Synthesis and leishmanicidal activity of new bis-alkylquinolines

Bis-alkylquinolines 1–6 were synthesized via Williamson reaction between 8-hydroxyquinoline with different 1,ω-dibromoalkanes. Structures of all the products were elucidated by spectroscopic analysis. Cytotoxic and leishmanicidal activities of synthesized compounds were determined on U-937 cells and L. (V.) panamensis amastigotes, respectively. Compound 5, [3,3'-(pentane-1,5-diylbis(oxy))bisquinoline], was the most selective against axenic and intracellular amastigotes (EC₅₀ = 1.13 and 2.26 µg/mL), with selectivity indices greater than 17.7 and 8.3, respectively; which makes this compound promising for the designing of new leishmanicidal drugs.

• Autores: Robledo Restrepo, Sara María; Vélez Bernal, Iván Darío; Muñoz Herrera, Diana Lorena; Cardona Galeano, Wilson; Arango Valencia, Víctor Hugo; Domínguez, Jorge J.; Figadere, Bruno; Sáez Vega, Jairo Antonio
• Tipo de recurso: Article of investigation
• Fecha de publicación: 2013
• Institución: Universidad de Antioquia
• Repositorio: Repositorio UdeA
• Idioma: eng
• OAI Identifier: oai:bibliotecadigital.udea.edu.co:10495/47247
• Acceso en línea: https://hdl.handle.net/10495/47247
• Palabra clave: Leishmaniasis; Antiprotozoarios; Antiprotozoal Agents; antiprotozoal, quinoline; https://id.nlm.nih.gov/mesh/D007896; https://id.nlm.nih.gov/mesh/D000981; ODS 3: Salud y bienestar. Garantizar una vida sana y promover el bienestar de todos a todas las edades
• Rights: openAccess
• License: http://creativecommons.org/licenses/by-nc/4.0/