Evidence for a Role of the NOS1AP (CAPON) Gene in Schizophrenia and Its Clinical Dimensions: An Association Study in a South American Population Isolate

ABSTRACT: Recent studies have implicated a region on chromosome 1q21-23, including the NOS1AP gene, in susceptibility to schizophrenia. However, replication studies have been inconsistent, a fact that could partly relate to the marked psychopathological heterogeneity of schizophrenia. The aim of this study is to evaluate association of polymorphisms in the NOS1AP gene region to schizophrenia, in patients from a South American population isolate, and to assess if these variants are associated with specific clinical dimensions of the disorder. Methods: We genotyped 24 densely spaced SNPs in the NOS1AP gene region in a schizophrenia trio sample. The transmission disequilibrium test (TDT) was applied to single marker and haplotype data. Association to clinical dimensions (identified by factor analysis) was evaluated using a quantitative transmission disequilibrium test (QTDT). Results: We found significant association between eight SNPs in the NOS1AP gene region to schizophrenia (minimum p value = 0.004). The QTDT analysis of clinical dimensions revealed an association to a dimension consisting mainly of negative symptoms (minimum p value 0.001). Conclusions: Our findings are consistent with a role for NOS1AP in susceptibility to schizophrenia, especially for the ‘negative syndrome’ of the disorder..

• Autores: Arbeláez Montoya, María Patricia; García Valencia, Jenny; Restrepo, Gabriel Jaime; López Jaramillo, Carlos Alberto; Palacio Acosta, Carlos Alberto; Restrepo, Margarita; Bedoya Berrío, Gabriel de Jesús; Ospina Duque, Jorge; Ruíz Linares, Andrés; Kremeyer, Barbara; Kymäläinen, Hanna; Wratten, Naomi; Miranda, Ana Lucía; Brzustowicz, Linda M.
• Tipo de recurso: Article of investigation
• Fecha de publicación: 2009
• Institución: Universidad de Antioquia
• Repositorio: Repositorio UdeA
• Idioma: eng
• OAI Identifier: oai:bibliotecadigital.udea.edu.co:10495/36486
• Acceso en línea: https://hdl.handle.net/10495/36486
• Palabra clave: Esquizofrenia; Schizophrenia; Estudios de Asociación Genética; Genetic Association Studies; Marcadores Genéticos; Genetic Markers; Predisposición Genética a la Enfermedad; Genetic Predisposition to Disease; Proteínas Adaptadoras Transductoras de Señales; Adaptor Proteins, Signal Transducing; Secuencia de Bases; Base Sequence; Estudio de Asociación del Genoma Completo; Genome-Wide Association Study; Polimorfismo de Nucleótido Simple; Polymorphism, Single Nucleotide
• Rights: openAccess
• License: http://creativecommons.org/licenses/by-nc-nd/2.5/co/