First Synthesis of Lissoclimide-Type Alkaloids
ABSTRACT: The first synthesis of lissoclimide-type alkaloids is described. Starting from commercial (+)-sclareolide, the al-dehyde-bicyclohomofarnesal is synthesized and coupled, through an aldol reaction, with succinimide. The antitumor activity of several lissoclimide analogues is also reported.
- Autores:
-
Zapata Londoño, María Bibiana
Betancur Galvis, Liliana Amparo
Ramírez, Dámaris
González Cardenete, Miguel Ángel
- Tipo de recurso:
- Article of investigation
- Fecha de publicación:
- 2009
- Institución:
- Universidad de Antioquia
- Repositorio:
- Repositorio UdeA
- Idioma:
- eng
- OAI Identifier:
- oai:bibliotecadigital.udea.edu.co:10495/43565
- Acceso en línea:
- https://hdl.handle.net/10495/43565
- Palabra clave:
- Diterpenos
Diterpenes
Alcaloides
Alkaloids
Citotoxicidad
Cytotoxicity
http://aims.fao.org/aos/agrovoc/c_34251
https://id.nlm.nih.gov/mesh/D004224
https://id.nlm.nih.gov/mesh/D000470
- Rights
- openAccess
- License
- https://creativecommons.org/licenses/by-nc-nd/4.0/
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| dc.title.spa.fl_str_mv |
First Synthesis of Lissoclimide-Type Alkaloids |
| title |
First Synthesis of Lissoclimide-Type Alkaloids |
| spellingShingle |
First Synthesis of Lissoclimide-Type Alkaloids Diterpenos Diterpenes Alcaloides Alkaloids Citotoxicidad Cytotoxicity http://aims.fao.org/aos/agrovoc/c_34251 https://id.nlm.nih.gov/mesh/D004224 https://id.nlm.nih.gov/mesh/D000470 |
| title_short |
First Synthesis of Lissoclimide-Type Alkaloids |
| title_full |
First Synthesis of Lissoclimide-Type Alkaloids |
| title_fullStr |
First Synthesis of Lissoclimide-Type Alkaloids |
| title_full_unstemmed |
First Synthesis of Lissoclimide-Type Alkaloids |
| title_sort |
First Synthesis of Lissoclimide-Type Alkaloids |
| dc.creator.fl_str_mv |
Zapata Londoño, María Bibiana Betancur Galvis, Liliana Amparo Ramírez, Dámaris González Cardenete, Miguel Ángel |
| dc.contributor.author.none.fl_str_mv |
Zapata Londoño, María Bibiana Betancur Galvis, Liliana Amparo Ramírez, Dámaris González Cardenete, Miguel Ángel |
| dc.contributor.researchgroup.spa.fl_str_mv |
GRID - Grupo de Investigación Dermatológica Infección y Cáncer |
| dc.subject.decs.none.fl_str_mv |
Diterpenos Diterpenes Alcaloides Alkaloids |
| topic |
Diterpenos Diterpenes Alcaloides Alkaloids Citotoxicidad Cytotoxicity http://aims.fao.org/aos/agrovoc/c_34251 https://id.nlm.nih.gov/mesh/D004224 https://id.nlm.nih.gov/mesh/D000470 |
| dc.subject.agrovoc.none.fl_str_mv |
Citotoxicidad Cytotoxicity |
| dc.subject.agrovocuri.none.fl_str_mv |
http://aims.fao.org/aos/agrovoc/c_34251 |
| dc.subject.meshuri.none.fl_str_mv |
https://id.nlm.nih.gov/mesh/D004224 https://id.nlm.nih.gov/mesh/D000470 |
| description |
ABSTRACT: The first synthesis of lissoclimide-type alkaloids is described. Starting from commercial (+)-sclareolide, the al-dehyde-bicyclohomofarnesal is synthesized and coupled, through an aldol reaction, with succinimide. The antitumor activity of several lissoclimide analogues is also reported. |
| publishDate |
2009 |
| dc.date.issued.none.fl_str_mv |
2009 |
| dc.date.accessioned.none.fl_str_mv |
2024-11-18T18:02:30Z |
| dc.date.available.none.fl_str_mv |
2024-11-18T18:02:30Z |
| dc.type.spa.fl_str_mv |
Artículo de investigación |
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http://purl.org/coar/resource_type/c_2df8fbb1 |
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https://purl.org/redcol/resource_type/ART |
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http://purl.org/coar/version/c_970fb48d4fbd8a85 |
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info:eu-repo/semantics/article |
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http://purl.org/coar/resource_type/c_2df8fbb1 |
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publishedVersion |
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Gonzalez, M., Romero, D., Zapata, B., & Betancur-Galvis, L. (2009). First synthesis of lissoclimide-type alkaloids. Letters in organic chemistry, 6(4), 289–292. https://doi.org/10.2174/157017809788489828 |
| dc.identifier.issn.none.fl_str_mv |
1570-1786 |
| dc.identifier.uri.none.fl_str_mv |
https://hdl.handle.net/10495/43565 |
| dc.identifier.doi.none.fl_str_mv |
10.2174/157017809788489828 |
| dc.identifier.eissn.none.fl_str_mv |
1875-6255 |
| identifier_str_mv |
Gonzalez, M., Romero, D., Zapata, B., & Betancur-Galvis, L. (2009). First synthesis of lissoclimide-type alkaloids. Letters in organic chemistry, 6(4), 289–292. https://doi.org/10.2174/157017809788489828 1570-1786 10.2174/157017809788489828 1875-6255 |
| url |
https://hdl.handle.net/10495/43565 |
| dc.language.iso.spa.fl_str_mv |
eng |
| language |
eng |
| dc.relation.ispartofjournalabbrev.spa.fl_str_mv |
Lett. Org. Chem. |
| dc.relation.citationendpage.spa.fl_str_mv |
292 |
| dc.relation.citationstartpage.spa.fl_str_mv |
289 |
| dc.relation.citationvolume.spa.fl_str_mv |
6 |
| dc.relation.ispartofjournal.spa.fl_str_mv |
Letters in Organic Chemistry |
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https://creativecommons.org/licenses/by-nc-nd/4.0/ |
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openAccess |
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4 páginas |
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application/pdf |
| dc.publisher.spa.fl_str_mv |
Bentham Science Publishers |
| dc.publisher.place.spa.fl_str_mv |
Sarja, Emiratos Árabes Unidos |
| institution |
Universidad de Antioquia |
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Zapata Londoño, María BibianaBetancur Galvis, Liliana AmparoRamírez, DámarisGonzález Cardenete, Miguel ÁngelGRID - Grupo de Investigación DermatológicaInfección y Cáncer2024-11-18T18:02:30Z2024-11-18T18:02:30Z2009Gonzalez, M., Romero, D., Zapata, B., & Betancur-Galvis, L. (2009). First synthesis of lissoclimide-type alkaloids. Letters in organic chemistry, 6(4), 289–292. https://doi.org/10.2174/1570178097884898281570-1786https://hdl.handle.net/10495/4356510.2174/1570178097884898281875-6255ABSTRACT: The first synthesis of lissoclimide-type alkaloids is described. Starting from commercial (+)-sclareolide, the al-dehyde-bicyclohomofarnesal is synthesized and coupled, through an aldol reaction, with succinimide. The antitumor activity of several lissoclimide analogues is also reported.Universidad de AntioquiaColombia. Ministerio de Ciencia, Tecnología e Innovación - MinCienciasCOL0050839COL00123284 páginasapplication/pdfengBentham Science PublishersSarja, Emiratos Árabes Unidoshttps://creativecommons.org/licenses/by-nc-nd/4.0/http://creativecommons.org/licenses/by-nc-nd/2.5/co/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2First Synthesis of Lissoclimide-Type AlkaloidsArtículo de investigaciónhttp://purl.org/coar/resource_type/c_2df8fbb1https://purl.org/redcol/resource_type/ARThttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionDiterpenosDiterpenesAlcaloidesAlkaloidsCitotoxicidadCytotoxicityhttp://aims.fao.org/aos/agrovoc/c_34251https://id.nlm.nih.gov/mesh/D004224https://id.nlm.nih.gov/mesh/D000470Lett. Org. 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