Huberine, a New Canthin-6-One Alkaloid from the Bark of Picrolemma huberi
ABSTRACT: A new alkaloid, Canthin-6-one, Huberine (1), together with three known compounds including 1-Hydroxy-canthin-6-one (2), Canthin-6-one (3) and stigma sterol (4), were isolated from the stem bark of Picrolemma huberi. The isolation was achieved by chromatographic techniques and the purificat...
- Autores:
-
López Córdoba, Carlos Alberto
Pastrana Restrepo, Manuel Humberto
Ríos Orrego, Alexandra Marcela
Cogollo Pacheco, Álvaro Alfonso
Pabón Vidal, Adriana Lucía
- Tipo de recurso:
- Article of investigation
- Fecha de publicación:
- 2018
- Institución:
- Universidad de Antioquia
- Repositorio:
- Repositorio UdeA
- Idioma:
- eng
- OAI Identifier:
- oai:bibliotecadigital.udea.edu.co:10495/23670
- Acceso en línea:
- http://hdl.handle.net/10495/23670
- Palabra clave:
- Simaroubaceae
Canthin-6-one
Picrolemma huberi
Actividad antiplasmodial
http://aims.fao.org/aos/agrovoc/c_26241
- Rights
- openAccess
- License
- https://creativecommons.org/licenses/by/4.0/
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| dc.title.spa.fl_str_mv |
Huberine, a New Canthin-6-One Alkaloid from the Bark of Picrolemma huberi |
| title |
Huberine, a New Canthin-6-One Alkaloid from the Bark of Picrolemma huberi |
| spellingShingle |
Huberine, a New Canthin-6-One Alkaloid from the Bark of Picrolemma huberi Simaroubaceae Canthin-6-one Picrolemma huberi Actividad antiplasmodial http://aims.fao.org/aos/agrovoc/c_26241 |
| title_short |
Huberine, a New Canthin-6-One Alkaloid from the Bark of Picrolemma huberi |
| title_full |
Huberine, a New Canthin-6-One Alkaloid from the Bark of Picrolemma huberi |
| title_fullStr |
Huberine, a New Canthin-6-One Alkaloid from the Bark of Picrolemma huberi |
| title_full_unstemmed |
Huberine, a New Canthin-6-One Alkaloid from the Bark of Picrolemma huberi |
| title_sort |
Huberine, a New Canthin-6-One Alkaloid from the Bark of Picrolemma huberi |
| dc.creator.fl_str_mv |
López Córdoba, Carlos Alberto Pastrana Restrepo, Manuel Humberto Ríos Orrego, Alexandra Marcela Cogollo Pacheco, Álvaro Alfonso Pabón Vidal, Adriana Lucía |
| dc.contributor.author.none.fl_str_mv |
López Córdoba, Carlos Alberto Pastrana Restrepo, Manuel Humberto Ríos Orrego, Alexandra Marcela Cogollo Pacheco, Álvaro Alfonso Pabón Vidal, Adriana Lucía |
| dc.contributor.researchgroup.spa.fl_str_mv |
Análisis de Residuos Grupo Malaria |
| dc.subject.agrovoc.none.fl_str_mv |
Simaroubaceae |
| topic |
Simaroubaceae Canthin-6-one Picrolemma huberi Actividad antiplasmodial http://aims.fao.org/aos/agrovoc/c_26241 |
| dc.subject.proposal.spa.fl_str_mv |
Canthin-6-one Picrolemma huberi Actividad antiplasmodial |
| dc.subject.agrovocuri.none.fl_str_mv |
http://aims.fao.org/aos/agrovoc/c_26241 |
| description |
ABSTRACT: A new alkaloid, Canthin-6-one, Huberine (1), together with three known compounds including 1-Hydroxy-canthin-6-one (2), Canthin-6-one (3) and stigma sterol (4), were isolated from the stem bark of Picrolemma huberi. The isolation was achieved by chromatographic techniques and the purification was performed on a C18 column using acetonitrile/water (90:10, v/v) with 0.1% formic acid as the mobile phase. The structural elucidation was performed via spectroscopic methods, notably 1D- and 2D-NMR, UV, IR, MS and HRMS. The antiplasmodial activity of the compounds was studied. |
| publishDate |
2018 |
| dc.date.issued.none.fl_str_mv |
2018 |
| dc.date.accessioned.none.fl_str_mv |
2021-10-30T00:40:05Z |
| dc.date.available.none.fl_str_mv |
2021-10-30T00:40:05Z |
| dc.type.spa.fl_str_mv |
Artículo de investigación |
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http://purl.org/coar/resource_type/c_2df8fbb1 |
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https://purl.org/redcol/resource_type/ART |
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http://purl.org/coar/version/c_970fb48d4fbd8a85 |
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info:eu-repo/semantics/article |
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http://purl.org/coar/resource_type/c_2df8fbb1 |
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López, C., Pastrana, M., Ríos, A., Cogollo, A. y Pabón, A. (2018). Huberine, un nuevo alcaloide Canthin-6-One de la corteza de Picrolemma huberi. Moléculas , 23 (4), 934. doi: 10.3390/moléculas23040934 |
| dc.identifier.uri.none.fl_str_mv |
http://hdl.handle.net/10495/23670 |
| dc.identifier.doi.none.fl_str_mv |
10.3390/molecules23040934 |
| dc.identifier.eissn.none.fl_str_mv |
1420-3049 |
| identifier_str_mv |
López, C., Pastrana, M., Ríos, A., Cogollo, A. y Pabón, A. (2018). Huberine, un nuevo alcaloide Canthin-6-One de la corteza de Picrolemma huberi. Moléculas , 23 (4), 934. doi: 10.3390/moléculas23040934 10.3390/molecules23040934 1420-3049 |
| url |
http://hdl.handle.net/10495/23670 |
| dc.language.iso.spa.fl_str_mv |
eng |
| language |
eng |
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Molecules |
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5 |
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4 |
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1 |
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23 |
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Molecules |
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https://creativecommons.org/licenses/by/4.0/ |
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MDPI |
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Basilea, Suiza |
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Universidad de Antioquia |
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López Córdoba, Carlos AlbertoPastrana Restrepo, Manuel HumbertoRíos Orrego, Alexandra MarcelaCogollo Pacheco, Álvaro AlfonsoPabón Vidal, Adriana LucíaAnálisis de ResiduosGrupo Malaria2021-10-30T00:40:05Z2021-10-30T00:40:05Z2018López, C., Pastrana, M., Ríos, A., Cogollo, A. y Pabón, A. (2018). Huberine, un nuevo alcaloide Canthin-6-One de la corteza de Picrolemma huberi. Moléculas , 23 (4), 934. doi: 10.3390/moléculas23040934http://hdl.handle.net/10495/2367010.3390/molecules230409341420-3049ABSTRACT: A new alkaloid, Canthin-6-one, Huberine (1), together with three known compounds including 1-Hydroxy-canthin-6-one (2), Canthin-6-one (3) and stigma sterol (4), were isolated from the stem bark of Picrolemma huberi. The isolation was achieved by chromatographic techniques and the purification was performed on a C18 column using acetonitrile/water (90:10, v/v) with 0.1% formic acid as the mobile phase. The structural elucidation was performed via spectroscopic methods, notably 1D- and 2D-NMR, UV, IR, MS and HRMS. The antiplasmodial activity of the compounds was studied.COL0007524COL00004615application/pdfengMDPIBasilea, Suizahttps://creativecommons.org/licenses/by/4.0/http://creativecommons.org/licenses/by/2.5/co/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Huberine, a New Canthin-6-One Alkaloid from the Bark of Picrolemma huberiArtículo de investigaciónhttp://purl.org/coar/resource_type/c_2df8fbb1https://purl.org/redcol/resource_type/ARThttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionSimaroubaceaeCanthin-6-onePicrolemma huberiActividad antiplasmodialhttp://aims.fao.org/aos/agrovoc/c_26241Molecules54123MoleculesPublicationORIGINALPabónAdriana_2018_HuberineAlkaloidPicrolemma.pdfPabónAdriana_2018_HuberineAlkaloidPicrolemma.pdfArtículo de investigaciónapplication/pdf403520https://bibliotecadigital.udea.edu.co/bitstreams/5c3e6b89-1ab8-4868-a1bc-bbf2fb32d3e0/download603934f1ca28ddbcbed2b90ff8c66c3bMD51trueAnonymousREADCC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-8927https://bibliotecadigital.udea.edu.co/bitstreams/d8171b0f-f120-4ed9-a649-b5e762e288be/download1646d1f6b96dbbbc38035efc9239ac9cMD52falseAnonymousREADLICENSElicense.txtlicense.txttext/plain; charset=utf-81748https://bibliotecadigital.udea.edu.co/bitstreams/7eab5a6e-12e5-4ac2-8ae9-4eed5ba366c3/download8a4605be74aa9ea9d79846c1fba20a33MD53falseAnonymousREADTEXTPabónAdriana_2018_HuberineAlkaloidPicrolemma.pdf.txtPabónAdriana_2018_HuberineAlkaloidPicrolemma.pdf.txtExtracted texttext/plain20856https://bibliotecadigital.udea.edu.co/bitstreams/8218f8c6-9dfa-4235-86ac-405dc06206f0/download714595456bfc411861b49d918e32268fMD54falseAnonymousREADTHUMBNAILPabónAdriana_2018_HuberineAlkaloidPicrolemma.pdf.jpgPabónAdriana_2018_HuberineAlkaloidPicrolemma.pdf.jpgGenerated Thumbnailimage/jpeg13716https://bibliotecadigital.udea.edu.co/bitstreams/e9e58a91-bfec-4a83-975f-f7b0a248fd4a/downloadac4d665e1e4635ec713c4059c7d04aa0MD55falseAnonymousREAD10495/23670oai:bibliotecadigital.udea.edu.co:10495/236702025-03-26 23:19:37.975https://creativecommons.org/licenses/by/4.0/open.accesshttps://bibliotecadigital.udea.edu.coRepositorio Institucional de la Universidad de Antioquiaaplicacionbibliotecadigitalbiblioteca@udea.edu.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 |