.edu.co/bitstreams/b7bb23ef-31e0-4c49-a2a0-7b29c3bb87b7/download8ce31753c59031e9b5b4218a7105966cMD51trueAnonymousREADCC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-81051https://bibliotecadigital.udea.edu.co/bitstreams/2f5bfad6-30bf-4166-850f-4559ea90d60c/downloade2060682c9c70d4d30c83c51448f4eedMD52falseAnonymousREADLICENSElicense.txtlicense.txttext/plain; charset=utf-81748https://bibliotecadigital.udea.edu.co/bitstreams/da7a3aad-c3c6-435f-805b-8e52d148cb56/download8a4605be74aa9ea9d79846c1fba20a33MD53falseAnonymousREADTEXTAlbertoAragón_2016_SynthesisCharacterizationBiological.pdf.txtAlbertoAragón_2016_SynthesisCharacterizationBiological.pdf.txtExtracted texttext/plain39557https://bibliotecadigital.udea.edu.co/bitstreams/88c160ed-f884-4011-8669-f76b2f4834dd/downloadce31666abf8027d1130481ce39694c3bMD54falseAnonymousREADTHUMBNAILAlbertoAragón_2016_SynthesisCharacterizationBiological.pdf.jpgAlbertoAragón_2016_SynthesisCharacterizationBiological.pdf.jpgGenerated Thumbnailimage/jpeg6800https://bibliotecadigital.udea.edu.co/bitstreams/f3ab6248-6cb7-4450-9977-e06790ed570f/download35aa1e083628eea63c51311d39edfe6dMD55falseAnonymousREAD10495/31652oai:bibliotecadigital.udea.edu.co:10495/316522025-03-27 01:19:41.467https://creativecommons.org/licenses/by-nc-sa/4.0/open.accesshttps://bibliotecadigital.udea.edu.coRepositorio Institucional de la Universidad de Antioquiaaplicacionbibliotecadigitalbiblioteca@udea.edu.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 |