First Synthesis of Lissoclimide-Type Alkaloids
ABSTRACT: The first synthesis of lissoclimide-type alkaloids is described. Starting from commercial (+)-sclareolide, the al-dehyde-bicyclohomofarnesal is synthesized and coupled, through an aldol reaction, with succinimide. The antitumor activity of several lissoclimide analogues is also reported.
- Autores:
-
Zapata Londoño, María Bibiana
Betancur Galvis, Liliana Amparo
Ramírez, Dámaris
González Cardenete, Miguel Ángel
- Tipo de recurso:
- Article of investigation
- Fecha de publicación:
- 2009
- Institución:
- Universidad de Antioquia
- Repositorio:
- Repositorio UdeA
- Idioma:
- eng
- OAI Identifier:
- oai:bibliotecadigital.udea.edu.co:10495/43565
- Acceso en línea:
- https://hdl.handle.net/10495/43565
- Palabra clave:
- Diterpenos
Diterpenes
Alcaloides
Alkaloids
Citotoxicidad
Cytotoxicity
http://aims.fao.org/aos/agrovoc/c_34251
https://id.nlm.nih.gov/mesh/D004224
https://id.nlm.nih.gov/mesh/D000470
- Rights
- openAccess
- License
- https://creativecommons.org/licenses/by-nc-nd/4.0/
| Summary: | ABSTRACT: The first synthesis of lissoclimide-type alkaloids is described. Starting from commercial (+)-sclareolide, the al-dehyde-bicyclohomofarnesal is synthesized and coupled, through an aldol reaction, with succinimide. The antitumor activity of several lissoclimide analogues is also reported. |
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