A Phenotypic Approach for IUIS PID Classification and Diagnosis: Guidelines for Clinicians at the Bedside

ABSTRACT: The number of genetically defined Primary Immunodeficiency Diseases (PID) has increased exponentially, especially in the past decade. The biennial classification published by the IUIS PID expert committee is therefore quickly expanding, providing valuable information regarding the disease-causing genotypes, the immunological anomalies, and the associated clinical features of PIDs. These are grouped in eight, somewhat overlapping, categories of immune dysfunction. However, based on this immunological classification, the diagnosis of a specific PID from the clinician's observation of an individual clinical and/or immunological phenotype remains difficult, especially for non-PID specialists. The purpose of this work is to suggest a phenotypic classification that forms the basis for diagnostic trees, leading the physician to particular groups of PIDs, starting from clinical features and combining routine immunological investigations along the way. We present 8 colored diagnostic figures that correspond to the 8 PID groups in the IUIS Classification, including all the PIDs cited in the 2011 update of the IUIS classification and most of those reported since.

• Autores: Franco Restrepo, José Luis; Bousfiha, Ahmed Aziz; Jeddane, Leïla; Ailal, Fatima; Al Herz, Waleed; Conley, Mary Ellen; Cunningham Rundles, Charlotte; Etzioni, Amos; Fischer, Alain; Geha, Raif S.; Hammarström, Lennart; Nonoyama, Shigeaki; Ochs, Hans D.; Roifman, Chaim M.; Seger, Reinhard; Tang, Mimi L. K.; Puck, Jennifer M.; Chapel, Helen; Notarangelo, Luigi D.; Casanova, Jean Laurent
• Tipo de recurso: Article of investigation
• Fecha de publicación: 2013
• Institución: Universidad de Antioquia
• Repositorio: Repositorio UdeA
• Idioma: eng
• OAI Identifier: oai:bibliotecadigital.udea.edu.co:10495/43126
• Acceso en línea: https://hdl.handle.net/10495/43126
• Palabra clave: Algorithms; Algoritmos; Diagnosis, Differential; Diagnóstico Diferencial; Diagnostic Tests, Routine; Pruebas Diagnósticas de Rutina; Genotype; Genotipo; Immunologic Deficiency Syndromes; Síndromes de Inmunodeficiencia; Immunologic Tests; Pruebas Inmunológicas; Phenotype; Fenotipo; Practice Guidelines as Topic; Guías de Práctica Clínica como Asunto; https://id.nlm.nih.gov/mesh/D000465; https://id.nlm.nih.gov/mesh/D003937; https://id.nlm.nih.gov/mesh/D003955; https://id.nlm.nih.gov/mesh/D005838; https://id.nlm.nih.gov/mesh/D007153; https://id.nlm.nih.gov/mesh/D007159; https://id.nlm.nih.gov/mesh/D010641; https://id.nlm.nih.gov/mesh/D017410
• Rights: openAccess
• License: https://creativecommons.org/licenses/by/4.0/