In vitro an in vivo efficacy of ether lipid edelfosine against leishmania spp. and SbV-Resistant parasites

ABSTRACT: Background: The leishmaniases are a complex of neglected tropical diseases caused by more than 20 Leishmania parasite species, for which available therapeutic arsenal is scarce and unsatisfactory. Pentavalent antimonials (SbV) are currently the first-line pharmacologic therapy for leishman...

Full description

Autores:

Muñoz Herrera, Diana Lorena
Robledo Restrepo, Sara María
Vélez Bernal, Iván Darío
Muskus López, Carlos Enrique
Varela M., Rubén E.
Villa Pulgarín, Janny A.
Yepes, Edward
Müller, Ingrid
López Abán, Julio
Muro, Antonio
Mollinedo, Faustino
Modolell, Manuel

Tipo de recurso:

Article of investigation

Fecha de publicación:

2012

Institución:

Universidad de Antioquia

Repositorio:

Repositorio UdeA

Idioma:

eng

OAI Identifier:

oai:bibliotecadigital.udea.edu.co:10495/39556

Acceso en línea:

https://hdl.handle.net/10495/39556

Palabra clave:

Antiprotozoarios
Antiprotozoal Agents
Apoptosis
Supervivencia Celular
Cell Survival
Cricetinae
Modelos Animales de Enfermedad
Disease Models, Animal
Éter
Ether
Citometría de Flujo
Flow Cytometry
Leishmania
Leishmaniasis
Lípidos
Lipids
Ratones Endogámicos BALB C
Mice, Inbred BALB C
Pruebas de Sensibilidad Parasitaria
Parasitic Sensitivity Tests
Éteres Fosfolípidos
Phospholipid Ethers
Macrófagos
Macrophages
Mesocricetus
https://id.nlm.nih.gov/mesh/D000981
https://id.nlm.nih.gov/mesh/D017209
https://id.nlm.nih.gov/mesh/D002470
https://id.nlm.nih.gov/mesh/D006224
https://id.nlm.nih.gov/mesh/D004195
https://id.nlm.nih.gov/mesh/D004986
https://id.nlm.nih.gov/mesh/D005434
https://id.nlm.nih.gov/mesh/D007891
https://id.nlm.nih.gov/mesh/D007896
https://id.nlm.nih.gov/mesh/D008055
https://id.nlm.nih.gov/mesh/D008807
https://id.nlm.nih.gov/mesh/D021261
https://id.nlm.nih.gov/mesh/D010742
https://id.nlm.nih.gov/mesh/D008264
https://id.nlm.nih.gov/mesh/D008647

Rights

openAccess

License

https://creativecommons.org/licenses/by/4.0/